Dimethyl fumarate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.153137
FAT1 FAT atypical cadherin 1 0.108854
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0921595
ITGA6 integrin, alpha 6 0.0912614
EZR ezrin 0.0907969
TNS4 tensin 4 0.0805649
NDRG1 N-myc downstream regulated 1 0.0756443
SPTBN1 spectrin, beta, non-erythrocytic 1 0.074454
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0739054
FAM13A family with sequence similarity 13, member A 0.0733003
ANXA2 annexin A2 0.072356
FLNB filamin B, beta 0.0716281
DSPP dentin sialophosphoprotein 0.0703605
KRT8 keratin 8, type II 0.0696437
ASPH aspartate beta-hydroxylase 0.0639293
TXNIP thioredoxin interacting protein 0.0619138
ACTN4 actinin, alpha 4 0.0613501
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0586034
FTH1 ferritin, heavy polypeptide 1 0.058213
MYH9 myosin, heavy chain 9, non-muscle 0.0560876
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0547534
PRELID2 PRELI domain containing 2 0.0540902
ARHGAP32 Rho GTPase activating protein 32 0.0536912
GPHN gephyrin 0.0521635
ARHGAP26 Rho GTPase activating protein 26 0.0508738
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0490715
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0478009
RREB1 ras responsive element binding protein 1 0.0469292
MED13L mediator complex subunit 13-like 0.0461687
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0444461
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0437703
CCNY cyclin Y 0.043085
PRSS3 protease, serine, 3 0.042526
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0419214
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0418327
EREG epiregulin 0.0414282
EEF2 eukaryotic translation elongation factor 2 0.0413807
CD46 CD46 molecule, complement regulatory protein 0.0411688
ZNF292 zinc finger protein 292 0.0408009
RNF43 ring finger protein 43 0.0406733
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.040451
ESYT2 extended synaptotagmin-like protein 2 0.0402302
ANXA11 annexin A11 0.0402088
H1-0 H1.0 linker histone 0.0394861
EPHA2 EPH receptor A2 0.0375136
TRIM2 tripartite motif containing 2 0.0374519
HSPA8 heat shock 70kDa protein 8 0.0374306
CADPS Ca++-dependent secretion activator 0.0371584
UBA6 ubiquitin-like modifier activating enzyme 6 0.0368804
MACF1 microtubule-actin crosslinking factor 1 0.0366484
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.036587
ENO1 enolase 1, (alpha) 0.0364599
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0361528
NPSR1 neuropeptide S receptor 1 0.0359385
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.035677
SRRM2 serine/arginine repetitive matrix 2 0.0353189
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0347667
ANKRD11 ankyrin repeat domain 11 0.0347249
LPP LIM domain containing preferred translocation partner in lipoma 0.034628
CALB1 calbindin 1, 28kDa 0.0343924
GREB1L growth regulation by estrogen in breast cancer-like 0.03433
ATXN1 ataxin 1 0.03432
UBE2H ubiquitin-conjugating enzyme E2H 0.0342841
GRB10 growth factor receptor-bound protein 10 0.0341924
GMDS GDP-mannose 4,6-dehydratase 0.0340857
ARHGAP12 Rho GTPase activating protein 12 0.0339
RPL3 ribosomal protein L3 0.0335723
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0334387
AKAP13 A kinase (PRKA) anchor protein 13 0.0330632
KMT2C lysine (K)-specific methyltransferase 2C 0.0327602
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0327446
DNM2 dynamin 2 0.0325783
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0324732
NALF1 NALCN channel auxiliary factor 1 0.0323898
PTEN phosphatase and tensin homolog 0.0322712
LDHA lactate dehydrogenase A 0.0322303
DSCAM Down syndrome cell adhesion molecule 0.0321705
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0319329
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0316342
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0315712
ABHD2 abhydrolase domain containing 2 0.0315689
SHB Src homology 2 domain containing adaptor protein B 0.031278
VEGFA vascular endothelial growth factor A 0.0309003
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0308262
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0304094
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0303619
MED13 mediator complex subunit 13 0.0302883
FOS FBJ murine osteosarcoma viral oncogene homolog 0.030287
FHL2 four and a half LIM domains 2 0.029962
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0298843
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.029841
KDM4C lysine (K)-specific demethylase 4C 0.0297345
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0296478
PPARG peroxisome proliferator-activated receptor gamma 0.0295557
BIRC6 baculoviral IAP repeat containing 6 0.0293701
CENPF centromere protein F, 350/400kDa 0.0292895
EHF ets homologous factor 0.0292819
PTK2 protein tyrosine kinase 2 0.0291448
DENND4C DENN/MADD domain containing 4C 0.028996
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0289498

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11518
TMSB10 thymosin beta 10 -0.0915009
RPS6 ribosomal protein S6 -0.0776963
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0736219
PTMA prothymosin, alpha -0.0683773
TPT1 tumor protein, translationally-controlled 1 -0.0632943
RPS19 ribosomal protein S19 -0.0589167
RPLP1 ribosomal protein, large, P1 -0.0565168
RPL34 ribosomal protein L34 -0.0507503
RPS8 ribosomal protein S8 -0.0499506
RPL35A ribosomal protein L35a -0.0480487
RPL12 ribosomal protein L12 -0.046008
RPLP2 ribosomal protein, large, P2 -0.0441969
MT2A metallothionein 2A -0.0439325
RPS23 ribosomal protein S23 -0.0429527
EIF1 eukaryotic translation initiation factor 1 -0.0418643
RPS24 ribosomal protein S24 -0.0395459
RPS27A ribosomal protein S27a -0.0392729
RPS29 ribosomal protein S29 -0.039177
RPL36 ribosomal protein L36 -0.0383823
AGR2 anterior gradient 2 -0.036305
S100P S100 calcium binding protein P -0.0359473
RPL31 ribosomal protein L31 -0.0348665
RPS25 ribosomal protein S25 -0.0346523
RPS27 ribosomal protein S27 -0.0343662
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0343188
FTL ferritin, light polypeptide -0.0333135
RPS3 ribosomal protein S3 -0.0325576
RPL32 ribosomal protein L32 -0.0315963
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0312395
RPL7 ribosomal protein L7 -0.031073
S100A9 S100 calcium binding protein A9 -0.0308485
RPS13 ribosomal protein S13 -0.0303604
RPL23 ribosomal protein L23 -0.0302874
RPL9 ribosomal protein L9 -0.0291414
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0289132
RPL37A ribosomal protein L37a -0.0288291
RPL26 ribosomal protein L26 -0.0287247
S100A6 S100 calcium binding protein A6 -0.0272199
RPS12 ribosomal protein S12 -0.0266816
RPS14 ribosomal protein S14 -0.0265953
RPS16 ribosomal protein S16 -0.0247988
RPL38 ribosomal protein L38 -0.0236472
RPL18 ribosomal protein L18 -0.0236127
RACK1 receptor for activated C kinase 1 -0.0232908
IER3 immediate early response 3 -0.0230964
S100A10 S100 calcium binding protein A10 -0.0223144
RPLP0 ribosomal protein, large, P0 -0.0219808
RPL19 ribosomal protein L19 -0.0214924
RPS11 ribosomal protein S11 -0.0213564
RPL8 ribosomal protein L8 -0.0200561
RPL36A ribosomal protein L36a -0.0199875
MT1X metallothionein 1X -0.0198234
MT1E metallothionein 1E -0.0195954
RPS20 ribosomal protein S20 -0.0193885
RPS21 ribosomal protein S21 -0.0188054
RPL5 ribosomal protein L5 -0.0184197
RPL30 ribosomal protein L30 -0.0184101
POF1B premature ovarian failure, 1B -0.0182571
RPS10 ribosomal protein S10 -0.0182031
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0177087
GDF15 growth differentiation factor 15 -0.0173517
ISG15 ISG15 ubiquitin-like modifier -0.0168747
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0168469
RPL35 ribosomal protein L35 -0.0164221
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0162784
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0161632
RPL28 ribosomal protein L28 -0.0159827
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0157776
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0156292
RPL11 ribosomal protein L11 -0.0155079
CALR calreticulin -0.015496
RPL7A ribosomal protein L7a -0.0153216
RPS15 ribosomal protein S15 -0.0150358
RPL10A ribosomal protein L10a -0.0149725
SELENOK selenoprotein K -0.014813
SOX4 SRY (sex determining region Y)-box 4 -0.0147779
RPL27A ribosomal protein L27a -0.0145289
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0144727
EIF5B eukaryotic translation initiation factor 5B -0.0141188
TFF1 trefoil factor 1 -0.0140207
BTN3A3 butyrophilin, subfamily 3, member A3 -0.0138836
RTN3 reticulon 3 -0.0137264
RPS17 ribosomal protein S17 -0.0134898
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.013404
TFF3 trefoil factor 3 (intestinal) -0.0133691
BTG1 B-cell translocation gene 1, anti-proliferative -0.0133088
SEC61G Sec61 gamma subunit -0.0132686
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.013152
RPS5 ribosomal protein S5 -0.0128968
CCND1 cyclin D1 -0.0128608
UQCRB ubiquinol-cytochrome c reductase binding protein -0.012525
RPL36AL ribosomal protein L36a-like -0.0123731
RPL15 ribosomal protein L15 -0.0122597
NPR2 natriuretic peptide receptor 2 -0.0121335
NAP1L1 nucleosome assembly protein 1-like 1 -0.0118257
CCNI cyclin I -0.0118104
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.011695
TBCA tubulin folding cofactor A -0.011538
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0114949