Dimethyl fumarate_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.15415
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.112676
TXNRD1 thioredoxin reductase 1 0.10172
EZR ezrin 0.0739086
TM4SF1 transmembrane 4 L six family member 1 0.0707307
AHNAK AHNAK nucleoprotein 0.0705489
SLC38A2 solute carrier family 38, member 2 0.0661563
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0641858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0613934
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0613736
APP amyloid beta (A4) precursor protein 0.0606404
SPAG9 sperm associated antigen 9 0.0594756
PGK1 phosphoglycerate kinase 1 0.0549646
BCAR3 breast cancer anti-estrogen resistance 3 0.054808
RTN4 reticulon 4 0.049718
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.048806
FMNL2 formin-like 2 0.0474757
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0466175
CANX calnexin 0.0463222
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0458765
EEF2 eukaryotic translation elongation factor 2 0.0456877
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0453663
MACF1 microtubule-actin crosslinking factor 1 0.0441123
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0440803
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0428914
HSPA8 heat shock 70kDa protein 8 0.0420843
EREG epiregulin 0.0420131
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0415399
ADAM17 ADAM metallopeptidase domain 17 0.0414832
JMJD1C jumonji domain containing 1C 0.0411771
RAI1 retinoic acid induced 1 0.0410566
ADGRG6 adhesion G protein-coupled receptor G6 0.0407506
TRIP12 thyroid hormone receptor interactor 12 0.040686
MYH9 myosin, heavy chain 9, non-muscle 0.0397678
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0384339
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0380077
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0369418
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0369417
LOC112694756 uncharaterized LOC112694756 0.036753
CENPF centromere protein F, 350/400kDa 0.0366527
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0364691
ENO1 enolase 1, (alpha) 0.036345
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0359683
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0358204
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0352865
KMT2C lysine (K)-specific methyltransferase 2C 0.0350128
LDHA lactate dehydrogenase A 0.0343367
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0342418
OGA O-GlcNAcase 0.0342291
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0340191
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0335914
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0334843
KMT2E lysine (K)-specific methyltransferase 2E 0.0334664
TRIO trio Rho guanine nucleotide exchange factor 0.03337
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.032646
XPO1 exportin 1 0.0324166
NAMPT nicotinamide phosphoribosyltransferase 0.0315572
PODXL podocalyxin-like 0.0313752
YEATS2 YEATS domain containing 2 0.0311023
CAPRIN2 caprin family member 2 0.0309908
HOOK2 hook microtubule-tethering protein 2 0.0309716
DENND5A DENN/MADD domain containing 5A 0.0308533
PYGB phosphorylase, glycogen; brain 0.0306611
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0306496
ANXA1 annexin A1 0.0303076
ANLN anillin, actin binding protein 0.0300579
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0300274
FLNB filamin B, beta 0.0298213
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0298048
TOP1 topoisomerase (DNA) I 0.0296593
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0291279
PRRC2A proline-rich coiled-coil 2A 0.0290464
TMSB4X thymosin beta 4, X-linked 0.0286981
RLF rearranged L-myc fusion 0.0282059
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0276214
KDM3A lysine (K)-specific demethylase 3A 0.0274943
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0274932
EMP1 epithelial membrane protein 1 0.0272893
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0269346
BIRC2 baculoviral IAP repeat containing 2 0.0269326
CD44 CD44 molecule (Indian blood group) 0.0267517
ZNF217 zinc finger protein 217 0.0265995
ARHGAP5 Rho GTPase activating protein 5 0.0265324
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0265034
USP34 ubiquitin specific peptidase 34 0.0264906
RBM39 RNA binding motif protein 39 0.0264825
USP9X ubiquitin specific peptidase 9, X-linked 0.0264322
ADAR adenosine deaminase, RNA-specific 0.0263969
PLK2 polo-like kinase 2 0.0260934
MATR3 matrin 3 0.0260561
SDC4 syndecan 4 0.0259625
CEP170 centrosomal protein 170kDa 0.0259488
PUM2 pumilio RNA-binding family member 2 0.0259202
WWTR1 WW domain containing transcription regulator 1 0.0258745
CKAP5 cytoskeleton associated protein 5 0.025705
WDR26 WD repeat domain 26 0.0256115
AFF4 AF4/FMR2 family, member 4 0.0255963
BIRC6 baculoviral IAP repeat containing 6 0.0255437
WDR43 WD repeat domain 43 0.0254075
IPO7 importin 7 0.025381

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.15075
TP63 tumor protein p63 -0.0953631
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0668594
CADM2 cell adhesion molecule 2 -0.066114
RPS8 ribosomal protein S8 -0.0630254
RPS19 ribosomal protein S19 -0.0590138
RPL35A ribosomal protein L35a -0.0528701
TMSB10 thymosin beta 10 -0.051498
RPL12 ribosomal protein L12 -0.0497346
RPS6 ribosomal protein S6 -0.0489636
RPS3 ribosomal protein S3 -0.0451307
RPL37A ribosomal protein L37a -0.0430881
RPL36 ribosomal protein L36 -0.0412596
RPS23 ribosomal protein S23 -0.0398217
PTMA prothymosin, alpha -0.0378611
FTL ferritin, light polypeptide -0.0376021
RPL26 ribosomal protein L26 -0.0369468
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0362714
RPS29 ribosomal protein S29 -0.035532
RPL28 ribosomal protein L28 -0.0344456
RPL23 ribosomal protein L23 -0.0335973
RPLP2 ribosomal protein, large, P2 -0.0334728
RPS12 ribosomal protein S12 -0.0334701
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0329874
RPS27 ribosomal protein S27 -0.0296787
RPL18 ribosomal protein L18 -0.0287954
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0286265
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0284175
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0282835
EFNA5 ephrin-A5 -0.0279244
RPL31 ribosomal protein L31 -0.0275736
TNS3 tensin 3 -0.0270498
SDK1 sidekick cell adhesion molecule 1 -0.0269093
RPLP1 ribosomal protein, large, P1 -0.0268902
RPS27A ribosomal protein S27a -0.0262134
S100A9 S100 calcium binding protein A9 -0.0258448
RPL34 ribosomal protein L34 -0.0258067
CSMD3 CUB and Sushi multiple domains 3 -0.0258052
INTS6 integrator complex subunit 6 -0.0256919
RPL36A ribosomal protein L36a -0.0253687
MT1X metallothionein 1X -0.0248057
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0246325
IFI6 interferon, alpha-inducible protein 6 -0.0235201
TPT1 tumor protein, translationally-controlled 1 -0.0226483
RPL37 ribosomal protein L37 -0.0226052
RPS14 ribosomal protein S14 -0.0222476
RPS24 ribosomal protein S24 -0.0221754
RPS10 ribosomal protein S10 -0.0217943
RPS25 ribosomal protein S25 -0.0216667
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0214636
RPL9 ribosomal protein L9 -0.0214099
RPS15 ribosomal protein S15 -0.0212721
RPL35 ribosomal protein L35 -0.0212414
RPS13 ribosomal protein S13 -0.0208116
PDE10A phosphodiesterase 10A -0.0205971
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.020555
RPL38 ribosomal protein L38 -0.0203731
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0200061
TBCA tubulin folding cofactor A -0.0198078
PRELID2 PRELI domain containing 2 -0.0194514
RPL8 ribosomal protein L8 -0.0193946
IFITM1 interferon induced transmembrane protein 1 -0.0192277
EPHA4 EPH receptor A4 -0.0187311
RPL19 ribosomal protein L19 -0.0183192
HDAC9 histone deacetylase 9 -0.0176847
HMGA1 high mobility group AT-hook 1 -0.0173247
RPS21 ribosomal protein S21 -0.0168193
AEBP2 AE binding protein 2 -0.0166418
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0164702
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0162031
RPL32 ribosomal protein L32 -0.0161156
RPL11 ribosomal protein L11 -0.0158593
RPL7A ribosomal protein L7a -0.0156842
MT1E metallothionein 1E -0.0152195
CFAP299 cilia and flagella associated protein 299 -0.0152031
RPS17 ribosomal protein S17 -0.0151498
ZBTB20 zinc finger and BTB domain containing 20 -0.0146123
RPS11 ribosomal protein S11 -0.0145675
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0142019
ASTN2 astrotactin 2 -0.0138706
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0136921
RPS16 ribosomal protein S16 -0.0135265
RPL21 ribosomal protein L21 -0.0134773
WDR27 WD repeat domain 27 -0.0133807
TTC3 tetratricopeptide repeat domain 3 -0.0133566
EGFR epidermal growth factor receptor -0.0132629
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0130117
IFIH1 interferon induced with helicase C domain 1 -0.0128904
PLSCR1 phospholipid scramblase 1 -0.0128601
NEK10 NIMA-related kinase 10 -0.0126663
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0124269
RPL30 ribosomal protein L30 -0.0123752
ISG15 ISG15 ubiquitin-like modifier -0.0119935
RPL27A ribosomal protein L27a -0.0119795
SP100 SP100 nuclear antigen -0.0119714
RACK1 receptor for activated C kinase 1 -0.0115522
RPS20 ribosomal protein S20 -0.0113765
RPS5 ribosomal protein S5 -0.0113026
DPYD dihydropyrimidine dehydrogenase -0.0111737
DPH6 diphthamine biosynthesis 6 -0.0110733