Dimethyl fumarate_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.111836
FNDC3B fibronectin type III domain containing 3B 0.097679
SMAD3 SMAD family member 3 0.0931567
GRB10 growth factor receptor-bound protein 10 0.0704344
NAV2 neuron navigator 2 0.0634294
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0538601
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0497716
SIK3 SIK family kinase 3 0.0494256
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0482871
PDE4D phosphodiesterase 4D, cAMP-specific 0.0476858
TRIO trio Rho guanine nucleotide exchange factor 0.0474102
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0467443
ATP13A3 ATPase type 13A3 0.0447975
ELL2 elongation factor, RNA polymerase II, 2 0.0432478
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0409054
OSMR oncostatin M receptor 0.0405712
RICTOR RPTOR independent companion of MTOR, complex 2 0.0403197
FAM13A family with sequence similarity 13, member A 0.0396684
AKAP13 A kinase (PRKA) anchor protein 13 0.0376621
DOCK5 dedicator of cytokinesis 5 0.0375195
RAB27B RAB27B, member RAS oncogene family 0.037158
RBM39 RNA binding motif protein 39 0.0370826
ZEB2 zinc finger E-box binding homeobox 2 0.0364586
ETV6 ets variant 6 0.0364095
TGM2 transglutaminase 2 0.0356394
CD44 CD44 molecule (Indian blood group) 0.0322169
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0321385
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0321277
EFNA5 ephrin-A5 0.0316557
GPC6 glypican 6 0.0313165
ADD3 adducin 3 (gamma) 0.0305968
RUNX2 runt-related transcription factor 2 0.0303589
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0301261
NRP1 neuropilin 1 0.0299683
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0298072
DSCAM Down syndrome cell adhesion molecule 0.0297731
NPC1 Niemann-Pick disease, type C1 0.0297471
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0290901
MYH9 myosin, heavy chain 9, non-muscle 0.0290877
KDM2A lysine (K)-specific demethylase 2A 0.0290862
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0280108
SPRED2 sprouty-related, EVH1 domain containing 2 0.0277786
KMT2C lysine (K)-specific methyltransferase 2C 0.0274729
DPYSL3 dihydropyrimidinase-like 3 0.0268035
SOD2 superoxide dismutase 2, mitochondrial 0.0255478
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0255477
RAD51B RAD51 paralog B 0.0252311
YEATS2 YEATS domain containing 2 0.0246736
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0245433
ZNF292 zinc finger protein 292 0.024297
MCL1 myeloid cell leukemia 1 0.0240552
FLNB filamin B, beta 0.0239736
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0237845
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0233959
RB1CC1 RB1-inducible coiled-coil 1 0.0230967
HELZ helicase with zinc finger 0.0227589
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0227312
STRN3 striatin, calmodulin binding protein 3 0.0226759
PIAS2 protein inhibitor of activated STAT, 2 0.0226173
UBA6 ubiquitin-like modifier activating enzyme 6 0.0225028
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0224849
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0218822
RUNX1 runt-related transcription factor 1 0.0215178
SLTM SAFB-like, transcription modulator 0.0212591
NBAS neuroblastoma amplified sequence 0.0210959
RAB8B RAB8B, member RAS oncogene family 0.0207236
PRELID2 PRELI domain containing 2 0.0204872
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.020422
MAML2 mastermind-like 2 (Drosophila) 0.0201614
OGA O-GlcNAcase 0.0199813
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0199285
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0198928
PALM2AKAP2 PALM2 and AKAP2 fusion 0.01912
SPRED1 sprouty-related, EVH1 domain containing 1 0.0189927
MSN moesin 0.0188551
PCNX1 pecanex 1 0.0185477
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0185065
CDK17 cyclin-dependent kinase 17 0.0185043
JMJD1C jumonji domain containing 1C 0.0183723
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0183389
VEGFC vascular endothelial growth factor C 0.0182669
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0182563
SDK1 sidekick cell adhesion molecule 1 0.0182399
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0181452
CTNND1 catenin (cadherin-associated protein), delta 1 0.0178949
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0176458
MYO1B myosin IB 0.0175418
AMPD3 adenosine monophosphate deaminase 3 0.0173488
ZFAND6 zinc finger, AN1-type domain 6 0.0173338
FAM20C family with sequence similarity 20, member C 0.0172653
AGFG1 ArfGAP with FG repeats 1 0.0172133
USP34 ubiquitin specific peptidase 34 0.0171151
LUZP1 leucine zipper protein 1 0.0170901
CTNNBL1 catenin, beta like 1 0.0170167
UBE2H ubiquitin-conjugating enzyme E2H 0.0169708
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0169384
PID1 phosphotyrosine interaction domain containing 1 0.0169071
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0168838
TBC1D15 TBC1 domain family, member 15 0.0167582
TTC28 tetratricopeptide repeat domain 28 0.0167158

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.223242
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201903
TMSB10 thymosin beta 10 -0.137953
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.118456
FTL ferritin, light polypeptide -0.107843
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0824881
RPLP1 ribosomal protein, large, P1 -0.0745602
PTMA prothymosin, alpha -0.0724242
LOX lysyl oxidase -0.0658992
FN1 fibronectin 1 -0.0646538
RPL35A ribosomal protein L35a -0.0551914
RPS8 ribosomal protein S8 -0.054418
RPS19 ribosomal protein S19 -0.052625
EIF1 eukaryotic translation initiation factor 1 -0.0522612
RPS6 ribosomal protein S6 -0.051895
AKAP12 A kinase (PRKA) anchor protein 12 -0.0497311
MT2A metallothionein 2A -0.0496423
RPL34 ribosomal protein L34 -0.0478121
S100A6 S100 calcium binding protein A6 -0.045106
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0443262
TPT1 tumor protein, translationally-controlled 1 -0.0441771
IER3 immediate early response 3 -0.0441697
RPS24 ribosomal protein S24 -0.0437791
STC1 stanniocalcin 1 -0.0432223
TFPI2 tissue factor pathway inhibitor 2 -0.0426264
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0425322
NAP1L1 nucleosome assembly protein 1-like 1 -0.0424989
ENO1 enolase 1, (alpha) -0.0408998
RPL31 ribosomal protein L31 -0.0407629
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0394414
RPL23 ribosomal protein L23 -0.03939
RPS29 ribosomal protein S29 -0.0384948
RPS25 ribosomal protein S25 -0.0383497
RPL32 ribosomal protein L32 -0.0360709
LDHA lactate dehydrogenase A -0.0356231
DDIT3 DNA-damage-inducible transcript 3 -0.0351742
RPLP0 ribosomal protein, large, P0 -0.035149
B2M beta-2-microglobulin -0.034846
BTG1 B-cell translocation gene 1, anti-proliferative -0.0347199
RPL12 ribosomal protein L12 -0.034516
PLIN2 perilipin 2 -0.0332921
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0332562
S100A10 S100 calcium binding protein A10 -0.0330029
RPLP2 ribosomal protein, large, P2 -0.0329729
CANX calnexin -0.0326573
RPL37A ribosomal protein L37a -0.0326036
RPS12 ribosomal protein S12 -0.0322696
RPS23 ribosomal protein S23 -0.0321772
RPL19 ribosomal protein L19 -0.0321483
RPS13 ribosomal protein S13 -0.0321297
C15ORF48 chromosome 15 open reading frame 48 -0.0318215
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314437
HMGA1 high mobility group AT-hook 1 -0.0312654
LMAN1 lectin, mannose-binding, 1 -0.0312299
IGFBP3 insulin-like growth factor binding protein 3 -0.0303324
RPS27 ribosomal protein S27 -0.0294496
RPL36 ribosomal protein L36 -0.0294405
RACK1 receptor for activated C kinase 1 -0.029036
RPL11 ribosomal protein L11 -0.0288335
IFI6 interferon, alpha-inducible protein 6 -0.0285241
HMGA2 high mobility group AT-hook 2 -0.0284286
TMSB4X thymosin beta 4, X-linked -0.0279696
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0279228
PKM pyruvate kinase, muscle -0.0275634
RPS3 ribosomal protein S3 -0.027425
GNAS GNAS complex locus -0.027299
CALR calreticulin -0.0272713
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0270883
RPS21 ribosomal protein S21 -0.0260516
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0258145
RPL9 ribosomal protein L9 -0.0257228
RPL37 ribosomal protein L37 -0.0253224
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0252966
RPS17 ribosomal protein S17 -0.025154
S100A9 S100 calcium binding protein A9 -0.0249023
RPS16 ribosomal protein S16 -0.0248131
RPL5 ribosomal protein L5 -0.024521
SLC38A1 solute carrier family 38, member 1 -0.0243501
AHNAK AHNAK nucleoprotein -0.0238007
RPL38 ribosomal protein L38 -0.0236264
CDH13 cadherin 13 -0.0235716
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0232593
RPL7A ribosomal protein L7a -0.022898
RPS11 ribosomal protein S11 -0.0227563
RIOK3 RIO kinase 3 -0.0227485
PGK1 phosphoglycerate kinase 1 -0.022651
IFITM3 interferon induced transmembrane protein 3 -0.0226191
PDGFA platelet-derived growth factor alpha polypeptide -0.0223428
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0223004
RPS5 ribosomal protein S5 -0.0222768
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0222254
PDIA3 protein disulfide isomerase family A, member 3 -0.022072
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0219459
FBN1 fibrillin 1 -0.0217732
UBC ubiquitin C -0.0216533
SAMD9 sterile alpha motif domain containing 9 -0.0215334
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0214362
RPL7 ribosomal protein L7 -0.0210694
RPL28 ribosomal protein L28 -0.0207559
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0206289