Dimethyl fumarate_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

199 genes differentially expressed following the Dimethyl fumarate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.297002
LAMA4 laminin, alpha 4 0.216027
EGFR epidermal growth factor receptor 0.215268
PDE4D phosphodiesterase 4D, cAMP-specific 0.140748
JMJD1C jumonji domain containing 1C 0.131109
VCL vinculin 0.123773
GPC6 glypican 6 0.0863665
PKM pyruvate kinase, muscle 0.0855296
PGK1 phosphoglycerate kinase 1 0.0805016
MAML2 mastermind-like 2 (Drosophila) 0.0783976
WAC WW domain containing adaptor with coiled-coil 0.0750663
ACTN4 actinin, alpha 4 0.0750593
EZR ezrin 0.0750062
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0735043
CD44 CD44 molecule (Indian blood group) 0.0729631
RPLP1 ribosomal protein, large, P1 0.0723426
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0702752
NAMPT nicotinamide phosphoribosyltransferase 0.0689838
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0689337
FTL ferritin, light polypeptide 0.0684494
RPL19 ribosomal protein L19 0.0618983
MT2A metallothionein 2A 0.0618816
RPL35A ribosomal protein L35a 0.0598489
SND1 staphylococcal nuclease and tudor domain containing 1 0.0585482
AKAP9 A kinase (PRKA) anchor protein 9 0.0566192
RPS6 ribosomal protein S6 0.0527497
TMSB10 thymosin beta 10 0.051947
ARHGAP12 Rho GTPase activating protein 12 0.0517041
RPS12 ribosomal protein S12 0.0512952
KMT2E lysine (K)-specific methyltransferase 2E 0.0501688
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0497683
RPL11 ribosomal protein L11 0.0476237
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0474556
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0448248
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0441464
EXT1 exostosin glycosyltransferase 1 0.0439851
STC1 stanniocalcin 1 0.0423649
USP34 ubiquitin specific peptidase 34 0.0422507
LPP LIM domain containing preferred translocation partner in lipoma 0.0371211
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0369973
LDHA lactate dehydrogenase A 0.0364934
RPS3 ribosomal protein S3 0.0359671
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0352126
POTEF POTE ankyrin domain family, member F 0.0348048
RUNX1 runt-related transcription factor 1 0.0347335
MCL1 myeloid cell leukemia 1 0.0332622
OSBPL8 oxysterol binding protein-like 8 0.0325505
MACF1 microtubule-actin crosslinking factor 1 0.0309639
H3-3B H3.3 histone B 0.0306249
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0305395
PUM2 pumilio RNA-binding family member 2 0.0301593
LMO7 LIM domain 7 0.0280554
NCOR2 nuclear receptor corepressor 2 0.0247628
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0238342
TAS2R14 taste receptor, type 2, member 14 0.0237862
SLC38A1 solute carrier family 38, member 1 0.0237504
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0233437
PTPRM protein tyrosine phosphatase, receptor type, M 0.0219798
ZNF292 zinc finger protein 292 0.0209353
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0201195
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0200133
SMYD3 SET and MYND domain containing 3 0.0198242
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0197537
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0194177
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0175812
ANO6 anoctamin 6 0.0148286
RPS8 ribosomal protein S8 0.0143047
PRELID2 PRELI domain containing 2 0.0141403
ZFAND3 zinc finger, AN1-type domain 3 0.0134068
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0133059
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0123296
RPLP2 ribosomal protein, large, P2 0.0107667
KDM3A lysine (K)-specific demethylase 3A 0.00975501
AKAP13 A kinase (PRKA) anchor protein 13 0.00945223
GOLGA4 golgin A4 0.00887926
NAP1L1 nucleosome assembly protein 1-like 1 0.00838288
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00797088
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00751756
PDIA3 protein disulfide isomerase family A, member 3 0.00736452
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00705307
ATXN1 ataxin 1 0.00689593
NKD1 naked cuticle homolog 1 (Drosophila) 0.00669695
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.00613736
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00599614
CALU calumenin 0.00566465
EIF1 eukaryotic translation initiation factor 1 0.00545658
GLIS3 GLIS family zinc finger 3 0.00537402
CXCL8 chemokine (C-X-C motif) ligand 8 0.00529025
AKAP12 A kinase (PRKA) anchor protein 12 0.00513064
RPL37A ribosomal protein L37a 0.00439275
RIGI RNA sensor RIG-I 0.00423832
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00329332
BPTF bromodomain PHD finger transcription factor 0.0028197
TOP1 topoisomerase (DNA) I 0.00196586
TPT1 tumor protein, translationally-controlled 1 0.00192319
NUP58 nucleoporin 58 0.00188662
ERC2 ELKS/RAB6-interacting/CAST family member 2 9.96181E-4
PARD3 par-3 family cell polarity regulator 3.38019E-4
KTN1 kinectin 1 (kinesin receptor) 1.87452E-4

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.131583
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.121182
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.111986
KMT2C lysine (K)-specific methyltransferase 2C -0.111335
FLNB filamin B, beta -0.107098
TRIO trio Rho guanine nucleotide exchange factor -0.104495
EFNA5 ephrin-A5 -0.0952748
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0949356
ZBTB20 zinc finger and BTB domain containing 20 -0.0928299
FNDC3B fibronectin type III domain containing 3B -0.088574
FN1 fibronectin 1 -0.0865168
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.085624
HELZ helicase with zinc finger -0.074548
NCOR1 nuclear receptor corepressor 1 -0.0721672
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0719055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0678683
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0664529
NDRG1 N-myc downstream regulated 1 -0.0645494
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0644334
MATR3 matrin 3 -0.0596956
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0596048
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0594354
NF1 neurofibromin 1 -0.0561155
ELL2 elongation factor, RNA polymerase II, 2 -0.0550036
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0540747
YAP1 Yes-associated protein 1 -0.0530595
ESYT2 extended synaptotagmin-like protein 2 -0.0528498
ANKRD28 ankyrin repeat domain 28 -0.0526739
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0516441
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0510866
OGA O-GlcNAcase -0.0510264
FRMD5 FERM domain containing 5 -0.0499266
STK24 serine/threonine kinase 24 -0.0495392
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0494264
RBM39 RNA binding motif protein 39 -0.0483078
ENO1 enolase 1, (alpha) -0.0474307
PCBP2 poly(rC) binding protein 2 -0.047368
SLC38A2 solute carrier family 38, member 2 -0.0467148
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0466312
TTC3 tetratricopeptide repeat domain 3 -0.046586
VMP1 vacuole membrane protein 1 -0.0458564
PDE10A phosphodiesterase 10A -0.0455036
MYOF myoferlin -0.0428565
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0393504
FTH1 ferritin, heavy polypeptide 1 -0.0390865
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0380297
MCTP1 multiple C2 domains, transmembrane 1 -0.0380212
PRKCA protein kinase C, alpha -0.0359186
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0357815
CLIP2 CAP-GLY domain containing linker protein 2 -0.0350566
PTK2 protein tyrosine kinase 2 -0.0350322
EEF2 eukaryotic translation elongation factor 2 -0.0349922
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0340726
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.033837
CAMKMT calmodulin-lysine N-methyltransferase -0.0326779
DSCAM Down syndrome cell adhesion molecule -0.0308695
ANKRD11 ankyrin repeat domain 11 -0.0304257
SBF2 SET binding factor 2 -0.0295576
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0284381
PTMA prothymosin, alpha -0.0283488
CANX calnexin -0.0279663
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0273291
NCOA3 nuclear receptor coactivator 3 -0.0267834
ASPH aspartate beta-hydroxylase -0.025817
RLF rearranged L-myc fusion -0.0250506
RACK1 receptor for activated C kinase 1 -0.024701
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0234028
CNKSR3 CNKSR family member 3 -0.0225513
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0223428
SQSTM1 sequestosome 1 -0.02221
PTPRG protein tyrosine phosphatase, receptor type, G -0.021076
RPS27A ribosomal protein S27a -0.020637
RPL12 ribosomal protein L12 -0.0204455
RPS24 ribosomal protein S24 -0.0193576
COL5A2 collagen, type V, alpha 2 -0.0183911
PDLIM5 PDZ and LIM domain 5 -0.0177879
DST dystonin -0.0176567
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0160477
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0134449
PRRC2C proline-rich coiled-coil 2C -0.0131941
WSB1 WD repeat and SOCS box containing 1 -0.0127001
MBD5 methyl-CpG binding domain protein 5 -0.0123403
NABP1 nucleic acid binding protein 1 -0.0121457
SOD2 superoxide dismutase 2, mitochondrial -0.0115366
KDM4C lysine (K)-specific demethylase 4C -0.0109215
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0109118
ACTG1 actin gamma 1 -0.00934075
ANXA2 annexin A2 -0.00902596
COL6A3 collagen, type VI, alpha 3 -0.00888899
VIM vimentin -0.00865257
TBC1D22A TBC1 domain family, member 22A -0.00847983
FNDC3A fibronectin type III domain containing 3A -0.00749105
ARB2A ARB2 cotranscriptional regulator A -0.00737297
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.00636767
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00635638
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00618727
MYO1E myosin IE -0.00588439
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.00549451
NPAS2 neuronal PAS domain protein 2 -0.00536306
FAM107B family with sequence similarity 107, member B -0.00495525