Dimethyl fumarate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.149792
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.129221
TRIO trio Rho guanine nucleotide exchange factor 0.118976
SEPTIN9 septin 9 0.113413
ERRFI1 ERBB receptor feedback inhibitor 1 0.0911348
SMAD3 SMAD family member 3 0.0858057
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0833529
JMJD1C jumonji domain containing 1C 0.0790107
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0778166
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0708942
ZCCHC7 zinc finger, CCHC domain containing 7 0.069067
MYH9 myosin, heavy chain 9, non-muscle 0.0685092
APLP2 amyloid beta (A4) precursor-like protein 2 0.0681024
DST dystonin 0.0653935
MYOF myoferlin 0.0639913
CDK19 cyclin-dependent kinase 19 0.0609548
SDK1 sidekick cell adhesion molecule 1 0.0575321
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0555725
FNDC3B fibronectin type III domain containing 3B 0.0548585
SBF2 SET binding factor 2 0.054756
NAV2 neuron navigator 2 0.0527613
PTK2 protein tyrosine kinase 2 0.051727
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0514369
ZNF292 zinc finger protein 292 0.0511102
ANXA2 annexin A2 0.0510194
ENO1 enolase 1, (alpha) 0.0504275
PRELID2 PRELI domain containing 2 0.0489386
SRRM2 serine/arginine repetitive matrix 2 0.0482352
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0470342
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0470042
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.04655
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0453819
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0449472
ANLN anillin, actin binding protein 0.0443849
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0435696
AFAP1 actin filament associated protein 1 0.0429237
USP34 ubiquitin specific peptidase 34 0.0428921
PDE10A phosphodiesterase 10A 0.0426144
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0420467
ATXN1 ataxin 1 0.0406254
APP amyloid beta (A4) precursor protein 0.0396303
SFTPA2 surfactant protein A2 0.0394942
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0392929
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0392499
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0389667
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0382539
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.037808
ASPH aspartate beta-hydroxylase 0.0373753
CMIP c-Maf inducing protein 0.0367444
LOC112694756 uncharaterized LOC112694756 0.0364858
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354908
SLC35F3 solute carrier family 35, member F3 0.0354809
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0351556
BIRC6 baculoviral IAP repeat containing 6 0.035117
MORF4L2 mortality factor 4 like 2 0.035061
EGFR epidermal growth factor receptor 0.0346689
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0343199
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0341987
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0336159
HSPG2 heparan sulfate proteoglycan 2 0.0333533
TBC1D5 TBC1 domain family, member 5 0.0329316
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0324825
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0324822
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0323421
PRRC2A proline-rich coiled-coil 2A 0.031915
CALU calumenin 0.0318151
RTN4 reticulon 4 0.0318055
CENPF centromere protein F, 350/400kDa 0.0317521
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0314611
MSN moesin 0.0313513
ANO6 anoctamin 6 0.0312396
TNS3 tensin 3 0.0311049
KMT2C lysine (K)-specific methyltransferase 2C 0.0309725
BRD2 bromodomain containing 2 0.0306527
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0305893
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0300491
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0299232
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0297642
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0294739
NCOR2 nuclear receptor corepressor 2 0.0292186
SNX14 sorting nexin 14 0.0286426
YEATS2 YEATS domain containing 2 0.0285528
MACF1 microtubule-actin crosslinking factor 1 0.0284138
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0283258
KDM2A lysine (K)-specific demethylase 2A 0.0283181
EEF2 eukaryotic translation elongation factor 2 0.0281845
TM9SF4 transmembrane 9 superfamily protein member 4 0.0278719
FNIP1 folliculin interacting protein 1 0.0278605
RUNX1 runt-related transcription factor 1 0.0277982
ARHGAP32 Rho GTPase activating protein 32 0.0276599
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027445
OGA O-GlcNAcase 0.0272241
FBL fibrillarin 0.0266893
BIRC2 baculoviral IAP repeat containing 2 0.0264035
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0262925
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0261876
PCBP2 poly(rC) binding protein 2 0.0261673
EIF4B eukaryotic translation initiation factor 4B 0.0257445
SAMD4B sterile alpha motif domain containing 4B 0.0256162
HSPA8 heat shock 70kDa protein 8 0.0255916

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.12871
RPS16 ribosomal protein S16 -0.107511
ZFP36 ZFP36 ring finger protein -0.0743624
TMSB10 thymosin beta 10 -0.0557535
PTMA prothymosin, alpha -0.0449076
MT2A metallothionein 2A -0.0440066
RPLP2 ribosomal protein, large, P2 -0.0424305
RPL35A ribosomal protein L35a -0.0333555
RPS24 ribosomal protein S24 -0.0297693
RPS3 ribosomal protein S3 -0.0281088
RAP1B RAP1B, member of RAS oncogene family -0.0275346
EGR1 early growth response 1 -0.0269407
TPT1 tumor protein, translationally-controlled 1 -0.0268339
RPLP1 ribosomal protein, large, P1 -0.0258156
TPM1 tropomyosin 1 (alpha) -0.025439
RPL12 ribosomal protein L12 -0.0250915
RPL36A ribosomal protein L36a -0.0244666
LOC102724023 ES1 protein homolog, mitochondrial -0.0242978
EXT1 exostosin glycosyltransferase 1 -0.024218
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0238948
RPS27A ribosomal protein S27a -0.0234727
RPS25 ribosomal protein S25 -0.0228486
RPS23 ribosomal protein S23 -0.022341
IER3 immediate early response 3 -0.0209919
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0209766
RPS12 ribosomal protein S12 -0.0208853
RPS8 ribosomal protein S8 -0.0205867
PDLIM5 PDZ and LIM domain 5 -0.0203759
RIGI RNA sensor RIG-I -0.0198236
RPS13 ribosomal protein S13 -0.0196968
RPS19 ribosomal protein S19 -0.0194187
EIF1 eukaryotic translation initiation factor 1 -0.0187677
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.018455
WSB1 WD repeat and SOCS box containing 1 -0.0182876
VIM vimentin -0.0178687
RPL38 ribosomal protein L38 -0.0178089
FTL ferritin, light polypeptide -0.0168497
INTS6 integrator complex subunit 6 -0.0166342
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0163967
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0163178
RPL37A ribosomal protein L37a -0.0163067
ITGAV integrin, alpha V -0.0163036
TBCA tubulin folding cofactor A -0.0160707
WWTR1 WW domain containing transcription regulator 1 -0.0160215
RPS29 ribosomal protein S29 -0.0158989
RPL36 ribosomal protein L36 -0.015627
RPL31 ribosomal protein L31 -0.0150483
IFITM3 interferon induced transmembrane protein 3 -0.0149484
ANKRD33B ankyrin repeat domain 33B -0.0146794
TM4SF1 transmembrane 4 L six family member 1 -0.0146321
RPL9 ribosomal protein L9 -0.0145651
S100A6 S100 calcium binding protein A6 -0.0145369
RPL34 ribosomal protein L34 -0.0143903
RAB7A RAB7A, member RAS oncogene family -0.0141484
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0140727
C15ORF48 chromosome 15 open reading frame 48 -0.0140652
RSU1 Ras suppressor protein 1 -0.0138032
BMAL2 basic helix-loop-helix ARNT like 2 -0.0138029
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0136476
RPS21 ribosomal protein S21 -0.013139
NAMPT nicotinamide phosphoribosyltransferase -0.0126982
RPS10 ribosomal protein S10 -0.0126663
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0126439
NAP1L1 nucleosome assembly protein 1-like 1 -0.0123737
ZNF780B zinc finger protein 780B -0.0123156
RPS14 ribosomal protein S14 -0.0122943
RPS27 ribosomal protein S27 -0.0122437
HLA-B major histocompatibility complex, class I, B -0.012234
IFI6 interferon, alpha-inducible protein 6 -0.012209
RAB31 RAB31, member RAS oncogene family -0.0121994
RPS6 ribosomal protein S6 -0.0121885
RPL26 ribosomal protein L26 -0.0121796
B2M beta-2-microglobulin -0.0118766
NT5E 5'-nucleotidase, ecto (CD73) -0.0117539
RPL23 ribosomal protein L23 -0.0112376
HMGB1 high mobility group box 1 -0.0112162
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0109691
ZBTB20 zinc finger and BTB domain containing 20 -0.0109079
RPL30 ribosomal protein L30 -0.0108684
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0108521
H3-3B H3.3 histone B -0.0107825
MSRB3 methionine sulfoxide reductase B3 -0.0107347
S100A9 S100 calcium binding protein A9 -0.0106991
RPS17 ribosomal protein S17 -0.0103888
OSMR oncostatin M receptor -0.0103715
ATP5F1E ATP synthase F1 subunit epsilon -0.0102468
YBX3 Y box binding protein 3 -0.0102171
KLF6 Kruppel-like factor 6 -0.0101217
UPP1 uridine phosphorylase 1 -0.0100008
SERF2 small EDRK-rich factor 2 -0.00998221
PLAU plasminogen activator, urokinase -0.00995432
IRF1 interferon regulatory factor 1 -0.00985842
EID2 EP300 interacting inhibitor of differentiation 2 -0.00983887
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00973423
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.00963657
BAIAP2L1 BAI1-associated protein 2-like 1 -0.00963021
RHEB Ras homolog enriched in brain -0.00949765
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.00948969
NDUFA4 NDUFA4, mitochondrial complex associated -0.00946926
RPL35 ribosomal protein L35 -0.00940561