Dimethyl fumarate_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PARP14 poly (ADP-ribose) polymerase family, member 14 0.119385
RNF213 ring finger protein 213 0.113243
NAV2 neuron navigator 2 0.110993
MAML2 mastermind-like 2 (Drosophila) 0.108349
MACF1 microtubule-actin crosslinking factor 1 0.105274
RUNX1 runt-related transcription factor 1 0.0899184
ASPH aspartate beta-hydroxylase 0.08574
SVIL supervillin 0.0788594
SMAD3 SMAD family member 3 0.0781645
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0779481
AHNAK AHNAK nucleoprotein 0.0762933
LAMA4 laminin, alpha 4 0.0746681
LAMB3 laminin, beta 3 0.07257
MUC16 mucin 16, cell surface associated 0.0710007
RAD51B RAD51 paralog B 0.0670251
FNDC3B fibronectin type III domain containing 3B 0.0663101
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.065711
SAMD12 sterile alpha motif domain containing 12 0.0649501
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0646569
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0627022
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0613689
MX1 MX dynamin-like GTPase 1 0.0605407
KRT8 keratin 8, type II 0.060477
TRIO trio Rho guanine nucleotide exchange factor 0.060119
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0581138
LPP LIM domain containing preferred translocation partner in lipoma 0.0552355
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0549572
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0544794
TPM4 tropomyosin 4 0.0542948
ANXA2 annexin A2 0.0541799
CD44 CD44 molecule (Indian blood group) 0.0538344
BACE2 beta-site APP-cleaving enzyme 2 0.0532609
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0531187
AFDN afadin, adherens junction formation factor 0.0528722
SAMD4A sterile alpha motif domain containing 4A 0.0526208
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0525726
DLG1 discs, large homolog 1 (Drosophila) 0.0520426
C3 complement component 3 0.051933
EZR ezrin 0.0517951
ARHGAP26 Rho GTPase activating protein 26 0.0506156
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.050246
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0494259
ZBTB20 zinc finger and BTB domain containing 20 0.0493024
PRELID2 PRELI domain containing 2 0.0489622
NRIP1 nuclear receptor interacting protein 1 0.0485683
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0484394
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.048404
FHIT fragile histidine triad 0.0481838
SMYD3 SET and MYND domain containing 3 0.0476894
FN1 fibronectin 1 0.0474801
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0471999
PTK2 protein tyrosine kinase 2 0.0470435
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0469364
PATJ PATJ crumbs cell polarity complex component 0.0464882
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0463977
MEF2A myocyte enhancer factor 2A 0.046289
SP100 SP100 nuclear antigen 0.0462146
SYT14 synaptotagmin XIV 0.0461122
ATXN1 ataxin 1 0.0458453
AFAP1 actin filament associated protein 1 0.0457972
INTS6 integrator complex subunit 6 0.0451475
LAMC2 laminin, gamma 2 0.0441321
TXNIP thioredoxin interacting protein 0.0440743
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0439371
PLAT plasminogen activator, tissue 0.0436543
KIAA1671 KIAA1671 0.0433959
EFNA5 ephrin-A5 0.0433653
MYH9 myosin, heavy chain 9, non-muscle 0.0433056
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0431796
CLMN calmin (calponin-like, transmembrane) 0.0426016
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0423374
SEPTIN9 septin 9 0.0416905
DOCK5 dedicator of cytokinesis 5 0.0410914
NDRG1 N-myc downstream regulated 1 0.0395695
DSPP dentin sialophosphoprotein 0.0394507
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0393623
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0391534
SULF2 sulfatase 2 0.0386407
DST dystonin 0.0386178
EHF ets homologous factor 0.0383666
FLNB filamin B, beta 0.0383086
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0379051
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0367103
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365987
EMP1 epithelial membrane protein 1 0.0364242
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.036253
MX2 MX dynamin-like GTPase 2 0.0359863
HMGA2 high mobility group AT-hook 2 0.03591
CD2AP CD2-associated protein 0.0357221
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0353539
SQSTM1 sequestosome 1 0.0349587
EGFR epidermal growth factor receptor 0.0348604
YEATS2 YEATS domain containing 2 0.0346462
APP amyloid beta (A4) precursor protein 0.0343951
TMSB4X thymosin beta 4, X-linked 0.0343007
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0342013
SKAP2 src kinase associated phosphoprotein 2 0.0336275
EXOC4 exocyst complex component 4 0.033201
RIGI RNA sensor RIG-I 0.0331914
HDAC9 histone deacetylase 9 0.0331913

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0841229
RPS6 ribosomal protein S6 -0.0745444
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0619288
KRT17 keratin 17, type I -0.050881
EIF1 eukaryotic translation initiation factor 1 -0.0494355
RPS3 ribosomal protein S3 -0.0462395
RPS8 ribosomal protein S8 -0.0460999
RPL35A ribosomal protein L35a -0.0455086
RPS19 ribosomal protein S19 -0.0448893
RPL36 ribosomal protein L36 -0.0430906
RACK1 receptor for activated C kinase 1 -0.0400988
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0388466
TMSB10 thymosin beta 10 -0.0373602
RPS13 ribosomal protein S13 -0.0370814
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0369205
RPS29 ribosomal protein S29 -0.036445
RPL28 ribosomal protein L28 -0.0329031
UGCG UDP-glucose ceramide glucosyltransferase -0.0324085
RPL8 ribosomal protein L8 -0.0320044
RPL21 ribosomal protein L21 -0.0315525
RPS23 ribosomal protein S23 -0.0314631
TSC22D2 TSC22 domain family, member 2 -0.0310667
RPL12 ribosomal protein L12 -0.0306583
RPL30 ribosomal protein L30 -0.0302907
RPS21 ribosomal protein S21 -0.0299318
WWC1 WW and C2 domain containing 1 -0.0294778
RPS27 ribosomal protein S27 -0.029105
RPS12 ribosomal protein S12 -0.0288127
MT2A metallothionein 2A -0.0285641
G0S2 G0/G1 switch 2 -0.0276878
RPL34 ribosomal protein L34 -0.0274558
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0274086
RPS14 ribosomal protein S14 -0.0273741
RPS27A ribosomal protein S27a -0.0271715
S100A9 S100 calcium binding protein A9 -0.0267187
TPI1 triosephosphate isomerase 1 -0.0267042
RPL23 ribosomal protein L23 -0.0265074
DDIT4 DNA-damage-inducible transcript 4 -0.0264975
GOLGA4 golgin A4 -0.0259051
RDX radixin -0.0247331
RPL37A ribosomal protein L37a -0.0242085
CALR calreticulin -0.0235179
RPL18 ribosomal protein L18 -0.0234297
S100A6 S100 calcium binding protein A6 -0.023163
MTDH metadherin -0.0231072
RPS15 ribosomal protein S15 -0.0229617
RPL9 ribosomal protein L9 -0.0226937
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0226163
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0222345
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0219458
IFITM3 interferon induced transmembrane protein 3 -0.0217285
FNBP4 formin binding protein 4 -0.0213121
EPCAM epithelial cell adhesion molecule -0.0207928
PNN pinin, desmosome associated protein -0.0206522
RPS11 ribosomal protein S11 -0.020598
RPL26 ribosomal protein L26 -0.0205855
ARHGAP29 Rho GTPase activating protein 29 -0.0205305
NOP58 NOP58 ribonucleoprotein -0.0203661
RPS16 ribosomal protein S16 -0.0200131
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0198259
RBM25 RNA binding motif protein 25 -0.0196049
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0192829
SRRM1 serine/arginine repetitive matrix 1 -0.0191332
RPL35 ribosomal protein L35 -0.0191261
S100A11 S100 calcium binding protein A11 -0.0190516
HMGA1 high mobility group AT-hook 1 -0.0190288
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0187957
RPL27 ribosomal protein L27 -0.0187697
KMT2E lysine (K)-specific methyltransferase 2E -0.0186024
LOC102724023 ES1 protein homolog, mitochondrial -0.0183615
RPL32 ribosomal protein L32 -0.0182774
RPL10A ribosomal protein L10a -0.0180733
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0179807
YBX3 Y box binding protein 3 -0.0179582
CLINT1 clathrin interactor 1 -0.0178617
LATS2 large tumor suppressor kinase 2 -0.0177325
DLC1 DLC1 Rho GTPase activating protein -0.0175049
YBX1 Y box binding protein 1 -0.017466
IFITM1 interferon induced transmembrane protein 1 -0.0171381
EIF5B eukaryotic translation initiation factor 5B -0.017123
SEC62 SEC62 homolog (S. cerevisiae) -0.0170919
RPL5 ribosomal protein L5 -0.0169672
PFN1 profilin 1 -0.0167125
KTN1 kinectin 1 (kinesin receptor) -0.0166481
SRSF11 serine/arginine-rich splicing factor 11 -0.0166401
RPS24 ribosomal protein S24 -0.0165119
RNF145 ring finger protein 145 -0.0163256
PRRC2C proline-rich coiled-coil 2C -0.0162558
RPL7 ribosomal protein L7 -0.0161275
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0160687
SRP54 signal recognition particle 54kDa -0.0159192
MYL12B myosin, light chain 12B, regulatory -0.0157468
COPB1 coatomer protein complex, subunit beta 1 -0.0156578
CD63 CD63 molecule -0.015649
NAP1L1 nucleosome assembly protein 1-like 1 -0.0156018
CAMLG calcium modulating ligand -0.0155368
RPL36A ribosomal protein L36a -0.0155083
RPL37 ribosomal protein L37 -0.0153703
RPS28 ribosomal protein S28 -0.0153535
UBE2B ubiquitin-conjugating enzyme E2B -0.0152152