Dimethyl fumarate_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0914217
ADAM10 ADAM metallopeptidase domain 10 0.0894937
PYGB phosphorylase, glycogen; brain 0.0708987
PRELID2 PRELI domain containing 2 0.0656829
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0613025
RBM39 RNA binding motif protein 39 0.059502
CAMTA1 calmodulin binding transcription activator 1 0.0590404
FLNB filamin B, beta 0.0565003
GOLGA4 golgin A4 0.0553096
ZNF292 zinc finger protein 292 0.0549489
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.05296
LPP LIM domain containing preferred translocation partner in lipoma 0.0507122
TMSB4X thymosin beta 4, X-linked 0.0486493
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0483689
NBAS neuroblastoma amplified sequence 0.0481316
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0467998
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0467873
SMYD3 SET and MYND domain containing 3 0.0454569
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0447408
ZFAND3 zinc finger, AN1-type domain 3 0.0434095
ANK2 ankyrin 2, neuronal 0.0426844
RTN4 reticulon 4 0.0426395
TJP1 tight junction protein 1 0.0419392
NFIA nuclear factor I/A 0.0417456
TMEM65 transmembrane protein 65 0.0408548
QKI QKI, KH domain containing, RNA binding 0.0408486
ANKRD11 ankyrin repeat domain 11 0.0407945
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0402488
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0389588
EFNA5 ephrin-A5 0.0384445
EZR ezrin 0.0383765
KDM3A lysine (K)-specific demethylase 3A 0.0379958
NBEA neurobeachin 0.0378936
NF1 neurofibromin 1 0.0378401
TGFBR3 transforming growth factor, beta receptor III 0.0376002
VCL vinculin 0.0367379
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0364203
GARS1 glycyl-tRNA synthetase 1 0.0363263
ELOVL5 ELOVL fatty acid elongase 5 0.0360169
EML4 echinoderm microtubule associated protein like 4 0.0349886
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0348784
TBC1D5 TBC1 domain family, member 5 0.0348399
CDC73 cell division cycle 73 0.0344686
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0339686
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0339658
CCNL1 cyclin L1 0.0338159
PTBP2 polypyrimidine tract binding protein 2 0.0337915
ZCCHC7 zinc finger, CCHC domain containing 7 0.033566
PTK2 protein tyrosine kinase 2 0.0335393
ZMYM2 zinc finger, MYM-type 2 0.0335097
BRWD1 bromodomain and WD repeat domain containing 1 0.0335026
METTL15 methyltransferase like 15 0.0326055
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0322109
GSK3B glycogen synthase kinase 3 beta 0.0317603
RNF145 ring finger protein 145 0.031708
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0316375
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0314404
SAMD4A sterile alpha motif domain containing 4A 0.0310525
SOX6 SRY (sex determining region Y)-box 6 0.0309273
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0308748
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0308358
PRPF38B pre-mRNA processing factor 38B 0.0306165
KMT2C lysine (K)-specific methyltransferase 2C 0.030595
ZBTB20 zinc finger and BTB domain containing 20 0.0304657
NCKAP1 NCK-associated protein 1 0.0304112
EIF4A2 eukaryotic translation initiation factor 4A2 0.0298199
LOC112694756 uncharaterized LOC112694756 0.0293397
TBC1D22A TBC1 domain family, member 22A 0.0293281
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0292919
PGK1 phosphoglycerate kinase 1 0.0291273
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0290286
MON2 MON2 homolog (S. cerevisiae) 0.0287864
KDM6A lysine (K)-specific demethylase 6A 0.0286587
SQSTM1 sequestosome 1 0.0286103
ECT2 epithelial cell transforming 2 0.0285337
MSI2 musashi RNA-binding protein 2 0.0284376
COG5 component of oligomeric golgi complex 5 0.0281005
MBD5 methyl-CpG binding domain protein 5 0.027956
PTPRG protein tyrosine phosphatase, receptor type, G 0.0275658
TRERF1 transcriptional regulating factor 1 0.0273744
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0271247
BIRC6 baculoviral IAP repeat containing 6 0.0267409
EIF4B eukaryotic translation initiation factor 4B 0.0266689
VGLL4 vestigial-like family member 4 0.0266265
BTBD9 BTB (POZ) domain containing 9 0.0265191
CD47 CD47 molecule 0.0263581
POU2F1 POU class 2 homeobox 1 0.026256
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0261769
AHNAK AHNAK nucleoprotein 0.0261745
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0261704
PNISR PNN-interacting serine/arginine-rich protein 0.0259562
ZEB1 zinc finger E-box binding homeobox 1 0.0256597
DSCAM Down syndrome cell adhesion molecule 0.0256214
ADAM9 ADAM metallopeptidase domain 9 0.025525
JMJD1C jumonji domain containing 1C 0.0249811
NAMPT nicotinamide phosphoribosyltransferase 0.0249683
YEATS2 YEATS domain containing 2 0.0249409
HDLBP high density lipoprotein binding protein 0.0246185
ANKRD17 ankyrin repeat domain 17 0.0243257
XPO1 exportin 1 0.0242099

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.235749
RPS8 ribosomal protein S8 -0.10774
RPS6 ribosomal protein S6 -0.104768
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0827204
BMP10 bone morphogenetic protein 10 -0.079169
TPT1 tumor protein, translationally-controlled 1 -0.0739262
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0693293
RPL35A ribosomal protein L35a -0.0685953
RPS23 ribosomal protein S23 -0.057964
RPL31 ribosomal protein L31 -0.057894
RPLP1 ribosomal protein, large, P1 -0.0567524
RPL34 ribosomal protein L34 -0.0556048
RPL12 ribosomal protein L12 -0.0529953
RPS19 ribosomal protein S19 -0.051155
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0499397
RPS13 ribosomal protein S13 -0.048826
RPLP2 ribosomal protein, large, P2 -0.0478244
RPL9 ribosomal protein L9 -0.0456948
RPS12 ribosomal protein S12 -0.0448641
RPL37A ribosomal protein L37a -0.0447058
RPL23 ribosomal protein L23 -0.0438173
RPS3 ribosomal protein S3 -0.0433094
RPS25 ribosomal protein S25 -0.0431569
RPS27A ribosomal protein S27a -0.0414957
RPL19 ribosomal protein L19 -0.0412081
RPL36 ribosomal protein L36 -0.04077
RPL26 ribosomal protein L26 -0.0391554
PDE4B phosphodiesterase 4B, cAMP-specific -0.0366051
MKI67 marker of proliferation Ki-67 -0.0359795
RPS29 ribosomal protein S29 -0.0357173
RACK1 receptor for activated C kinase 1 -0.0346907
LOC102724023 ES1 protein homolog, mitochondrial -0.0341187
RPL7A ribosomal protein L7a -0.0337541
RPS27 ribosomal protein S27 -0.0323276
HSPB1 heat shock 27kDa protein 1 -0.0322518
RPS14 ribosomal protein S14 -0.0321505
S100A9 S100 calcium binding protein A9 -0.0320517
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0309713
CCND1 cyclin D1 -0.0308818
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0301832
RPL8 ribosomal protein L8 -0.0294724
RPL7 ribosomal protein L7 -0.0293169
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0282427
RPS24 ribosomal protein S24 -0.0274472
RPL32 ribosomal protein L32 -0.0270423
RPL11 ribosomal protein L11 -0.0263997
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0254262
TUBA1B tubulin, alpha 1b -0.0253784
RPL37 ribosomal protein L37 -0.0252003
RPS17 ribosomal protein S17 -0.0248426
RPL27A ribosomal protein L27a -0.0243509
RPS11 ribosomal protein S11 -0.0242044
TMSB10 thymosin beta 10 -0.0240118
RPL18 ribosomal protein L18 -0.0238798
RPS15 ribosomal protein S15 -0.0238134
RPS10 ribosomal protein S10 -0.0237215
ANXA1 annexin A1 -0.0237014
FER1L6 fer-1-like family member 6 -0.0236467
ACTG1 actin gamma 1 -0.0233738
RPL28 ribosomal protein L28 -0.0232554
RPL30 ribosomal protein L30 -0.0232294
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.023094
RPS16 ribosomal protein S16 -0.0225818
RPL38 ribosomal protein L38 -0.0222075
RPS21 ribosomal protein S21 -0.0221182
RPL36A ribosomal protein L36a -0.0218047
FTL ferritin, light polypeptide -0.0215259
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0214514
DIAPH3 diaphanous-related formin 3 -0.0213163
RPS5 ribosomal protein S5 -0.0212715
EMP3 epithelial membrane protein 3 -0.0212567
RPL35 ribosomal protein L35 -0.0212404
RFC3 replication factor C (activator 1) 3, 38kDa -0.020959
TUBB4B tubulin, beta 4B class IVb -0.0208223
EBNA1BP2 EBNA1 binding protein 2 -0.0207178
RPS20 ribosomal protein S20 -0.0206076
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0205847
S100A10 S100 calcium binding protein A10 -0.0205771
EIF1 eukaryotic translation initiation factor 1 -0.0202155
ARL4C ADP-ribosylation factor-like 4C -0.0201657
RPL15 ribosomal protein L15 -0.0199223
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0199094
RPL10A ribosomal protein L10a -0.0196773
TM4SF1 transmembrane 4 L six family member 1 -0.0195768
TBCA tubulin folding cofactor A -0.0192688
RAN RAN, member RAS oncogene family -0.0192049
TPM4 tropomyosin 4 -0.0191252
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0187998
HMGB1 high mobility group box 1 -0.0186817
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0186488
UNC13A unc-13 homolog A (C. elegans) -0.0186197
AEBP2 AE binding protein 2 -0.0185322
MT2A metallothionein 2A -0.0185018
RPLP0 ribosomal protein, large, P0 -0.0180977
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0179794
NAP1L1 nucleosome assembly protein 1-like 1 -0.0179222
SMC4 structural maintenance of chromosomes 4 -0.017756
S100A11 S100 calcium binding protein A11 -0.017739
ITGA10 integrin, alpha 10 -0.0177114
RPS4X ribosomal protein S4, X-linked -0.0176527