Dimethyl fumarate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0821237
PALM2AKAP2 PALM2 and AKAP2 fusion 0.074559
MYH9 myosin, heavy chain 9, non-muscle 0.0708975
NAV2 neuron navigator 2 0.0703526
OSMR oncostatin M receptor 0.0625375
DSCAM Down syndrome cell adhesion molecule 0.0594178
MACF1 microtubule-actin crosslinking factor 1 0.0544341
FNDC3B fibronectin type III domain containing 3B 0.0509651
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.048333
DST dystonin 0.0478418
TBC1D5 TBC1 domain family, member 5 0.0474245
ZNF292 zinc finger protein 292 0.0467823
FMNL2 formin-like 2 0.0458532
ATP13A3 ATPase type 13A3 0.0443995
THSD4 thrombospondin, type I, domain containing 4 0.0435167
ANKRD12 ankyrin repeat domain 12 0.0433181
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.04307
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0421214
HSPA8 heat shock 70kDa protein 8 0.0420686
DGKD diacylglycerol kinase, delta 130kDa 0.0412888
DERA deoxyribose-phosphate aldolase (putative) 0.0410887
MCL1 myeloid cell leukemia 1 0.0406836
PRKCA protein kinase C, alpha 0.0405669
ENO1 enolase 1, (alpha) 0.0403459
SMAD3 SMAD family member 3 0.0402351
AKAP13 A kinase (PRKA) anchor protein 13 0.0401212
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0393581
EEF2 eukaryotic translation elongation factor 2 0.0388832
CD44 CD44 molecule (Indian blood group) 0.0383346
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0383101
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0383011
CEP250 centrosomal protein 250kDa 0.0381512
FLNB filamin B, beta 0.0376956
MBNL1 muscleblind-like splicing regulator 1 0.0371704
MSN moesin 0.0369143
TAS2R14 taste receptor, type 2, member 14 0.0360701
ASPH aspartate beta-hydroxylase 0.0339019
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0337842
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0332497
TRIO trio Rho guanine nucleotide exchange factor 0.0328885
PTK2 protein tyrosine kinase 2 0.0323656
SDC4 syndecan 4 0.0323026
PYGL phosphorylase, glycogen, liver 0.0322847
ANKRD11 ankyrin repeat domain 11 0.0318505
RNF213 ring finger protein 213 0.0317851
MRE11 MRE11 homolog, double strand break repair nuclease 0.0315603
RAD51B RAD51 paralog B 0.0314263
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0312784
HJURP Holliday junction recognition protein 0.0310695
SMYD3 SET and MYND domain containing 3 0.0309284
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0305296
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0303734
PICALM phosphatidylinositol binding clathrin assembly protein 0.0303516
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0303162
ADAM10 ADAM metallopeptidase domain 10 0.0300324
SS18 synovial sarcoma translocation, chromosome 18 0.0300059
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0298865
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0295556
ANKRD28 ankyrin repeat domain 28 0.0294778
ITCH itchy E3 ubiquitin protein ligase 0.0294291
PRPF8 pre-mRNA processing factor 8 0.0293593
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0291954
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0289493
TPX2 TPX2, microtubule-associated 0.0289277
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0285743
PRRC2A proline-rich coiled-coil 2A 0.0282736
FLNA filamin A, alpha 0.0279639
LDHA lactate dehydrogenase A 0.0279149
BHLHE40 basic helix-loop-helix family, member e40 0.0278509
WNK1 WNK lysine deficient protein kinase 1 0.0277926
ANGPTL4 angiopoietin-like 4 0.0277479
SEPTIN2 septin 2 0.0276252
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0274805
ELL2 elongation factor, RNA polymerase II, 2 0.027319
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0272698
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0272458
ERCC6L2 excision repair cross-complementation group 6-like 2 0.027171
ADNP activity-dependent neuroprotector homeobox 0.0271697
CDCP1 CUB domain containing protein 1 0.0270871
NXN nucleoredoxin 0.0269502
NIBAN2 niban apoptosis regulator 2 0.0268268
NAMPT nicotinamide phosphoribosyltransferase 0.0267273
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0266665
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0265563
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0260504
MYO9B myosin IXB 0.0260196
KIAA1328 KIAA1328 0.0259212
NBAS neuroblastoma amplified sequence 0.0259049
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257591
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0257102
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0256015
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0255463
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0251299
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0251239
ABI2 abl-interactor 2 0.0250786
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0249559
PRKCE protein kinase C, epsilon 0.0246479
PDE8A phosphodiesterase 8A 0.0246311
TNRC18 trinucleotide repeat containing 18 0.024527
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.02451

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.0861252
TPT1 tumor protein, translationally-controlled 1 -0.0807166
MT2A metallothionein 2A -0.0683387
TMSB10 thymosin beta 10 -0.0666642
VIM vimentin -0.0546812
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0530992
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0495018
RPL35A ribosomal protein L35a -0.0491233
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0473985
DEK DEK proto-oncogene -0.0442226
RPS8 ribosomal protein S8 -0.0441468
IER3 immediate early response 3 -0.0436776
RPS19 ribosomal protein S19 -0.0402529
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0367757
FTL ferritin, light polypeptide -0.0361259
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.033955
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0333069
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0329746
RPL32 ribosomal protein L32 -0.0326049
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0321763
RPS25 ribosomal protein S25 -0.032055
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0314139
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0311389
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0311034
RPL27A ribosomal protein L27a -0.0304158
S100A9 S100 calcium binding protein A9 -0.029808
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0298019
RACK1 receptor for activated C kinase 1 -0.029623
TPI1 triosephosphate isomerase 1 -0.0286434
HMGA2 high mobility group AT-hook 2 -0.0285128
RPS24 ribosomal protein S24 -0.0284845
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.027961
RPS3 ribosomal protein S3 -0.0277406
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0276931
B2M beta-2-microglobulin -0.0274674
PHIP pleckstrin homology domain interacting protein -0.0269606
WBP11 WW domain binding protein 11 -0.0267797
BMERB1 bMERB domain containing 1 -0.0267223
RPL12 ribosomal protein L12 -0.0265126
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0263711
RPS23 ribosomal protein S23 -0.0263576
RPL38 ribosomal protein L38 -0.0257497
PURA purine-rich element binding protein A -0.0255725
EIF5B eukaryotic translation initiation factor 5B -0.0254821
PTMA prothymosin, alpha -0.0254716
TAOK1 TAO kinase 1 -0.0252455
OGA O-GlcNAcase -0.0252067
POTEF POTE ankyrin domain family, member F -0.0249935
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0246148
CLINT1 clathrin interactor 1 -0.0244569
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0243715
RPS11 ribosomal protein S11 -0.0243071
RPS13 ribosomal protein S13 -0.0241201
ATP5F1E ATP synthase F1 subunit epsilon -0.0240995
AKAP10 A kinase (PRKA) anchor protein 10 -0.0234965
RPL23 ribosomal protein L23 -0.0225793
RSRP1 arginine/serine-rich protein 1 -0.0224839
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0224783
RPL36AL ribosomal protein L36a-like -0.0222517
S100A6 S100 calcium binding protein A6 -0.0222351
PGGT1B protein geranylgeranyltransferase type I, beta subunit -0.0221173
BTG1 B-cell translocation gene 1, anti-proliferative -0.022007
ATG12 autophagy related 12 -0.0216264
BIRC3 baculoviral IAP repeat containing 3 -0.0215177
ATAD1 ATPase family, AAA domain containing 1 -0.021451
KLF6 Kruppel-like factor 6 -0.021379
IFIH1 interferon induced with helicase C domain 1 -0.0210926
PIAS2 protein inhibitor of activated STAT, 2 -0.0210504
RSRC2 arginine/serine-rich coiled-coil 2 -0.0209678
KLHL24 kelch-like family member 24 -0.0208304
FAM3C family with sequence similarity 3, member C -0.0208284
H3-3B H3.3 histone B -0.0207475
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0207136
HLA-C major histocompatibility complex, class I, C -0.0206867
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0205928
LOC102724023 ES1 protein homolog, mitochondrial -0.0205615
SRSF11 serine/arginine-rich splicing factor 11 -0.0204326
PRRC1 proline-rich coiled-coil 1 -0.0204194
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0203552
RPL6 ribosomal protein L6 -0.0201006
RPS6 ribosomal protein S6 -0.020079
LMAN1 lectin, mannose-binding, 1 -0.0198726
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -0.0198547
MEF2A myocyte enhancer factor 2A -0.019835
TUBA1B tubulin, alpha 1b -0.0197971
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0197287
RPS17 ribosomal protein S17 -0.0196081
RPL19 ribosomal protein L19 -0.0195972
ISG15 ISG15 ubiquitin-like modifier -0.0195422
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0193927
RPL18 ribosomal protein L18 -0.0193554
ZC3H13 zinc finger CCCH-type containing 13 -0.0193152
JUND jun D proto-oncogene -0.0192395
UBC ubiquitin C -0.0191927
RPL8 ribosomal protein L8 -0.0190505
IFT20 intraflagellar transport 20 -0.0189984
RPL31 ribosomal protein L31 -0.0189226
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0188959
GOLT1B golgi transport 1B -0.0186726
UGCG UDP-glucose ceramide glucosyltransferase -0.0186381