Dimethyl fumarate_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.177444
MACC1 metastasis associated in colon cancer 1 0.131932
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.129919
KRT8 keratin 8, type II 0.105685
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.100195
BCL2L1 BCL2-like 1 0.0985591
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0966813
MAML2 mastermind-like 2 (Drosophila) 0.0952647
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0830133
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0811264
FAT1 FAT atypical cadherin 1 0.0751298
SDK1 sidekick cell adhesion molecule 1 0.075098
PRELID2 PRELI domain containing 2 0.0727507
CEMIP cell migration inducing protein, hyaluronan binding 0.0719666
DSPP dentin sialophosphoprotein 0.0683126
MYOF myoferlin 0.0672865
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0644167
ANXA2 annexin A2 0.0639068
TBC1D5 TBC1 domain family, member 5 0.063504
FNDC3B fibronectin type III domain containing 3B 0.0610111
FRMD5 FERM domain containing 5 0.058089
ANXA11 annexin A11 0.0577943
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0558588
ESYT2 extended synaptotagmin-like protein 2 0.0556034
FTH1 ferritin, heavy polypeptide 1 0.0552358
APLP2 amyloid beta (A4) precursor-like protein 2 0.0550833
TOP1 topoisomerase (DNA) I 0.0542516
MYH9 myosin, heavy chain 9, non-muscle 0.0531322
FLNA filamin A, alpha 0.0529352
H1-0 H1.0 linker histone 0.0516636
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0510683
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0509916
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0508938
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0503218
OSBPL10 oxysterol binding protein-like 10 0.0501824
SRRM2 serine/arginine repetitive matrix 2 0.0490402
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0486976
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0486155
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0484246
ZNRF3 zinc and ring finger 3 0.0469978
ARHGAP32 Rho GTPase activating protein 32 0.045666
MYO10 myosin X 0.0450649
LPP LIM domain containing preferred translocation partner in lipoma 0.0450292
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0448896
TRIO trio Rho guanine nucleotide exchange factor 0.0440571
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0439546
KMT2C lysine (K)-specific methyltransferase 2C 0.0435352
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0433456
ACTN4 actinin, alpha 4 0.0433298
APP amyloid beta (A4) precursor protein 0.0414373
SDC4 syndecan 4 0.0410375
EHBP1 EH domain binding protein 1 0.0404881
SAMD4A sterile alpha motif domain containing 4A 0.0401518
SEPTIN9 septin 9 0.0395626
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0393825
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0393371
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0392898
TPM4 tropomyosin 4 0.0390608
PTK2 protein tyrosine kinase 2 0.0387143
PLEC plectin 0.0385954
RNF43 ring finger protein 43 0.0385651
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0385435
SHB Src homology 2 domain containing adaptor protein B 0.0380784
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0379539
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0379146
SBF2 SET binding factor 2 0.037781
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0377069
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0371217
CTNND1 catenin (cadherin-associated protein), delta 1 0.0371008
ACTG1 actin gamma 1 0.0367555
SNX9 sorting nexin 9 0.0367291
MACF1 microtubule-actin crosslinking factor 1 0.036674
SQSTM1 sequestosome 1 0.0361974
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0359167
STC2 stanniocalcin 2 0.0359079
CALU calumenin 0.0356932
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0354596
CLDN4 claudin 4 0.0354099
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0350462
SVIL supervillin 0.0347784
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0346187
RUNX1 runt-related transcription factor 1 0.0343445
YAP1 Yes-associated protein 1 0.0340406
CCND1 cyclin D1 0.0334918
EXOC4 exocyst complex component 4 0.0331559
DOCK4 dedicator of cytokinesis 4 0.0331419
BBX bobby sox homolog (Drosophila) 0.0330189
CCNL1 cyclin L1 0.0330005
KRT18 keratin 18, type I 0.032758
GOLGA4 golgin A4 0.032477
AHNAK AHNAK nucleoprotein 0.0324001
KIAA1671 KIAA1671 0.0323797
ANO1 anoctamin 1, calcium activated chloride channel 0.0322773
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0322194
LOC112694756 uncharaterized LOC112694756 0.0322045
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0321884
MYO5B myosin VB 0.0318938
RBM39 RNA binding motif protein 39 0.0318848
KDM2A lysine (K)-specific demethylase 2A 0.0318596
TMF1 TATA element modulatory factor 1 0.0317976

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.0780421
PTMA prothymosin, alpha -0.0596967
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0364777
EIF1 eukaryotic translation initiation factor 1 -0.0321262
GARS1 glycyl-tRNA synthetase 1 -0.0310561
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0303825
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303469
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0287665
IER3 immediate early response 3 -0.0270454
SMAD2 SMAD family member 2 -0.0261871
RPLP2 ribosomal protein, large, P2 -0.0256139
RPS24 ribosomal protein S24 -0.024638
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0239869
RPL23 ribosomal protein L23 -0.0207597
DDIT4 DNA-damage-inducible transcript 4 -0.0203633
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0202539
RPS19 ribosomal protein S19 -0.0193875
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0184119
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0181289
RPL35A ribosomal protein L35a -0.0179399
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.017876
RPL34 ribosomal protein L34 -0.0178656
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0175077
ZNF706 zinc finger protein 706 -0.0172838
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0170988
RPS11 ribosomal protein S11 -0.0170575
RPS23 ribosomal protein S23 -0.0169169
RPLP1 ribosomal protein, large, P1 -0.0166818
TMSB10 thymosin beta 10 -0.0166053
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.016458
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.016411
RPS5 ribosomal protein S5 -0.0161696
RPL32 ribosomal protein L32 -0.0161229
NDUFA4 NDUFA4, mitochondrial complex associated -0.015669
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0145077
ZC3H15 zinc finger CCCH-type containing 15 -0.0144115
FNBP1L formin binding protein 1-like -0.0140096
WDR45B WD repeat domain 45B -0.0139741
DEK DEK proto-oncogene -0.0137433
RPL9 ribosomal protein L9 -0.0137252
SMAD5 SMAD family member 5 -0.013486
RPS13 ribosomal protein S13 -0.0133737
WAC WW domain containing adaptor with coiled-coil -0.0133464
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0133277
RAB7A RAB7A, member RAS oncogene family -0.0132727
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0132421
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.0131935
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0131434
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0131141
IFIH1 interferon induced with helicase C domain 1 -0.0130006
OAZ1 ornithine decarboxylase antizyme 1 -0.0129687
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0128022
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0127869
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0126661
H3-3B H3.3 histone B -0.0126499
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0124754
UBA2 ubiquitin-like modifier activating enzyme 2 -0.012462
GPBP1 GC-rich promoter binding protein 1 -0.0122709
RPL36 ribosomal protein L36 -0.0121122
FNDC3A fibronectin type III domain containing 3A -0.0120962
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0120012
PDCD5 programmed cell death 5 -0.0119939
RPL38 ribosomal protein L38 -0.0119089
ABI1 abl-interactor 1 -0.0119021
RPS25 ribosomal protein S25 -0.0118725
MT2A metallothionein 2A -0.0118568
AFF4 AF4/FMR2 family, member 4 -0.0118158
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.01168
EPCAM epithelial cell adhesion molecule -0.0116179
CSNK1A1 casein kinase 1, alpha 1 -0.0116032
FBXO34 F-box protein 34 -0.0115548
STRN3 striatin, calmodulin binding protein 3 -0.0114774
UGCG UDP-glucose ceramide glucosyltransferase -0.0114431
RPL6 ribosomal protein L6 -0.011392
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.0111846
FUBP3 far upstream element (FUSE) binding protein 3 -0.0111681
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0111258
CKAP2 cytoskeleton associated protein 2 -0.0111021
GPATCH8 G patch domain containing 8 -0.0110825
ATP5F1E ATP synthase F1 subunit epsilon -0.0110419
RPL36AL ribosomal protein L36a-like -0.0110172
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0109922
RPS27A ribosomal protein S27a -0.0109086
RPS21 ribosomal protein S21 -0.0108788
SRSF11 serine/arginine-rich splicing factor 11 -0.0108065
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0107422
SPAG9 sperm associated antigen 9 -0.0106438
CLINT1 clathrin interactor 1 -0.0105597
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.010555
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0105399
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -0.0105348
WASL Wiskott-Aldrich syndrome-like -0.010508
HINT1 histidine triad nucleotide binding protein 1 -0.0104708
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0104529
NOL7 nucleolar protein 7, 27kDa -0.0104527
TSNAX translin-associated factor X -0.0104252
USP37 ubiquitin specific peptidase 37 -0.0103764
VBP1 von Hippel-Lindau binding protein 1 -0.0103386
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0103125
RYBP RING1 and YY1 binding protein -0.0102767