Dimethyl fumarate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.111705
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0983398
EGFR epidermal growth factor receptor 0.0926729
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0763887
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0710382
RAD51B RAD51 paralog B 0.0686378
FAT1 FAT atypical cadherin 1 0.0622808
ATXN1 ataxin 1 0.0609921
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0589266
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0581113
RUNX2 runt-related transcription factor 2 0.0539273
CCSER1 coiled-coil serine-rich protein 1 0.0527904
HSPA8 heat shock 70kDa protein 8 0.0518003
HMGA2 high mobility group AT-hook 2 0.0477377
FLOT1 flotillin 1 0.0473188
PLAUR plasminogen activator, urokinase receptor 0.0455319
ITPRID2 ITPR interacting domain containing 2 0.0426597
AXIN2 axin 2 0.0414474
LAMC2 laminin, gamma 2 0.0409839
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0390929
RPL3 ribosomal protein L3 0.0388638
NCEH1 neutral cholesterol ester hydrolase 1 0.0381953
PDE4B phosphodiesterase 4B, cAMP-specific 0.0379715
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0379249
ZNRF3 zinc and ring finger 3 0.0371744
FHIT fragile histidine triad 0.0370919
SRRM2 serine/arginine repetitive matrix 2 0.0363526
DOCK5 dedicator of cytokinesis 5 0.0359396
FHL2 four and a half LIM domains 2 0.0355916
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0343147
CPOX coproporphyrinogen oxidase 0.0338924
RNF43 ring finger protein 43 0.0331339
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0331038
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0322582
EPHA2 EPH receptor A2 0.0319531
BCL2L1 BCL2-like 1 0.030871
EZR ezrin 0.0306172
MBNL1 muscleblind-like splicing regulator 1 0.0291838
CD9 CD9 molecule 0.0290537
ACTN4 actinin, alpha 4 0.0278939
SMAD3 SMAD family member 3 0.0274642
AKAP13 A kinase (PRKA) anchor protein 13 0.0272673
GPHN gephyrin 0.0271508
KITLG KIT ligand 0.0269642
ANXA11 annexin A11 0.026907
YAP1 Yes-associated protein 1 0.0263621
SEPTIN9 septin 9 0.0257668
ITGA6 integrin, alpha 6 0.0254663
FOSL1 FOS-like antigen 1 0.0251684
EIF4B eukaryotic translation initiation factor 4B 0.0248336
PFKP phosphofructokinase, platelet 0.0248043
LAMA4 laminin, alpha 4 0.024799
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0236023
NTSR1 neurotensin receptor 1 (high affinity) 0.0234935
PRELID2 PRELI domain containing 2 0.0234846
LMO7 LIM domain 7 0.0234118
DUSP4 dual specificity phosphatase 4 0.0232751
FERMT1 fermitin family member 1 0.0231803
MKI67 marker of proliferation Ki-67 0.0227738
RANBP9 RAN binding protein 9 0.0226911
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0225648
EDAR ectodysplasin A receptor 0.0225458
SMYD3 SET and MYND domain containing 3 0.0225245
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0224104
MACF1 microtubule-actin crosslinking factor 1 0.02238
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0222712
SCFD1 sec1 family domain containing 1 0.0222273
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.02127
TNS3 tensin 3 0.020983
EGR1 early growth response 1 0.0208258
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0206947
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0206284
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0206218
TBC1D5 TBC1 domain family, member 5 0.0204172
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0202983
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0202392
MSI2 musashi RNA-binding protein 2 0.0199193
DSPP dentin sialophosphoprotein 0.0198766
UTRN utrophin 0.0198314
KIAA0040 KIAA0040 0.0197671
VMP1 vacuole membrane protein 1 0.0196374
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.019433
KMT2C lysine (K)-specific methyltransferase 2C 0.019353
ARHGAP32 Rho GTPase activating protein 32 0.019069
GSK3B glycogen synthase kinase 3 beta 0.0188051
OXR1 oxidation resistance 1 0.0187706
MED13L mediator complex subunit 13-like 0.0187496
PDE4D phosphodiesterase 4D, cAMP-specific 0.0186161
LPP LIM domain containing preferred translocation partner in lipoma 0.018489
NIBAN2 niban apoptosis regulator 2 0.0184607
MPRIP myosin phosphatase Rho interacting protein 0.0182763
EXOC4 exocyst complex component 4 0.0181995
RPL21 ribosomal protein L21 0.0181979
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0180829
RPS2 ribosomal protein S2 0.0179897
KDM6A lysine (K)-specific demethylase 6A 0.0179281
NBAS neuroblastoma amplified sequence 0.0179135
TGFB2 transforming growth factor, beta 2 0.0175772
ATL2 atlastin GTPase 2 0.0173861
SHB Src homology 2 domain containing adaptor protein B 0.0173706

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.216211
PTMA prothymosin, alpha -0.189756
TMSB10 thymosin beta 10 -0.176428
IER3 immediate early response 3 -0.135916
RPL35A ribosomal protein L35a -0.0892588
TPT1 tumor protein, translationally-controlled 1 -0.087872
RPLP1 ribosomal protein, large, P1 -0.0767583
RPS24 ribosomal protein S24 -0.0695435
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0629191
RPL34 ribosomal protein L34 -0.0568827
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0561305
EIF1 eukaryotic translation initiation factor 1 -0.0443858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442634
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.043657
RPL31 ribosomal protein L31 -0.0403301
RPL32 ribosomal protein L32 -0.0397285
S100A6 S100 calcium binding protein A6 -0.0377854
RPS25 ribosomal protein S25 -0.036136
RPS8 ribosomal protein S8 -0.033531
RPS19 ribosomal protein S19 -0.032891
RPL5 ribosomal protein L5 -0.0328142
GARS1 glycyl-tRNA synthetase 1 -0.0327044
RPS6 ribosomal protein S6 -0.0326967
RPLP0 ribosomal protein, large, P0 -0.032128
RPL23 ribosomal protein L23 -0.0303472
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0303118
RPL12 ribosomal protein L12 -0.0298544
RPS4X ribosomal protein S4, X-linked -0.029817
NPR2 natriuretic peptide receptor 2 -0.0294348
RSL1D1 ribosomal L1 domain containing 1 -0.0285715
RPL36 ribosomal protein L36 -0.0282014
FTL ferritin, light polypeptide -0.0279749
RPL19 ribosomal protein L19 -0.0275716
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.027142
RPS27A ribosomal protein S27a -0.0270801
ARF1 ADP-ribosylation factor 1 -0.0270182
RPL4 ribosomal protein L4 -0.0257021
RPS29 ribosomal protein S29 -0.0254134
RPS16 ribosomal protein S16 -0.0253124
RPS28 ribosomal protein S28 -0.0251494
RPL7 ribosomal protein L7 -0.023835
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0236794
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0234371
GNAS GNAS complex locus -0.0233713
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0227799
MT1X metallothionein 1X -0.0226832
RPS5 ribosomal protein S5 -0.0216645
RPS15 ribosomal protein S15 -0.0215983
RPS14 ribosomal protein S14 -0.0215873
RACK1 receptor for activated C kinase 1 -0.0214465
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0209604
RLF rearranged L-myc fusion -0.0208846
MATR3 matrin 3 -0.0207374
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0206617
MT2A metallothionein 2A -0.0205058
PKM pyruvate kinase, muscle -0.0200788
S100A9 S100 calcium binding protein A9 -0.0199686
RPS13 ribosomal protein S13 -0.0198506
RPL26 ribosomal protein L26 -0.0196241
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0193674
RPS23 ribosomal protein S23 -0.0189567
NAP1L1 nucleosome assembly protein 1-like 1 -0.0189508
GSTP1 glutathione S-transferase pi 1 -0.0187604
RPL10A ribosomal protein L10a -0.0186983
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0185232
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0184663
RPL15 ribosomal protein L15 -0.0182482
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0181538
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.018003
MARS1 methionyl-tRNA synthetase 1 -0.0179193
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0178967
LMAN1 lectin, mannose-binding, 1 -0.0176905
ESYT2 extended synaptotagmin-like protein 2 -0.0175446
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0171438
S100A10 S100 calcium binding protein A10 -0.0171435
USP3 ubiquitin specific peptidase 3 -0.0170673
RNF145 ring finger protein 145 -0.0169081
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0168893
NOP58 NOP58 ribonucleoprotein -0.0167865
LMNA lamin A/C -0.0166959
MARCHF6 membrane associated ring-CH-type finger 6 -0.0166727
RPL18 ribosomal protein L18 -0.0166336
MTDH metadherin -0.0165645
RPL11 ribosomal protein L11 -0.0165564
GDF15 growth differentiation factor 15 -0.0164905
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0164565
RPL6 ribosomal protein L6 -0.016385
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0163366
SRP72 signal recognition particle 72kDa -0.0162874
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0162772
RPL36AL ribosomal protein L36a-like -0.0162264
RTN3 reticulon 3 -0.016069
RPL35 ribosomal protein L35 -0.0157947
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0156532
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0156524
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0156258
UBC ubiquitin C -0.0155614
HDAC3 histone deacetylase 3 -0.0150607
EMP1 epithelial membrane protein 1 -0.0149754
RBM39 RNA binding motif protein 39 -0.0149337