Dimethyl fumarate_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.194766
EZR ezrin 0.15802
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.125019
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.119008
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.115696
MAML2 mastermind-like 2 (Drosophila) 0.109526
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.102085
NKD1 naked cuticle homolog 1 (Drosophila) 0.0995262
CEMIP2 cell migration inducing hyaluronidase 2 0.0904571
ATXN1 ataxin 1 0.0874236
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0869456
RUNX1 runt-related transcription factor 1 0.0836592
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0786657
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0779217
MYH9 myosin, heavy chain 9, non-muscle 0.0778613
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0747075
EEF2 eukaryotic translation elongation factor 2 0.0744129
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0715263
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0709101
NAV2 neuron navigator 2 0.0697134
TNS3 tensin 3 0.0682663
KRT8 keratin 8, type II 0.0680475
KIZ kizuna centrosomal protein 0.0650334
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0639948
DSPP dentin sialophosphoprotein 0.0635458
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.062628
ENO1 enolase 1, (alpha) 0.0567253
EGR1 early growth response 1 0.0555244
PCBP2 poly(rC) binding protein 2 0.0546911
BCL2L1 BCL2-like 1 0.0539548
CD46 CD46 molecule, complement regulatory protein 0.0535916
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0533269
TXNIP thioredoxin interacting protein 0.0509894
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0502472
AKAP9 A kinase (PRKA) anchor protein 9 0.0501561
MACC1 metastasis associated in colon cancer 1 0.0494982
CENPF centromere protein F, 350/400kDa 0.04862
DST dystonin 0.0485928
EFNB2 ephrin-B2 0.0463726
PDE4D phosphodiesterase 4D, cAMP-specific 0.0458323
ANXA2 annexin A2 0.0453039
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0446688
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0442081
SRRM2 serine/arginine repetitive matrix 2 0.0434935
ZBTB20 zinc finger and BTB domain containing 20 0.0431519
ARF4 ADP-ribosylation factor 4 0.0430015
MACF1 microtubule-actin crosslinking factor 1 0.0428276
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0424998
ETNK1 ethanolamine kinase 1 0.0415491
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0405326
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0403888
TBC1D5 TBC1 domain family, member 5 0.0402409
MBD5 methyl-CpG binding domain protein 5 0.0397221
HDAC8 histone deacetylase 8 0.0390937
SBF2 SET binding factor 2 0.0390527
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0389783
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0389434
HDAC4 histone deacetylase 4 0.0389353
MSN moesin 0.0381723
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0378675
RPL3 ribosomal protein L3 0.0377675
EIF4B eukaryotic translation initiation factor 4B 0.0376421
MBNL2 muscleblind-like splicing regulator 2 0.0369572
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.036791
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0366313
MCL1 myeloid cell leukemia 1 0.0361247
RAD51B RAD51 paralog B 0.0360842
APLP2 amyloid beta (A4) precursor-like protein 2 0.0360357
PGK1 phosphoglycerate kinase 1 0.0359403
CDK19 cyclin-dependent kinase 19 0.0359096
CMIP c-Maf inducing protein 0.0358189
PEAK1 pseudopodium-enriched atypical kinase 1 0.0358176
LRP6 low density lipoprotein receptor-related protein 6 0.0357682
NONO non-POU domain containing, octamer-binding 0.0357486
BCLAF1 BCL2-associated transcription factor 1 0.0355492
OXR1 oxidation resistance 1 0.0353323
ITGA6 integrin, alpha 6 0.0352728
SFPQ splicing factor proline/glutamine-rich 0.0351748
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0351641
SVIL supervillin 0.035137
TNS4 tensin 4 0.0350547
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0348497
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0345071
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0339915
VMP1 vacuole membrane protein 1 0.0339597
SPRED2 sprouty-related, EVH1 domain containing 2 0.0338444
SYT1 synaptotagmin I 0.0338333
POTEF POTE ankyrin domain family, member F 0.0338028
ANO6 anoctamin 6 0.0337433
ABHD2 abhydrolase domain containing 2 0.0336882
PRELID2 PRELI domain containing 2 0.0334765
WWOX WW domain containing oxidoreductase 0.033266
ACTN1 actinin, alpha 1 0.0331784
KDM4C lysine (K)-specific demethylase 4C 0.0330251
PROX1 prospero homeobox 1 0.0329902
ZNF638 zinc finger protein 638 0.0328723
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0325054
ZNRF3 zinc and ring finger 3 0.0322635
EMP1 epithelial membrane protein 1 0.0322203
VGLL4 vestigial-like family member 4 0.0320649

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.105926
TMSB10 thymosin beta 10 -0.0742614
TPT1 tumor protein, translationally-controlled 1 -0.0615417
CCND1 cyclin D1 -0.060708
RPS24 ribosomal protein S24 -0.056933
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0539011
RPL35A ribosomal protein L35a -0.0492116
AKAP12 A kinase (PRKA) anchor protein 12 -0.0428911
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0394106
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0383341
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0367152
MT2A metallothionein 2A -0.0352759
RPL36A ribosomal protein L36a -0.0335604
AHNAK AHNAK nucleoprotein -0.033288
IER3 immediate early response 3 -0.0323126
SDK1 sidekick cell adhesion molecule 1 -0.0320117
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.029538
RPLP1 ribosomal protein, large, P1 -0.0294279
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0290264
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0287638
NAP1L1 nucleosome assembly protein 1-like 1 -0.0282146
NOP56 NOP56 ribonucleoprotein -0.0274071
TFRC transferrin receptor -0.026297
RPS23 ribosomal protein S23 -0.0261902
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0261082
RPL38 ribosomal protein L38 -0.0253207
HMGB1 high mobility group box 1 -0.0244779
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0237117
RPS27A ribosomal protein S27a -0.0236602
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0229368
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0226412
MARCHF6 membrane associated ring-CH-type finger 6 -0.0220727
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0212828
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0212073
EPCAM epithelial cell adhesion molecule -0.020957
PDGFA platelet-derived growth factor alpha polypeptide -0.0209305
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0204725
FTL ferritin, light polypeptide -0.0203408
NPR2 natriuretic peptide receptor 2 -0.0200183
RPS21 ribosomal protein S21 -0.0194103
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0194001
CBFB core-binding factor, beta subunit -0.0192412
RPLP2 ribosomal protein, large, P2 -0.0187052
RPL31 ribosomal protein L31 -0.0184387
RPL34 ribosomal protein L34 -0.0184297
KDM3A lysine (K)-specific demethylase 3A -0.0183468
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.018296
TMSB4X thymosin beta 4, X-linked -0.0182691
RPL32 ribosomal protein L32 -0.0181971
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.017945
RPL6 ribosomal protein L6 -0.017645
RPS13 ribosomal protein S13 -0.0174201
KHSRP KH-type splicing regulatory protein -0.017363
MTAP methylthioadenosine phosphorylase -0.017304
ABI2 abl-interactor 2 -0.0166876
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0166669
LARP1 La ribonucleoprotein domain family, member 1 -0.0165773
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0164664
ACACA acetyl-CoA carboxylase alpha -0.0164259
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0163232
GMDS GDP-mannose 4,6-dehydratase -0.016268
GTF2IRD1 GTF2I repeat domain containing 1 -0.0161578
MT1X metallothionein 1X -0.0158102
UBE2I ubiquitin-conjugating enzyme E2I -0.0157646
RBP1 retinol binding protein 1, cellular -0.0156781
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0154671
CALR calreticulin -0.0153959
HPCAL1 hippocalcin-like 1 -0.0153103
RPS19 ribosomal protein S19 -0.015284
RPS25 ribosomal protein S25 -0.0152529
UBE2K ubiquitin-conjugating enzyme E2K -0.0152135
ABLIM1 actin binding LIM protein 1 -0.0150116
SLC38A1 solute carrier family 38, member 1 -0.014988
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0148778
EIF5B eukaryotic translation initiation factor 5B -0.0148408
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0147032
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0143401
RPS29 ribosomal protein S29 -0.014276
SINHCAF SIN3-HDAC complex associated factor -0.0141111
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0139852
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0138355
TRIM56 tripartite motif containing 56 -0.0138131
PA2G4 proliferation-associated 2G4, 38kDa -0.0137476
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -0.0136833
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0136585
IPO7 importin 7 -0.0136551
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0135618
ANKRD10 ankyrin repeat domain 10 -0.0135276
NOP58 NOP58 ribonucleoprotein -0.013516
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0135087
RPL19 ribosomal protein L19 -0.0134748
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0134501
PARK7 parkinson protein 7 -0.0134422
ANO1 anoctamin 1, calcium activated chloride channel -0.0134146
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0134093
AK1 adenylate kinase 1 -0.0133718
CUL1 cullin 1 -0.0133177
TUBA1B tubulin, alpha 1b -0.0131792
GCLC glutamate-cysteine ligase, catalytic subunit -0.0131697
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0131413