Dimethyl fumarate_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dimethyl fumarate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dimethyl fumarate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.274307
FN1 fibronectin 1 0.178996
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.150007
MYH9 myosin, heavy chain 9, non-muscle 0.127538
MYO10 myosin X 0.120149
ADGRB3 adhesion G protein-coupled receptor B3 0.101507
FNDC3B fibronectin type III domain containing 3B 0.0953208
TRIO trio Rho guanine nucleotide exchange factor 0.0911112
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.088022
NAV1 neuron navigator 1 0.0880214
COL6A2 collagen, type VI, alpha 2 0.085179
COL6A1 collagen, type VI, alpha 1 0.0792872
FAM13A family with sequence similarity 13, member A 0.0752641
CD44 CD44 molecule (Indian blood group) 0.0704061
COL1A1 collagen, type I, alpha 1 0.0654476
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0637682
PDE4D phosphodiesterase 4D, cAMP-specific 0.0622888
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0615426
MSN moesin 0.0613486
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.060778
NALF1 NALCN channel auxiliary factor 1 0.0586249
ATP13A3 ATPase type 13A3 0.0574419
RUNX1 runt-related transcription factor 1 0.0559775
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0555171
GLIS3 GLIS family zinc finger 3 0.0546457
DST dystonin 0.0529821
P4HB prolyl 4-hydroxylase, beta polypeptide 0.051959
EXT1 exostosin glycosyltransferase 1 0.0510056
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0503057
TGFBI transforming growth factor, beta-induced, 68kDa 0.0501733
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.05
ELL2 elongation factor, RNA polymerase II, 2 0.0499855
ENO1 enolase 1, (alpha) 0.0499444
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0494641
LOXL2 lysyl oxidase-like 2 0.048277
COL1A2 collagen, type I, alpha 2 0.0480635
NAV2 neuron navigator 2 0.0474926
SEPTIN9 septin 9 0.0469328
SOD2 superoxide dismutase 2, mitochondrial 0.0451868
HIPK2 homeodomain interacting protein kinase 2 0.0445292
CALU calumenin 0.044385
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0443699
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0430805
FLNA filamin A, alpha 0.0430599
SMAD3 SMAD family member 3 0.0429848
CD59 CD59 molecule, complement regulatory protein 0.0428492
FRMD6 FERM domain containing 6 0.0427701
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0424972
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0421209
VEGFA vascular endothelial growth factor A 0.0419726
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0418512
JARID2 jumonji, AT rich interactive domain 2 0.0413446
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.040746
PICALM phosphatidylinositol binding clathrin assembly protein 0.0404385
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0404004
ANXA5 annexin A5 0.0394411
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0388506
DSCAM Down syndrome cell adhesion molecule 0.0386317
SETD5 SET domain containing 5 0.0377591
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0373456
COL5A2 collagen, type V, alpha 2 0.0367687
GOLGA4 golgin A4 0.036441
MYOF myoferlin 0.0358802
OXR1 oxidation resistance 1 0.0357172
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0349488
ANO6 anoctamin 6 0.0342287
FBN1 fibrillin 1 0.0335299
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0334403
RAI14 retinoic acid induced 14 0.0331429
TNS1 tensin 1 0.0329055
NDRG1 N-myc downstream regulated 1 0.0328897
NBAS neuroblastoma amplified sequence 0.0326968
UBA6 ubiquitin-like modifier activating enzyme 6 0.0324032
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.032175
ZFAND3 zinc finger, AN1-type domain 3 0.0321109
ARHGAP21 Rho GTPase activating protein 21 0.031586
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0314655
SEPTIN11 septin 11 0.0314214
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0309529
ASPH aspartate beta-hydroxylase 0.0308509
EEF2 eukaryotic translation elongation factor 2 0.0308487
LIMS1 LIM and senescent cell antigen-like domains 1 0.0305893
TPM3 tropomyosin 3 0.0301814
MCL1 myeloid cell leukemia 1 0.0301593
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.030134
MED13L mediator complex subunit 13-like 0.0296674
COL4A2 collagen, type IV, alpha 2 0.0295988
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0295238
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0294466
TIMP2 TIMP metallopeptidase inhibitor 2 0.0294123
LTBP1 latent transforming growth factor beta binding protein 1 0.0290456
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0289605
COL4A1 collagen, type IV, alpha 1 0.0289565
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0289074
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0285002
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0281397
SRRM2 serine/arginine repetitive matrix 2 0.0280813
RTN4 reticulon 4 0.0277229
VEGFC vascular endothelial growth factor C 0.0270933
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0268387

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0929176
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0773551
TMSB10 thymosin beta 10 -0.0582186
VIM vimentin -0.0574587
FTL ferritin, light polypeptide -0.0566809
INHBA inhibin, beta A -0.0497117
PTMA prothymosin, alpha -0.0472514
MT2A metallothionein 2A -0.0437505
B2M beta-2-microglobulin -0.0412729
TPT1 tumor protein, translationally-controlled 1 -0.0409052
RPL34 ribosomal protein L34 -0.0391999
HLA-B major histocompatibility complex, class I, B -0.0352812
RPS6 ribosomal protein S6 -0.0352072
EIF1 eukaryotic translation initiation factor 1 -0.0351594
STC1 stanniocalcin 1 -0.0340848
RPL35A ribosomal protein L35a -0.0339247
CAVIN1 caveolae associated protein 1 -0.0328462
RPLP1 ribosomal protein, large, P1 -0.0323787
RPL12 ribosomal protein L12 -0.0319195
RPL23 ribosomal protein L23 -0.0308981
RPS19 ribosomal protein S19 -0.0305914
TFPI2 tissue factor pathway inhibitor 2 -0.030453
RPS8 ribosomal protein S8 -0.0302028
RPS3 ribosomal protein S3 -0.0299272
RPL36 ribosomal protein L36 -0.0265041
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0263538
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0249294
RPL9 ribosomal protein L9 -0.0241424
RPLP2 ribosomal protein, large, P2 -0.0233985
RPL11 ribosomal protein L11 -0.0216338
RPL38 ribosomal protein L38 -0.0209849
ADM adrenomedullin -0.0204661
RPL28 ribosomal protein L28 -0.0201658
RPS23 ribosomal protein S23 -0.0198735
RPL31 ribosomal protein L31 -0.0198591
RPS29 ribosomal protein S29 -0.0197478
RPL37A ribosomal protein L37a -0.0196107
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0194706
RPS24 ribosomal protein S24 -0.0192942
CALR calreticulin -0.0185797
IER3 immediate early response 3 -0.0181189
RPS13 ribosomal protein S13 -0.0179847
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0179232
RPS27A ribosomal protein S27a -0.0177969
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0174486
RPL19 ribosomal protein L19 -0.0171005
INTS6 integrator complex subunit 6 -0.0167322
IFI6 interferon, alpha-inducible protein 6 -0.0157788
RPS25 ribosomal protein S25 -0.0154842
CD63 CD63 molecule -0.0154541
S100A9 S100 calcium binding protein A9 -0.0151284
RPS17 ribosomal protein S17 -0.0150647
RPS11 ribosomal protein S11 -0.0150139
GK glycerol kinase -0.0149382
RPL7 ribosomal protein L7 -0.0147837
RPS27 ribosomal protein S27 -0.0144023
RPL26 ribosomal protein L26 -0.0143472
RPL32 ribosomal protein L32 -0.0143441
GNAS GNAS complex locus -0.0142038
RPL37 ribosomal protein L37 -0.0139622
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0138621
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0136899
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.013602
RHOQ ras homolog family member Q -0.013033
LMAN1 lectin, mannose-binding, 1 -0.0129568
SRGN serglycin -0.0128098
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0127277
DNER delta/notch-like EGF repeat containing -0.0126737
RPL18 ribosomal protein L18 -0.0124661
RPS21 ribosomal protein S21 -0.0124057
WSB1 WD repeat and SOCS box containing 1 -0.0121937
VCL vinculin -0.0121793
TM4SF1 transmembrane 4 L six family member 1 -0.0121781
RPS16 ribosomal protein S16 -0.0120934
RPS14 ribosomal protein S14 -0.01193
RPS5 ribosomal protein S5 -0.011839
RACK1 receptor for activated C kinase 1 -0.011826
RPL8 ribosomal protein L8 -0.0118259
RPS12 ribosomal protein S12 -0.0116656
MMP1 matrix metallopeptidase 1 -0.0116454
RPL30 ribosomal protein L30 -0.0115774
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0115023
IGFBP7 insulin-like growth factor binding protein 7 -0.011422
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0112337
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0111823
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0109093
RPL36A ribosomal protein L36a -0.0108815
S100A6 S100 calcium binding protein A6 -0.0108723
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0107579
CCND1 cyclin D1 -0.0105078
IFITM2 interferon induced transmembrane protein 2 -0.0104075
ASTN2 astrotactin 2 -0.010348
RPL36AL ribosomal protein L36a-like -0.0101825
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.010133
IFI16 interferon, gamma-inducible protein 16 -0.00998663
H3-3B H3.3 histone B -0.00991842
SERF2 small EDRK-rich factor 2 -0.00981963
RPL5 ribosomal protein L5 -0.00981808
NPTX1 neuronal pentraxin I -0.00974198
IFITM3 interferon induced transmembrane protein 3 -0.00953448