Dinaciclib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.278734
POTEF POTE ankyrin domain family, member F 0.089705
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0682449
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0612531
EEF2 eukaryotic translation elongation factor 2 0.0556282
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.054973
TPM4 tropomyosin 4 0.0511888
RPS6 ribosomal protein S6 0.0496577
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0480526
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0478477
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0452713
COL1A2 collagen, type I, alpha 2 0.0450777
CLU clusterin 0.0408267
PKM pyruvate kinase, muscle 0.0399514
ZC3H3 zinc finger CCCH-type containing 3 0.0359794
RPLP1 ribosomal protein, large, P1 0.0357519
YBX1 Y box binding protein 1 0.0353739
MSN moesin 0.034841
FOSL1 FOS-like antigen 1 0.0342786
RPS3 ribosomal protein S3 0.0342126
MT2A metallothionein 2A 0.0339819
NAMPT nicotinamide phosphoribosyltransferase 0.0339466
RPS19 ribosomal protein S19 0.0327265
IER3 immediate early response 3 0.0327174
FLNA filamin A, alpha 0.0313612
RPS12 ribosomal protein S12 0.0307998
COL3A1 collagen, type III, alpha 1 0.0293893
COL6A1 collagen, type VI, alpha 1 0.0287626
RPL31 ribosomal protein L31 0.0287344
PTMA prothymosin, alpha 0.0286744
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0276272
NEFL neurofilament, light polypeptide 0.0276241
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0270638
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.027035
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.026293
TIMP2 TIMP metallopeptidase inhibitor 2 0.0261679
IER2 immediate early response 2 0.0255246
RPS17 ribosomal protein S17 0.0253009
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0252892
GNAS GNAS complex locus 0.0250879
RPL36 ribosomal protein L36 0.0244391
RPS20 ribosomal protein S20 0.0242503
RPS8 ribosomal protein S8 0.02411
H2AZ2 H2A.Z variant histone 2 0.0239769
PEA15 phosphoprotein enriched in astrocytes 15 0.023413
RPL19 ribosomal protein L19 0.0233533
FTL ferritin, light polypeptide 0.0231546
TPM3 tropomyosin 3 0.0230935
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0230541
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0229089
HDGF hepatoma-derived growth factor 0.0227639
RPS25 ribosomal protein S25 0.0224913
SERF2 small EDRK-rich factor 2 0.0224644
RPL23 ribosomal protein L23 0.022314
SFTPA2 surfactant protein A2 0.0221738
SET SET nuclear proto-oncogene 0.0219983
RPS4X ribosomal protein S4, X-linked 0.0217644
RPL35A ribosomal protein L35a 0.0215684
ZMAT3 zinc finger, matrin-type 3 0.0215043
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0213251
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0209498
ANXA1 annexin A1 0.0197768
CALU calumenin 0.019702
TEX14 testis expressed 14 0.0196338
RPS23 ribosomal protein S23 0.01958
RPS2 ribosomal protein S2 0.0192891
TPT1 tumor protein, translationally-controlled 1 0.0192795
RPL5 ribosomal protein L5 0.0192551
RPL11 ribosomal protein L11 0.0191195
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0190902
B2M beta-2-microglobulin 0.0189117
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0188737
RPL35 ribosomal protein L35 0.0188015
RPL8 ribosomal protein L8 0.0187626
PDIA3 protein disulfide isomerase family A, member 3 0.0187345
RPS11 ribosomal protein S11 0.0187112
RPS27A ribosomal protein S27a 0.0185924
CXCL8 chemokine (C-X-C motif) ligand 8 0.0185492
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0183836
CALD1 caldesmon 1 0.0183307
RPLP2 ribosomal protein, large, P2 0.0183172
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0183072
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0181823
PCYOX1 prenylcysteine oxidase 1 0.0181246
DPYSL3 dihydropyrimidinase-like 3 0.0179047
RPS16 ribosomal protein S16 0.0178942
RPL7 ribosomal protein L7 0.0178654
MYH9 myosin, heavy chain 9, non-muscle 0.0177917
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0174046
RPL37A ribosomal protein L37a 0.0173641
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0173419
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0172655
PNN pinin, desmosome associated protein 0.0169761
PCBP2 poly(rC) binding protein 2 0.0169594
RPL34 ribosomal protein L34 0.0167038
TCP1 t-complex 1 0.0166233
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0165909
TPX2 TPX2, microtubule-associated 0.0165809
CRTAP cartilage associated protein 0.0165623
ACTN4 actinin, alpha 4 0.0165489

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.143437
LOX lysyl oxidase -0.140858
TRIO trio Rho guanine nucleotide exchange factor -0.136703
IGFBP3 insulin-like growth factor binding protein 3 -0.132078
NAV1 neuron navigator 1 -0.121874
AKAP12 A kinase (PRKA) anchor protein 12 -0.12132
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103185
VIM vimentin -0.102205
THBS2 thrombospondin 2 -0.0715466
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0665472
PODXL podocalyxin-like -0.0638683
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0625274
FBXL7 F-box and leucine-rich repeat protein 7 -0.0576764
MEIS2 Meis homeobox 2 -0.0566151
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0552344
ZBTB20 zinc finger and BTB domain containing 20 -0.0548289
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0528053
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0512945
LOXL2 lysyl oxidase-like 2 -0.0506409
AHNAK AHNAK nucleoprotein -0.0503856
SLC39A11 solute carrier family 39, member 11 -0.0503676
AUTS2 autism susceptibility candidate 2 -0.049079
GLIS3 GLIS family zinc finger 3 -0.0482712
MX2 MX dynamin-like GTPase 2 -0.0472404
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0461708
RIGI RNA sensor RIG-I -0.0456546
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0437911
COL5A1 collagen, type V, alpha 1 -0.0427594
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0421038
CDH13 cadherin 13 -0.0420245
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0418091
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0417913
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0409639
OGA O-GlcNAcase -0.0396898
SAMD9 sterile alpha motif domain containing 9 -0.0393665
PRELID2 PRELI domain containing 2 -0.0390081
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0385069
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0383993
FNDC3B fibronectin type III domain containing 3B -0.0382469
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0375118
LDHA lactate dehydrogenase A -0.0367847
CD44 CD44 molecule (Indian blood group) -0.0366178
RNF213 ring finger protein 213 -0.036242
DST dystonin -0.0361404
RAI14 retinoic acid induced 14 -0.0357133
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0352507
SP100 SP100 nuclear antigen -0.0344396
DLG1 discs, large homolog 1 (Drosophila) -0.0343476
USP34 ubiquitin specific peptidase 34 -0.0339854
VEGFC vascular endothelial growth factor C -0.0338294
SMYD3 SET and MYND domain containing 3 -0.0335957
FBN1 fibrillin 1 -0.0334751
PRSS23 protease, serine, 23 -0.0329404
GOLGB1 golgin B1 -0.0328482
NAV2 neuron navigator 2 -0.0328375
GPC6 glypican 6 -0.0325942
MAP4 microtubule-associated protein 4 -0.03217
ANXA2 annexin A2 -0.0320757
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0319096
NF1 neurofibromin 1 -0.0310917
COL5A2 collagen, type V, alpha 2 -0.0309679
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0308399
EHBP1 EH domain binding protein 1 -0.0304854
MAP1B microtubule-associated protein 1B -0.0303753
SBF2 SET binding factor 2 -0.0303329
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0303286
MYOF myoferlin -0.0300989
COL8A1 collagen, type VIII, alpha 1 -0.0300059
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0295292
JMJD1C jumonji domain containing 1C -0.0293571
EGFR epidermal growth factor receptor -0.0293532
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.029103
VCL vinculin -0.0290122
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0290023
ZEB1 zinc finger E-box binding homeobox 1 -0.0289713
RUNX1 runt-related transcription factor 1 -0.0288718
EFNA5 ephrin-A5 -0.0288109
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0286039
CSTB cystatin B (stefin B) -0.0284593
NDRG1 N-myc downstream regulated 1 -0.0282746
CEP350 centrosomal protein 350kDa -0.0280833
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0279551
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0278368
SEC31A SEC31 homolog A (S. cerevisiae) -0.0276493
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0275692
JAZF1 JAZF zinc finger 1 -0.0273417
CDK13 cyclin-dependent kinase 13 -0.0273344
COPA coatomer protein complex, subunit alpha -0.0273289
PARD3 par-3 family cell polarity regulator -0.0270016
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0269781
RABGAP1L RAB GTPase activating protein 1-like -0.0269234
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0268958
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0268909
HIP1 huntingtin interacting protein 1 -0.026367
FRMD4A FERM domain containing 4A -0.0262292
MBD5 methyl-CpG binding domain protein 5 -0.0259881
CUX1 cut-like homeobox 1 -0.0259228
IFI16 interferon, gamma-inducible protein 16 -0.0258917
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0258819
BRWD1 bromodomain and WD repeat domain containing 1 -0.0255605