Dinaciclib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.115914
POTEF POTE ankyrin domain family, member F 0.0716206
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0386895
FTH1 ferritin, heavy polypeptide 1 0.0362311
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0360701
MYH9 myosin, heavy chain 9, non-muscle 0.0358702
CCND1 cyclin D1 0.0328015
TPM3 tropomyosin 3 0.0326911
TMSB4X thymosin beta 4, X-linked 0.0309593
ZC3H3 zinc finger CCCH-type containing 3 0.0308924
RPS8 ribosomal protein S8 0.0300628
TMSB10 thymosin beta 10 0.0297338
NES nestin 0.0294847
HDGF hepatoma-derived growth factor 0.0293536
RPL19 ribosomal protein L19 0.0293052
YBX1 Y box binding protein 1 0.0289431
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0280633
SCG2 secretogranin II 0.0264855
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0263609
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0262705
RPL8 ribosomal protein L8 0.0247347
MT2A metallothionein 2A 0.0246577
APLP2 amyloid beta (A4) precursor-like protein 2 0.0241349
COL6A1 collagen, type VI, alpha 1 0.0237004
PLEC plectin 0.0232724
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0225651
PDIA6 protein disulfide isomerase family A, member 6 0.0224777
RPS2 ribosomal protein S2 0.0221728
EEF2 eukaryotic translation elongation factor 2 0.0221663
RPS12 ribosomal protein S12 0.021529
RPS4X ribosomal protein S4, X-linked 0.0215091
RPL12 ribosomal protein L12 0.0213591
SET SET nuclear proto-oncogene 0.0209073
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0208453
PNN pinin, desmosome associated protein 0.0200003
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0198334
ADAM9 ADAM metallopeptidase domain 9 0.0198276
RRM2 ribonucleotide reductase M2 0.0193249
RPS3 ribosomal protein S3 0.0192238
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0191946
IER2 immediate early response 2 0.0191303
PKM pyruvate kinase, muscle 0.0190604
TPM4 tropomyosin 4 0.0190398
RAI1 retinoic acid induced 1 0.0185367
RPS11 ribosomal protein S11 0.0184805
TUBB tubulin, beta class I 0.0183095
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0181659
CDC37 cell division cycle 37 0.0180979
RPL11 ribosomal protein L11 0.0179258
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0177686
SFTPA2 surfactant protein A2 0.0177413
SFPQ splicing factor proline/glutamine-rich 0.0176024
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0175096
PFN1 profilin 1 0.0172517
PDIA4 protein disulfide isomerase family A, member 4 0.0172356
RPL35 ribosomal protein L35 0.0172343
TLN1 talin 1 0.0172254
RPL21 ribosomal protein L21 0.017097
RHOA ras homolog family member A 0.017031
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0169756
COL1A2 collagen, type I, alpha 2 0.0162707
CENPF centromere protein F, 350/400kDa 0.0161641
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0161525
EMP1 epithelial membrane protein 1 0.0160993
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0160463
CACYBP calcyclin binding protein 0.0160303
IQGAP1 IQ motif containing GTPase activating protein 1 0.0159721
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0158488
RAP1GAP2 RAP1 GTPase activating protein 2 0.0156414
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.0153906
INHBA inhibin, beta A 0.0152455
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0148833
HP1BP3 heterochromatin protein 1, binding protein 3 0.0147817
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0147778
SEPTIN11 septin 11 0.0147735
CBX3 chromobox homolog 3 0.0147657
RCAN2 regulator of calcineurin 2 0.0146473
MSN moesin 0.014643
PCBP2 poly(rC) binding protein 2 0.014508
HMGA1 high mobility group AT-hook 1 0.0144635
RPL27A ribosomal protein L27a 0.0144384
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0143584
LMNB2 lamin B2 0.0142674
FLNA filamin A, alpha 0.0142462
SYT4 synaptotagmin IV 0.014217
FGFR2 fibroblast growth factor receptor 2 0.014195
RPL23A ribosomal protein L23a 0.0140834
GADD45B growth arrest and DNA-damage-inducible, beta 0.0139655
RPS16 ribosomal protein S16 0.0139436
HDAC9 histone deacetylase 9 0.0139305
RPS20 ribosomal protein S20 0.0137944
CD63 CD63 molecule 0.0137725
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0137455
MAP1B microtubule-associated protein 1B 0.0137336
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0136705
TPM2 tropomyosin 2 (beta) 0.0135839
RPL41 ribosomal protein L41 0.0135762
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0134808
LAMB3 laminin, beta 3 0.0134016
RPL3 ribosomal protein L3 0.0133494

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.157383
FMN1 formin 1 -0.144693
NRG1 neuregulin 1 -0.136336
AKAP12 A kinase (PRKA) anchor protein 12 -0.133288
IGF2 insulin-like growth factor 2 -0.129225
MEIS2 Meis homeobox 2 -0.127517
NALF1 NALCN channel auxiliary factor 1 -0.114877
PTPRD protein tyrosine phosphatase, receptor type, D -0.104932
EXT1 exostosin glycosyltransferase 1 -0.0981934
SYT1 synaptotagmin I -0.0976632
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0926573
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0791521
TRIO trio Rho guanine nucleotide exchange factor -0.0779127
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0747053
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0741071
FNDC3B fibronectin type III domain containing 3B -0.0729848
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0669214
ZBTB20 zinc finger and BTB domain containing 20 -0.0656491
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0649721
TLE4 transducin-like enhancer of split 4 -0.0634326
VCL vinculin -0.0629463
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0618092
SOS1 son of sevenless homolog 1 (Drosophila) -0.0596815
HELZ helicase with zinc finger -0.0586354
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0552872
FNBP1 formin binding protein 1 -0.0548311
DPH6 diphthamine biosynthesis 6 -0.0547772
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.052582
LPIN1 lipin 1 -0.0519977
BPTF bromodomain PHD finger transcription factor -0.051208
FAM13A family with sequence similarity 13, member A -0.0499919
TRIB2 tribbles pseudokinase 2 -0.0497229
KLHL13 kelch-like family member 13 -0.0484284
NCAM2 neural cell adhesion molecule 2 -0.0483938
DSCAM Down syndrome cell adhesion molecule -0.0468217
PRKCA protein kinase C, alpha -0.0463579
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0455887
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0449874
MSI2 musashi RNA-binding protein 2 -0.0449557
RNF213 ring finger protein 213 -0.0448542
THSD4 thrombospondin, type I, domain containing 4 -0.0442175
MBD5 methyl-CpG binding domain protein 5 -0.0421999
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0418337
NREP neuronal regeneration related protein -0.0413626
AUTS2 autism susceptibility candidate 2 -0.0412069
ZNF804A zinc finger protein 804A -0.0409003
TPST1 tyrosylprotein sulfotransferase 1 -0.0408542
BCAS3 breast carcinoma amplified sequence 3 -0.0406343
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0395349
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0387482
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0387201
NPEPPS aminopeptidase puromycin sensitive -0.0386793
TAS2R14 taste receptor, type 2, member 14 -0.0377885
DST dystonin -0.0375983
PTK2 protein tyrosine kinase 2 -0.0375587
AOPEP aminopeptidase O (putative) -0.0362612
PCDH9 protocadherin 9 -0.0360038
VMP1 vacuole membrane protein 1 -0.0358869
CHD9 chromodomain helicase DNA binding protein 9 -0.0357749
FRMD4A FERM domain containing 4A -0.0355021
RPTOR regulatory associated protein of MTOR, complex 1 -0.0354162
MEF2A myocyte enhancer factor 2A -0.0351352
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0350598
COL1A1 collagen, type I, alpha 1 -0.0348121
NDRG1 N-myc downstream regulated 1 -0.0347563
SMYD3 SET and MYND domain containing 3 -0.0337131
IGF1R insulin-like growth factor 1 receptor -0.0335627
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.033455
UNC5C unc-5 homolog C (C. elegans) -0.0329661
MED13 mediator complex subunit 13 -0.0327957
NAMPT nicotinamide phosphoribosyltransferase -0.0324942
ANTXR1 anthrax toxin receptor 1 -0.0324465
PSD3 pleckstrin and Sec7 domain containing 3 -0.0324413
KDM3A lysine (K)-specific demethylase 3A -0.0322555
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0317166
WDR45B WD repeat domain 45B -0.0315549
TNRC6B trinucleotide repeat containing 6B -0.0315113
TPR translocated promoter region, nuclear basket protein -0.0314972
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.031214
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0311342
KMT2C lysine (K)-specific methyltransferase 2C -0.0307825
BIRC6 baculoviral IAP repeat containing 6 -0.0305403
MED13L mediator complex subunit 13-like -0.0305177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0303278
NPAS2 neuronal PAS domain protein 2 -0.0302789
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0302127
RAD51B RAD51 paralog B -0.0301999
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0301618
MYO6 myosin VI -0.0296961
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0296386
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0294165
MAPK10 mitogen-activated protein kinase 10 -0.029242
LIMCH1 LIM and calponin homology domains 1 -0.029157
IFI16 interferon, gamma-inducible protein 16 -0.0290646
DNAH14 dynein, axonemal, heavy chain 14 -0.0290056
EIF1 eukaryotic translation initiation factor 1 -0.0289993
PLAT plasminogen activator, tissue -0.0289247
PRRC2C proline-rich coiled-coil 2C -0.0288657
NBEA neurobeachin -0.0288212
ZNF292 zinc finger protein 292 -0.0287202