Dinaciclib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0914294
FTH1 ferritin, heavy polypeptide 1 0.0895061
RPS6 ribosomal protein S6 0.0665261
VIM vimentin 0.0611073
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0602384
YBX1 Y box binding protein 1 0.059975
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0556017
PTMA prothymosin, alpha 0.0534134
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0523823
TMSB4X thymosin beta 4, X-linked 0.0476679
TEX14 testis expressed 14 0.0462582
RPLP1 ribosomal protein, large, P1 0.0437682
POTEF POTE ankyrin domain family, member F 0.0431435
TMSB10 thymosin beta 10 0.0428004
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0406237
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0371787
RPS4X ribosomal protein S4, X-linked 0.0370084
RPS12 ribosomal protein S12 0.0369595
FTL ferritin, light polypeptide 0.0369337
ZC3H3 zinc finger CCCH-type containing 3 0.036168
RPL37A ribosomal protein L37a 0.0352046
IER3 immediate early response 3 0.0342865
RPL19 ribosomal protein L19 0.0340014
FN1 fibronectin 1 0.0331364
RPLP0 ribosomal protein, large, P0 0.0327159
EEF2 eukaryotic translation elongation factor 2 0.0318991
RPLP2 ribosomal protein, large, P2 0.0318108
RPS8 ribosomal protein S8 0.0297863
RPS19 ribosomal protein S19 0.0295866
EGR1 early growth response 1 0.0294633
KRT18 keratin 18, type I 0.0285499
RPL11 ribosomal protein L11 0.0282747
RPL12 ribosomal protein L12 0.0280694
S100A6 S100 calcium binding protein A6 0.0268762
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0252624
RPL23 ribosomal protein L23 0.0242069
SET SET nuclear proto-oncogene 0.0238685
RPL35A ribosomal protein L35a 0.0237655
AKAP12 A kinase (PRKA) anchor protein 12 0.023669
HMGA1 high mobility group AT-hook 1 0.0235489
TPM3 tropomyosin 3 0.0233714
RPS3 ribosomal protein S3 0.0233305
ATP5F1B ATP synthase F1 subunit beta 0.0226162
RPL26 ribosomal protein L26 0.0218349
RPS21 ribosomal protein S21 0.0215778
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0214568
RPL5 ribosomal protein L5 0.0214484
GNAS GNAS complex locus 0.0210986
FLNA filamin A, alpha 0.0208785
RPS27A ribosomal protein S27a 0.0208195
MAP1B microtubule-associated protein 1B 0.0205849
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02024
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0202324
RPS17 ribosomal protein S17 0.0201632
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0198503
RPS25 ribosomal protein S25 0.0196938
RPL3 ribosomal protein L3 0.0193879
EEF1G eukaryotic translation elongation factor 1 gamma 0.0190452
RPL13A ribosomal protein L13a 0.0188512
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0187286
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0186564
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0185162
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0183057
RPL36 ribosomal protein L36 0.0180168
RPL37 ribosomal protein L37 0.0178729
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0178278
RPL9 ribosomal protein L9 0.0177368
RPS13 ribosomal protein S13 0.0176885
RPS24 ribosomal protein S24 0.0175748
HDGF hepatoma-derived growth factor 0.0175565
RPL30 ribosomal protein L30 0.0174432
RPL34 ribosomal protein L34 0.0173895
RACK1 receptor for activated C kinase 1 0.0172675
RPS20 ribosomal protein S20 0.0171344
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0169958
ECI1 enoyl-CoA delta isomerase 1 0.0169928
RANBP1 RAN binding protein 1 0.0169765
HLA-A major histocompatibility complex, class I, A 0.0165897
RPL8 ribosomal protein L8 0.0165243
RPL10A ribosomal protein L10a 0.0165053
RPL36A ribosomal protein L36a 0.0164823
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0164215
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.016129
RPS2 ribosomal protein S2 0.0161177
CYB5D2 cytochrome b5 domain containing 2 0.0159335
CCND1 cyclin D1 0.0159226
DEK DEK proto-oncogene 0.015919
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0159118
RPL32 ribosomal protein L32 0.0159082
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0158424
S100A10 S100 calcium binding protein A10 0.0158059
PFN1 profilin 1 0.0157845
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0157673
RPL7 ribosomal protein L7 0.0156141
ATP5F1E ATP synthase F1 subunit epsilon 0.0156094
RPL35 ribosomal protein L35 0.0155972
KRT8 keratin 8, type II 0.0154219
RPS5 ribosomal protein S5 0.0153928
MSN moesin 0.0153485
LDHB lactate dehydrogenase B 0.0152716

decreased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 -0.141446
PRKCA protein kinase C, alpha -0.140391
EPSTI1 epithelial stromal interaction 1 (breast) -0.122694
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0833917
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0809829
PHF3 PHD finger protein 3 -0.0805663
DSCAM Down syndrome cell adhesion molecule -0.080291
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0788307
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0743142
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0742396
ZMYND8 zinc finger, MYND-type containing 8 -0.0737002
RNF213 ring finger protein 213 -0.0736115
FNDC3B fibronectin type III domain containing 3B -0.0707977
ARHGAP26 Rho GTPase activating protein 26 -0.0698785
EXT1 exostosin glycosyltransferase 1 -0.0667898
LMO7 LIM domain 7 -0.0662462
GMDS GDP-mannose 4,6-dehydratase -0.0642872
ZBTB20 zinc finger and BTB domain containing 20 -0.0642291
MBNL2 muscleblind-like splicing regulator 2 -0.061178
AHI1 Abelson helper integration site 1 -0.0607098
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0595367
MAP7 microtubule-associated protein 7 -0.0590392
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0573588
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0562714
RAD51B RAD51 paralog B -0.0558949
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0558276
TXNIP thioredoxin interacting protein -0.0549497
RUNX1 runt-related transcription factor 1 -0.0547884
INTS6 integrator complex subunit 6 -0.0543623
GOLGB1 golgin B1 -0.0543406
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0540277
GCLC glutamate-cysteine ligase, catalytic subunit -0.0532513
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0529306
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0521809
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0504728
IFNGR1 interferon gamma receptor 1 -0.0500671
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0499869
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0486099
B2M beta-2-microglobulin -0.047914
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0472339
ERBIN erbb2 interacting protein -0.0471676
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0466607
TSC22D1 TSC22 domain family, member 1 -0.0464391
NF1 neurofibromin 1 -0.045978
NCKAP5 NCK-associated protein 5 -0.0458964
FNDC3A fibronectin type III domain containing 3A -0.0458683
SAMD12 sterile alpha motif domain containing 12 -0.0454684
NDRG1 N-myc downstream regulated 1 -0.0446287
LPP LIM domain containing preferred translocation partner in lipoma -0.044142
MX1 MX dynamin-like GTPase 1 -0.042758
ZMYM2 zinc finger, MYM-type 2 -0.0427026
TRIO trio Rho guanine nucleotide exchange factor -0.0425739
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0422602
ZNF292 zinc finger protein 292 -0.0422589
MEIS2 Meis homeobox 2 -0.0416556
LCN2 lipocalin 2 -0.0410745
STK24 serine/threonine kinase 24 -0.0403124
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0400547
SORBS1 sorbin and SH3 domain containing 1 -0.0398675
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0397594
ATP11A ATPase, class VI, type 11A -0.0395759
C6ORF132 chromosome 6 open reading frame 132 -0.0393768
PATJ PATJ crumbs cell polarity complex component -0.039347
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0393121
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0390795
MSI2 musashi RNA-binding protein 2 -0.0387437
SMAD3 SMAD family member 3 -0.038709
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0385335
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0385181
EFNB2 ephrin-B2 -0.0378
SP100 SP100 nuclear antigen -0.0377351
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.037661
TMC5 transmembrane channel-like 5 -0.0373687
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0372162
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0371659
VMP1 vacuole membrane protein 1 -0.0366483
ATXN1 ataxin 1 -0.0366013
PTBP3 polypyrimidine tract binding protein 3 -0.0361272
TRERF1 transcriptional regulating factor 1 -0.0360882
SSH2 slingshot protein phosphatase 2 -0.0359859
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.035179
FNIP1 folliculin interacting protein 1 -0.0349297
PLSCR1 phospholipid scramblase 1 -0.0346278
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0345028
MYO1E myosin IE -0.0343981
PRELID2 PRELI domain containing 2 -0.0342614
AKAP13 A kinase (PRKA) anchor protein 13 -0.0341275
RBM39 RNA binding motif protein 39 -0.0339942
STS steroid sulfatase (microsomal), isozyme S -0.0334904
RABGAP1L RAB GTPase activating protein 1-like -0.0333859
RRBP1 ribosome binding protein 1 -0.0333085
ANXA2 annexin A2 -0.0332869
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0327622
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0326045
MED13 mediator complex subunit 13 -0.0325952
SBF2 SET binding factor 2 -0.0317999
AFF1 AF4/FMR2 family, member 1 -0.0317669
IGF1R insulin-like growth factor 1 receptor -0.031629
ARHGAP32 Rho GTPase activating protein 32 -0.0316189
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0314664