Dinaciclib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0881388
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.086589
MYH9 myosin, heavy chain 9, non-muscle 0.0698647
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0583371
CALD1 caldesmon 1 0.0535887
IER3 immediate early response 3 0.0534746
YBX1 Y box binding protein 1 0.0441993
RPS6 ribosomal protein S6 0.0439851
EGR1 early growth response 1 0.0427011
FLNA filamin A, alpha 0.0417578
ZC3H3 zinc finger CCCH-type containing 3 0.0399259
POTEF POTE ankyrin domain family, member F 0.0396666
TPM2 tropomyosin 2 (beta) 0.0376077
FTH1 ferritin, heavy polypeptide 1 0.0363978
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.035715
IER2 immediate early response 2 0.0351181
THBS1 thrombospondin 1 0.0340296
DSTN destrin (actin depolymerizing factor) 0.0319368
COL1A1 collagen, type I, alpha 1 0.0304675
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0297758
RPL19 ribosomal protein L19 0.0297618
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296764
TMSB4X thymosin beta 4, X-linked 0.0296032
RPS8 ribosomal protein S8 0.0295508
FN1 fibronectin 1 0.0287991
EEF2 eukaryotic translation elongation factor 2 0.0270048
PTMA prothymosin, alpha 0.0262631
RPL12 ribosomal protein L12 0.0247916
RPL11 ribosomal protein L11 0.0247523
POSTN periostin, osteoblast specific factor 0.0244959
THY1 Thy-1 cell surface antigen 0.0240383
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0240234
CSDE1 cold shock domain containing E1, RNA-binding 0.0234352
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0229921
RPS12 ribosomal protein S12 0.0225544
BHLHE40 basic helix-loop-helix family, member e40 0.0220498
CALR calreticulin 0.0214098
ALCAM activated leukocyte cell adhesion molecule 0.0211257
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0210895
RPLP1 ribosomal protein, large, P1 0.0201972
RPS19 ribosomal protein S19 0.019684
RPS2 ribosomal protein S2 0.0194317
FTL ferritin, light polypeptide 0.019152
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.019086
CCDC80 coiled-coil domain containing 80 0.0189798
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0187312
RPL37A ribosomal protein L37a 0.0186362
RPL8 ribosomal protein L8 0.0182544
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0181679
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0177114
RPL7 ribosomal protein L7 0.0175413
RPS3 ribosomal protein S3 0.0173149
CALU calumenin 0.0173056
COL4A1 collagen, type IV, alpha 1 0.016966
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0169409
MAP1B microtubule-associated protein 1B 0.0167797
TEX14 testis expressed 14 0.0165924
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0164307
RPLP2 ribosomal protein, large, P2 0.0160901
COL6A1 collagen, type VI, alpha 1 0.0160204
RANBP1 RAN binding protein 1 0.0158954
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0156653
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0153744
LAMB1 laminin, beta 1 0.0151514
RPS4X ribosomal protein S4, X-linked 0.0151423
CROCC ciliary rootlet coiled-coil, rootletin 0.0150316
SERBP1 SERPINE1 mRNA binding protein 1 0.0148238
RPS20 ribosomal protein S20 0.0147365
TPM1 tropomyosin 1 (alpha) 0.0145661
HMGN2 high mobility group nucleosomal binding domain 2 0.0145183
MYL9 myosin, light chain 9, regulatory 0.0144052
TPM4 tropomyosin 4 0.0143666
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0141568
KRT18 keratin 18, type I 0.0141222
RPL5 ribosomal protein L5 0.0140232
S100A9 S100 calcium binding protein A9 0.0137779
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0137063
ARC activity-regulated cytoskeleton-associated protein 0.0136824
RPS17 ribosomal protein S17 0.0133746
OAZ1 ornithine decarboxylase antizyme 1 0.0132946
PFN1 profilin 1 0.0130955
RPL36 ribosomal protein L36 0.0128955
IL6ST interleukin 6 signal transducer 0.012706
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0126767
ATP5F1E ATP synthase F1 subunit epsilon 0.0126468
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0124905
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0124843
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0124837
RPL32 ribosomal protein L32 0.0123891
SET SET nuclear proto-oncogene 0.0123703
RPS27A ribosomal protein S27a 0.0122823
RNASEH2A ribonuclease H2, subunit A 0.0122193
CAV1 caveolin 1, caveolae protein, 22kDa 0.0122155
FSTL1 follistatin-like 1 0.0120665
RPL35A ribosomal protein L35a 0.0120333
PERP PERP, TP53 apoptosis effector 0.0119612
RPLP0 ribosomal protein, large, P0 0.0119532
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0119495
RPS11 ribosomal protein S11 0.0119299
RPL26 ribosomal protein L26 0.0118906

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.269067
NDRG1 N-myc downstream regulated 1 -0.163944
TRIO trio Rho guanine nucleotide exchange factor -0.104515
EXT1 exostosin glycosyltransferase 1 -0.0897407
FNDC3B fibronectin type III domain containing 3B -0.0876581
CDH13 cadherin 13 -0.0863426
PSD3 pleckstrin and Sec7 domain containing 3 -0.0780083
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.076258
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.064707
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.058607
ZBTB20 zinc finger and BTB domain containing 20 -0.0579606
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0566515
PDE10A phosphodiesterase 10A -0.0534248
PTK2 protein tyrosine kinase 2 -0.0518357
LOXL2 lysyl oxidase-like 2 -0.051784
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0496103
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0492092
FBN1 fibrillin 1 -0.0456628
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0431298
STC1 stanniocalcin 1 -0.0398487
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0387643
JARID2 jumonji, AT rich interactive domain 2 -0.038048
VEGFA vascular endothelial growth factor A -0.0373728
COL6A3 collagen, type VI, alpha 3 -0.0371896
DPYD dihydropyrimidine dehydrogenase -0.035864
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0351213
LOX lysyl oxidase -0.034439
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0344369
CADM1 cell adhesion molecule 1 -0.0343104
PRELID2 PRELI domain containing 2 -0.0339247
HMGA2 high mobility group AT-hook 2 -0.0332928
COL5A1 collagen, type V, alpha 1 -0.0325385
GLIS3 GLIS family zinc finger 3 -0.0318428
CD44 CD44 molecule (Indian blood group) -0.0315362
NAV1 neuron navigator 1 -0.0311802
TRPS1 trichorhinophalangeal syndrome I -0.0299701
DLG1 discs, large homolog 1 (Drosophila) -0.0298866
NALF1 NALCN channel auxiliary factor 1 -0.0290514
ATXN1 ataxin 1 -0.0289014
LDHA lactate dehydrogenase A -0.0281711
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0281357
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0276844
RUNX1 runt-related transcription factor 1 -0.0276785
TGFBI transforming growth factor, beta-induced, 68kDa -0.0274097
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0270317
DOCK5 dedicator of cytokinesis 5 -0.0270018
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0268362
EGFR epidermal growth factor receptor -0.0268175
ELL2 elongation factor, RNA polymerase II, 2 -0.0267836
ATP13A3 ATPase type 13A3 -0.0266312
ZFAND3 zinc finger, AN1-type domain 3 -0.026626
MTSS1 metastasis suppressor 1 -0.0261012
GOLGB1 golgin B1 -0.025565
SMYD3 SET and MYND domain containing 3 -0.0252878
GOLGA4 golgin A4 -0.0252229
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.024536
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0244981
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0241136
ANKRD11 ankyrin repeat domain 11 -0.023986
KMT2C lysine (K)-specific methyltransferase 2C -0.0238754
LTBP1 latent transforming growth factor beta binding protein 1 -0.0237485
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0236579
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0235567
SBF2 SET binding factor 2 -0.0233985
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0233894
NAV2 neuron navigator 2 -0.0228444
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0226364
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0226207
F3 coagulation factor III (thromboplastin, tissue factor) -0.0225938
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0225783
WWTR1 WW domain containing transcription regulator 1 -0.0225366
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0221805
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0221649
GRB10 growth factor receptor-bound protein 10 -0.0218195
ZNF292 zinc finger protein 292 -0.0217642
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0214105
LPP LIM domain containing preferred translocation partner in lipoma -0.0213992
FMNL2 formin-like 2 -0.0212267
MAP4 microtubule-associated protein 4 -0.0210575
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0208457
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0207834
OSMR oncostatin M receptor -0.0206964
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0206777
EFNA5 ephrin-A5 -0.0206392
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0206341
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0206085
CAMTA1 calmodulin binding transcription activator 1 -0.0205029
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0203078
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0203008
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0199888
COG5 component of oligomeric golgi complex 5 -0.01975
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0196892
TTC3 tetratricopeptide repeat domain 3 -0.0195311
CMIP c-Maf inducing protein -0.0192291
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0191608
TMEM165 transmembrane protein 165 -0.0189513
RAB2A RAB2A, member RAS oncogene family -0.0188661
MAML2 mastermind-like 2 (Drosophila) -0.0186371
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0183383
TM4SF1 transmembrane 4 L six family member 1 -0.0183231