Dinaciclib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.151337
POTEF POTE ankyrin domain family, member F 0.126623
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.104218
FTH1 ferritin, heavy polypeptide 1 0.0901336
PTMA prothymosin, alpha 0.0730092
TPT1 tumor protein, translationally-controlled 1 0.0685372
YBX1 Y box binding protein 1 0.0675355
TMSB4X thymosin beta 4, X-linked 0.0610494
RPL11 ribosomal protein L11 0.0597484
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0591209
RPS6 ribosomal protein S6 0.0587627
RPLP2 ribosomal protein, large, P2 0.0469154
FLNA filamin A, alpha 0.0445844
RPS21 ribosomal protein S21 0.0429029
RPS4X ribosomal protein S4, X-linked 0.0416035
MYH9 myosin, heavy chain 9, non-muscle 0.0407346
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0402095
RPLP1 ribosomal protein, large, P1 0.0400563
RPS8 ribosomal protein S8 0.039147
CLU clusterin 0.0389189
RPL19 ribosomal protein L19 0.0387519
B2M beta-2-microglobulin 0.0386427
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0378121
KRT14 keratin 14, type I 0.0378105
TMSB10 thymosin beta 10 0.0366578
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0356127
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.035461
RPS19 ribosomal protein S19 0.0341391
KRT18 keratin 18, type I 0.0331383
KRT17 keratin 17, type I 0.0329745
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0326356
RPL35A ribosomal protein L35a 0.0320923
LMNA lamin A/C 0.0319568
RPS12 ribosomal protein S12 0.0312154
RANBP1 RAN binding protein 1 0.0311971
EEF2 eukaryotic translation elongation factor 2 0.0311883
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0301707
S100A10 S100 calcium binding protein A10 0.0297728
HLA-B major histocompatibility complex, class I, B 0.0294213
RPL12 ribosomal protein L12 0.0290966
PLEC plectin 0.0287584
RPL23 ribosomal protein L23 0.0279501
RPS24 ribosomal protein S24 0.0274269
TPM3 tropomyosin 3 0.0272098
GNAS GNAS complex locus 0.026959
RPS13 ribosomal protein S13 0.0268005
DEK DEK proto-oncogene 0.0265822
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0265742
RPL35 ribosomal protein L35 0.0265468
RPL8 ribosomal protein L8 0.0265403
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0258106
ATP5F1E ATP synthase F1 subunit epsilon 0.025666
RPL26 ribosomal protein L26 0.0253209
RPL37 ribosomal protein L37 0.0252268
FTL ferritin, light polypeptide 0.0251583
CAV1 caveolin 1, caveolae protein, 22kDa 0.0243142
ZC3H3 zinc finger CCCH-type containing 3 0.0242366
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0241883
ACTG1 actin gamma 1 0.0235729
RPS3 ribosomal protein S3 0.0234692
RPS25 ribosomal protein S25 0.0232449
RPLP0 ribosomal protein, large, P0 0.023107
RPL34 ribosomal protein L34 0.0230954
RPS27A ribosomal protein S27a 0.0230478
IFITM3 interferon induced transmembrane protein 3 0.0229974
S100A6 S100 calcium binding protein A6 0.0225405
CSDE1 cold shock domain containing E1, RNA-binding 0.0224684
RPL37A ribosomal protein L37a 0.0224289
RPL31 ribosomal protein L31 0.0222671
CCND1 cyclin D1 0.022053
IGFBP6 insulin-like growth factor binding protein 6 0.0215559
HMGB1 high mobility group box 1 0.0215297
HDGF hepatoma-derived growth factor 0.0210625
RPL13A ribosomal protein L13a 0.0209714
RPS17 ribosomal protein S17 0.0208784
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0208467
HMGA1 high mobility group AT-hook 1 0.0208211
RPS20 ribosomal protein S20 0.0207255
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0206334
MDK midkine (neurite growth-promoting factor 2) 0.0205535
CNRIP1 cannabinoid receptor interacting protein 1 0.020525
RPS23 ribosomal protein S23 0.0204587
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.020426
KRT5 keratin 5, type II 0.0200015
PFN1 profilin 1 0.0195443
SET SET nuclear proto-oncogene 0.0192577
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0192237
SYPL1 synaptophysin-like 1 0.019178
S100A11 S100 calcium binding protein A11 0.0191464
RPL9 ribosomal protein L9 0.0190476
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0190113
RPL36 ribosomal protein L36 0.0188724
TPM2 tropomyosin 2 (beta) 0.0188355
SARM1 sterile alpha and TIR motif containing 1 0.0186231
RPS11 ribosomal protein S11 0.0185014
KRT8 keratin 8, type II 0.018458
PA2G4 proliferation-associated 2G4, 38kDa 0.0183657
HMGN2 high mobility group nucleosomal binding domain 2 0.0182971
RPS14 ribosomal protein S14 0.0182959
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0179752

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.161367
MTSS1 metastasis suppressor 1 -0.130853
FLNB filamin B, beta -0.130661
TRIO trio Rho guanine nucleotide exchange factor -0.130212
MEF2A myocyte enhancer factor 2A -0.113734
MYOF myoferlin -0.0904161
NAMPT nicotinamide phosphoribosyltransferase -0.0774837
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0689866
ITCH itchy E3 ubiquitin protein ligase -0.0673099
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0671707
RBM39 RNA binding motif protein 39 -0.0639915
KIAA1217 KIAA1217 -0.0626161
FNDC3B fibronectin type III domain containing 3B -0.0625575
FOXO1 forkhead box O1 -0.0606941
ESYT2 extended synaptotagmin-like protein 2 -0.0605831
PTK2 protein tyrosine kinase 2 -0.0584209
KMT2E lysine (K)-specific methyltransferase 2E -0.057585
NRIP1 nuclear receptor interacting protein 1 -0.0554618
CEMIP cell migration inducing protein, hyaluronan binding -0.0537362
CUL4B cullin 4B -0.0535351
GOLGA4 golgin A4 -0.0533146
FNIP1 folliculin interacting protein 1 -0.0520934
SMAD3 SMAD family member 3 -0.0516387
MBNL1 muscleblind-like splicing regulator 1 -0.0514392
PRELID2 PRELI domain containing 2 -0.0512405
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0495776
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0495402
RAI14 retinoic acid induced 14 -0.0495253
MBNL2 muscleblind-like splicing regulator 2 -0.0487364
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0478315
JMJD1C jumonji domain containing 1C -0.0465633
OGA O-GlcNAcase -0.046389
DOCK5 dedicator of cytokinesis 5 -0.0443096
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0429027
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0425931
ZNF292 zinc finger protein 292 -0.0424253
ANKRD33B ankyrin repeat domain 33B -0.042305
RIN2 Ras and Rab interactor 2 -0.0414314
DPYD dihydropyrimidine dehydrogenase -0.0412894
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0406036
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0400243
SULF1 sulfatase 1 -0.0395589
NAV2 neuron navigator 2 -0.0394606
ASPH aspartate beta-hydroxylase -0.0390424
SBF2 SET binding factor 2 -0.0384949
PSD3 pleckstrin and Sec7 domain containing 3 -0.0383079
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0380855
NCOA3 nuclear receptor coactivator 3 -0.0378019
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0373414
PGK1 phosphoglycerate kinase 1 -0.0372249
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0362001
AKAP13 A kinase (PRKA) anchor protein 13 -0.0356086
KDM6A lysine (K)-specific demethylase 6A -0.0352614
OSMR oncostatin M receptor -0.0344845
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0344684
AKAP9 A kinase (PRKA) anchor protein 9 -0.0338721
COG5 component of oligomeric golgi complex 5 -0.0334429
KIF16B kinesin family member 16B -0.03296
SPAG9 sperm associated antigen 9 -0.0327082
ARRDC3 arrestin domain containing 3 -0.032578
PICALM phosphatidylinositol binding clathrin assembly protein -0.0324544
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0322453
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0316889
GRB10 growth factor receptor-bound protein 10 -0.0316539
ARHGAP29 Rho GTPase activating protein 29 -0.0315855
KMT2C lysine (K)-specific methyltransferase 2C -0.0315392
EXT1 exostosin glycosyltransferase 1 -0.0315389
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0314477
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0313138
NEK7 NIMA-related kinase 7 -0.0312717
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0309621
KDM3A lysine (K)-specific demethylase 3A -0.0308822
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0306847
RLF rearranged L-myc fusion -0.0306489
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0304962
FOXP1 forkhead box P1 -0.0303231
HM13 histocompatibility (minor) 13 -0.0302508
LMO7 LIM domain 7 -0.0301225
BCL2L1 BCL2-like 1 -0.0300006
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0299998
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0299319
NIPBL Nipped-B homolog (Drosophila) -0.0295335
SUCO SUN domain containing ossification factor -0.0293793
COPA coatomer protein complex, subunit alpha -0.0293397
ARHGAP21 Rho GTPase activating protein 21 -0.0292906
METTL15 methyltransferase like 15 -0.0292421
STC1 stanniocalcin 1 -0.0288735
MARCHF6 membrane associated ring-CH-type finger 6 -0.0288067
SEC31A SEC31 homolog A (S. cerevisiae) -0.0285801
SMYD3 SET and MYND domain containing 3 -0.0284147
KDM7A lysine (K)-specific demethylase 7A -0.0283823
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0280971
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0280352
BCAR3 breast cancer anti-estrogen resistance 3 -0.0279389
MYO10 myosin X -0.0278897
AOPEP aminopeptidase O (putative) -0.027831
COPB1 coatomer protein complex, subunit beta 1 -0.0276632
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0276117
COG6 component of oligomeric golgi complex 6 -0.0273446
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0272768