Dinaciclib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.102695
YBX1 Y box binding protein 1 0.0632442
RPS6 ribosomal protein S6 0.0626532
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0572568
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0532537
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0493254
TMSB4X thymosin beta 4, X-linked 0.039505
RPLP2 ribosomal protein, large, P2 0.0355296
RPLP1 ribosomal protein, large, P1 0.0354209
B2M beta-2-microglobulin 0.0354163
RPS12 ribosomal protein S12 0.0350348
RPS2 ribosomal protein S2 0.0314154
S100A10 S100 calcium binding protein A10 0.0306188
POTEF POTE ankyrin domain family, member F 0.0304792
RPL12 ribosomal protein L12 0.0304401
ATP5F1B ATP synthase F1 subunit beta 0.0301889
EEF2 eukaryotic translation elongation factor 2 0.0287447
RPL36 ribosomal protein L36 0.0276255
RPL11 ribosomal protein L11 0.0265076
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0259512
RPL19 ribosomal protein L19 0.0255821
RPL21 ribosomal protein L21 0.0254966
RPL23 ribosomal protein L23 0.0250566
RPL5 ribosomal protein L5 0.0250546
RPS29 ribosomal protein S29 0.0236028
RPS19 ribosomal protein S19 0.0235587
HLA-A major histocompatibility complex, class I, A 0.0232433
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0232038
RPS8 ribosomal protein S8 0.0229714
FTL ferritin, light polypeptide 0.0223234
HDGF hepatoma-derived growth factor 0.0222326
ZC3H3 zinc finger CCCH-type containing 3 0.0219881
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0215354
MATR3 matrin 3 0.0210408
SERF2 small EDRK-rich factor 2 0.0207103
CCND1 cyclin D1 0.0207023
RPL34 ribosomal protein L34 0.0206281
LYZ lysozyme 0.0202875
PDIA3 protein disulfide isomerase family A, member 3 0.0202857
RPL3 ribosomal protein L3 0.0202023
TFRC transferrin receptor 0.019943
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0197471
RPS13 ribosomal protein S13 0.0194938
RANBP1 RAN binding protein 1 0.0194644
RPS3 ribosomal protein S3 0.0191417
GUK1 guanylate kinase 1 0.0189777
PNN pinin, desmosome associated protein 0.0186612
FN1 fibronectin 1 0.0185772
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.017973
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0174151
RPS23 ribosomal protein S23 0.017252
RPS4X ribosomal protein S4, X-linked 0.0171542
SFPQ splicing factor proline/glutamine-rich 0.0170642
ACADVL acyl-CoA dehydrogenase, very long chain 0.0170139
YBX3 Y box binding protein 3 0.0169308
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0169253
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0166691
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0165581
CSDE1 cold shock domain containing E1, RNA-binding 0.0164296
BSG basigin (Ok blood group) 0.0161587
EEF1G eukaryotic translation elongation factor 1 gamma 0.0159108
PLEC plectin 0.0158835
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0155549
RYR3 ryanodine receptor 3 0.0153389
ANAPC5 anaphase promoting complex subunit 5 0.0151358
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0151099
SET SET nuclear proto-oncogene 0.0151004
PTMS parathymosin 0.0150212
AKAP12 A kinase (PRKA) anchor protein 12 0.0148149
KRT17 keratin 17, type I 0.0146285
PDIA6 protein disulfide isomerase family A, member 6 0.0145285
APLP2 amyloid beta (A4) precursor-like protein 2 0.0144451
HMGA1 high mobility group AT-hook 1 0.0142604
RPL31 ribosomal protein L31 0.0141229
RPS11 ribosomal protein S11 0.0140924
RPS27A ribosomal protein S27a 0.0140556
DHFR dihydrofolate reductase 0.0139948
KTN1 kinectin 1 (kinesin receptor) 0.0139186
RAD23B RAD23 homolog B (S. cerevisiae) 0.0138959
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0137305
KRT18 keratin 18, type I 0.0137271
HMGN2 high mobility group nucleosomal binding domain 2 0.0136154
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0136116
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.013603
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0135553
ANXA1 annexin A1 0.0134613
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0133533
RPL7 ribosomal protein L7 0.0132821
ARGLU1 arginine and glutamate rich 1 0.0132159
KPNB1 karyopherin (importin) beta 1 0.0132092
NUCB2 nucleobindin 2 0.0131634
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0131473
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0131115
MUC2 mucin 2, oligomeric mucus/gel-forming 0.013026
SDK1 sidekick cell adhesion molecule 1 0.0130136
IFI6 interferon, alpha-inducible protein 6 0.012986
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0129697
SSRP1 structure specific recognition protein 1 0.0128333
FADS2 fatty acid desaturase 2 0.0126846
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.012681

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.144096
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.135281
FAT1 FAT atypical cadherin 1 -0.134853
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.128925
CEMIP cell migration inducing protein, hyaluronan binding -0.108217
VCL vinculin -0.107774
MYO1E myosin IE -0.105239
GMDS GDP-mannose 4,6-dehydratase -0.102026
NALF1 NALCN channel auxiliary factor 1 -0.0904024
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0843778
ANTXR2 anthrax toxin receptor 2 -0.0783758
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0774025
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.076223
ALCAM activated leukocyte cell adhesion molecule -0.0720584
EXT1 exostosin glycosyltransferase 1 -0.0713533
PTPRK protein tyrosine phosphatase, receptor type, K -0.0697262
ONECUT3 one cut homeobox 3 -0.0667872
PATJ PATJ crumbs cell polarity complex component -0.062702
FLNB filamin B, beta -0.0626852
SMYD3 SET and MYND domain containing 3 -0.0624759
LAMA4 laminin, alpha 4 -0.0617037
CADPS Ca++-dependent secretion activator -0.0604778
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0597662
GREB1L growth regulation by estrogen in breast cancer-like -0.0583301
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0581581
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.057453
GPHN gephyrin -0.0570229
PDLIM5 PDZ and LIM domain 5 -0.0566444
FHIT fragile histidine triad -0.0559168
PRELID2 PRELI domain containing 2 -0.05566
ITGA6 integrin, alpha 6 -0.0551543
AHNAK AHNAK nucleoprotein -0.0543235
MACF1 microtubule-actin crosslinking factor 1 -0.0526641
CCSER1 coiled-coil serine-rich protein 1 -0.0513872
LPP LIM domain containing preferred translocation partner in lipoma -0.0510046
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0504685
KLF5 Kruppel-like factor 5 (intestinal) -0.0499618
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0485884
PDE4D phosphodiesterase 4D, cAMP-specific -0.0476423
MAML3 mastermind-like 3 (Drosophila) -0.0467014
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0459322
PSD3 pleckstrin and Sec7 domain containing 3 -0.0458198
MBNL1 muscleblind-like splicing regulator 1 -0.0449827
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0433664
PARD3 par-3 family cell polarity regulator -0.0411329
MYO1D myosin ID -0.0409217
MBD5 methyl-CpG binding domain protein 5 -0.0408494
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0405588
POF1B premature ovarian failure, 1B -0.0404304
ARHGAP26 Rho GTPase activating protein 26 -0.0399968
ANKRD17 ankyrin repeat domain 17 -0.039786
RAD51B RAD51 paralog B -0.0393398
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0390738
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0386989
ARHGAP5 Rho GTPase activating protein 5 -0.0386199
LDHA lactate dehydrogenase A -0.0385861
FRMD5 FERM domain containing 5 -0.0384401
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.038138
FOXP1 forkhead box P1 -0.0372508
TRIM2 tripartite motif containing 2 -0.03701
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0369711
ACTG1 actin gamma 1 -0.0365086
PARD3B par-3 family cell polarity regulator beta -0.0364368
ARHGAP32 Rho GTPase activating protein 32 -0.0362901
ANKRD11 ankyrin repeat domain 11 -0.0360394
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0359844
NFIA nuclear factor I/A -0.0359671
DENND1A DENN/MADD domain containing 1A -0.0358851
ATXN1 ataxin 1 -0.0354121
PPARG peroxisome proliferator-activated receptor gamma -0.0351222
FOXO1 forkhead box O1 -0.0348467
PALLD palladin, cytoskeletal associated protein -0.0348129
SAMD5 sterile alpha motif domain containing 5 -0.0346355
DIAPH2 diaphanous-related formin 2 -0.0344881
TNS4 tensin 4 -0.034379
BIRC6 baculoviral IAP repeat containing 6 -0.034302
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0339921
KDM4C lysine (K)-specific demethylase 4C -0.0336786
NEBL nebulette -0.0329642
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0327587
MAML2 mastermind-like 2 (Drosophila) -0.0327146
LMO7 LIM domain 7 -0.0325915
ZFAND3 zinc finger, AN1-type domain 3 -0.03221
TBC1D5 TBC1 domain family, member 5 -0.0320467
SLC35F3 solute carrier family 35, member F3 -0.0319569
ZBTB20 zinc finger and BTB domain containing 20 -0.0316741
SH3D19 SH3 domain containing 19 -0.0314124
FHL2 four and a half LIM domains 2 -0.0312102
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.031053
PTPRB protein tyrosine phosphatase, receptor type, B -0.0310232
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0309709
ASPH aspartate beta-hydroxylase -0.0307149
RAB10 RAB10, member RAS oncogene family -0.0305735
TBC1D22A TBC1 domain family, member 22A -0.0303717
TNRC6B trinucleotide repeat containing 6B -0.0303381
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0301506
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0301005
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0299898
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0295261
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0295158