Dinaciclib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.255119
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.120703
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.120096
KLF6 Kruppel-like factor 6 0.0982034
YBX1 Y box binding protein 1 0.0920745
KRT18 keratin 18, type I 0.0841129
RPS6 ribosomal protein S6 0.0759652
EEF2 eukaryotic translation elongation factor 2 0.0750804
TMSB4X thymosin beta 4, X-linked 0.0740557
JUN jun proto-oncogene 0.0699578
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0688427
PTMA prothymosin, alpha 0.0666253
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0655994
RPS4X ribosomal protein S4, X-linked 0.0623527
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0620879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0603244
ANXA1 annexin A1 0.0600961
RPS12 ribosomal protein S12 0.0589888
RPL19 ribosomal protein L19 0.056147
RPS8 ribosomal protein S8 0.052747
RPS3 ribosomal protein S3 0.0526578
POTEF POTE ankyrin domain family, member F 0.0516482
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0512357
RPL37A ribosomal protein L37a 0.0492431
BHLHE40 basic helix-loop-helix family, member e40 0.0486686
RPL11 ribosomal protein L11 0.0466845
RPLP2 ribosomal protein, large, P2 0.0466071
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0457432
RPS2 ribosomal protein S2 0.0454144
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0445347
TEX14 testis expressed 14 0.0440585
RPL5 ribosomal protein L5 0.043438
SET SET nuclear proto-oncogene 0.0415203
FTH1 ferritin, heavy polypeptide 1 0.0411941
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0393632
EMP1 epithelial membrane protein 1 0.0390202
HMGB1 high mobility group box 1 0.038819
RPL26 ribosomal protein L26 0.0380206
TPT1 tumor protein, translationally-controlled 1 0.0378597
RPL8 ribosomal protein L8 0.0371561
RPL23 ribosomal protein L23 0.0351999
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0342401
RPL12 ribosomal protein L12 0.0335387
RPLP1 ribosomal protein, large, P1 0.0335352
RPS19 ribosomal protein S19 0.0333032
RACK1 receptor for activated C kinase 1 0.0322546
RPL13A ribosomal protein L13a 0.0321148
RPS23 ribosomal protein S23 0.0312191
RPS17 ribosomal protein S17 0.0309763
FTL ferritin, light polypeptide 0.0305979
RANBP1 RAN binding protein 1 0.0299187
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0298968
PNN pinin, desmosome associated protein 0.0295133
CSDE1 cold shock domain containing E1, RNA-binding 0.0293693
SFPQ splicing factor proline/glutamine-rich 0.0284427
RPS27A ribosomal protein S27a 0.0282833
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0273626
DEK DEK proto-oncogene 0.0272723
TPM3 tropomyosin 3 0.0268778
SMC4 structural maintenance of chromosomes 4 0.0263191
RPL9 ribosomal protein L9 0.0257457
RPL18 ribosomal protein L18 0.0257432
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0255145
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0254552
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0252499
RPL35 ribosomal protein L35 0.0251365
LMNA lamin A/C 0.0248002
ARL5B ADP-ribosylation factor-like 5B 0.0239852
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236672
ADGRG6 adhesion G protein-coupled receptor G6 0.0236066
MYH9 myosin, heavy chain 9, non-muscle 0.0235842
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0235229
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0234508
HDGF hepatoma-derived growth factor 0.0233276
ATP5F1B ATP synthase F1 subunit beta 0.023096
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0230645
EEF1G eukaryotic translation elongation factor 1 gamma 0.0229847
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0229819
RPLP0 ribosomal protein, large, P0 0.0227919
RPL7 ribosomal protein L7 0.0224901
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0222119
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0220923
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0217546
RPS29 ribosomal protein S29 0.0217165
KRT8 keratin 8, type II 0.021649
RPS16 ribosomal protein S16 0.0214268
SSB Sjogren syndrome antigen B (autoantigen La) 0.0211411
RPS20 ribosomal protein S20 0.0204519
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0202339
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0200886
RPL27 ribosomal protein L27 0.0200649
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0197654
RPL7A ribosomal protein L7a 0.0195914
S100A10 S100 calcium binding protein A10 0.0194851
RASAL2 RAS protein activator like 2 0.0193384
RPL38 ribosomal protein L38 0.0193273
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0192978
RPL37 ribosomal protein L37 0.0192199
FOSL1 FOS-like antigen 1 0.0191721
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0191423

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210516
PSD3 pleckstrin and Sec7 domain containing 3 -0.110358
TP63 tumor protein p63 -0.0938834
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0933229
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0925701
HLA-B major histocompatibility complex, class I, B -0.0744859
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0735183
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0697601
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0672602
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0665834
FMNL2 formin-like 2 -0.0647377
DLG1 discs, large homolog 1 (Drosophila) -0.0607432
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0529556
SLC38A2 solute carrier family 38, member 2 -0.0523901
ZMYND8 zinc finger, MYND-type containing 8 -0.0509718
EHBP1 EH domain binding protein 1 -0.0501389
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0488144
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0481881
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0464645
TSC22D1 TSC22 domain family, member 1 -0.0462129
PTK2 protein tyrosine kinase 2 -0.0460239
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.04594
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0442613
TM4SF1 transmembrane 4 L six family member 1 -0.0440113
WARS1 tryptophanyl-tRNA synthetase 1 -0.0439603
JMJD1C jumonji domain containing 1C -0.0435985
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0422271
ANKRD12 ankyrin repeat domain 12 -0.0420201
MT2A metallothionein 2A -0.0415083
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0414389
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0412102
DST dystonin -0.040158
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0387544
BCAR3 breast cancer anti-estrogen resistance 3 -0.0384338
CD44 CD44 molecule (Indian blood group) -0.0381534
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0379522
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0374431
TXNRD1 thioredoxin reductase 1 -0.0362739
USP34 ubiquitin specific peptidase 34 -0.0362054
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0361856
RIGI RNA sensor RIG-I -0.0360516
EXOC4 exocyst complex component 4 -0.0355983
WWTR1 WW domain containing transcription regulator 1 -0.0355954
KMT2E lysine (K)-specific methyltransferase 2E -0.0351915
TMSB10 thymosin beta 10 -0.0345129
CAPRIN2 caprin family member 2 -0.0344104
NPAS2 neuronal PAS domain protein 2 -0.0341217
IFI6 interferon, alpha-inducible protein 6 -0.0333361
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0330849
RAD51B RAD51 paralog B -0.0330847
LDHA lactate dehydrogenase A -0.0328847
MT1E metallothionein 1E -0.0324037
TXNIP thioredoxin interacting protein -0.0321509
WSB1 WD repeat and SOCS box containing 1 -0.0321316
FNIP1 folliculin interacting protein 1 -0.0317974
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0317742
RNF213 ring finger protein 213 -0.0314798
IFITM1 interferon induced transmembrane protein 1 -0.0312062
CADM2 cell adhesion molecule 2 -0.0311731
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0309764
SP100 SP100 nuclear antigen -0.0307468
BRWD1 bromodomain and WD repeat domain containing 1 -0.030722
ARHGAP5 Rho GTPase activating protein 5 -0.0306365
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0306276
BIRC6 baculoviral IAP repeat containing 6 -0.0303984
PDE10A phosphodiesterase 10A -0.0300204
FBXO11 F-box protein 11 -0.0300072
SMYD3 SET and MYND domain containing 3 -0.0299575
ADAM10 ADAM metallopeptidase domain 10 -0.0293763
SRPK2 SRSF protein kinase 2 -0.0291167
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0290866
ZNF292 zinc finger protein 292 -0.0289392
ANKRD11 ankyrin repeat domain 11 -0.0288181
MACF1 microtubule-actin crosslinking factor 1 -0.0287549
YEATS2 YEATS domain containing 2 -0.0287412
KMT2C lysine (K)-specific methyltransferase 2C -0.0284848
EFNA5 ephrin-A5 -0.027543
CMIP c-Maf inducing protein -0.0273237
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0273213
TNS3 tensin 3 -0.0272347
TTC28 tetratricopeptide repeat domain 28 -0.0270938
CSMD3 CUB and Sushi multiple domains 3 -0.0270161
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0267962
RAB7A RAB7A, member RAS oncogene family -0.0267846
GSK3B glycogen synthase kinase 3 beta -0.0266033
RUNX1 runt-related transcription factor 1 -0.0265309
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0257894
FAF1 Fas (TNFRSF6) associated factor 1 -0.025581
ENO2 enolase 2 (gamma, neuronal) -0.0255476
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0253293
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0251848
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.025142
DPYD dihydropyrimidine dehydrogenase -0.024965
EPHA4 EPH receptor A4 -0.0249319
PARD3 par-3 family cell polarity regulator -0.0249187
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0248923
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0247022
MT1X metallothionein 1X -0.024672
PUM1 pumilio RNA-binding family member 1 -0.0245271
PRELID2 PRELI domain containing 2 -0.0243817