Dinaciclib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.116574
ASPH aspartate beta-hydroxylase 0.0741112
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0682244
FTH1 ferritin, heavy polypeptide 1 0.0653506
INTS6 integrator complex subunit 6 0.0648479
PM20D1 peptidase M20 domain containing 1 0.064099
KRT18 keratin 18, type I 0.0576922
TMSB10 thymosin beta 10 0.0572593
CXCL8 chemokine (C-X-C motif) ligand 8 0.0566248
CLU clusterin 0.056407
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.056152
SLC38A1 solute carrier family 38, member 1 0.0529126
KRT7 keratin 7, type II 0.0528807
THSD4 thrombospondin, type I, domain containing 4 0.0519756
PDE4D phosphodiesterase 4D, cAMP-specific 0.0504289
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0504233
PRDX1 peroxiredoxin 1 0.0482319
CCND1 cyclin D1 0.0469629
EGR1 early growth response 1 0.0455591
ANXA2 annexin A2 0.0442992
CST3 cystatin C 0.0418947
CPE carboxypeptidase E 0.0417245
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0412532
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0388468
GRAMD1B GRAM domain containing 1B 0.0384799
KRT8 keratin 8, type II 0.0377745
S100A10 S100 calcium binding protein A10 0.0358368
RPS6 ribosomal protein S6 0.0357345
FTL ferritin, light polypeptide 0.0348896
ENO1 enolase 1, (alpha) 0.0339819
PKM pyruvate kinase, muscle 0.0329988
PTMA prothymosin, alpha 0.0323158
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0322742
IGFBP5 insulin-like growth factor binding protein 5 0.0322261
YBX1 Y box binding protein 1 0.0319832
NQO1 NAD(P)H dehydrogenase, quinone 1 0.031792
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306905
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0302988
RPLP1 ribosomal protein, large, P1 0.0294716
RNF213 ring finger protein 213 0.0288962
CES1 carboxylesterase 1 0.0287578
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.028044
CAV1 caveolin 1, caveolae protein, 22kDa 0.0271104
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0261543
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0254472
GSTP1 glutathione S-transferase pi 1 0.025035
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249404
CHML choroideremia-like (Rab escort protein 2) 0.0243866
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0240533
DSPP dentin sialophosphoprotein 0.0239395
UGDH UDP-glucose 6-dehydrogenase 0.0227214
RPS12 ribosomal protein S12 0.0226817
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0225018
AKAP12 A kinase (PRKA) anchor protein 12 0.0222509
RPS17 ribosomal protein S17 0.0221657
IFI6 interferon, alpha-inducible protein 6 0.0221494
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0220809
RPS3 ribosomal protein S3 0.0217944
RPS24 ribosomal protein S24 0.0216869
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0216222
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0215605
APLP2 amyloid beta (A4) precursor-like protein 2 0.021487
AREG amphiregulin 0.0212693
GNAS GNAS complex locus 0.0210775
RPL37A ribosomal protein L37a 0.0208203
TXNRD1 thioredoxin reductase 1 0.0207393
MYOF myoferlin 0.0206848
CSDE1 cold shock domain containing E1, RNA-binding 0.0205007
DST dystonin 0.0198813
AKR1C1 aldo-keto reductase family 1, member C1 0.0198172
RPL11 ribosomal protein L11 0.0196641
RPS8 ribosomal protein S8 0.0196082
SERF2 small EDRK-rich factor 2 0.0192964
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0192895
B2M beta-2-microglobulin 0.019093
POTEF POTE ankyrin domain family, member F 0.0190821
APP amyloid beta (A4) precursor protein 0.0189827
LOC112694756 uncharaterized LOC112694756 0.0187721
TPM4 tropomyosin 4 0.0187363
RPLP0 ribosomal protein, large, P0 0.0186695
RPLP2 ribosomal protein, large, P2 0.0185082
RPL19 ribosomal protein L19 0.0181762
FN1 fibronectin 1 0.0179451
MAP7 microtubule-associated protein 7 0.0177621
IER2 immediate early response 2 0.0177444
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0176861
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0176539
PA2G4 proliferation-associated 2G4, 38kDa 0.0176079
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0175875
CHD3 chromodomain helicase DNA binding protein 3 0.0175224
RPS25 ribosomal protein S25 0.0174919
RPL12 ribosomal protein L12 0.0172078
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0171863
EFNA5 ephrin-A5 0.0170859
ACTG1 actin gamma 1 0.0169595
KTN1 kinectin 1 (kinesin receptor) 0.0166998
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0165554
RPS2 ribosomal protein S2 0.0164909
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0163729
RAB10 RAB10, member RAS oncogene family 0.016352

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.180272
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.161587
NDRG1 N-myc downstream regulated 1 -0.0890506
FAM13A family with sequence similarity 13, member A -0.0473431
CAMTA1 calmodulin binding transcription activator 1 -0.043551
TMEM165 transmembrane protein 165 -0.0420438
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0385839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0379793
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0374897
SEC31A SEC31 homolog A (S. cerevisiae) -0.0353392
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0339469
NGLY1 N-glycanase 1 -0.0317911
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.031572
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0304998
BRWD1 bromodomain and WD repeat domain containing 1 -0.0303877
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0299732
ZC3H11A zinc finger CCCH-type containing 11A -0.0290046
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0288383
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0287783
RAB1A RAB1A, member RAS oncogene family -0.0286644
TBC1D22A TBC1 domain family, member 22A -0.0281072
AGO2 argonaute RISC catalytic component 2 -0.0277617
OGA O-GlcNAcase -0.0273285
SPAG9 sperm associated antigen 9 -0.0269175
PATJ PATJ crumbs cell polarity complex component -0.0267826
SOD2 superoxide dismutase 2, mitochondrial -0.0259081
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0253165
TOP1 topoisomerase (DNA) I -0.0243601
MON2 MON2 homolog (S. cerevisiae) -0.0242145
BIRC6 baculoviral IAP repeat containing 6 -0.024032
ZNF292 zinc finger protein 292 -0.0237509
KMT2E lysine (K)-specific methyltransferase 2E -0.0235472
SRP54 signal recognition particle 54kDa -0.0231672
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0230308
GOLGB1 golgin B1 -0.0230293
KDM2A lysine (K)-specific demethylase 2A -0.0229539
WDR45B WD repeat domain 45B -0.0229419
WASF2 WAS protein family, member 2 -0.0227525
FNIP1 folliculin interacting protein 1 -0.0226615
PRRC2C proline-rich coiled-coil 2C -0.0225869
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0223415
USP34 ubiquitin specific peptidase 34 -0.0221921
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.021849
TMCO3 transmembrane and coiled-coil domains 3 -0.0217148
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0216229
ANKRD12 ankyrin repeat domain 12 -0.021538
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0213068
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0209638
HDLBP high density lipoprotein binding protein -0.0207559
KDM5B lysine (K)-specific demethylase 5B -0.0207014
SEPTIN2 septin 2 -0.0203314
ANO6 anoctamin 6 -0.0201886
DSCAM Down syndrome cell adhesion molecule -0.0199837
GSK3B glycogen synthase kinase 3 beta -0.0196296
KMT2A lysine (K)-specific methyltransferase 2A -0.019505
ZNF638 zinc finger protein 638 -0.0194873
ZBTB20 zinc finger and BTB domain containing 20 -0.0192538
UVRAG UV radiation resistance associated -0.0189185
SEC24D SEC24 family member D -0.0188349
COPA coatomer protein complex, subunit alpha -0.0188183
ARRDC3 arrestin domain containing 3 -0.0187912
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0187243
SUCO SUN domain containing ossification factor -0.018684
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0186353
SCFD1 sec1 family domain containing 1 -0.0186177
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0185349
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0183837
HM13 histocompatibility (minor) 13 -0.0182798
KCMF1 potassium channel modulatory factor 1 -0.0181315
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0179061
PUM2 pumilio RNA-binding family member 2 -0.017597
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0175922
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0174279
BRWD3 bromodomain and WD repeat domain containing 3 -0.0172729
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0171632
USP9X ubiquitin specific peptidase 9, X-linked -0.0171597
DTNA dystrobrevin, alpha -0.0170846
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0169836
RNMT RNA (guanine-7-) methyltransferase -0.0169288
NIPBL Nipped-B homolog (Drosophila) -0.0167918
ADAM17 ADAM metallopeptidase domain 17 -0.0167692
HOOK2 hook microtubule-tethering protein 2 -0.016733
H1-0 H1.0 linker histone -0.0167038
FBXO11 F-box protein 11 -0.0166843
TMF1 TATA element modulatory factor 1 -0.0165534
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0165306
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0164965
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0164282
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0164204
MORF4L2 mortality factor 4 like 2 -0.016352
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0163335
KDM3A lysine (K)-specific demethylase 3A -0.0163009
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0162136
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0162126
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0160554
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0160346
SLMAP sarcolemma associated protein -0.015904
NAMPT nicotinamide phosphoribosyltransferase -0.015832
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0157976
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0157749