Dinaciclib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Dinaciclib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.0992249
FTL ferritin, light polypeptide 0.0919895
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0902094
MT2A metallothionein 2A 0.0781496
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0635209
PTMA prothymosin, alpha 0.0615402
RPS6 ribosomal protein S6 0.056501
YBX1 Y box binding protein 1 0.0533853
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0525319
VIM vimentin 0.0511611
TMSB10 thymosin beta 10 0.0508582
PCBP2 poly(rC) binding protein 2 0.0480581
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0422409
RPS19 ribosomal protein S19 0.0421275
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0397861
RPLP1 ribosomal protein, large, P1 0.0391088
EEF2 eukaryotic translation elongation factor 2 0.0366833
RPL11 ribosomal protein L11 0.036159
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0342138
FTH1 ferritin, heavy polypeptide 1 0.033847
PDIA3 protein disulfide isomerase family A, member 3 0.0332777
RPL23 ribosomal protein L23 0.0317377
RPS12 ribosomal protein S12 0.0306686
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.029875
HMGA1 high mobility group AT-hook 1 0.0288211
MYH9 myosin, heavy chain 9, non-muscle 0.0282355
RPL35A ribosomal protein L35a 0.0282129
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0278807
RPS17 ribosomal protein S17 0.0268681
EGR1 early growth response 1 0.0267041
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0263319
RPS23 ribosomal protein S23 0.0261368
RPL12 ribosomal protein L12 0.0261097
B2M beta-2-microglobulin 0.0260221
PKM pyruvate kinase, muscle 0.025673
RPS8 ribosomal protein S8 0.0245644
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0240641
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.023614
RPL19 ribosomal protein L19 0.0234715
RPL31 ribosomal protein L31 0.0222682
RPL32 ribosomal protein L32 0.022198
RPLP2 ribosomal protein, large, P2 0.022082
RPL36 ribosomal protein L36 0.0218706
RPL34 ribosomal protein L34 0.0213367
RPL37A ribosomal protein L37a 0.0212421
RPS3 ribosomal protein S3 0.0203387
EEF1G eukaryotic translation elongation factor 1 gamma 0.0203275
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0202672
GSTP1 glutathione S-transferase pi 1 0.0201579
YBX3 Y box binding protein 3 0.0199247
EIF1 eukaryotic translation initiation factor 1 0.0196544
SSRP1 structure specific recognition protein 1 0.0194868
RPS13 ribosomal protein S13 0.0190307
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.018931
TPM3 tropomyosin 3 0.0187809
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0187325
RPL5 ribosomal protein L5 0.0186847
RPS11 ribosomal protein S11 0.0186205
CSDE1 cold shock domain containing E1, RNA-binding 0.0185396
RPS29 ribosomal protein S29 0.0182253
HDGF hepatoma-derived growth factor 0.018218
COTL1 coactosin-like F-actin binding protein 1 0.0177589
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0177484
RPS24 ribosomal protein S24 0.0175257
RPL9 ribosomal protein L9 0.0175013
LDHB lactate dehydrogenase B 0.0173177
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0172986
RPS5 ribosomal protein S5 0.0168477
ATP5F1A ATP synthase F1 subunit alpha 0.0167532
RPL37 ribosomal protein L37 0.0166562
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0165827
RPLP0 ribosomal protein, large, P0 0.0163695
ZC3H3 zinc finger CCCH-type containing 3 0.0161308
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0160941
ATP5F1B ATP synthase F1 subunit beta 0.0160493
RPL30 ribosomal protein L30 0.0159274
FLNA filamin A, alpha 0.0159023
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0158616
PNN pinin, desmosome associated protein 0.0157696
TEX14 testis expressed 14 0.0156365
RPS14 ribosomal protein S14 0.0154091
TMSB4X thymosin beta 4, X-linked 0.0151438
RPL7 ribosomal protein L7 0.0151158
RPS4X ribosomal protein S4, X-linked 0.014977
RACK1 receptor for activated C kinase 1 0.0149663
PFN1 profilin 1 0.0148213
RPL7A ribosomal protein L7a 0.0147698
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0146803
PRDX1 peroxiredoxin 1 0.0146083
RAD18 RAD18 E3 ubiquitin protein ligase 0.0145484
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0143706
RPL28 ribosomal protein L28 0.0143569
FOSL1 FOS-like antigen 1 0.0142579
RPL35 ribosomal protein L35 0.0142383
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0142024
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0141971
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0139911
TXNRD1 thioredoxin reductase 1 0.0138098
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0137074
SERF2 small EDRK-rich factor 2 0.0136939

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.206507
FNDC3B fibronectin type III domain containing 3B -0.139542
GRB10 growth factor receptor-bound protein 10 -0.0880456
TRIO trio Rho guanine nucleotide exchange factor -0.0846183
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0825217
SDK1 sidekick cell adhesion molecule 1 -0.0817672
USP34 ubiquitin specific peptidase 34 -0.0816992
NAMPT nicotinamide phosphoribosyltransferase -0.0794147
EFNA5 ephrin-A5 -0.0789168
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0779808
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0778817
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0756588
LOX lysyl oxidase -0.0689215
GPC6 glypican 6 -0.0671369
CDH13 cadherin 13 -0.0663846
AKAP12 A kinase (PRKA) anchor protein 12 -0.0652088
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0622555
HMGA2 high mobility group AT-hook 2 -0.0595744
PSD3 pleckstrin and Sec7 domain containing 3 -0.0588683
DPYD dihydropyrimidine dehydrogenase -0.0581142
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0563376
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0557309
FAM20C family with sequence similarity 20, member C -0.0556117
FN1 fibronectin 1 -0.0549198
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0540936
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0525013
IGFBP3 insulin-like growth factor binding protein 3 -0.0508062
PRELID2 PRELI domain containing 2 -0.0502773
KDM2A lysine (K)-specific demethylase 2A -0.0499924
NRG1 neuregulin 1 -0.0494976
EXT1 exostosin glycosyltransferase 1 -0.048972
SOD2 superoxide dismutase 2, mitochondrial -0.0486131
RICTOR RPTOR independent companion of MTOR, complex 2 -0.048597
OSMR oncostatin M receptor -0.047926
RAD51B RAD51 paralog B -0.0470777
ATXN1 ataxin 1 -0.0469992
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0467464
AKAP13 A kinase (PRKA) anchor protein 13 -0.0463509
RAI14 retinoic acid induced 14 -0.046244
TAS2R14 taste receptor, type 2, member 14 -0.0455234
ETV6 ets variant 6 -0.0454102
RBM39 RNA binding motif protein 39 -0.0449209
CD44 CD44 molecule (Indian blood group) -0.0431248
MEF2A myocyte enhancer factor 2A -0.0420383
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0415622
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0406908
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0395134
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0393017
ZEB2 zinc finger E-box binding homeobox 2 -0.0378494
DOCK5 dedicator of cytokinesis 5 -0.0376078
KYNU kynureninase -0.0371786
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0370043
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.036859
RAB1A RAB1A, member RAS oncogene family -0.0367374
DSCAM Down syndrome cell adhesion molecule -0.0363939
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0361268
KMT2C lysine (K)-specific methyltransferase 2C -0.0359684
JMJD1C jumonji domain containing 1C -0.0359378
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0358466
ARHGAP5 Rho GTPase activating protein 5 -0.0351636
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0347776
PARD3 par-3 family cell polarity regulator -0.0347488
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0342102
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0341364
EHBP1 EH domain binding protein 1 -0.0338905
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0338429
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0338096
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0338096
NPAS2 neuronal PAS domain protein 2 -0.033568
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0335353
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0334448
SMAD3 SMAD family member 3 -0.0334222
NAV2 neuron navigator 2 -0.0333043
DLG1 discs, large homolog 1 (Drosophila) -0.0331024
GLCCI1 glucocorticoid induced 1 -0.0326666
MSRB3 methionine sulfoxide reductase B3 -0.0323025
MAML3 mastermind-like 3 (Drosophila) -0.0322569
FAM13A family with sequence similarity 13, member A -0.0319034
DST dystonin -0.03167
EGFR epidermal growth factor receptor -0.0316483
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.031263
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0309224
ZMYND8 zinc finger, MYND-type containing 8 -0.0309224
NCOA7 nuclear receptor coactivator 7 -0.0306865
ELL2 elongation factor, RNA polymerase II, 2 -0.030573
LRMDA leucine rich melanocyte differentiation associated -0.03034
ANTXR2 anthrax toxin receptor 2 -0.030206
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0296557
NF1 neurofibromin 1 -0.0295135
RAP1B RAP1B, member of RAS oncogene family -0.0292904
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0292412
EXOC4 exocyst complex component 4 -0.0291723
ZBTB20 zinc finger and BTB domain containing 20 -0.028791
NRP1 neuropilin 1 -0.0286592
OXR1 oxidation resistance 1 -0.0286464
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0285244
SIK3 SIK family kinase 3 -0.0283542
RUNX2 runt-related transcription factor 2 -0.0283019
TPST1 tyrosylprotein sulfotransferase 1 -0.0282515
IGF1R insulin-like growth factor 1 receptor -0.0281327