Dinaciclib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.163256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.103659
ZC3H3 zinc finger CCCH-type containing 3 0.05104
POTEF POTE ankyrin domain family, member F 0.0499787
FLNA filamin A, alpha 0.0358151
THBS1 thrombospondin 1 0.0317709
CALR calreticulin 0.030042
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0267973
YBX1 Y box binding protein 1 0.0264803
RANBP1 RAN binding protein 1 0.0223145
TPM4 tropomyosin 4 0.021311
TEX14 testis expressed 14 0.0200516
KLF6 Kruppel-like factor 6 0.0197122
CYB5D2 cytochrome b5 domain containing 2 0.0194428
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0194413
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0185445
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0182508
SLC16A13 solute carrier family 16, member 13 0.0181842
HDGF hepatoma-derived growth factor 0.0180638
MYH9 myosin, heavy chain 9, non-muscle 0.0176743
TGM2 transglutaminase 2 0.0176466
TFPI2 tissue factor pathway inhibitor 2 0.0170139
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0164926
IGFBP4 insulin-like growth factor binding protein 4 0.0163796
LMNA lamin A/C 0.015785
COTL1 coactosin-like F-actin binding protein 1 0.0155981
CLU clusterin 0.0155727
HMGN2 high mobility group nucleosomal binding domain 2 0.0154983
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0152346
TPM1 tropomyosin 1 (alpha) 0.0152344
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0150882
RMI1 RecQ mediated genome instability 1 0.0148546
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0146823
LDHB lactate dehydrogenase B 0.0143072
TMSB4X thymosin beta 4, X-linked 0.0143051
HMGA1 high mobility group AT-hook 1 0.0139317
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0138125
PFN1 profilin 1 0.0136831
RPL11 ribosomal protein L11 0.0136652
S100A9 S100 calcium binding protein A9 0.0136167
RPS4X ribosomal protein S4, X-linked 0.0133703
PLEC plectin 0.0133409
CNRIP1 cannabinoid receptor interacting protein 1 0.0132939
BEX3 brain expressed X-linked 3 0.0130131
ATP5F1E ATP synthase F1 subunit epsilon 0.0129701
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0127854
CDC37 cell division cycle 37 0.0127645
TPM3 tropomyosin 3 0.0127453
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0124405
LMNB1 lamin B1 0.0124199
SFTPA2 surfactant protein A2 0.0123386
EMC10 ER membrane protein complex subunit 10 0.0120341
HMGB1 high mobility group box 1 0.0117423
S100A11 S100 calcium binding protein A11 0.011726
ENO1 enolase 1, (alpha) 0.0113089
CANX calnexin 0.0111695
IFITM3 interferon induced transmembrane protein 3 0.0111575
NBDY negative regulator of P-body association 0.0109094
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0108606
EGR1 early growth response 1 0.0108282
PDIA4 protein disulfide isomerase family A, member 4 0.0108118
DHFR dihydrofolate reductase 0.0107896
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0107028
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0105985
MROH8 maestro heat-like repeat family member 8 0.010498
ECI1 enoyl-CoA delta isomerase 1 0.0104323
MYL9 myosin, light chain 9, regulatory 0.0103768
FN1 fibronectin 1 0.0103341
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0102909
CCND1 cyclin D1 0.0102907
GIPC2 GIPC PDZ domain containing family, member 2 0.0102743
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0102302
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.0101742
CXCL2 chemokine (C-X-C motif) ligand 2 0.0101257
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0099953
CCL2 chemokine (C-C motif) ligand 2 0.00996575
DEK DEK proto-oncogene 0.00993957
HLA-A major histocompatibility complex, class I, A 0.00975065
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 0.00974436
ATP5MG ATP synthase membrane subunit g 0.00972933
RPL19 ribosomal protein L19 0.00958995
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00958124
ARMC7 armadillo repeat containing 7 0.00951456
CBX3 chromobox homolog 3 0.00933547
CXCL3 chemokine (C-X-C motif) ligand 3 0.00929068
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.00925767
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.00925212
SOD1 superoxide dismutase 1, soluble 0.00922148
TPT1 tumor protein, translationally-controlled 1 0.00913271
IRAK1 interleukin-1 receptor-associated kinase 1 0.00905828
ATP13A2 ATPase type 13A2 0.00894487
DSTN destrin (actin depolymerizing factor) 0.00894073
TMEM219 transmembrane protein 219 0.00887515
LMO7 LIM domain 7 0.00887194
FKBP10 FK506 binding protein 10, 65 kDa 0.0088345
KRT18 keratin 18, type I 0.00872509
RPS20 ribosomal protein S20 0.00860994
H2BC5 H2B clustered histone 5 0.00844327
HYOU1 hypoxia up-regulated 1 0.00841256
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.00839337

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.214801
PDE4D phosphodiesterase 4D, cAMP-specific -0.167433
GRAMD1B GRAM domain containing 1B -0.162997
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.149841
PM20D1 peptidase M20 domain containing 1 -0.117082
PARD3 par-3 family cell polarity regulator -0.116599
ZFAND3 zinc finger, AN1-type domain 3 -0.107562
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10146
TM4SF1 transmembrane 4 L six family member 1 -0.0979423
TXNRD1 thioredoxin reductase 1 -0.0970973
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0913009
FNDC3B fibronectin type III domain containing 3B -0.0792739
RBM39 RNA binding motif protein 39 -0.078604
AKAP12 A kinase (PRKA) anchor protein 12 -0.0745554
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0732864
DOCK4 dedicator of cytokinesis 4 -0.0726647
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0719892
PTK2 protein tyrosine kinase 2 -0.0672293
RTN4 reticulon 4 -0.0670252
TRIO trio Rho guanine nucleotide exchange factor -0.0667951
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0636692
ERBIN erbb2 interacting protein -0.063594
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0635009
FMNL2 formin-like 2 -0.0628487
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0619323
SAMD4A sterile alpha motif domain containing 4A -0.0616129
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0613002
WDR43 WD repeat domain 43 -0.0612711
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0612
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0601304
MACF1 microtubule-actin crosslinking factor 1 -0.0587421
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0570545
THSD4 thrombospondin, type I, domain containing 4 -0.0559208
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0552311
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0547585
AKAP13 A kinase (PRKA) anchor protein 13 -0.0543464
LPP LIM domain containing preferred translocation partner in lipoma -0.0536282
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0534319
ZNF292 zinc finger protein 292 -0.0525432
USP34 ubiquitin specific peptidase 34 -0.0525156
ELL2 elongation factor, RNA polymerase II, 2 -0.0524604
ANKRD11 ankyrin repeat domain 11 -0.052248
CMIP c-Maf inducing protein -0.0516444
SLC38A2 solute carrier family 38, member 2 -0.0513731
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0502883
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0502683
UBASH3B ubiquitin associated and SH3 domain containing B -0.0501737
DENND4A DENN/MADD domain containing 4A -0.0492741
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0491166
WAC WW domain containing adaptor with coiled-coil -0.0490485
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0478864
PUM2 pumilio RNA-binding family member 2 -0.0467989
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0467816
BIRC6 baculoviral IAP repeat containing 6 -0.0465309
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0462979
SVIL supervillin -0.0458957
PDE8A phosphodiesterase 8A -0.0458421
KIF5B kinesin family member 5B -0.0454677
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0449725
USP3 ubiquitin specific peptidase 3 -0.0439216
KTN1 kinectin 1 (kinesin receptor) -0.0434927
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0430063
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0429554
STC1 stanniocalcin 1 -0.0429002
CYRIB CYFIP related Rac1 interactor B -0.0428046
JMJD1C jumonji domain containing 1C -0.0427276
GLG1 golgi glycoprotein 1 -0.0418345
PTPRM protein tyrosine phosphatase, receptor type, M -0.0418222
RBM25 RNA binding motif protein 25 -0.0415802
FBXO11 F-box protein 11 -0.0414928
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0414305
FAM107B family with sequence similarity 107, member B -0.0412523
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0411633
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0407168
PDLIM5 PDZ and LIM domain 5 -0.0405894
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0405315
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0404529
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0404322
PUM1 pumilio RNA-binding family member 1 -0.0404009
ZNF207 zinc finger protein 207 -0.0399942
TPD52 tumor protein D52 -0.0396142
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0394409
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0393266
TMSB10 thymosin beta 10 -0.0391753
DOCK5 dedicator of cytokinesis 5 -0.0389369
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0388244
SETD5 SET domain containing 5 -0.0386479
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0385257
RAD21 RAD21 homolog (S. pombe) -0.0384421
TLK1 tousled-like kinase 1 -0.0381741
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0380853
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0380476
CCNL1 cyclin L1 -0.0379616
RASAL2 RAS protein activator like 2 -0.0376887
COG5 component of oligomeric golgi complex 5 -0.0375012
ADAM17 ADAM metallopeptidase domain 17 -0.0373833
NIPBL Nipped-B homolog (Drosophila) -0.0367229
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0365732
HSPA8 heat shock 70kDa protein 8 -0.0365045
TFG TRK-fused gene -0.036007