Dinaciclib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.137876
EGR1 early growth response 1 0.0677108
TMSB4X thymosin beta 4, X-linked 0.0614815
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0600205
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0532517
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0500106
RPN1 ribophorin I 0.0495232
RCAN3 RCAN family member 3 0.0495175
TEX14 testis expressed 14 0.0488065
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0481732
CDA cytidine deaminase 0.0462845
POTEF POTE ankyrin domain family, member F 0.0439111
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0437319
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0436202
KRT8 keratin 8, type II 0.0419326
SAE1 SUMO1 activating enzyme subunit 1 0.0417133
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0415243
TYW5 tRNA-yW synthesizing protein 5 0.0397151
CIZ1 CDKN1A interacting zinc finger protein 1 0.0391328
KRT18 keratin 18, type I 0.038987
PRC1 protein regulator of cytokinesis 1 0.0384829
C12ORF75 chromosome 12 open reading frame 75 0.0376133
KPNB1 karyopherin (importin) beta 1 0.0370971
PRR11 proline rich 11 0.036627
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0361239
RPL21 ribosomal protein L21 0.0360139
YBX1 Y box binding protein 1 0.0357789
MAP1B microtubule-associated protein 1B 0.0354038
TLN1 talin 1 0.0352762
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0342731
SET SET nuclear proto-oncogene 0.0339569
PLEC plectin 0.0338511
HMGN2 high mobility group nucleosomal binding domain 2 0.0336565
FLNA filamin A, alpha 0.0334289
NBDY negative regulator of P-body association 0.0330973
FKBP1A FK506 binding protein 1A, 12kDa 0.0329614
RPS4X ribosomal protein S4, X-linked 0.0328478
TAGLN2 transgelin 2 0.0328165
SRP9 signal recognition particle 9kDa 0.0325949
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.0321945
MYH9 myosin, heavy chain 9, non-muscle 0.0321828
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0320873
MGST1 microsomal glutathione S-transferase 1 0.0320211
TFRC transferrin receptor 0.0317576
MKI67 marker of proliferation Ki-67 0.0317167
CDK12 cyclin-dependent kinase 12 0.0316853
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0310797
EXOSC8 exosome component 8 0.0310224
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0307605
CBX5 chromobox homolog 5 0.0306827
RPL3 ribosomal protein L3 0.0306114
VCAN versican 0.0303141
RPL23 ribosomal protein L23 0.0302591
FTH1 ferritin, heavy polypeptide 1 0.0302174
LRP1B low density lipoprotein receptor-related protein 1B 0.0299012
ZNF721 zinc finger protein 721 0.0297168
ARC activity-regulated cytoskeleton-associated protein 0.0295382
HSPB1 heat shock 27kDa protein 1 0.0294909
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.028361
USP45 ubiquitin specific peptidase 45 0.0279984
SBDS Shwachman-Bodian-Diamond syndrome 0.0277834
PFDN2 prefoldin subunit 2 0.0277155
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0276958
PNKD paroxysmal nonkinesigenic dyskinesia 0.0276616
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0276497
COTL1 coactosin-like F-actin binding protein 1 0.0275188
LBR lamin B receptor 0.0275072
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0271929
KIAA0319L KIAA0319-like 0.0269077
TMPO thymopoietin 0.026807
RPS27A ribosomal protein S27a 0.0267416
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0263835
EIF4A1 eukaryotic translation initiation factor 4A1 0.0263771
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0262063
KAZN kazrin, periplakin interacting protein 0.0261053
SFPQ splicing factor proline/glutamine-rich 0.026096
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0260264
CHMP5 charged multivesicular body protein 5 0.0260242
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0258927
BSG basigin (Ok blood group) 0.025649
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0255129
RPL4 ribosomal protein L4 0.0252452
HP1BP3 heterochromatin protein 1, binding protein 3 0.0252162
APP amyloid beta (A4) precursor protein 0.0251955
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0250729
TPM1 tropomyosin 1 (alpha) 0.0249178
FSCN1 fascin actin-bundling protein 1 0.0247461
SOD1 superoxide dismutase 1, soluble 0.0246145
OPTN optineurin 0.0243969
TRAM1 translocation associated membrane protein 1 0.0243961
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0242467
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0241986
C11ORF58 chromosome 11 open reading frame 58 0.0240412
PBX1 pre-B-cell leukemia homeobox 1 0.0239792
UBQLN1 ubiquilin 1 0.023953
LMAN1 lectin, mannose-binding, 1 0.0239161
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0238936
RPL15 ribosomal protein L15 0.0235932
PDAP1 PDGFA associated protein 1 0.0233121
GRHL1 grainyhead-like 1 (Drosophila) 0.0231667

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.113478
NDRG1 N-myc downstream regulated 1 -0.108746
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.107674
MYO1E myosin IE -0.101572
BACE2 beta-site APP-cleaving enzyme 2 -0.0950314
GRB10 growth factor receptor-bound protein 10 -0.0886912
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.07947
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0785822
DSCAM Down syndrome cell adhesion molecule -0.0769526
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0750052
FNDC3B fibronectin type III domain containing 3B -0.0747059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0739441
SAMD4A sterile alpha motif domain containing 4A -0.0689617
EXT1 exostosin glycosyltransferase 1 -0.0656123
LAMB3 laminin, beta 3 -0.0649544
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0584822
ESYT2 extended synaptotagmin-like protein 2 -0.0566572
AKAP13 A kinase (PRKA) anchor protein 13 -0.0563561
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0539425
KMT2C lysine (K)-specific methyltransferase 2C -0.0528149
ZNF292 zinc finger protein 292 -0.0525659
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0507823
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0501279
IGF1R insulin-like growth factor 1 receptor -0.0488393
KRT17 keratin 17, type I -0.0486444
ANXA2 annexin A2 -0.0486428
PARD3 par-3 family cell polarity regulator -0.0462978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0451125
ATOSA atos homolog A -0.0450259
RPS6 ribosomal protein S6 -0.044936
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0447562
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0437049
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0427488
MCL1 myeloid cell leukemia 1 -0.0416708
SVIL supervillin -0.0414286
ELL2 elongation factor, RNA polymerase II, 2 -0.0412139
JMJD1C jumonji domain containing 1C -0.0405168
PLAUR plasminogen activator, urokinase receptor -0.0381917
PTPRM protein tyrosine phosphatase, receptor type, M -0.038168
MUC16 mucin 16, cell surface associated -0.0371669
ACTG1 actin gamma 1 -0.037059
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0369012
PGK1 phosphoglycerate kinase 1 -0.0359612
TPT1 tumor protein, translationally-controlled 1 -0.0355728
ERBIN erbb2 interacting protein -0.0349676
OSMR oncostatin M receptor -0.0346854
KYNU kynureninase -0.0344063
PTK2 protein tyrosine kinase 2 -0.0342127
TJP1 tight junction protein 1 -0.0339842
ARID4B AT rich interactive domain 4B (RBP1-like) -0.033841
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.033448
CEMIP cell migration inducing protein, hyaluronan binding -0.0332283
CANX calnexin -0.0330859
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0316706
TRIO trio Rho guanine nucleotide exchange factor -0.0316149
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0314161
CSNK1A1 casein kinase 1, alpha 1 -0.0312671
STC1 stanniocalcin 1 -0.0311848
AKAP9 A kinase (PRKA) anchor protein 9 -0.0306797
RAB1A RAB1A, member RAS oncogene family -0.0306269
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0296262
RBM39 RNA binding motif protein 39 -0.0294486
MXD1 MAX dimerization protein 1 -0.0289115
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0288448
TM4SF1 transmembrane 4 L six family member 1 -0.0285984
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.028397
FBXO11 F-box protein 11 -0.0282882
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.028229
NPEPPS aminopeptidase puromycin sensitive -0.0281209
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0279819
MACF1 microtubule-actin crosslinking factor 1 -0.027657
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0273703
MBD5 methyl-CpG binding domain protein 5 -0.0270973
MED13L mediator complex subunit 13-like -0.027086
EFNA5 ephrin-A5 -0.0270767
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0269954
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0264197
FOXO3 forkhead box O3 -0.02641
BPTF bromodomain PHD finger transcription factor -0.0263592
LAMC2 laminin, gamma 2 -0.0257208
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0256587
TSC22D2 TSC22 domain family, member 2 -0.0254549
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0253326
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0252487
ZNF638 zinc finger protein 638 -0.0247834
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0247758
ATXN1 ataxin 1 -0.0246796
SRPK2 SRSF protein kinase 2 -0.0246508
ABHD17C abhydrolase domain containing 17C -0.0244982
SBF2 SET binding factor 2 -0.0243261
UBE2H ubiquitin-conjugating enzyme E2H -0.0242078
KLF6 Kruppel-like factor 6 -0.0240553
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0240131
MED13 mediator complex subunit 13 -0.0240044
ZFAND3 zinc finger, AN1-type domain 3 -0.0239739
IFIH1 interferon induced with helicase C domain 1 -0.0239075
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0236657
EGFR epidermal growth factor receptor -0.0235001
AHNAK AHNAK nucleoprotein -0.0233745
VIM vimentin -0.0233547