Dinaciclib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPM3 tropomyosin 3 0.122642
TFPI2 tissue factor pathway inhibitor 2 0.11194
KRT18 keratin 18, type I 0.0908051
TPM2 tropomyosin 2 (beta) 0.0895631
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0869971
POTEF POTE ankyrin domain family, member F 0.081699
HDGF hepatoma-derived growth factor 0.0801828
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0795387
YBX1 Y box binding protein 1 0.0604811
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0595598
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0574603
SFPQ splicing factor proline/glutamine-rich 0.0549026
MYH9 myosin, heavy chain 9, non-muscle 0.0508859
FTH1 ferritin, heavy polypeptide 1 0.0483745
FLNA filamin A, alpha 0.047552
PTMS parathymosin 0.0450956
CSDE1 cold shock domain containing E1, RNA-binding 0.0422264
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0411041
SET SET nuclear proto-oncogene 0.0400223
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.036989
RPS12 ribosomal protein S12 0.0367497
RPL11 ribosomal protein L11 0.035975
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0359574
EBNA1BP2 EBNA1 binding protein 2 0.0356204
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0350785
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.034872
TPM4 tropomyosin 4 0.0345335
RPS4X ribosomal protein S4, X-linked 0.0328253
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.030254
KRT8 keratin 8, type II 0.0293138
PLEC plectin 0.029167
SFTPA2 surfactant protein A2 0.0291093
RPLP2 ribosomal protein, large, P2 0.0285517
APLP2 amyloid beta (A4) precursor-like protein 2 0.0277535
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0274882
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0268019
PA2G4 proliferation-associated 2G4, 38kDa 0.0264474
EIF5B eukaryotic translation initiation factor 5B 0.0262103
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0261743
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0260756
CALR calreticulin 0.0258038
CDC37 cell division cycle 37 0.0252623
EEF2 eukaryotic translation elongation factor 2 0.0250867
HLA-A major histocompatibility complex, class I, A 0.0250836
TMSB4X thymosin beta 4, X-linked 0.0250782
TEX14 testis expressed 14 0.0248898
LDHB lactate dehydrogenase B 0.0247071
HLA-B major histocompatibility complex, class I, B 0.0245578
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.024502
ATP5F1E ATP synthase F1 subunit epsilon 0.0243498
IER3 immediate early response 3 0.0242189
CALD1 caldesmon 1 0.0237934
RPL3 ribosomal protein L3 0.0230436
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0230099
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 0.0230079
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0228063
RPS2 ribosomal protein S2 0.02279
PNN pinin, desmosome associated protein 0.0225116
ATP5F1B ATP synthase F1 subunit beta 0.0220696
RANBP1 RAN binding protein 1 0.0216005
PDLIM5 PDZ and LIM domain 5 0.0214658
PTMA prothymosin, alpha 0.0213782
HMGN2 high mobility group nucleosomal binding domain 2 0.0213225
MSN moesin 0.0210899
DSTN destrin (actin depolymerizing factor) 0.0210368
RYR3 ryanodine receptor 3 0.0208822
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.020662
MCL1 myeloid cell leukemia 1 0.0204646
C1QBP complement component 1, q subcomponent binding protein 0.020367
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0202804
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0199677
CCND1 cyclin D1 0.0199355
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.0198986
PDAP1 PDGFA associated protein 1 0.0195877
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0194767
CCL20 chemokine (C-C motif) ligand 20 0.0194257
FN1 fibronectin 1 0.0187888
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0184863
PABPN1 poly(A) binding protein, nuclear 1 0.0183729
AKAP12 A kinase (PRKA) anchor protein 12 0.0183668
DEK DEK proto-oncogene 0.0183554
IER2 immediate early response 2 0.0182707
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0181531
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0180407
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0179997
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0177937
ANXA1 annexin A1 0.0174624
KLF6 Kruppel-like factor 6 0.0170829
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0166893
RPS17 ribosomal protein S17 0.0164719
TPM1 tropomyosin 1 (alpha) 0.0164256
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0163758
HTATSF1 HIV-1 Tat specific factor 1 0.016363
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0161842
TAGLN2 transgelin 2 0.0159481
TPX2 TPX2, microtubule-associated 0.0158582
SSRP1 structure specific recognition protein 1 0.0157888
PDIA6 protein disulfide isomerase family A, member 6 0.0156662
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.015407
S100A10 S100 calcium binding protein A10 0.0153252

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113026
TXNRD1 thioredoxin reductase 1 -0.0970895
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0736762
TRIO trio Rho guanine nucleotide exchange factor -0.0726869
RAD51B RAD51 paralog B -0.0699286
OGA O-GlcNAcase -0.069139
NF1 neurofibromin 1 -0.0660721
ZFAND3 zinc finger, AN1-type domain 3 -0.0651327
BBX bobby sox homolog (Drosophila) -0.0646467
KDM3A lysine (K)-specific demethylase 3A -0.0635142
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0626879
FBXO11 F-box protein 11 -0.0615917
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0588323
PHIP pleckstrin homology domain interacting protein -0.0583933
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0577766
WSB1 WD repeat and SOCS box containing 1 -0.0560105
RSF1 remodeling and spacing factor 1 -0.055709
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.055577
TAS2R14 taste receptor, type 2, member 14 -0.0554423
NIPBL Nipped-B homolog (Drosophila) -0.0551948
KDM2A lysine (K)-specific demethylase 2A -0.0540629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0538269
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0516046
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0508033
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0484922
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0484426
GRAMD1B GRAM domain containing 1B -0.0478285
XPO1 exportin 1 -0.0475251
UBE2H ubiquitin-conjugating enzyme E2H -0.0473195
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0472053
ZNF292 zinc finger protein 292 -0.0462267
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0456655
BIRC6 baculoviral IAP repeat containing 6 -0.0451547
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0443628
TPI1 triosephosphate isomerase 1 -0.0438755
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0434927
PDE4D phosphodiesterase 4D, cAMP-specific -0.0424427
CAMKMT calmodulin-lysine N-methyltransferase -0.0418217
USP34 ubiquitin specific peptidase 34 -0.0417096
CAMTA1 calmodulin binding transcription activator 1 -0.0416242
CSNK1A1 casein kinase 1, alpha 1 -0.041416
MORF4L2 mortality factor 4 like 2 -0.0411295
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0405627
ZBTB20 zinc finger and BTB domain containing 20 -0.0400934
PTK2 protein tyrosine kinase 2 -0.039291
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0392031
H1-0 H1.0 linker histone -0.0389028
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0388944
ANKRD12 ankyrin repeat domain 12 -0.0388591
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0385935
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0382597
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0382493
RB1CC1 RB1-inducible coiled-coil 1 -0.0380539
KMT2A lysine (K)-specific methyltransferase 2A -0.0379317
RBM39 RNA binding motif protein 39 -0.0375364
JMJD1C jumonji domain containing 1C -0.0375362
KMT2C lysine (K)-specific methyltransferase 2C -0.0375214
EML4 echinoderm microtubule associated protein like 4 -0.0374562
EXOC4 exocyst complex component 4 -0.0373544
GOLGA4 golgin A4 -0.0372416
PGK1 phosphoglycerate kinase 1 -0.0372362
RAB1A RAB1A, member RAS oncogene family -0.0371782
PCNX1 pecanex 1 -0.0370472
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0369436
COPA coatomer protein complex, subunit alpha -0.036628
MYL12B myosin, light chain 12B, regulatory -0.0365177
MARCHF6 membrane associated ring-CH-type finger 6 -0.036382
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0360197
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0359337
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0353448
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0350734
PUM2 pumilio RNA-binding family member 2 -0.0346578
ZFR zinc finger RNA binding protein -0.0344335
MON2 MON2 homolog (S. cerevisiae) -0.0343321
TM4SF1 transmembrane 4 L six family member 1 -0.0342019
VIM vimentin -0.0340686
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0340641
ZMYM2 zinc finger, MYM-type 2 -0.0338824
GPHN gephyrin -0.0337525
GATAD2B GATA zinc finger domain containing 2B -0.0336535
ATXN2 ataxin 2 -0.0336403
KMT2E lysine (K)-specific methyltransferase 2E -0.0331148
MARCHF4 membrane associated ring-CH-type finger 4 -0.0327189
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0326564
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0325751
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.032469
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0323957
PRRC2C proline-rich coiled-coil 2C -0.0323575
SCAF11 SR-related CTD-associated factor 11 -0.0321941
BRWD1 bromodomain and WD repeat domain containing 1 -0.0316685
SETD5 SET domain containing 5 -0.0315097
PHF20 PHD finger protein 20 -0.0314901
WDPCP WD repeat containing planar cell polarity effector -0.0313766
BCAS3 breast carcinoma amplified sequence 3 -0.0312652
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.031152
WNK1 WNK lysine deficient protein kinase 1 -0.0309356
TMEM165 transmembrane protein 165 -0.030737
TBC1D5 TBC1 domain family, member 5 -0.030619
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0304476