Dinaciclib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Dinaciclib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.132379
POTEF POTE ankyrin domain family, member F 0.127658
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.105129
FN1 fibronectin 1 0.099545
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0804785
HMGA1 high mobility group AT-hook 1 0.0709021
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0663863
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.065355
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0594361
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0572778
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0557935
TMSB10 thymosin beta 10 0.0552863
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0543133
ASPH aspartate beta-hydroxylase 0.0496483
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0480032
EEF2 eukaryotic translation elongation factor 2 0.0463536
FTL ferritin, light polypeptide 0.0440358
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0434431
PLAU plasminogen activator, urokinase 0.0433799
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0417306
RPL23 ribosomal protein L23 0.0409112
FTH1 ferritin, heavy polypeptide 1 0.0402219
RCAN3 RCAN family member 3 0.0400064
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0398556
BHLHE40 basic helix-loop-helix family, member e40 0.0378615
CSDE1 cold shock domain containing E1, RNA-binding 0.0362728
RPS12 ribosomal protein S12 0.0337366
CALR calreticulin 0.0332947
CCND1 cyclin D1 0.0325295
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0323153
RPL7 ribosomal protein L7 0.032275
RPS3 ribosomal protein S3 0.0320034
YBX1 Y box binding protein 1 0.0317078
TPM3 tropomyosin 3 0.0314821
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0306908
RPL32 ribosomal protein L32 0.0297246
RPS6 ribosomal protein S6 0.0294013
MAP1B microtubule-associated protein 1B 0.0288397
CAPN2 calpain 2, (m/II) large subunit 0.0281956
HMGN2 high mobility group nucleosomal binding domain 2 0.0279889
SCEL sciellin 0.027561
PCBP2 poly(rC) binding protein 2 0.0274699
MSN moesin 0.0266003
HDGF hepatoma-derived growth factor 0.0257575
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0252616
RPL3 ribosomal protein L3 0.0252374
RPL8 ribosomal protein L8 0.024698
ZC3H3 zinc finger CCCH-type containing 3 0.0246754
G0S2 G0/G1 switch 2 0.0246608
KRT7 keratin 7, type II 0.024484
MT2A metallothionein 2A 0.0243994
LDHB lactate dehydrogenase B 0.0242673
PEG10 paternally expressed 10 0.0240378
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0237028
PTMA prothymosin, alpha 0.0232853
RPS2 ribosomal protein S2 0.0231572
ADAM9 ADAM metallopeptidase domain 9 0.023112
RPS23 ribosomal protein S23 0.0229054
RPLP2 ribosomal protein, large, P2 0.0227177
RPS25 ribosomal protein S25 0.0226041
CD9 CD9 molecule 0.0225136
CAV1 caveolin 1, caveolae protein, 22kDa 0.0221398
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0217016
EEF1G eukaryotic translation elongation factor 1 gamma 0.0215067
APLP2 amyloid beta (A4) precursor-like protein 2 0.0214382
TM4SF1 transmembrane 4 L six family member 1 0.0213968
RPL35A ribosomal protein L35a 0.0209433
RPL4 ribosomal protein L4 0.0209389
PERP PERP, TP53 apoptosis effector 0.0208482
AXL AXL receptor tyrosine kinase 0.0207529
SET SET nuclear proto-oncogene 0.0207353
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206134
ANXA2 annexin A2 0.0202783
NBDY negative regulator of P-body association 0.020083
RPS17 ribosomal protein S17 0.0200113
CBX3 chromobox homolog 3 0.0199668
RPS13 ribosomal protein S13 0.0197666
NUDC nudC nuclear distribution protein 0.0195173
RPL15 ribosomal protein L15 0.0194764
RPL37A ribosomal protein L37a 0.0194338
RACK1 receptor for activated C kinase 1 0.0192251
FOSL1 FOS-like antigen 1 0.0190678
NT5E 5'-nucleotidase, ecto (CD73) 0.0188884
CALU calumenin 0.0188057
PEA15 phosphoprotein enriched in astrocytes 15 0.0186261
RPL5 ribosomal protein L5 0.0185535
RPL27 ribosomal protein L27 0.0184302
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0183009
EREG epiregulin 0.0179731
SLC38A1 solute carrier family 38, member 1 0.0179441
RPL9 ribosomal protein L9 0.0177654
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0176837
COX7C cytochrome c oxidase subunit VIIc 0.017546
TMEM123 transmembrane protein 123 0.0174687
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0174219
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0173087
TPM4 tropomyosin 4 0.0172432
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0170727
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0170127
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.0169766

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.142455
SAMD4A sterile alpha motif domain containing 4A -0.129585
LPP LIM domain containing preferred translocation partner in lipoma -0.108656
EXT1 exostosin glycosyltransferase 1 -0.104022
GRB10 growth factor receptor-bound protein 10 -0.097999
TRIO trio Rho guanine nucleotide exchange factor -0.0913038
EFNA5 ephrin-A5 -0.0894309
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0866078
NDRG1 N-myc downstream regulated 1 -0.0863905
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0853173
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0812908
LIMCH1 LIM and calponin homology domains 1 -0.0789763
PTK2 protein tyrosine kinase 2 -0.0773084
ERBIN erbb2 interacting protein -0.0659771
ACTG1 actin gamma 1 -0.0606597
AKAP13 A kinase (PRKA) anchor protein 13 -0.0606453
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0586113
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0584181
PDLIM5 PDZ and LIM domain 5 -0.0575475
NAV2 neuron navigator 2 -0.0549445
ZFAND3 zinc finger, AN1-type domain 3 -0.0538655
ELL2 elongation factor, RNA polymerase II, 2 -0.0537815
RCOR1 REST corepressor 1 -0.053188
TSC22D2 TSC22 domain family, member 2 -0.0525869
FBXO32 F-box protein 32 -0.0520275
MYO6 myosin VI -0.0517737
DTNA dystrobrevin, alpha -0.0514307
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0512364
CTBP2 C-terminal binding protein 2 -0.0481164
WSB1 WD repeat and SOCS box containing 1 -0.0471624
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0468975
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0468619
MYO1E myosin IE -0.0467952
PARD3 par-3 family cell polarity regulator -0.0463702
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0457479
NIPBL Nipped-B homolog (Drosophila) -0.0453055
GOLGA4 golgin A4 -0.0451998
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0444891
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.044323
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.04401
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0425988
FNIP1 folliculin interacting protein 1 -0.0397977
RNF213 ring finger protein 213 -0.0396311
RAI14 retinoic acid induced 14 -0.0395576
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0393883
FAM13A family with sequence similarity 13, member A -0.039264
VCL vinculin -0.0391977
SH3KBP1 SH3-domain kinase binding protein 1 -0.0389252
STRN3 striatin, calmodulin binding protein 3 -0.0387222
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0385432
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0383762
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0379698
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0379038
MCU mitochondrial calcium uniporter -0.0376002
UBE2H ubiquitin-conjugating enzyme E2H -0.0374366
ERRFI1 ERBB receptor feedback inhibitor 1 -0.037311
KDM3A lysine (K)-specific demethylase 3A -0.0368821
CEP350 centrosomal protein 350kDa -0.0363991
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0358166
RASA2 RAS p21 protein activator 2 -0.0355526
KDM5B lysine (K)-specific demethylase 5B -0.0355386
MEF2A myocyte enhancer factor 2A -0.0352749
GOLGB1 golgin B1 -0.0351099
SMAD3 SMAD family member 3 -0.0350949
MARCHF6 membrane associated ring-CH-type finger 6 -0.034985
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0349499
CERT1 ceramide transporter 1 -0.0347057
NPEPPS aminopeptidase puromycin sensitive -0.0346322
DSCAM Down syndrome cell adhesion molecule -0.0345836
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0345768
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0345715
IFI16 interferon, gamma-inducible protein 16 -0.0345639
SEC31A SEC31 homolog A (S. cerevisiae) -0.0342278
RBM39 RNA binding motif protein 39 -0.0341424
NF1 neurofibromin 1 -0.0340819
JMJD1C jumonji domain containing 1C -0.034007
USP53 ubiquitin specific peptidase 53 -0.0339268
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0338129
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0335711
ARHGAP5 Rho GTPase activating protein 5 -0.0335183
KMT2C lysine (K)-specific methyltransferase 2C -0.0333042
PGBD5 piggyBac transposable element derived 5 -0.0332439
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0329684
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0329209
ATP11A ATPase, class VI, type 11A -0.0327471
FHIT fragile histidine triad -0.032747
MAML2 mastermind-like 2 (Drosophila) -0.0320214
ARHGAP20 Rho GTPase activating protein 20 -0.0318515
PPARD peroxisome proliferator-activated receptor delta -0.0318213
ATXN1 ataxin 1 -0.031383
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.031339
FBXO34 F-box protein 34 -0.0313308
ALCAM activated leukocyte cell adhesion molecule -0.0313074
CD2AP CD2-associated protein -0.0312183
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0311906
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0311864
ITCH itchy E3 ubiquitin protein ligase -0.0311046
BLZF1 basic leucine zipper nuclear factor 1 -0.0310071
ANKRD17 ankyrin repeat domain 17 -0.0309704
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0308643