Dinaciclib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.179211
TEX14 testis expressed 14 0.127735
PTPRK protein tyrosine phosphatase, receptor type, K 0.106239
MYH9 myosin, heavy chain 9, non-muscle 0.100987
C3 complement component 3 0.0913331
TMSB4X thymosin beta 4, X-linked 0.0878323
RPL12 ribosomal protein L12 0.0858073
FTH1 ferritin, heavy polypeptide 1 0.0848866
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0835099
RACK1 receptor for activated C kinase 1 0.0799887
PEG10 paternally expressed 10 0.078014
RPLP2 ribosomal protein, large, P2 0.0775234
ZC3H3 zinc finger CCCH-type containing 3 0.0749948
MAP1B microtubule-associated protein 1B 0.074757
CSDE1 cold shock domain containing E1, RNA-binding 0.0745419
RPS29 ribosomal protein S29 0.0742287
RPL19 ribosomal protein L19 0.0741761
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0741617
RPS12 ribosomal protein S12 0.0739501
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0700022
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0688731
POTEF POTE ankyrin domain family, member F 0.0681477
RPS6 ribosomal protein S6 0.066416
RPS11 ribosomal protein S11 0.0661805
CANX calnexin 0.0635349
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.061924
GNAS GNAS complex locus 0.0611484
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0596225
CCNI cyclin I 0.0586427
RPL37A ribosomal protein L37a 0.0585129
FLNA filamin A, alpha 0.0575381
SET SET nuclear proto-oncogene 0.0575022
NBDY negative regulator of P-body association 0.0570054
IER2 immediate early response 2 0.0546156
RPL8 ribosomal protein L8 0.0545189
FN1 fibronectin 1 0.0542988
AKAP12 A kinase (PRKA) anchor protein 12 0.053461
CALR calreticulin 0.0528242
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0513501
YBX1 Y box binding protein 1 0.0499732
RPS16 ribosomal protein S16 0.0481771
JUN jun proto-oncogene 0.0480865
RPS4X ribosomal protein S4, X-linked 0.0472982
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0462674
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0462517
SFTPA2 surfactant protein A2 0.0457187
B2M beta-2-microglobulin 0.0437961
KRT8 keratin 8, type II 0.042761
RPL30 ribosomal protein L30 0.0413223
RPS8 ribosomal protein S8 0.0409807
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0409323
S100A10 S100 calcium binding protein A10 0.040788
EIF1 eukaryotic translation initiation factor 1 0.0403816
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0399978
SFPQ splicing factor proline/glutamine-rich 0.0386506
RPL26 ribosomal protein L26 0.0384733
SQSTM1 sequestosome 1 0.0381582
MYL12B myosin, light chain 12B, regulatory 0.0376462
HMGA1 high mobility group AT-hook 1 0.0376217
IER3 immediate early response 3 0.0374594
TPM3 tropomyosin 3 0.0373652
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0365523
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0358242
RPL11 ribosomal protein L11 0.0354897
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0354006
RPS15 ribosomal protein S15 0.0343117
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0341872
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0338008
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0333532
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0329454
TPT1 tumor protein, translationally-controlled 1 0.0321084
DEK DEK proto-oncogene 0.0319651
RPL9 ribosomal protein L9 0.031714
KRT18 keratin 18, type I 0.0316526
TMSB10 thymosin beta 10 0.031504
RPS17 ribosomal protein S17 0.0311011
TM9SF3 transmembrane 9 superfamily member 3 0.0298702
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0294923
LOC112694756 uncharaterized LOC112694756 0.0294281
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0287735
RPS21 ribosomal protein S21 0.027754
MT2A metallothionein 2A 0.0277152
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.02746
ANKRD10 ankyrin repeat domain 10 0.0261688
SLC38A1 solute carrier family 38, member 1 0.0254374
PNISR PNN-interacting serine/arginine-rich protein 0.0250901
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0250702
DSTN destrin (actin depolymerizing factor) 0.0246382
ENO1 enolase 1, (alpha) 0.0245253
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0228865
MATR3 matrin 3 0.0223706
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0220955
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0210659
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0209047
CSPP1 centrosome and spindle pole associated protein 1 0.0204257
RPL23 ribosomal protein L23 0.0201199
NAP1L1 nucleosome assembly protein 1-like 1 0.0195568
TGM2 transglutaminase 2 0.0189787
EEF2 eukaryotic translation elongation factor 2 0.0178849
APLP2 amyloid beta (A4) precursor-like protein 2 0.0168582

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230105
PDE4D phosphodiesterase 4D, cAMP-specific -0.227548
EFNA5 ephrin-A5 -0.152312
RORA RAR-related orphan receptor A -0.146847
PSD3 pleckstrin and Sec7 domain containing 3 -0.135788
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.129505
NDRG1 N-myc downstream regulated 1 -0.128432
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.120616
NKD1 naked cuticle homolog 1 (Drosophila) -0.100234
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0996699
PDE10A phosphodiesterase 10A -0.0911699
RAP1B RAP1B, member of RAS oncogene family -0.0892192
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0890363
ASPH aspartate beta-hydroxylase -0.0843368
FLNB filamin B, beta -0.0839338
NALF1 NALCN channel auxiliary factor 1 -0.079051
FNDC3B fibronectin type III domain containing 3B -0.0725977
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0716203
MYO1E myosin IE -0.0699411
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0691664
PTPRM protein tyrosine phosphatase, receptor type, M -0.068297
GPC6 glypican 6 -0.0679283
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0662863
DST dystonin -0.0647724
NCOR1 nuclear receptor corepressor 1 -0.06464
PUM2 pumilio RNA-binding family member 2 -0.0639272
AKAP13 A kinase (PRKA) anchor protein 13 -0.0632472
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0626618
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0625253
PRKCA protein kinase C, alpha -0.0617484
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0613486
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0612197
SEC31A SEC31 homolog A (S. cerevisiae) -0.0596974
NAV2 neuron navigator 2 -0.0595768
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0591127
NIPBL Nipped-B homolog (Drosophila) -0.0585113
NAMPT nicotinamide phosphoribosyltransferase -0.0582887
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0560394
ZBTB20 zinc finger and BTB domain containing 20 -0.0540008
ANKRD11 ankyrin repeat domain 11 -0.0538972
DSCAM Down syndrome cell adhesion molecule -0.0535835
ANKRD12 ankyrin repeat domain 12 -0.0516653
PCBP3 poly(rC) binding protein 3 -0.0502675
SETD5 SET domain containing 5 -0.0502485
VCL vinculin -0.048213
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0480548
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0479805
FGF14 fibroblast growth factor 14 -0.0464809
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0453285
RAD51B RAD51 paralog B -0.042889
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.042773
SND1 staphylococcal nuclease and tudor domain containing 1 -0.041345
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0399948
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0393606
VMP1 vacuole membrane protein 1 -0.0383797
MBNL2 muscleblind-like splicing regulator 2 -0.0379427
HELZ helicase with zinc finger -0.0378613
FBXO11 F-box protein 11 -0.036318
DOCK4 dedicator of cytokinesis 4 -0.0361581
INTS6 integrator complex subunit 6 -0.0354757
TRIO trio Rho guanine nucleotide exchange factor -0.0349054
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0332088
STAG2 stromal antigen 2 -0.0327261
PARD3 par-3 family cell polarity regulator -0.0306974
SMYD3 SET and MYND domain containing 3 -0.0298279
FNIP1 folliculin interacting protein 1 -0.028332
MED13L mediator complex subunit 13-like -0.0273442
TXNRD1 thioredoxin reductase 1 -0.0265975
VIM vimentin -0.0260302
ELL2 elongation factor, RNA polymerase II, 2 -0.0257268
MAML2 mastermind-like 2 (Drosophila) -0.0256181
JMJD1C jumonji domain containing 1C -0.0242555
SYAP1 synapse associated protein 1 -0.0237719
PTK2 protein tyrosine kinase 2 -0.0235995
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0235107
RPS19 ribosomal protein S19 -0.0230107
RTN4 reticulon 4 -0.02299
KTN1 kinectin 1 (kinesin receptor) -0.0228736
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0227578
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0219302
AFDN afadin, adherens junction formation factor -0.0214621
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0214276
EXT1 exostosin glycosyltransferase 1 -0.0213332
ATXN1 ataxin 1 -0.0206564
FTL ferritin, light polypeptide -0.0205645
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0196819
HDLBP high density lipoprotein binding protein -0.0196761
TBC1D22A TBC1 domain family, member 22A -0.0195592
PRRC2C proline-rich coiled-coil 2C -0.0188282
EGR1 early growth response 1 -0.0175124
CDH13 cadherin 13 -0.0175084
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0172538
CUX1 cut-like homeobox 1 -0.0168213
NPAS2 neuronal PAS domain protein 2 -0.0162162
FNDC3A fibronectin type III domain containing 3A -0.0148814
GOLGA4 golgin A4 -0.0148013
PDIA6 protein disulfide isomerase family A, member 6 -0.0125537
PTMA prothymosin, alpha -0.0122958
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.011611
BPTF bromodomain PHD finger transcription factor -0.0115349