Dinaciclib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0883675
IER2 immediate early response 2 0.0600487
RPS6 ribosomal protein S6 0.0592577
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0562518
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0554909
TMSB10 thymosin beta 10 0.054717
YBX1 Y box binding protein 1 0.0516884
RPLP1 ribosomal protein, large, P1 0.0499362
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0493019
JUN jun proto-oncogene 0.0464705
FTL ferritin, light polypeptide 0.0443303
TPT1 tumor protein, translationally-controlled 1 0.0442283
RPS19 ribosomal protein S19 0.0434435
EGR1 early growth response 1 0.0411582
PTMA prothymosin, alpha 0.040528
ALCAM activated leukocyte cell adhesion molecule 0.039695
EEF2 eukaryotic translation elongation factor 2 0.0394098
FN1 fibronectin 1 0.038056
VIM vimentin 0.0380518
RPL11 ribosomal protein L11 0.0378639
PCBP2 poly(rC) binding protein 2 0.0374035
CALR calreticulin 0.0369874
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0367905
CYB5D2 cytochrome b5 domain containing 2 0.0366114
RPS8 ribosomal protein S8 0.0362464
RPS17 ribosomal protein S17 0.0357967
RPL26 ribosomal protein L26 0.0355576
MYH9 myosin, heavy chain 9, non-muscle 0.0353789
TMSB4X thymosin beta 4, X-linked 0.0349481
APLP2 amyloid beta (A4) precursor-like protein 2 0.0341958
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0339355
RPS29 ribosomal protein S29 0.0327656
RPLP2 ribosomal protein, large, P2 0.0319595
RPL32 ribosomal protein L32 0.031842
RPS16 ribosomal protein S16 0.0314967
RTN4 reticulon 4 0.0312369
S100A6 S100 calcium binding protein A6 0.0310945
RPLP0 ribosomal protein, large, P0 0.0305246
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0301718
RPS2 ribosomal protein S2 0.0300295
ARC activity-regulated cytoskeleton-associated protein 0.0298365
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0292555
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0287516
MT2A metallothionein 2A 0.0275555
RYR3 ryanodine receptor 3 0.0270515
GOLGA4 golgin A4 0.0263983
RPS4X ribosomal protein S4, X-linked 0.0254384
RPL8 ribosomal protein L8 0.0253662
RPL13A ribosomal protein L13a 0.025102
EEF1G eukaryotic translation elongation factor 1 gamma 0.0249011
PLEC plectin 0.0247759
CD44 CD44 molecule (Indian blood group) 0.0247063
RPL36 ribosomal protein L36 0.0241221
RPL35 ribosomal protein L35 0.0240329
RPS23 ribosomal protein S23 0.0236306
RBM39 RNA binding motif protein 39 0.0235877
RPL37A ribosomal protein L37a 0.023233
RPL18 ribosomal protein L18 0.0230657
HMGN2 high mobility group nucleosomal binding domain 2 0.0229852
CALU calumenin 0.0228886
IER3 immediate early response 3 0.0228442
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0227203
RPL12 ribosomal protein L12 0.0226412
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.022522
ASPH aspartate beta-hydroxylase 0.0224107
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0222702
RPL19 ribosomal protein L19 0.022248
EXOSC8 exosome component 8 0.0219769
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.021904
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0214262
CSDE1 cold shock domain containing E1, RNA-binding 0.0213088
RBM25 RNA binding motif protein 25 0.0211485
ZC3H3 zinc finger CCCH-type containing 3 0.0210323
KRT18 keratin 18, type I 0.0208948
S100A9 S100 calcium binding protein A9 0.0206474
RPL9 ribosomal protein L9 0.020153
GARS1 glycyl-tRNA synthetase 1 0.0201193
RPL23 ribosomal protein L23 0.0200355
EIF3M eukaryotic translation initiation factor 3, subunit M 0.0199405
BHLHE40 basic helix-loop-helix family, member e40 0.0199305
POTEF POTE ankyrin domain family, member F 0.0197879
RPS11 ribosomal protein S11 0.0195989
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0193576
SARM1 sterile alpha and TIR motif containing 1 0.0191608
RPS12 ribosomal protein S12 0.0190822
RPS3 ribosomal protein S3 0.0189583
RPL34 ribosomal protein L34 0.0189122
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0186762
B2M beta-2-microglobulin 0.0181972
RPS5 ribosomal protein S5 0.0178538
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0173425
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0171515
PERP PERP, TP53 apoptosis effector 0.0169151
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0169007
PAPOLA poly(A) polymerase alpha 0.0168187
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0166683
PFN1 profilin 1 0.0166207
NUCB2 nucleobindin 2 0.0165908
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0164659
SERF2 small EDRK-rich factor 2 0.0163549

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.132443
PDE4B phosphodiesterase 4B, cAMP-specific -0.11835
VCL vinculin -0.100964
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0924889
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0911819
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0761055
FOXP1 forkhead box P1 -0.0736542
BMP10 bone morphogenetic protein 10 -0.0695881
AHNAK AHNAK nucleoprotein -0.0691491
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0673626
SOX6 SRY (sex determining region Y)-box 6 -0.0648863
EGFR epidermal growth factor receptor -0.0635016
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0629607
ADAM10 ADAM metallopeptidase domain 10 -0.0628006
NBEA neurobeachin -0.0620045
DLG1 discs, large homolog 1 (Drosophila) -0.0584645
HDAC9 histone deacetylase 9 -0.0578752
GLI3 GLI family zinc finger 3 -0.0479222
FLNB filamin B, beta -0.0467773
GLI2 GLI family zinc finger 2 -0.0451846
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0434939
TJP1 tight junction protein 1 -0.0432455
EFNA5 ephrin-A5 -0.0425261
ZEB1 zinc finger E-box binding homeobox 1 -0.0424978
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0361509
TAS2R14 taste receptor, type 2, member 14 -0.0360654
SSBP2 single-stranded DNA binding protein 2 -0.0355732
SMYD3 SET and MYND domain containing 3 -0.0350907
PYGB phosphorylase, glycogen; brain -0.034454
PDGFC platelet derived growth factor C -0.0340537
MYO5C myosin VC -0.0328493
CCND1 cyclin D1 -0.0326777
GLS2 glutaminase 2 (liver, mitochondrial) -0.0324306
TTC28 tetratricopeptide repeat domain 28 -0.0310908
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0310359
MKI67 marker of proliferation Ki-67 -0.0308651
NPAS2 neuronal PAS domain protein 2 -0.0307158
PRELID2 PRELI domain containing 2 -0.0300108
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0297422
ARL4C ADP-ribosylation factor-like 4C -0.0296873
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0296091
CAMKMT calmodulin-lysine N-methyltransferase -0.0295496
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0290882
BMP2K BMP2 inducible kinase -0.0282374
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0281857
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.028112
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0280018
GSE1 Gse1 coiled-coil protein -0.0278266
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0276785
ZMYND8 zinc finger, MYND-type containing 8 -0.0256875
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0252916
CUX1 cut-like homeobox 1 -0.0252248
LPP LIM domain containing preferred translocation partner in lipoma -0.0252051
FHIT fragile histidine triad -0.0250042
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0249855
ZNF438 zinc finger protein 438 -0.0236172
RFC3 replication factor C (activator 1) 3, 38kDa -0.0236021
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0235695
ATAD2 ATPase family, AAA domain containing 2 -0.0235423
EVI5 ecotropic viral integration site 5 -0.0234817
GPHN gephyrin -0.0231541
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -0.0231177
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0230637
JMJD1C jumonji domain containing 1C -0.0229834
TMEM65 transmembrane protein 65 -0.0227244
FAF1 Fas (TNFRSF6) associated factor 1 -0.0226603
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0224922
DIAPH3 diaphanous-related formin 3 -0.0224922
TSC22D1 TSC22 domain family, member 1 -0.022369
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0222552
TM4SF1 transmembrane 4 L six family member 1 -0.0221335
MYOF myoferlin -0.0218892
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0218655
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0217653
PRUNE2 prune homolog 2 (Drosophila) -0.0216706
SDK1 sidekick cell adhesion molecule 1 -0.021434
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0211582
PTPRG protein tyrosine phosphatase, receptor type, G -0.020933
DPYD dihydropyrimidine dehydrogenase -0.0208183
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.02075
CORO1C coronin, actin binding protein, 1C -0.0206497
MACROD2 MACRO domain containing 2 -0.0205611
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0204652
LOXL3 lysyl oxidase-like 3 -0.020309
DUSP4 dual specificity phosphatase 4 -0.0202867
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0200468
IGF1R insulin-like growth factor 1 receptor -0.0199379
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0196459
PARD3 par-3 family cell polarity regulator -0.0190033
PDE7B phosphodiesterase 7B -0.0189149
KMT2A lysine (K)-specific methyltransferase 2A -0.0186969
TXNRD1 thioredoxin reductase 1 -0.0186777
TNPO1 transportin 1 -0.0186121
AFG2A AFG2 AAA ATPase homolog A -0.0183825
DGKH diacylglycerol kinase, eta -0.0183494
RABGAP1L RAB GTPase activating protein 1-like -0.0182358
ANLN anillin, actin binding protein -0.0181954
UNC13A unc-13 homolog A (C. elegans) -0.0181718
USP34 ubiquitin specific peptidase 34 -0.0181181
DOCK1 dedicator of cytokinesis 1 -0.0179618