Dinaciclib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0888391
PTMA prothymosin, alpha 0.0565395
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0537935
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0522251
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517573
RPS6 ribosomal protein S6 0.0463056
FTL ferritin, light polypeptide 0.044353
KRT18 keratin 18, type I 0.0411023
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0405154
CYB5D2 cytochrome b5 domain containing 2 0.0400874
YBX1 Y box binding protein 1 0.0377602
EEF2 eukaryotic translation elongation factor 2 0.0367679
RPL11 ribosomal protein L11 0.0360422
RPL12 ribosomal protein L12 0.0352119
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0348455
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.034001
RPL4 ribosomal protein L4 0.0338091
RPL19 ribosomal protein L19 0.0336699
RPS8 ribosomal protein S8 0.032731
RPS16 ribosomal protein S16 0.0327279
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0320132
RAN RAN, member RAS oncogene family 0.0319245
PAPOLA poly(A) polymerase alpha 0.0318187
RPLP0 ribosomal protein, large, P0 0.0311372
LDHB lactate dehydrogenase B 0.0306011
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.0305524
EPCAM epithelial cell adhesion molecule 0.0295924
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0291779
RPLP1 ribosomal protein, large, P1 0.0284172
SET SET nuclear proto-oncogene 0.028129
RPS12 ribosomal protein S12 0.0278581
EMC10 ER membrane protein complex subunit 10 0.0277366
RPS27A ribosomal protein S27a 0.0275086
HDGF hepatoma-derived growth factor 0.0272816
TPT1 tumor protein, translationally-controlled 1 0.0271751
SFTPA2 surfactant protein A2 0.0262234
RPS29 ribosomal protein S29 0.0257853
RPL7 ribosomal protein L7 0.025705
KRT8 keratin 8, type II 0.0255487
RPS17 ribosomal protein S17 0.0249511
CCND1 cyclin D1 0.0248998
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0248643
APLP2 amyloid beta (A4) precursor-like protein 2 0.0248151
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0246597
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0245784
TMSB4X thymosin beta 4, X-linked 0.0245621
RPS3 ribosomal protein S3 0.0245103
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0239488
RPL41 ribosomal protein L41 0.0239044
RPL26 ribosomal protein L26 0.0236008
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0232246
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0232008
DSTN destrin (actin depolymerizing factor) 0.022852
TXN2 thioredoxin 2 0.0228086
RPL15 ribosomal protein L15 0.0225122
RPS27 ribosomal protein S27 0.0223582
NACA nascent polypeptide-associated complex alpha subunit 0.0222827
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0222566
RPL35A ribosomal protein L35a 0.0222497
RPS23 ribosomal protein S23 0.0219947
EIF4B eukaryotic translation initiation factor 4B 0.0218903
EIF3K eukaryotic translation initiation factor 3, subunit K 0.0218755
KTN1 kinectin 1 (kinesin receptor) 0.0216214
CS citrate synthase 0.0214462
RSRC2 arginine/serine-rich coiled-coil 2 0.0212762
RPS19 ribosomal protein S19 0.0212503
RPL8 ribosomal protein L8 0.021193
SKAP1 src kinase associated phosphoprotein 1 0.0211525
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.020833
HMGN2 high mobility group nucleosomal binding domain 2 0.0207838
EEF1G eukaryotic translation elongation factor 1 gamma 0.0207399
SERF2 small EDRK-rich factor 2 0.0206782
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0206427
PERP PERP, TP53 apoptosis effector 0.0204284
RPL37 ribosomal protein L37 0.0202962
RPL13A ribosomal protein L13a 0.0199266
RPS14 ribosomal protein S14 0.0198581
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0195706
RHOA ras homolog family member A 0.0195657
RPS11 ribosomal protein S11 0.0195471
PCBP2 poly(rC) binding protein 2 0.0195383
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0195102
SFPQ splicing factor proline/glutamine-rich 0.0194792
TPM3 tropomyosin 3 0.0193449
RPS2 ribosomal protein S2 0.0191953
DSPP dentin sialophosphoprotein 0.0191563
RPL36A ribosomal protein L36a 0.0191051
ANXA1 annexin A1 0.0187905
SSB Sjogren syndrome antigen B (autoantigen La) 0.0187853
BCAP31 B-cell receptor-associated protein 31 0.0187041
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0186803
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0186664
ATP5F1A ATP synthase F1 subunit alpha 0.0186544
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.0186508
CNTNAP2 contactin associated protein-like 2 0.0186141
RPL3 ribosomal protein L3 0.0185993
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0184243
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0183876
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0183858
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0182411

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.32011
COL6A3 collagen, type VI, alpha 3 -0.315331
FN1 fibronectin 1 -0.173918
TGFBI transforming growth factor, beta-induced, 68kDa -0.122529
TRIO trio Rho guanine nucleotide exchange factor -0.117209
CDH13 cadherin 13 -0.0939253
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0926524
NRXN3 neurexin 3 -0.0926025
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0890119
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0872365
EGFR epidermal growth factor receptor -0.0805132
LOX lysyl oxidase -0.0795854
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0765526
CD44 CD44 molecule (Indian blood group) -0.0753279
CALD1 caldesmon 1 -0.0728494
PSD3 pleckstrin and Sec7 domain containing 3 -0.071977
F3 coagulation factor III (thromboplastin, tissue factor) -0.0671022
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0667444
EXT1 exostosin glycosyltransferase 1 -0.0662782
FNDC3B fibronectin type III domain containing 3B -0.065898
NDRG1 N-myc downstream regulated 1 -0.0655007
LOXL2 lysyl oxidase-like 2 -0.0653482
COL5A1 collagen, type V, alpha 1 -0.0647879
HMGA2 high mobility group AT-hook 2 -0.0635395
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0600034
COL1A1 collagen, type I, alpha 1 -0.0590363
GLIS3 GLIS family zinc finger 3 -0.0589805
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0585882
CALU calumenin -0.0581338
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0580733
PRSS23 protease, serine, 23 -0.0576073
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.057138
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0542803
STC1 stanniocalcin 1 -0.0518644
MACF1 microtubule-actin crosslinking factor 1 -0.0506631
COL1A2 collagen, type I, alpha 2 -0.050583
VCL vinculin -0.0500541
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0491066
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0487737
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.04725
MAP1B microtubule-associated protein 1B -0.0455069
PRELID2 PRELI domain containing 2 -0.045369
TENT5A terminal nucleotidyltransferase 5A -0.0447339
VEGFC vascular endothelial growth factor C -0.0440665
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0439226
AHNAK AHNAK nucleoprotein -0.0434352
COL6A1 collagen, type VI, alpha 1 -0.0433442
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0427032
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0426847
ELL2 elongation factor, RNA polymerase II, 2 -0.0423247
MYOF myoferlin -0.0408245
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0402955
TNS3 tensin 3 -0.0400421
DPYD dihydropyrimidine dehydrogenase -0.038939
MYH9 myosin, heavy chain 9, non-muscle -0.038831
RUNX1 runt-related transcription factor 1 -0.0385654
NAV1 neuron navigator 1 -0.0383378
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0383269
MBD5 methyl-CpG binding domain protein 5 -0.0378632
MEF2A myocyte enhancer factor 2A -0.0365648
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0363727
SEC31A SEC31 homolog A (S. cerevisiae) -0.0362622
RAD51B RAD51 paralog B -0.0359772
HLA-B major histocompatibility complex, class I, B -0.035882
KMT2C lysine (K)-specific methyltransferase 2C -0.0356748
PRKCA protein kinase C, alpha -0.035673
SOD2 superoxide dismutase 2, mitochondrial -0.0354814
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0354322
CAV1 caveolin 1, caveolae protein, 22kDa -0.0353674
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0352043
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0351661
TMSB10 thymosin beta 10 -0.0351498
ATXN1 ataxin 1 -0.0345382
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0342225
NAMPT nicotinamide phosphoribosyltransferase -0.0339912
TTC3 tetratricopeptide repeat domain 3 -0.0334707
COL6A2 collagen, type VI, alpha 2 -0.033268
PGK1 phosphoglycerate kinase 1 -0.0328201
VIM vimentin -0.0325901
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0325177
RTN4 reticulon 4 -0.0325039
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0320117
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0315075
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0312242
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0310819
CLIC4 chloride intracellular channel 4 -0.0308522
RRBP1 ribosome binding protein 1 -0.0308197
HIPK2 homeodomain interacting protein kinase 2 -0.0308009
MT2A metallothionein 2A -0.0306709
PDLIM5 PDZ and LIM domain 5 -0.0299317
MAML2 mastermind-like 2 (Drosophila) -0.0298104
SEC24D SEC24 family member D -0.0296956
SDC4 syndecan 4 -0.0294909
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0294709
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0294612
RAI14 retinoic acid induced 14 -0.0293943
CHD9 chromodomain helicase DNA binding protein 9 -0.029261
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0290558
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0289305
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0286698