Dinaciclib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.240019
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0883971
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0836511
POTEF POTE ankyrin domain family, member F 0.0741882
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0618659
YBX1 Y box binding protein 1 0.0609219
SET SET nuclear proto-oncogene 0.0559103
TPM4 tropomyosin 4 0.0540397
TPT1 tumor protein, translationally-controlled 1 0.0536071
RPL19 ribosomal protein L19 0.0523891
RPS6 ribosomal protein S6 0.0523547
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0505378
RPLP1 ribosomal protein, large, P1 0.050341
MYH9 myosin, heavy chain 9, non-muscle 0.0502903
RPS12 ribosomal protein S12 0.0499979
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0461535
FLNA filamin A, alpha 0.0450052
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0446031
RPL12 ribosomal protein L12 0.044073
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.041597
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0414446
RPLP2 ribosomal protein, large, P2 0.0413723
HMGB1 high mobility group box 1 0.040722
ZC3H3 zinc finger CCCH-type containing 3 0.0403294
RPS17 ribosomal protein S17 0.0402238
RPL35 ribosomal protein L35 0.0391244
RPL11 ribosomal protein L11 0.0377915
TPM3 tropomyosin 3 0.0372018
PTMA prothymosin, alpha 0.0364107
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0348663
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0339143
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.033578
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.032844
RPL37A ribosomal protein L37a 0.032774
S100A10 S100 calcium binding protein A10 0.0315534
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0313274
CCND1 cyclin D1 0.0307013
RPL26 ribosomal protein L26 0.0302733
RPL36 ribosomal protein L36 0.0295041
RPS8 ribosomal protein S8 0.0294032
BIRC5 baculoviral IAP repeat containing 5 0.0293942
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0290352
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0287539
RPL9 ribosomal protein L9 0.0285817
IL6ST interleukin 6 signal transducer 0.0282259
TGM2 transglutaminase 2 0.0282189
NBDY negative regulator of P-body association 0.0280833
APLP2 amyloid beta (A4) precursor-like protein 2 0.0272089
LMNA lamin A/C 0.0269114
SFTPA2 surfactant protein A2 0.0267182
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0265237
PA2G4 proliferation-associated 2G4, 38kDa 0.0265064
MSN moesin 0.0264665
EEF2 eukaryotic translation elongation factor 2 0.0260349
LDHB lactate dehydrogenase B 0.0260267
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0259957
MCFD2 multiple coagulation factor deficiency 2 0.0258692
ACTN4 actinin, alpha 4 0.0256161
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0255882
RPS20 ribosomal protein S20 0.0254959
DSTN destrin (actin depolymerizing factor) 0.0251042
ANXA1 annexin A1 0.0245454
CALR calreticulin 0.0243884
RPS2 ribosomal protein S2 0.0242022
RPL35A ribosomal protein L35a 0.024191
RPL32 ribosomal protein L32 0.0241644
DEK DEK proto-oncogene 0.0239801
RPS19 ribosomal protein S19 0.0237132
KIF5B kinesin family member 5B 0.0236429
RPL23 ribosomal protein L23 0.0234603
IER2 immediate early response 2 0.0231624
ANXA2 annexin A2 0.0227512
ATP5F1B ATP synthase F1 subunit beta 0.0226488
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.022517
PLEC plectin 0.022505
S100A6 S100 calcium binding protein A6 0.0223228
LIMA1 LIM domain and actin binding 1 0.0223066
MAP1B microtubule-associated protein 1B 0.022288
RPL30 ribosomal protein L30 0.0221627
ATP5F1E ATP synthase F1 subunit epsilon 0.0221237
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0220932
RPL37 ribosomal protein L37 0.0220868
HMGA1 high mobility group AT-hook 1 0.0220824
EMP1 epithelial membrane protein 1 0.0219609
HDGF hepatoma-derived growth factor 0.0219208
PFN1 profilin 1 0.0218063
RPL27 ribosomal protein L27 0.0217382
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0216441
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0215849
BIRC2 baculoviral IAP repeat containing 2 0.0215403
RPL5 ribosomal protein L5 0.0214713
AKAP12 A kinase (PRKA) anchor protein 12 0.0213899
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0213034
FTL ferritin, light polypeptide 0.0212764
RPS27A ribosomal protein S27a 0.0210104
RPL4 ribosomal protein L4 0.02091
RPS27 ribosomal protein S27 0.0207919
EIF1 eukaryotic translation initiation factor 1 0.0207552
SFPQ splicing factor proline/glutamine-rich 0.0206563
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0205301

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176238
FNDC3B fibronectin type III domain containing 3B -0.144464
IGFBP3 insulin-like growth factor binding protein 3 -0.105899
LDHA lactate dehydrogenase A -0.0923384
SMYD3 SET and MYND domain containing 3 -0.0692298
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0603459
TRIO trio Rho guanine nucleotide exchange factor -0.0600215
FMNL2 formin-like 2 -0.0532012
PRKCA protein kinase C, alpha -0.0519255
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0507936
ATXN1 ataxin 1 -0.0502059
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.049521
AKAP13 A kinase (PRKA) anchor protein 13 -0.0492583
ZBTB20 zinc finger and BTB domain containing 20 -0.0484095
ANKRD28 ankyrin repeat domain 28 -0.0452568
TAS2R14 taste receptor, type 2, member 14 -0.0447445
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0444302
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0438337
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.042902
ITCH itchy E3 ubiquitin protein ligase -0.042411
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0408416
RORA RAR-related orphan receptor A -0.0391409
DSCAM Down syndrome cell adhesion molecule -0.0384839
ATM ATM serine/threonine kinase -0.0383506
PHF3 PHD finger protein 3 -0.0378284
WAC WW domain containing adaptor with coiled-coil -0.0376414
NAV2 neuron navigator 2 -0.0374488
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0370375
BASP1 brain abundant, membrane attached signal protein 1 -0.0366593
DNER delta/notch-like EGF repeat containing -0.0366231
BIRC6 baculoviral IAP repeat containing 6 -0.0364156
PARD3 par-3 family cell polarity regulator -0.0363173
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0360594
FNIP1 folliculin interacting protein 1 -0.0354632
DPYD dihydropyrimidine dehydrogenase -0.0347075
OSMR oncostatin M receptor -0.0345472
NCOR1 nuclear receptor corepressor 1 -0.0345289
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0344529
FMN1 formin 1 -0.0340797
TMSB10 thymosin beta 10 -0.0336067
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0334884
PHF21A PHD finger protein 21A -0.0329853
JMJD1C jumonji domain containing 1C -0.0328009
ZNF292 zinc finger protein 292 -0.0327735
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0326261
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0324969
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0324599
PBX3 pre-B-cell leukemia homeobox 3 -0.0324389
RSF1 remodeling and spacing factor 1 -0.0323693
RAD51B RAD51 paralog B -0.0316977
SAMD4A sterile alpha motif domain containing 4A -0.0315615
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0309347
FBXL17 F-box and leucine-rich repeat protein 17 -0.0309037
MBD5 methyl-CpG binding domain protein 5 -0.0308721
ZMYND8 zinc finger, MYND-type containing 8 -0.0306398
ERBIN erbb2 interacting protein -0.0305889
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0300878
SVIL supervillin -0.0299241
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0298495
GPC6 glypican 6 -0.0295218
GSK3B glycogen synthase kinase 3 beta -0.0294566
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0294094
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0293891
ZNF609 zinc finger protein 609 -0.0290982
MACF1 microtubule-actin crosslinking factor 1 -0.0290686
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0288642
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0287373
USP34 ubiquitin specific peptidase 34 -0.0286752
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0285637
TTC17 tetratricopeptide repeat domain 17 -0.0281566
NF1 neurofibromin 1 -0.0280024
FLNB filamin B, beta -0.0276982
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0276884
ATG7 autophagy related 7 -0.0275092
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0273798
HILPDA hypoxia inducible lipid droplet-associated -0.0273539
PDE8A phosphodiesterase 8A -0.0271298
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0269471
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0268628
SLC38A2 solute carrier family 38, member 2 -0.0267369
NALCN sodium leak channel, non selective -0.0267063
TBC1D5 TBC1 domain family, member 5 -0.0266373
DLG1 discs, large homolog 1 (Drosophila) -0.0263902
ZFAND3 zinc finger, AN1-type domain 3 -0.0263629
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0261658
PYGL phosphorylase, glycogen, liver -0.0261025
TNRC6B trinucleotide repeat containing 6B -0.0259226
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0259106
NIPBL Nipped-B homolog (Drosophila) -0.0257272
VCL vinculin -0.0257231
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0254661
MYO9A myosin IXA -0.0254567
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0254168
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0254023
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0253946
DERA deoxyribose-phosphate aldolase (putative) -0.0253444
YAP1 Yes-associated protein 1 -0.0251564
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0250881
MCTP1 multiple C2 domains, transmembrane 1 -0.0250057
TAOK1 TAO kinase 1 -0.0249278