Dinaciclib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dinaciclib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dinaciclib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3H3 zinc finger CCCH-type containing 3 0.0686692
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0603728
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.0539264
FLNA filamin A, alpha 0.0452553
POTEF POTE ankyrin domain family, member F 0.0386608
RCAN3 RCAN family member 3 0.0318248
FN1 fibronectin 1 0.0305216
TEX14 testis expressed 14 0.0277131
PLAU plasminogen activator, urokinase 0.0273519
SFTPA2 surfactant protein A2 0.0247332
YBX1 Y box binding protein 1 0.0239371
MYH9 myosin, heavy chain 9, non-muscle 0.0217835
CCND1 cyclin D1 0.0213982
GRHL1 grainyhead-like 1 (Drosophila) 0.0203424
KNOP1 lysine-rich nucleolar protein 1 0.0202862
PEG10 paternally expressed 10 0.0169029
NBDY negative regulator of P-body association 0.0168124
FOSL1 FOS-like antigen 1 0.0160915
THBS1 thrombospondin 1 0.0158109
S100A6 S100 calcium binding protein A6 0.0152735
LMO7 LIM domain 7 0.0152496
HLA-A major histocompatibility complex, class I, A 0.0151624
GALC galactosylceramidase 0.0143882
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.0142248
TMSB4X thymosin beta 4, X-linked 0.0140658
CANX calnexin 0.0138355
RPL19 ribosomal protein L19 0.0135429
FTH1 ferritin, heavy polypeptide 1 0.0134942
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0133178
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0131538
KRT81 keratin 81, type II 0.0130821
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.013042
ECI1 enoyl-CoA delta isomerase 1 0.0126507
PLEC plectin 0.0126134
CXCL3 chemokine (C-X-C motif) ligand 3 0.0124453
EEF2 eukaryotic translation elongation factor 2 0.012155
HLA-B major histocompatibility complex, class I, B 0.0120208
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0119973
DNAL1 dynein, axonemal, light chain 1 0.0119561
RAP1GAP2 RAP1 GTPase activating protein 2 0.0118244
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 0.0118072
KIAA2012 KIAA2012 0.0117374
IER2 immediate early response 2 0.011326
RPL37A ribosomal protein L37a 0.0112886
RHOF ras homolog family member F (in filopodia) 0.0111768
NXN nucleoredoxin 0.0110658
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.0110594
PTX3 pentraxin 3, long 0.0108925
SARM1 sterile alpha and TIR motif containing 1 0.0106212
CYB5D2 cytochrome b5 domain containing 2 0.0104734
TPM4 tropomyosin 4 0.0104173
HMGA1 high mobility group AT-hook 1 0.010333
RIN2 Ras and Rab interactor 2 0.0102492
SERBP1 SERPINE1 mRNA binding protein 1 0.0101786
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0101458
CTSD cathepsin D 0.0100953
TPM3 tropomyosin 3 0.0100809
LDHB lactate dehydrogenase B 0.00984433
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.00984336
PA2G4 proliferation-associated 2G4, 38kDa 0.00981024
KRT18 keratin 18, type I 0.0097889
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00963048
BICRAL BICRA like chromatin remodeling complex associated protein 0.00956082
DHFR dihydrofolate reductase 0.00954752
RPN1 ribophorin I 0.00951378
SMC1A structural maintenance of chromosomes 1A 0.0093461
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00924779
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.00924556
KIF9 kinesin family member 9 0.0091843
CST3 cystatin C 0.00913741
CYCS cytochrome c, somatic 0.00913417
RPS12 ribosomal protein S12 0.00904622
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.00896583
RPL35 ribosomal protein L35 0.00895872
SFRP1 secreted frizzled-related protein 1 0.00884534
ZNF354A zinc finger protein 354A 0.00883793
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.00878289
CAPN2 calpain 2, (m/II) large subunit 0.0086804
MRPL16 mitochondrial ribosomal protein L16 0.00866027
RANBP1 RAN binding protein 1 0.00865029
HLA-C major histocompatibility complex, class I, C 0.00864836
PDAP1 PDGFA associated protein 1 0.00861743
TMSB10 thymosin beta 10 0.00859703
ACADVL acyl-CoA dehydrogenase, very long chain 0.00858504
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.00842806
PDE8B phosphodiesterase 8B 0.00841817
ATP5F1B ATP synthase F1 subunit beta 0.00830286
PEA15 phosphoprotein enriched in astrocytes 15 0.00825751
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.00808026
RPL11 ribosomal protein L11 0.00805552
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00800415
TPM2 tropomyosin 2 (beta) 0.00800373
CCDC183 coiled-coil domain containing 183 0.00797867
RPS17 ribosomal protein S17 0.00796659
STXBP1 syntaxin binding protein 1 0.00795837
CDA cytidine deaminase 0.00791422
DCAF7 DDB1 and CUL4 associated factor 7 0.00782048
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.00781655
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.00778353
GANAB glucosidase, alpha; neutral AB 0.00777127

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.241118
NAMPT nicotinamide phosphoribosyltransferase -0.147962
FNDC3B fibronectin type III domain containing 3B -0.103574
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.101304
NDRG1 N-myc downstream regulated 1 -0.0889932
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0879069
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0840179
EXT1 exostosin glycosyltransferase 1 -0.0836998
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0780158
PRRC2C proline-rich coiled-coil 2C -0.0756784
TRIO trio Rho guanine nucleotide exchange factor -0.0722381
MT2A metallothionein 2A -0.0699384
AHR aryl hydrocarbon receptor -0.0664861
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0632877
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0623815
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0615155
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0600488
PTK2 protein tyrosine kinase 2 -0.0590036
ITGA1 integrin, alpha 1 -0.058299
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0563351
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0555378
TXNIP thioredoxin interacting protein -0.0535577
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0516129
TPR translocated promoter region, nuclear basket protein -0.0506085
KMT2E lysine (K)-specific methyltransferase 2E -0.0491465
JMJD1C jumonji domain containing 1C -0.0478737
ELL2 elongation factor, RNA polymerase II, 2 -0.0475708
CENPF centromere protein F, 350/400kDa -0.0450736
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0450445
RBM39 RNA binding motif protein 39 -0.0447695
KMT2C lysine (K)-specific methyltransferase 2C -0.0446552
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0440981
BIRC6 baculoviral IAP repeat containing 6 -0.043856
ZNF292 zinc finger protein 292 -0.0429303
ACBD3 acyl-CoA binding domain containing 3 -0.0429139
WAC WW domain containing adaptor with coiled-coil -0.0425726
GOLGA4 golgin A4 -0.0423532
HMGA2 high mobility group AT-hook 2 -0.0423113
SMAD3 SMAD family member 3 -0.0417399
OGA O-GlcNAcase -0.0416711
MCTP2 multiple C2 domains, transmembrane 2 -0.0411794
NIPBL Nipped-B homolog (Drosophila) -0.040425
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0403638
NEK7 NIMA-related kinase 7 -0.0399791
OSMR oncostatin M receptor -0.0398571
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0393762
FNBP1 formin binding protein 1 -0.0392006
SQSTM1 sequestosome 1 -0.0389265
COPA coatomer protein complex, subunit alpha -0.0387187
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0381806
RNF145 ring finger protein 145 -0.0377879
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0368713
KDM5B lysine (K)-specific demethylase 5B -0.0368443
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0367595
TMEM165 transmembrane protein 165 -0.0363467
EFNA5 ephrin-A5 -0.0362564
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0362083
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0360139
MBD5 methyl-CpG binding domain protein 5 -0.0358688
RAB1A RAB1A, member RAS oncogene family -0.0358128
SMYD3 SET and MYND domain containing 3 -0.0356046
SPAG9 sperm associated antigen 9 -0.0354552
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0352069
SUCO SUN domain containing ossification factor -0.0351203
LCORL ligand dependent nuclear receptor corepressor-like -0.0350819
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.034405
HELZ helicase with zinc finger -0.0344028
RTN4 reticulon 4 -0.0337937
DENND5B DENN/MADD domain containing 5B -0.0337643
CD109 CD109 molecule -0.0337207
FAM13A family with sequence similarity 13, member A -0.0336398
GLIS3 GLIS family zinc finger 3 -0.033533
ZFAND3 zinc finger, AN1-type domain 3 -0.0334892
RB1CC1 RB1-inducible coiled-coil 1 -0.0331099
DOCK5 dedicator of cytokinesis 5 -0.0330416
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0330295
TAS2R14 taste receptor, type 2, member 14 -0.0327968
CEP350 centrosomal protein 350kDa -0.0326273
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0320851
ERBIN erbb2 interacting protein -0.0320397
ETNK1 ethanolamine kinase 1 -0.0316568
ASPH aspartate beta-hydroxylase -0.0308403
CDC73 cell division cycle 73 -0.0304671
SEC31A SEC31 homolog A (S. cerevisiae) -0.0302852
SETD5 SET domain containing 5 -0.0301938
CARD16 caspase recruitment domain family, member 16 -0.0299166
GCC2 GRIP and coiled-coil domain containing 2 -0.0298622
UGCG UDP-glucose ceramide glucosyltransferase -0.0293824
CLTC clathrin, heavy chain (Hc) -0.0293176
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0291967
ANKRD28 ankyrin repeat domain 28 -0.0291483
PUM2 pumilio RNA-binding family member 2 -0.0291321
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0291103
TENT2 terminal nucleotidyltransferase 2 -0.0289592
AKAP9 A kinase (PRKA) anchor protein 9 -0.0284398
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0284037
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0283211
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0281917
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281071
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.028094