| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Diphenhydramine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Diphenhydramine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.240785 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.213156 |
| AREG | amphiregulin | 0.122107 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.11418 |
| ANXA1 | annexin A1 | 0.112817 |
| PCBP2 | poly(rC) binding protein 2 | 0.106847 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0969218 |
| MKI67 | marker of proliferation Ki-67 | 0.0931668 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0903757 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0768229 |
| TPI1 | triosephosphate isomerase 1 | 0.0722658 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.068522 |
| RPS2 | ribosomal protein S2 | 0.0664735 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0636577 |
| KIF5B | kinesin family member 5B | 0.0631367 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0595688 |
| ENO1 | enolase 1, (alpha) | 0.0591774 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0590512 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0587657 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0564969 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0564504 |
| TPM3 | tropomyosin 3 | 0.0549337 |
| HDGF | hepatoma-derived growth factor | 0.0548786 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0533091 |
| PTMA | prothymosin, alpha | 0.0529578 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0504021 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0501286 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0482649 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0480795 |
| CENPF | centromere protein F, 350/400kDa | 0.0472687 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0450487 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0445177 |
| VIM | vimentin | 0.044301 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0432423 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0413931 |
| RPS12 | ribosomal protein S12 | 0.0407297 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0406898 |
| RPS3 | ribosomal protein S3 | 0.0405333 |
| XPOT | exportin, tRNA | 0.0397306 |
| H1-0 | H1.0 linker histone | 0.0390329 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.037037 |
| MAP1B | microtubule-associated protein 1B | 0.0366785 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0362969 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0362281 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0358555 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.035659 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0348452 |
| BRD2 | bromodomain containing 2 | 0.0347029 |
| SET | SET nuclear proto-oncogene | 0.0346818 |
| DST | dystonin | 0.0345357 |
| RRM2 | ribonucleotide reductase M2 | 0.0343117 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0327406 |
| SFTPA2 | surfactant protein A2 | 0.0325761 |
| SSRP1 | structure specific recognition protein 1 | 0.0315814 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0307049 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0304305 |
| RPS7 | ribosomal protein S7 | 0.0300958 |
| YAP1 | Yes-associated protein 1 | 0.0299995 |
| PTMS | parathymosin | 0.029791 |
| RPL3 | ribosomal protein L3 | 0.0296872 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0296785 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0290162 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0287983 |
| POTEF | POTE ankyrin domain family, member F | 0.0283422 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.028334 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0282546 |
| PNN | pinin, desmosome associated protein | 0.0278544 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0278254 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0277062 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0271822 |
| TPM4 | tropomyosin 4 | 0.0268952 |
| YBX1 | Y box binding protein 1 | 0.0268571 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0260379 |
| LDHB | lactate dehydrogenase B | 0.0258663 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0256691 |
| RACK1 | receptor for activated C kinase 1 | 0.0256548 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0254857 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0251372 |
| LDHA | lactate dehydrogenase A | 0.0249699 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0246606 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0244847 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0243328 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0243282 |
| ATF4 | activating transcription factor 4 | 0.0242554 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0241557 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0240934 |
| PRKCI | protein kinase C, iota | 0.024078 |
| DSPP | dentin sialophosphoprotein | 0.0240659 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0240096 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0235355 |
| EHBP1 | EH domain binding protein 1 | 0.0235132 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0223943 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.022368 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0221902 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.022011 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0218004 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0217978 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0217841 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.021781 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0216534 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.297658 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.180824 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.119194 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0866128 |
| MGAT4C | MGAT4 family, member C | -0.0701093 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0688355 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0627099 |
| PCDH7 | protocadherin 7 | -0.0592386 |
| TMSB10 | thymosin beta 10 | -0.0529312 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0505256 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0474998 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0474102 |
| NLGN1 | neuroligin 1 | -0.0445123 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0441158 |
| RPS24 | ribosomal protein S24 | -0.0434778 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0422105 |
| FUS | FUS RNA binding protein | -0.0420807 |
| USP34 | ubiquitin specific peptidase 34 | -0.0408773 |
| TMEM123 | transmembrane protein 123 | -0.0405569 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0401719 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0401436 |
| ACTG1 | actin gamma 1 | -0.0386023 |
| RPL34 | ribosomal protein L34 | -0.0381426 |
| EXOC6B | exocyst complex component 6B | -0.0373284 |
| RPL38 | ribosomal protein L38 | -0.03638 |
| MMP12 | matrix metallopeptidase 12 | -0.036367 |
| NEK7 | NIMA-related kinase 7 | -0.0351581 |
| RPS15 | ribosomal protein S15 | -0.0335533 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0330061 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0319886 |
| TMEM41B | transmembrane protein 41B | -0.0311114 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0309807 |
| RPL32 | ribosomal protein L32 | -0.0309301 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0298452 |
| RPS21 | ribosomal protein S21 | -0.0297694 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0287381 |
| MTAP | methylthioadenosine phosphorylase | -0.028648 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0285186 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0281221 |
| BCHE | butyrylcholinesterase | -0.0280498 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0277517 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0276892 |
| RPLP0 | ribosomal protein, large, P0 | -0.0273816 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0272711 |
| GNAS | GNAS complex locus | -0.027224 |
| LMO7 | LIM domain 7 | -0.0267297 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0265819 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0253184 |
| VCL | vinculin | -0.0248394 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0246943 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0244896 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0244746 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0239946 |
| ATP11A | ATPase, class VI, type 11A | -0.0239702 |
| TXNRD1 | thioredoxin reductase 1 | -0.0239155 |
| RASA2 | RAS p21 protein activator 2 | -0.0237083 |
| AHNAK | AHNAK nucleoprotein | -0.0236304 |
| CCNI | cyclin I | -0.0231817 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0228099 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0227886 |
| RPL6 | ribosomal protein L6 | -0.0227402 |
| RPS5 | ribosomal protein S5 | -0.0227142 |
| RPL4 | ribosomal protein L4 | -0.0223599 |
| RPLP1 | ribosomal protein, large, P1 | -0.0220813 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0218026 |
| PRR16 | proline rich 16 | -0.021708 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0213752 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0212064 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0211899 |
| ZNF217 | zinc finger protein 217 | -0.0211842 |
| TNPO1 | transportin 1 | -0.0211815 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.0210772 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.020998 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0207056 |
| IL6ST | interleukin 6 signal transducer | -0.0194767 |
| CCND1 | cyclin D1 | -0.0193547 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0191687 |
| GOLT1B | golgi transport 1B | -0.019135 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.018929 |
| RNF13 | ring finger protein 13 | -0.018859 |
| NABP1 | nucleic acid binding protein 1 | -0.0187968 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0187547 |
| ADNP | activity-dependent neuroprotector homeobox | -0.018514 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0185106 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0184598 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0184051 |
| ABI2 | abl-interactor 2 | -0.0183542 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0183507 |
| RPL35A | ribosomal protein L35a | -0.0182053 |
| FBXO11 | F-box protein 11 | -0.0181509 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0181405 |
| RPS23 | ribosomal protein S23 | -0.0181029 |
| RPL5 | ribosomal protein L5 | -0.018092 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0180443 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0180084 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0180041 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0179524 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0179401 |
| COG5 | component of oligomeric golgi complex 5 | -0.0179084 |
| KLHL24 | kelch-like family member 24 | -0.0177889 |
