Diphenhydramine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Diphenhydramine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0646706
PTBP3 polypyrimidine tract binding protein 3 0.0516262
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0511512
TXNIP thioredoxin interacting protein 0.0469463
MBNL2 muscleblind-like splicing regulator 2 0.0461811
RNF149 ring finger protein 149 0.0419469
ERRFI1 ERBB receptor feedback inhibitor 1 0.0414579
BCLAF1 BCL2-associated transcription factor 1 0.0414449
PTEN phosphatase and tensin homolog 0.0410653
MACC1 metastasis associated in colon cancer 1 0.0409878
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0397231
CCNL1 cyclin L1 0.0393484
EHF ets homologous factor 0.0381786
RNF43 ring finger protein 43 0.0356271
RUNX1 runt-related transcription factor 1 0.033683
SREBF2 sterol regulatory element binding transcription factor 2 0.0309527
ARGLU1 arginine and glutamate rich 1 0.0305532
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0291308
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0290481
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0286652
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0284455
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0279284
ARRDC3 arrestin domain containing 3 0.0275816
NRIP1 nuclear receptor interacting protein 1 0.0273011
ZMYM2 zinc finger, MYM-type 2 0.0267069
PDIA3 protein disulfide isomerase family A, member 3 0.0262243
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0255073
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0246245
BHLHE40 basic helix-loop-helix family, member e40 0.0245981
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.024272
ZDHHC20 zinc finger, DHHC-type containing 20 0.0241013
TMEM51 transmembrane protein 51 0.023471
HELZ helicase with zinc finger 0.0229492
IFNGR1 interferon gamma receptor 1 0.0229463
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0223113
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0219501
UBAC2 UBA domain containing 2 0.0214024
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0213402
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0213322
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0210278
SORBS1 sorbin and SH3 domain containing 1 0.020922
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.020574
RREB1 ras responsive element binding protein 1 0.0204671
PRELID2 PRELI domain containing 2 0.0204375
GRAMD2B GRAM domain containing 2B 0.0203898
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0200492
MKI67 marker of proliferation Ki-67 0.0199891
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0198325
AFF1 AF4/FMR2 family, member 1 0.0197408
H1-0 H1.0 linker histone 0.0195695
MCTP2 multiple C2 domains, transmembrane 2 0.0195328
RHOBTB3 Rho-related BTB domain containing 3 0.0193448
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.019276
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0192179
GOLGA4 golgin A4 0.019133
NAMPT nicotinamide phosphoribosyltransferase 0.0189138
SUCO SUN domain containing ossification factor 0.018875
LMTK2 lemur tyrosine kinase 2 0.0186336
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0185667
TMEM39A transmembrane protein 39A 0.0185049
RBM26 RNA binding motif protein 26 0.0184808
TENT2 terminal nucleotidyltransferase 2 0.0180436
ZC3H11A zinc finger CCCH-type containing 11A 0.0180109
CENPF centromere protein F, 350/400kDa 0.0179482
TFG TRK-fused gene 0.0179168
SEC24D SEC24 family member D 0.0178712
ARHGAP32 Rho GTPase activating protein 32 0.0178322
USP9X ubiquitin specific peptidase 9, X-linked 0.0177711
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0176637
FTH1 ferritin, heavy polypeptide 1 0.0175409
RBM39 RNA binding motif protein 39 0.0174161
GRK3 G protein-coupled receptor kinase 3 0.0173146
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0172024
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0171064
ESYT2 extended synaptotagmin-like protein 2 0.0169861
ETNK1 ethanolamine kinase 1 0.0168686
DIAPH3 diaphanous-related formin 3 0.0168175
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0167428
STK24 serine/threonine kinase 24 0.0166395
MYH9 myosin, heavy chain 9, non-muscle 0.0164865
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0164504
FNDC3A fibronectin type III domain containing 3A 0.0164445
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0163525
TRIM2 tripartite motif containing 2 0.0163192
USPL1 ubiquitin specific peptidase like 1 0.0162751
TNRC6A trinucleotide repeat containing 6A 0.0161263
TMEM62 transmembrane protein 62 0.0160664
CD46 CD46 molecule, complement regulatory protein 0.0159493
TSC22D2 TSC22 domain family, member 2 0.0157858
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 0.0157487
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0156907
BTBD9 BTB (POZ) domain containing 9 0.0155478
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0154974
FRK fyn-related Src family tyrosine kinase 0.0154191
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0152835
METTL15 methyltransferase like 15 0.0151788
YEATS2 YEATS domain containing 2 0.0151704
UBL3 ubiquitin-like 3 0.0150827
USP3 ubiquitin specific peptidase 3 0.0150542
DENND4C DENN/MADD domain containing 4C 0.0150389

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.210394
INTS6 integrator complex subunit 6 -0.141293
PTMA prothymosin, alpha -0.127125
RNF213 ring finger protein 213 -0.123681
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12331
B2M beta-2-microglobulin -0.117235
SP100 SP100 nuclear antigen -0.113633
EPSTI1 epithelial stromal interaction 1 (breast) -0.108243
ANXA2 annexin A2 -0.101658
LCN2 lipocalin 2 -0.100672
LYZ lysozyme -0.0974229
EGR1 early growth response 1 -0.0937012
HLA-B major histocompatibility complex, class I, B -0.0902697
ACTG1 actin gamma 1 -0.0899585
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0892534
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0882852
RIGI RNA sensor RIG-I -0.0865779
GCLC glutamate-cysteine ligase, catalytic subunit -0.0833419
IFI6 interferon, alpha-inducible protein 6 -0.0818726
AREG amphiregulin -0.0808645
PERP PERP, TP53 apoptosis effector -0.0803254
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0798933
XAF1 XIAP associated factor 1 -0.0792775
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0758575
FTL ferritin, light polypeptide -0.0748077
C6ORF132 chromosome 6 open reading frame 132 -0.0738466
PLSCR2 phospholipid scramblase 2 -0.0737675
RAB7A RAB7A, member RAS oncogene family -0.0730001
GMDS GDP-mannose 4,6-dehydratase -0.072759
MX2 MX dynamin-like GTPase 2 -0.0696809
TM4SF1 transmembrane 4 L six family member 1 -0.0660084
VCL vinculin -0.0654031
SQSTM1 sequestosome 1 -0.065286
RPL35A ribosomal protein L35a -0.0650977
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0644886
LMO7 LIM domain 7 -0.0631066
PKM pyruvate kinase, muscle -0.0606722
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0601842
RPL34 ribosomal protein L34 -0.0597782
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0578725
MX1 MX dynamin-like GTPase 1 -0.0573183
MUC20 mucin 20, cell surface associated -0.0570953
EXT1 exostosin glycosyltransferase 1 -0.0558274
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0533016
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0525765
RPL23 ribosomal protein L23 -0.0502376
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.049624
TM4SF19 transmembrane 4 L six family member 19 -0.0493379
RPL7L1 ribosomal protein L7-like 1 -0.0488872
TMSB10 thymosin beta 10 -0.0482873
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0480245
RPS24 ribosomal protein S24 -0.0471625
IGFBP3 insulin-like growth factor binding protein 3 -0.0469278
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0457559
CATSPERB catsper channel auxiliary subunit beta -0.0457097
LOC102724023 ES1 protein homolog, mitochondrial -0.0456907
NPSR1 neuropeptide S receptor 1 -0.0454908
ASPH aspartate beta-hydroxylase -0.0452067
MCL1 myeloid cell leukemia 1 -0.0444474
PMP22 peripheral myelin protein 22 -0.044181
SLC38A2 solute carrier family 38, member 2 -0.0432643
ANKRD10 ankyrin repeat domain 10 -0.0431992
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0424174
RPL31 ribosomal protein L31 -0.0424088
POU2F2 POU class 2 homeobox 2 -0.0419734
STS steroid sulfatase (microsomal), isozyme S -0.0412752
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0408061
RPS6 ribosomal protein S6 -0.0407107
IER3 immediate early response 3 -0.0405557
RABGAP1L RAB GTPase activating protein 1-like -0.0403713
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0393478
MT2A metallothionein 2A -0.0392639
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0389675
HLA-E major histocompatibility complex, class I, E -0.0388873
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0388222
SLC38A1 solute carrier family 38, member 1 -0.0385461
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0381885
IFI27 interferon, alpha-inducible protein 27 -0.0380312
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0368101
LAMA4 laminin, alpha 4 -0.036694
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0366485
RPL19 ribosomal protein L19 -0.0365644
SMAD3 SMAD family member 3 -0.0364015
MAP7 microtubule-associated protein 7 -0.0362437
CUX1 cut-like homeobox 1 -0.036035
RPLP1 ribosomal protein, large, P1 -0.0356106
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0354461
KPNB1 karyopherin (importin) beta 1 -0.0348898
UBAP2 ubiquitin associated protein 2 -0.0344143
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0343563
S100A6 S100 calcium binding protein A6 -0.0341522
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0341028
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0335437
MAML2 mastermind-like 2 (Drosophila) -0.0335327
TSHZ2 teashirt zinc finger homeobox 2 -0.0335248
HLA-C major histocompatibility complex, class I, C -0.033294
IFIH1 interferon induced with helicase C domain 1 -0.0332792
STAU1 staufen double-stranded RNA binding protein 1 -0.0331671
EIF1 eukaryotic translation initiation factor 1 -0.0331497
RPS29 ribosomal protein S29 -0.032279