| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Diphenhydramine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Diphenhydramine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.287011 |
| COL6A3 | collagen, type VI, alpha 3 | 0.259357 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.17743 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.159192 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.147064 |
| VEGFA | vascular endothelial growth factor A | 0.106118 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0975226 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0778995 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0770691 |
| ATP13A3 | ATPase type 13A3 | 0.0735851 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0679291 |
| CADM1 | cell adhesion molecule 1 | 0.0662808 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0661675 |
| ARRDC3 | arrestin domain containing 3 | 0.0656757 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0584766 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0536089 |
| PDE10A | phosphodiesterase 10A | 0.0532906 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0505412 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.048302 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0476441 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0474252 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0474146 |
| FLNA | filamin A, alpha | 0.0472837 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0448222 |
| ADM | adrenomedullin | 0.0420468 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0412213 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0407869 |
| TMSB4X | thymosin beta 4, X-linked | 0.0384136 |
| MSN | moesin | 0.0383473 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0376847 |
| CTSB | cathepsin B | 0.0367489 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0364706 |
| APP | amyloid beta (A4) precursor protein | 0.0352037 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0328381 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.03255 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0325383 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0323486 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0314092 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0313244 |
| COL5A1 | collagen, type V, alpha 1 | 0.0300844 |
| PCBP2 | poly(rC) binding protein 2 | 0.0291873 |
| CCNL1 | cyclin L1 | 0.0290078 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0287063 |
| RPS2 | ribosomal protein S2 | 0.0276478 |
| RNF145 | ring finger protein 145 | 0.0275985 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0275458 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0274418 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0274312 |
| SFTPA2 | surfactant protein A2 | 0.0268851 |
| MYO10 | myosin X | 0.0266872 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0266494 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.026493 |
| PLEC | plectin | 0.0263307 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0259863 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0250386 |
| RPL3 | ribosomal protein L3 | 0.0247806 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0245513 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0241039 |
| CALR | calreticulin | 0.0240849 |
| QKI | QKI, KH domain containing, RNA binding | 0.024002 |
| TNS1 | tensin 1 | 0.0239805 |
| RASA2 | RAS p21 protein activator 2 | 0.0236135 |
| MAP1B | microtubule-associated protein 1B | 0.0235242 |
| YBX1 | Y box binding protein 1 | 0.0233811 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0230927 |
| VCAN | versican | 0.0229925 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.02252 |
| NAV2 | neuron navigator 2 | 0.0223298 |
| ZNF292 | zinc finger protein 292 | 0.0220566 |
| SPAG9 | sperm associated antigen 9 | 0.021975 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0209607 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0208068 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.020702 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0204889 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0202558 |
| SMAD3 | SMAD family member 3 | 0.0201897 |
| TLN1 | talin 1 | 0.0200401 |
| MKI67 | marker of proliferation Ki-67 | 0.0200174 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0197593 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0197073 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0196396 |
| SDC2 | syndecan 2 | 0.0193917 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0193513 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0192681 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0191315 |
| CD44 | CD44 molecule (Indian blood group) | 0.0191184 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0190271 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0189847 |
| SDF4 | stromal cell derived factor 4 | 0.0188518 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0188054 |
| AXL | AXL receptor tyrosine kinase | 0.0184592 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0184025 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0183905 |
| CLIC1 | chloride intracellular channel 1 | 0.0183365 |
| CENPF | centromere protein F, 350/400kDa | 0.0180465 |
| B2M | beta-2-microglobulin | 0.0179423 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0179032 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0176095 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0174952 |
| MED13L | mediator complex subunit 13-like | 0.0174683 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.375587 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.171833 |
| NDRG1 | N-myc downstream regulated 1 | -0.126261 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.113319 |
| FN1 | fibronectin 1 | -0.0972762 |
| ACTG1 | actin gamma 1 | -0.0806446 |
| VIM | vimentin | -0.0788245 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0769644 |
| CDH13 | cadherin 13 | -0.075193 |
| IER3 | immediate early response 3 | -0.0702023 |
| TMSB10 | thymosin beta 10 | -0.0687734 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0646527 |
| COL1A1 | collagen, type I, alpha 1 | -0.0605627 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0536553 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0504007 |
| COL1A2 | collagen, type I, alpha 2 | -0.0461845 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0459198 |
| HMGA2 | high mobility group AT-hook 2 | -0.0452715 |
| HLA-B | major histocompatibility complex, class I, B | -0.0451763 |
| S100A9 | S100 calcium binding protein A9 | -0.0447802 |
| FTL | ferritin, light polypeptide | -0.0443925 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.043051 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0422498 |
| RPL35A | ribosomal protein L35a | -0.042183 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0417367 |
| LOX | lysyl oxidase | -0.0402289 |
| DPYD | dihydropyrimidine dehydrogenase | -0.039734 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0396743 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0389699 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.038857 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0385532 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0382003 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0381273 |
| RPL8 | ribosomal protein L8 | -0.0378151 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0368017 |
| TRAM1 | translocation associated membrane protein 1 | -0.0366399 |
| OSMR | oncostatin M receptor | -0.0350745 |
| GLIS3 | GLIS family zinc finger 3 | -0.0342577 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0340844 |
| IL6ST | interleukin 6 signal transducer | -0.032969 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0326155 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0320778 |
| RAB2A | RAB2A, member RAS oncogene family | -0.031997 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0317808 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0311798 |
| TAPBP | TAP binding protein (tapasin) | -0.0310249 |
| PALLD | palladin, cytoskeletal associated protein | -0.030749 |
| ASPH | aspartate beta-hydroxylase | -0.0301888 |
| RPS5 | ribosomal protein S5 | -0.0297151 |
| SMYD3 | SET and MYND domain containing 3 | -0.0295589 |
| RPLP0 | ribosomal protein, large, P0 | -0.0288473 |
| RPS8 | ribosomal protein S8 | -0.0285737 |
| RPL28 | ribosomal protein L28 | -0.0285631 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0284151 |
| RPS11 | ribosomal protein S11 | -0.0280533 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0278934 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0278058 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0276668 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0273268 |
| RPL34 | ribosomal protein L34 | -0.0272739 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0272281 |
| SEC24D | SEC24 family member D | -0.0268941 |
| EGR1 | early growth response 1 | -0.0267268 |
| FNDC3B | fibronectin type III domain containing 3B | -0.026681 |
| MTDH | metadherin | -0.0265745 |
| HDLBP | high density lipoprotein binding protein | -0.0263205 |
| WASF2 | WAS protein family, member 2 | -0.0262173 |
| TPM4 | tropomyosin 4 | -0.0261238 |
| FOXP1 | forkhead box P1 | -0.0260979 |
| HM13 | histocompatibility (minor) 13 | -0.0260312 |
| GOLGB1 | golgin B1 | -0.0260039 |
| POSTN | periostin, osteoblast specific factor | -0.0259744 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.025622 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0255587 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0255534 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0253785 |
| PXDN | peroxidasin | -0.0250421 |
| NABP1 | nucleic acid binding protein 1 | -0.0249536 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0248853 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0247113 |
| VCL | vinculin | -0.0244134 |
| NAV1 | neuron navigator 1 | -0.0241575 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0240384 |
| RPS15 | ribosomal protein S15 | -0.023974 |
| CD99 | CD99 molecule | -0.0239615 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0239281 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0238088 |
| UBC | ubiquitin C | -0.0229545 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0228915 |
| CNTN5 | contactin 5 | -0.02284 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0228109 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0227775 |
| GNAS | GNAS complex locus | -0.0225929 |
| MAP4 | microtubule-associated protein 4 | -0.0225209 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.02242 |
| RND3 | Rho family GTPase 3 | -0.0222317 |
| RPL19 | ribosomal protein L19 | -0.0220728 |
| RIGI | RNA sensor RIG-I | -0.0219403 |
| TMEM263 | transmembrane protein 263 | -0.0219194 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0216708 |
