Diphenhydramine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Diphenhydramine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.144516
ERRFI1 ERBB receptor feedback inhibitor 1 0.137011
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.135925
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0909577
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0723783
EEF2 eukaryotic translation elongation factor 2 0.0626475
VEGFA vascular endothelial growth factor A 0.0622461
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0620483
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0616615
DDIT4 DNA-damage-inducible transcript 4 0.0577024
DSPP dentin sialophosphoprotein 0.054952
PLIN2 perilipin 2 0.0519131
ENO1 enolase 1, (alpha) 0.04887
PCBP2 poly(rC) binding protein 2 0.0481234
FTH1 ferritin, heavy polypeptide 1 0.0474596
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0474559
MT2A metallothionein 2A 0.0433477
TF transferrin 0.0418007
RPS2 ribosomal protein S2 0.0325041
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0312271
RPS3 ribosomal protein S3 0.0310309
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0294872
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0292784
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0285805
RPL3 ribosomal protein L3 0.027807
SRRM1 serine/arginine repetitive matrix 1 0.0274271
LDHA lactate dehydrogenase A 0.0267689
RPL37A ribosomal protein L37a 0.0267038
TNS1 tensin 1 0.0265065
RPS12 ribosomal protein S12 0.0261073
SFTPA2 surfactant protein A2 0.0259779
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0248133
BHLHE40 basic helix-loop-helix family, member e40 0.0245365
INSIG2 insulin induced gene 2 0.0242159
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0241577
ARRDC3 arrestin domain containing 3 0.0236339
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0230525
RPL11 ribosomal protein L11 0.0227775
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0226914
EIF4B eukaryotic translation initiation factor 4B 0.0224937
B2M beta-2-microglobulin 0.0219105
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0218639
CTSB cathepsin B 0.0215275
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207252
ORM1 orosomucoid 1 0.0207231
CCNL1 cyclin L1 0.0204506
ADM adrenomedullin 0.0201996
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0200617
HOOK2 hook microtubule-tethering protein 2 0.0197519
RACK1 receptor for activated C kinase 1 0.0191561
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0187872
IGFBP3 insulin-like growth factor binding protein 3 0.018714
PDIA6 protein disulfide isomerase family A, member 6 0.0181491
SRRM2 serine/arginine repetitive matrix 2 0.0180504
NFE2L1 nuclear factor, erythroid 2-like 1 0.017708
RPS17 ribosomal protein S17 0.0175268
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0174435
ZFP36L1 ZFP36 ring finger protein-like 1 0.0173994
ZFP36 ZFP36 ring finger protein 0.0169781
RPS7 ribosomal protein S7 0.0169397
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0169191
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.016874
TOP1 topoisomerase (DNA) I 0.0167463
HMGA1 high mobility group AT-hook 1 0.0164463
DTNA dystrobrevin, alpha 0.016123
CPE carboxypeptidase E 0.0160277
YTHDC1 YTH domain containing 1 0.0159254
KIF5B kinesin family member 5B 0.0159243
SET SET nuclear proto-oncogene 0.0159207
TCIM transcriptional and immune response regulator 0.015692
YBX1 Y box binding protein 1 0.0156686
RPL26 ribosomal protein L26 0.0155179
TPM3 tropomyosin 3 0.0155045
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0152514
KDM3A lysine (K)-specific demethylase 3A 0.0151742
RPS18 ribosomal protein S18 0.0151069
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0149725
UBA6 ubiquitin-like modifier activating enzyme 6 0.014964
APOA1 apolipoprotein A-I 0.0147854
CALR calreticulin 0.014525
RBM17 RNA binding motif protein 17 0.014508
APLP2 amyloid beta (A4) precursor-like protein 2 0.0144194
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.014333
STC2 stanniocalcin 2 0.0142883
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0142066
EIF1 eukaryotic translation initiation factor 1 0.0142008
MYO6 myosin VI 0.0141615
NGLY1 N-glycanase 1 0.0139559
EFNA1 ephrin-A1 0.0138548
SDF4 stromal cell derived factor 4 0.0138407
IWS1 IWS1 homolog (S. cerevisiae) 0.0137529
XPO1 exportin 1 0.0135135
KTN1 kinectin 1 (kinesin receptor) 0.0133644
TMF1 TATA element modulatory factor 1 0.013157
CCL20 chemokine (C-C motif) ligand 20 0.0131195
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0129883
CSDE1 cold shock domain containing E1, RNA-binding 0.0129479
RNMT RNA (guanine-7-) methyltransferase 0.0129428
HELZ helicase with zinc finger 0.0128336
MXI1 MAX interactor 1, dimerization protein 0.0128031

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.247157
FN1 fibronectin 1 -0.145165
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.119415
NKD1 naked cuticle homolog 1 (Drosophila) -0.10383
GPC6 glypican 6 -0.093093
TPT1 tumor protein, translationally-controlled 1 -0.0905409
FNDC3B fibronectin type III domain containing 3B -0.086416
LRMDA leucine rich melanocyte differentiation associated -0.0799321
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0795441
MAML2 mastermind-like 2 (Drosophila) -0.076377
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0754401
NPAS2 neuronal PAS domain protein 2 -0.0735163
TM4SF1 transmembrane 4 L six family member 1 -0.0707656
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.068657
EHBP1 EH domain binding protein 1 -0.0669511
GPC3 glypican 3 -0.0655609
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0641617
A2M alpha-2-macroglobulin -0.0626224
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.062081
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0602396
IGF2 insulin-like growth factor 2 -0.0589733
MBNL3 muscleblind-like splicing regulator 3 -0.0549472
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0516532
SLC38A2 solute carrier family 38, member 2 -0.0515615
ZMYND8 zinc finger, MYND-type containing 8 -0.0512248
ITGAV integrin, alpha V -0.0505027
PTCHD4 patched domain containing 4 -0.0504877
ACTN4 actinin, alpha 4 -0.0504531
ZBTB20 zinc finger and BTB domain containing 20 -0.0492508
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0471595
IGF1R insulin-like growth factor 1 receptor -0.0470532
DNAH17 dynein, axonemal, heavy chain 17 -0.0451114
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0449194
DOCK4 dedicator of cytokinesis 4 -0.0441082
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0433378
IGFBP1 insulin-like growth factor binding protein 1 -0.0431175
EXT1 exostosin glycosyltransferase 1 -0.0413779
EML4 echinoderm microtubule associated protein like 4 -0.0410116
ATXN1 ataxin 1 -0.0409251
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0400443
TMEM123 transmembrane protein 123 -0.0393098
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0391127
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0388821
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0387546
VCL vinculin -0.0380798
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0374426
RBM39 RNA binding motif protein 39 -0.0364964
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0357949
ARL5A ADP-ribosylation factor-like 5A -0.0356418
SVIL supervillin -0.035608
SOX5 SRY (sex determining region Y)-box 5 -0.0354256
OSMR oncostatin M receptor -0.0350571
NRIP1 nuclear receptor interacting protein 1 -0.0345397
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0345014
PARD3 par-3 family cell polarity regulator -0.034257
RPS24 ribosomal protein S24 -0.0341307
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0341251
STAU1 staufen double-stranded RNA binding protein 1 -0.0339148
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0331044
JMJD1C jumonji domain containing 1C -0.0329625
TRIM26 tripartite motif containing 26 -0.0328449
TNS3 tensin 3 -0.0325919
EGR1 early growth response 1 -0.0324637
ZNF644 zinc finger protein 644 -0.0316946
PTPRK protein tyrosine phosphatase, receptor type, K -0.0314136
FBF1 Fas (TNFRSF6) binding factor 1 -0.031111
NCOA7 nuclear receptor coactivator 7 -0.0310527
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0310515
PTPRM protein tyrosine phosphatase, receptor type, M -0.030954
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0308883
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0306946
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0300697
GMDS GDP-mannose 4,6-dehydratase -0.0297498
FAM135A family with sequence similarity 135, member A -0.0293871
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0290336
BIRC6 baculoviral IAP repeat containing 6 -0.0286648
TGFBI transforming growth factor, beta-induced, 68kDa -0.0281581
TAS2R14 taste receptor, type 2, member 14 -0.0280885
FRMD5 FERM domain containing 5 -0.0276209
LOC112694756 uncharaterized LOC112694756 -0.0276008
SYN3 synapsin III -0.0275133
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0274414
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0271086
BPTF bromodomain PHD finger transcription factor -0.0270003
CNKSR3 CNKSR family member 3 -0.0268641
IER3 immediate early response 3 -0.0266298
GNAS GNAS complex locus -0.026577
SOD2 superoxide dismutase 2, mitochondrial -0.0265348
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.026414
ARID1B AT rich interactive domain 1B (SWI1-like) -0.026341
FOXP1 forkhead box P1 -0.0262133
MBD5 methyl-CpG binding domain protein 5 -0.0259599
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0258988
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0258382
KIAA1217 KIAA1217 -0.0255627
C3 complement component 3 -0.0254391
RNF213 ring finger protein 213 -0.0253764
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0253005
DOCK5 dedicator of cytokinesis 5 -0.0252417
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0251935