Diphenhydramine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diphenhydramine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.11735
FAM13A family with sequence similarity 13, member A 0.0941749
VEGFA vascular endothelial growth factor A 0.0877468
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0683703
ZNF292 zinc finger protein 292 0.0641812
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0606679
RNF145 ring finger protein 145 0.0585782
NDRG1 N-myc downstream regulated 1 0.0578179
MUC6 mucin 6, oligomeric mucus/gel-forming 0.057384
ANKRD11 ankyrin repeat domain 11 0.0557093
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0543876
TNS4 tensin 4 0.0540316
NUP58 nucleoporin 58 0.0538805
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0535708
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0515284
MED13L mediator complex subunit 13-like 0.0509245
UBA6 ubiquitin-like modifier activating enzyme 6 0.0485336
CCNY cyclin Y 0.0484774
EEF2 eukaryotic translation elongation factor 2 0.0479388
RREB1 ras responsive element binding protein 1 0.0467611
SRRM2 serine/arginine repetitive matrix 2 0.0456465
NAMPT nicotinamide phosphoribosyltransferase 0.0456276
TXNIP thioredoxin interacting protein 0.0433798
WAC WW domain containing adaptor with coiled-coil 0.0431138
CCNL1 cyclin L1 0.0424857
RBM39 RNA binding motif protein 39 0.041405
KMT2E lysine (K)-specific methyltransferase 2E 0.0413996
FLNB filamin B, beta 0.0413991
KDM6A lysine (K)-specific demethylase 6A 0.0403632
ERRFI1 ERBB receptor feedback inhibitor 1 0.037319
PCBP2 poly(rC) binding protein 2 0.0372661
PLAUR plasminogen activator, urokinase receptor 0.0343027
EREG epiregulin 0.0339154
TFG TRK-fused gene 0.0325256
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0324112
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0316664
TMSB4X thymosin beta 4, X-linked 0.0315525
LRRC1 leucine rich repeat containing 1 0.0307433
BCLAF1 BCL2-associated transcription factor 1 0.0300417
RPL3 ribosomal protein L3 0.02999
FXR1 fragile X mental retardation, autosomal homolog 1 0.0295731
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0293389
EIF4B eukaryotic translation initiation factor 4B 0.0293209
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0292568
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0289843
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0289575
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0286801
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0281782
ESYT2 extended synaptotagmin-like protein 2 0.0279906
RAB6A RAB6A, member RAS oncogene family 0.0279735
CALB1 calbindin 1, 28kDa 0.0277116
TPM3 tropomyosin 3 0.027333
PICALM phosphatidylinositol binding clathrin assembly protein 0.0272499
CD46 CD46 molecule, complement regulatory protein 0.0271956
YTHDC1 YTH domain containing 1 0.0266947
STRN3 striatin, calmodulin binding protein 3 0.0266291
SFPQ splicing factor proline/glutamine-rich 0.0262636
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0261616
ADAM17 ADAM metallopeptidase domain 17 0.0260514
MYH9 myosin, heavy chain 9, non-muscle 0.0257526
CDC73 cell division cycle 73 0.0255241
RYBP RING1 and YY1 binding protein 0.0254739
PRRC2C proline-rich coiled-coil 2C 0.0254156
FNBP1L formin binding protein 1-like 0.0250929
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0250893
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0249455
SLK STE20-like kinase 0.0249249
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0246063
YAP1 Yes-associated protein 1 0.0244061
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024176
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240182
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0239458
SREBF1 sterol regulatory element binding transcription factor 1 0.0238643
PUM1 pumilio RNA-binding family member 1 0.0234461
FOSL1 FOS-like antigen 1 0.0232858
EWSR1 EWS RNA-binding protein 1 0.0230266
NCKAP1 NCK-associated protein 1 0.0227452
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.022647
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0222899
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0220765
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0219626
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.0219541
HOOK2 hook microtubule-tethering protein 2 0.0219324
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0219296
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0217372
USP3 ubiquitin specific peptidase 3 0.0214878
ZFAND3 zinc finger, AN1-type domain 3 0.0214599
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0213839
ABHD2 abhydrolase domain containing 2 0.0213531
ESRP1 epithelial splicing regulatory protein 1 0.0213245
CUL3 cullin 3 0.0212899
HSPA8 heat shock 70kDa protein 8 0.0212699
RPS18 ribosomal protein S18 0.0212364
ATP13A3 ATPase type 13A3 0.0211135
KCMF1 potassium channel modulatory factor 1 0.0210362
COPA coatomer protein complex, subunit alpha 0.0210354
HELZ helicase with zinc finger 0.020938
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0208923
SESN2 sestrin 2 0.0204171
XPO1 exportin 1 0.0203307

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.434226
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.126508
TPT1 tumor protein, translationally-controlled 1 -0.122027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.106495
TMSB10 thymosin beta 10 -0.097434
PTMA prothymosin, alpha -0.0885511
NPSR1 neuropeptide S receptor 1 -0.0809388
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0790661
GMDS GDP-mannose 4,6-dehydratase -0.0750276
RPLP1 ribosomal protein, large, P1 -0.0724319
ACTG1 actin gamma 1 -0.0718434
PTPRK protein tyrosine phosphatase, receptor type, K -0.0699448
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0679626
RPS6 ribosomal protein S6 -0.06586
LOC112694756 uncharaterized LOC112694756 -0.0655163
NALF1 NALCN channel auxiliary factor 1 -0.0643254
RPLP0 ribosomal protein, large, P0 -0.057896
MYO1E myosin IE -0.0574138
RPS8 ribosomal protein S8 -0.0568977
RPL34 ribosomal protein L34 -0.0561235
EXT1 exostosin glycosyltransferase 1 -0.0556491
FTL ferritin, light polypeptide -0.0555602
ALCAM activated leukocyte cell adhesion molecule -0.0543719
VCL vinculin -0.0515993
CADPS Ca++-dependent secretion activator -0.0513562
GDF15 growth differentiation factor 15 -0.0495467
ONECUT3 one cut homeobox 3 -0.0485094
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0469065
RPS24 ribosomal protein S24 -0.0437443
AHNAK AHNAK nucleoprotein -0.0437292
RPL35A ribosomal protein L35a -0.0432417
RPL8 ribosomal protein L8 -0.0431209
POF1B premature ovarian failure, 1B -0.0429192
GPHN gephyrin -0.0413987
S100A10 S100 calcium binding protein A10 -0.0412544
RPL19 ribosomal protein L19 -0.0406805
AGR2 anterior gradient 2 -0.0404252
EIF1 eukaryotic translation initiation factor 1 -0.0401285
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0397993
RPS19 ribosomal protein S19 -0.0387129
RPL32 ribosomal protein L32 -0.0383336
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0375461
RPL12 ribosomal protein L12 -0.0372831
RPL11 ribosomal protein L11 -0.0370594
TAS2R14 taste receptor, type 2, member 14 -0.0368623
PIGR polymeric immunoglobulin receptor -0.0364971
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0362725
GREB1L growth regulation by estrogen in breast cancer-like -0.0352537
HDLBP high density lipoprotein binding protein -0.0350646
RPL23 ribosomal protein L23 -0.0343439
LOC102724023 ES1 protein homolog, mitochondrial -0.0342997
RPS23 ribosomal protein S23 -0.033233
TTC3 tetratricopeptide repeat domain 3 -0.0330597
RPL27A ribosomal protein L27a -0.0326807
KRT18 keratin 18, type I -0.0326787
ASPH aspartate beta-hydroxylase -0.0326324
RPL28 ribosomal protein L28 -0.032442
PTPRB protein tyrosine phosphatase, receptor type, B -0.0323664
MBNL1 muscleblind-like splicing regulator 1 -0.0320485
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0320016
SLC38A2 solute carrier family 38, member 2 -0.031683
RPLP2 ribosomal protein, large, P2 -0.0310902
PATJ PATJ crumbs cell polarity complex component -0.030951
RPS21 ribosomal protein S21 -0.0307806
EZR ezrin -0.0304831
S100P S100 calcium binding protein P -0.030185
LDHA lactate dehydrogenase A -0.030108
CD44 CD44 molecule (Indian blood group) -0.0300739
EHBP1 EH domain binding protein 1 -0.0299022
LAMA4 laminin, alpha 4 -0.0296048
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0296045
RPS29 ribosomal protein S29 -0.0289754
SMYD3 SET and MYND domain containing 3 -0.02881
EMP1 epithelial membrane protein 1 -0.0287734
HMGA1 high mobility group AT-hook 1 -0.0287303
ARF1 ADP-ribosylation factor 1 -0.0286628
S100A9 S100 calcium binding protein A9 -0.0284353
IER3 immediate early response 3 -0.0284197
RPL31 ribosomal protein L31 -0.0282724
ZBTB20 zinc finger and BTB domain containing 20 -0.0282453
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.027941
SVIL supervillin -0.0277537
ANXA1 annexin A1 -0.0276012
GNAS GNAS complex locus -0.0275555
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.027525
ZSWIM6 zinc finger, SWIM-type containing 6 -0.027353
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0272836
RRBP1 ribosome binding protein 1 -0.0270724
RPL26 ribosomal protein L26 -0.0269727
MT2A metallothionein 2A -0.026922
RPS11 ribosomal protein S11 -0.0268263
RPS5 ribosomal protein S5 -0.0264597
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0261491
ACTN4 actinin, alpha 4 -0.0259472
RPL36 ribosomal protein L36 -0.025922
RPL7A ribosomal protein L7a -0.0258151
MARCHF3 membrane associated ring-CH-type finger 3 -0.0255789
FHIT fragile histidine triad -0.0255498
RPS25 ribosomal protein S25 -0.0251696
RPL13A ribosomal protein L13a -0.0248224