| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Diphenhydramine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Diphenhydramine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.24611 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.200749 |
| VIM | vimentin | 0.195825 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.170343 |
| TMSB4X | thymosin beta 4, X-linked | 0.128468 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.113021 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.105892 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.104961 |
| CENPF | centromere protein F, 350/400kDa | 0.104851 |
| RAI1 | retinoic acid induced 1 | 0.103533 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.103303 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.094034 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0907345 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0825735 |
| EZR | ezrin | 0.0794665 |
| DST | dystonin | 0.0793576 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0767206 |
| AHNAK | AHNAK nucleoprotein | 0.0765332 |
| MKI67 | marker of proliferation Ki-67 | 0.072574 |
| MT2A | metallothionein 2A | 0.0692268 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0692253 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0688512 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0637218 |
| FMNL2 | formin-like 2 | 0.0615293 |
| PGK1 | phosphoglycerate kinase 1 | 0.0609627 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0599263 |
| LDHA | lactate dehydrogenase A | 0.0597603 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0586171 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.058388 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0581033 |
| ENO1 | enolase 1, (alpha) | 0.0571077 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0569858 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0539868 |
| CANX | calnexin | 0.0520835 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0515549 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0507513 |
| PTMA | prothymosin, alpha | 0.0501431 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0489446 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0485424 |
| SET | SET nuclear proto-oncogene | 0.048462 |
| EREG | epiregulin | 0.0482713 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.048147 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.048024 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0471166 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0465653 |
| EMP1 | epithelial membrane protein 1 | 0.0450441 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0447269 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0444891 |
| TXNRD1 | thioredoxin reductase 1 | 0.0431945 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0431624 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0409436 |
| TXNIP | thioredoxin interacting protein | 0.0401871 |
| SON | SON DNA binding protein | 0.0394175 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0390992 |
| RACK1 | receptor for activated C kinase 1 | 0.0390424 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0386682 |
| PCBP2 | poly(rC) binding protein 2 | 0.0383611 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0382797 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0377904 |
| MYOF | myoferlin | 0.0374745 |
| CD44 | CD44 molecule (Indian blood group) | 0.0372005 |
| ADAR | adenosine deaminase, RNA-specific | 0.0367677 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.036595 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0361522 |
| TOP1 | topoisomerase (DNA) I | 0.0360967 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.035529 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0348867 |
| FLNB | filamin B, beta | 0.0348171 |
| SLK | STE20-like kinase | 0.034628 |
| TPR | translocated promoter region, nuclear basket protein | 0.0346108 |
| CAPRIN2 | caprin family member 2 | 0.0344903 |
| TPI1 | triosephosphate isomerase 1 | 0.0344265 |
| F2R | coagulation factor II (thrombin) receptor | 0.0342187 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.033963 |
| ARRDC3 | arrestin domain containing 3 | 0.0338299 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0337058 |
| MYO10 | myosin X | 0.0336441 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0331155 |
| RPS2 | ribosomal protein S2 | 0.032719 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0325755 |
| ANXA1 | annexin A1 | 0.0325479 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0318954 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0317966 |
| XPO1 | exportin 1 | 0.0313654 |
| ANKRD36 | ankyrin repeat domain 36 | 0.031282 |
| PLK2 | polo-like kinase 2 | 0.0312796 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0309051 |
| MSN | moesin | 0.0303421 |
| H1-0 | H1.0 linker histone | 0.0303383 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0302453 |
| PODXL | podocalyxin-like | 0.030036 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0300341 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.029988 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0299341 |
| RRM2 | ribonucleotide reductase M2 | 0.0297951 |
| SOCS6 | suppressor of cytokine signaling 6 | 0.0294954 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0293141 |
| KLF6 | Kruppel-like factor 6 | 0.0292729 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0291335 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0288355 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.302742 |
| TP63 | tumor protein p63 | -0.125244 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.103843 |
| HLA-B | major histocompatibility complex, class I, B | -0.0915349 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0497456 |
| CADM2 | cell adhesion molecule 2 | -0.0489405 |
| TMSB10 | thymosin beta 10 | -0.0458914 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0456759 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0455287 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0415312 |
| EGR1 | early growth response 1 | -0.0408832 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0404328 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0402867 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0399587 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0390306 |
| TNS3 | tensin 3 | -0.0380975 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0330759 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0328647 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0321314 |
| EPHA4 | EPH receptor A4 | -0.0320281 |
| EFNA5 | ephrin-A5 | -0.0315371 |
| HMGA1 | high mobility group AT-hook 1 | -0.030462 |
| RPL28 | ribosomal protein L28 | -0.0293216 |
| RPL31 | ribosomal protein L31 | -0.0284332 |
| RPL36A | ribosomal protein L36a | -0.0280487 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0269897 |
| PDE10A | phosphodiesterase 10A | -0.0268886 |
| TMEM123 | transmembrane protein 123 | -0.0267024 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0262533 |
| RIGI | RNA sensor RIG-I | -0.0260998 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0260598 |
| RPL38 | ribosomal protein L38 | -0.0256933 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0250852 |
| RPS23 | ribosomal protein S23 | -0.0249267 |
| RPS29 | ribosomal protein S29 | -0.0243215 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0239415 |
| RPS24 | ribosomal protein S24 | -0.0239094 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0236992 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0228439 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0222102 |
| RPL36 | ribosomal protein L36 | -0.0220929 |
| RPL35A | ribosomal protein L35a | -0.0217252 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.021254 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0211653 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0209988 |
| PTK2 | protein tyrosine kinase 2 | -0.0209657 |
| GNAS | GNAS complex locus | -0.0208166 |
| HDAC9 | histone deacetylase 9 | -0.0207912 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0205787 |
| RPS25 | ribosomal protein S25 | -0.0204534 |
| RPS10 | ribosomal protein S10 | -0.0204506 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0202847 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0196188 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0195323 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0193595 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0192085 |
| TAPBP | TAP binding protein (tapasin) | -0.0191015 |
| RPS6 | ribosomal protein S6 | -0.0190275 |
| RPL34 | ribosomal protein L34 | -0.0185099 |
| RPL27A | ribosomal protein L27a | -0.0180128 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.017747 |
| FTL | ferritin, light polypeptide | -0.0175171 |
| ECE1 | endothelin converting enzyme 1 | -0.01748 |
| UBAP2 | ubiquitin associated protein 2 | -0.0174069 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0173702 |
| FBXO11 | F-box protein 11 | -0.0173203 |
| RPLP2 | ribosomal protein, large, P2 | -0.0172406 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0171822 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.017022 |
| ZNF644 | zinc finger protein 644 | -0.0168765 |
| RPS28 | ribosomal protein S28 | -0.0168525 |
| RPS21 | ribosomal protein S21 | -0.0168169 |
| RPS15 | ribosomal protein S15 | -0.0165015 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0161399 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0159906 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0159743 |
| ZNF207 | zinc finger protein 207 | -0.0159135 |
| FUS | FUS RNA binding protein | -0.0159018 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0158628 |
| TRIM56 | tripartite motif containing 56 | -0.015704 |
| RPS19 | ribosomal protein S19 | -0.0155926 |
| HLA-A | major histocompatibility complex, class I, A | -0.0155781 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0155622 |
| TGM2 | transglutaminase 2 | -0.0153511 |
| ENOSF1 | enolase superfamily member 1 | -0.0152785 |
| LRRC49 | leucine rich repeat containing 49 | -0.015263 |
| RPLP1 | ribosomal protein, large, P1 | -0.0152371 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.015118 |
| DPH6 | diphthamine biosynthesis 6 | -0.0150794 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0150378 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0148279 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0147363 |
| SP100 | SP100 nuclear antigen | -0.0145855 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0145219 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0144147 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0144077 |
| ASTN2 | astrotactin 2 | -0.0143616 |
| OLA1 | Obg-like ATPase 1 | -0.0142867 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0140466 |
| RYBP | RING1 and YY1 binding protein | -0.014 |
