| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Diphenhydramine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Diphenhydramine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.155833 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.154969 |
| CES1 | carboxylesterase 1 | 0.0943238 |
| FAM13A | family with sequence similarity 13, member A | 0.091008 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0693545 |
| RUNX1 | runt-related transcription factor 1 | 0.0629835 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0581473 |
| MKI67 | marker of proliferation Ki-67 | 0.055701 |
| ARRDC3 | arrestin domain containing 3 | 0.0552613 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0526401 |
| NGLY1 | N-glycanase 1 | 0.051535 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0509611 |
| LAMA4 | laminin, alpha 4 | 0.0493817 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0492729 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0489393 |
| ATP13A3 | ATPase type 13A3 | 0.0487153 |
| MT2A | metallothionein 2A | 0.0475627 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0458102 |
| TMEM165 | transmembrane protein 165 | 0.0456912 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0453946 |
| TOP1 | topoisomerase (DNA) I | 0.0452679 |
| TXNRD1 | thioredoxin reductase 1 | 0.0444646 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0425343 |
| NDRG1 | N-myc downstream regulated 1 | 0.0414904 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0409695 |
| HELZ | helicase with zinc finger | 0.0405678 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0401055 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0400511 |
| PCBP2 | poly(rC) binding protein 2 | 0.0394988 |
| LAMB3 | laminin, beta 3 | 0.0393325 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0372691 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0367567 |
| OGA | O-GlcNAcase | 0.0358639 |
| ZNF292 | zinc finger protein 292 | 0.0357112 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0355864 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0333685 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0331408 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0330945 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0329042 |
| DTNA | dystrobrevin, alpha | 0.0326243 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0326112 |
| SPAG9 | sperm associated antigen 9 | 0.0325698 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0320863 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0309959 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0308542 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0308399 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0305606 |
| H1-0 | H1.0 linker histone | 0.030429 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0302115 |
| CCNL1 | cyclin L1 | 0.0301551 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0300763 |
| RNF145 | ring finger protein 145 | 0.0298785 |
| RBM39 | RNA binding motif protein 39 | 0.0296908 |
| UVRAG | UV radiation resistance associated | 0.0281376 |
| USP3 | ubiquitin specific peptidase 3 | 0.027956 |
| ANXA5 | annexin A5 | 0.027903 |
| RTN4 | reticulon 4 | 0.0275972 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0274774 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0269692 |
| NPTN | neuroplastin | 0.0268019 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0263564 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0263446 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0263421 |
| CDCP1 | CUB domain containing protein 1 | 0.0259593 |
| MCL1 | myeloid cell leukemia 1 | 0.0258435 |
| RASA2 | RAS p21 protein activator 2 | 0.0249511 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0248117 |
| PUM2 | pumilio RNA-binding family member 2 | 0.024591 |
| PGK1 | phosphoglycerate kinase 1 | 0.0243269 |
| YTHDC1 | YTH domain containing 1 | 0.0234353 |
| TBK1 | TANK-binding kinase 1 | 0.0233952 |
| MYO1B | myosin IB | 0.0231433 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0230111 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0229302 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0229266 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0228495 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0226487 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0224354 |
| SUCO | SUN domain containing ossification factor | 0.0220729 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0218028 |
| NCKAP1 | NCK-associated protein 1 | 0.0217413 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0216402 |
| GRAMD1B | GRAM domain containing 1B | 0.0214557 |
| TFG | TRK-fused gene | 0.0214454 |
| HYOU1 | hypoxia up-regulated 1 | 0.0212474 |
| NUP58 | nucleoporin 58 | 0.0210881 |
| WDR26 | WD repeat domain 26 | 0.0209242 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0208517 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0207467 |
| ARGLU1 | arginine and glutamate rich 1 | 0.02071 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0206782 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0206479 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0205087 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0204284 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0203076 |
| RNF149 | ring finger protein 149 | 0.0202947 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0202353 |
| WDR45B | WD repeat domain 45B | 0.0201269 |
| MREG | melanoregulin | 0.0196913 |
| PYGL | phosphorylase, glycogen, liver | 0.0192362 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.281894 |
| EGFR | epidermal growth factor receptor | -0.204175 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.131379 |
| ASPH | aspartate beta-hydroxylase | -0.128569 |
| TMSB10 | thymosin beta 10 | -0.105658 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.105329 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.10327 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0997344 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0974068 |
| INTS6 | integrator complex subunit 6 | -0.0806818 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0788076 |
| ACTG1 | actin gamma 1 | -0.077861 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0778171 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0774656 |
| LMO7 | LIM domain 7 | -0.0735859 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0722617 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0721488 |
| EFNA5 | ephrin-A5 | -0.0673838 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0661996 |
| EGR1 | early growth response 1 | -0.0635199 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0617496 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0602887 |
| S100A10 | S100 calcium binding protein A10 | -0.0586463 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0555528 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.052952 |
| KRT7 | keratin 7, type II | -0.0511275 |
| MYO1E | myosin IE | -0.0484273 |
| PKM | pyruvate kinase, muscle | -0.0473026 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0456948 |
| CUX1 | cut-like homeobox 1 | -0.0456785 |
| ANXA2 | annexin A2 | -0.0430462 |
| CCND1 | cyclin D1 | -0.0429327 |
| HOMER1 | homer scaffolding protein 1 | -0.0422357 |
| RNF213 | ring finger protein 213 | -0.0404543 |
| KRT18 | keratin 18, type I | -0.0401625 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.039733 |
| PATJ | PATJ crumbs cell polarity complex component | -0.039479 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0382682 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0360758 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0360116 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0358701 |
| CST3 | cystatin C | -0.0350768 |
| SCEL | sciellin | -0.0332641 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0332595 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0330278 |
| LDHA | lactate dehydrogenase A | -0.032799 |
| VCL | vinculin | -0.032696 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0326822 |
| PRKCA | protein kinase C, alpha | -0.0323118 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0321639 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0319944 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0318829 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.031654 |
| TNS3 | tensin 3 | -0.0313757 |
| SLC38A2 | solute carrier family 38, member 2 | -0.031268 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0310169 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0297628 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0295085 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0294118 |
| MCU | mitochondrial calcium uniporter | -0.0293221 |
| MYO1D | myosin ID | -0.0293138 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0291704 |
| MYOF | myoferlin | -0.0289307 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0288677 |
| SP100 | SP100 nuclear antigen | -0.0286442 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0284012 |
| AHNAK | AHNAK nucleoprotein | -0.0283952 |
| KRT8 | keratin 8, type II | -0.027986 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0279793 |
| CAV2 | caveolin 2 | -0.0277762 |
| EHBP1 | EH domain binding protein 1 | -0.0276466 |
| NABP1 | nucleic acid binding protein 1 | -0.0272015 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0270661 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0269451 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0259753 |
| CMIP | c-Maf inducing protein | -0.0255073 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0253881 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0252721 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0248681 |
| AGR2 | anterior gradient 2 | -0.0244281 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0240404 |
| DSG2 | desmoglein 2 | -0.0239976 |
| FOXP1 | forkhead box P1 | -0.0239676 |
| TPM4 | tropomyosin 4 | -0.0239479 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0233912 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0232525 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0232221 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.022996 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0227479 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0227041 |
| KRT19 | keratin 19, type I | -0.0226981 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0223067 |
| AREG | amphiregulin | -0.0221649 |
| NTN4 | netrin 4 | -0.0221145 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0219729 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.0218476 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0216085 |
| FNDC3A | fibronectin type III domain containing 3A | -0.021571 |
| GNAS | GNAS complex locus | -0.0215394 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0213786 |
