Diphenhydramine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Diphenhydramine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.205696
GRAMD1B GRAM domain containing 1B 0.156194
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.150371
AKAP12 A kinase (PRKA) anchor protein 12 0.147613
PDE4D phosphodiesterase 4D, cAMP-specific 0.124791
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0871274
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0834216
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0776918
ERRFI1 ERBB receptor feedback inhibitor 1 0.0736317
THSD4 thrombospondin, type I, domain containing 4 0.0724255
SAMD4A sterile alpha motif domain containing 4A 0.0587392
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0538463
PM20D1 peptidase M20 domain containing 1 0.05161
DOCK4 dedicator of cytokinesis 4 0.0504912
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0495608
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0493899
UBASH3B ubiquitin associated and SH3 domain containing B 0.049218
TPM3 tropomyosin 3 0.048036
RAD51B RAD51 paralog B 0.0470543
FMNL2 formin-like 2 0.0468915
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0441006
KTN1 kinectin 1 (kinesin receptor) 0.0436833
TRIO trio Rho guanine nucleotide exchange factor 0.0432825
MACF1 microtubule-actin crosslinking factor 1 0.042855
EEF2 eukaryotic translation elongation factor 2 0.0420852
WWOX WW domain containing oxidoreductase 0.0416556
TXNRD1 thioredoxin reductase 1 0.0409539
CMIP c-Maf inducing protein 0.0404449
KIF5B kinesin family member 5B 0.0383738
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0381956
HSPA8 heat shock 70kDa protein 8 0.0368521
BICC1 BicC family RNA binding protein 1 0.0357052
PDLIM5 PDZ and LIM domain 5 0.0353148
TTC28 tetratricopeptide repeat domain 28 0.0337604
SRRM2 serine/arginine repetitive matrix 2 0.0330392
DST dystonin 0.0328289
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0317946
FGB fibrinogen beta chain 0.0315996
ASPH aspartate beta-hydroxylase 0.0315876
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0304502
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0304326
IGFBP3 insulin-like growth factor binding protein 3 0.0295988
LPP LIM domain containing preferred translocation partner in lipoma 0.0275312
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.027487
FLNB filamin B, beta 0.0274128
BRD2 bromodomain containing 2 0.0270343
PCBP2 poly(rC) binding protein 2 0.0269642
SFTPA2 surfactant protein A2 0.0269592
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0269115
MKI67 marker of proliferation Ki-67 0.0265976
MAML3 mastermind-like 3 (Drosophila) 0.0265247
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0260762
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0260571
NEBL nebulette 0.025759
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0256366
MBNL1 muscleblind-like splicing regulator 1 0.0252843
MYH9 myosin, heavy chain 9, non-muscle 0.0252242
HDGF hepatoma-derived growth factor 0.0249867
PTPRM protein tyrosine phosphatase, receptor type, M 0.0248444
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0245762
CFDP1 craniofacial development protein 1 0.0243897
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0242897
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0241361
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0240894
UTRN utrophin 0.0238824
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0230636
ELL2 elongation factor, RNA polymerase II, 2 0.022892
MYOF myoferlin 0.0226167
BIRC3 baculoviral IAP repeat containing 3 0.0223606
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0223294
RPS2 ribosomal protein S2 0.0223257
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0222296
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0220854
SMOC1 SPARC related modular calcium binding 1 0.0215111
PYGL phosphorylase, glycogen, liver 0.0212864
PDE8A phosphodiesterase 8A 0.0211752
GOLGA4 golgin A4 0.0208858
BASP1 brain abundant, membrane attached signal protein 1 0.0204881
ACTN1 actinin, alpha 1 0.0203223
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0202432
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0202145
PRRC2C proline-rich coiled-coil 2C 0.0200812
APP amyloid beta (A4) precursor protein 0.0200757
TBC1D5 TBC1 domain family, member 5 0.0199251
EIF4B eukaryotic translation initiation factor 4B 0.0197031
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0195803
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.019576
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0195211
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0195005
EGFR epidermal growth factor receptor 0.0194604
LDHA lactate dehydrogenase A 0.0189156
SNX14 sorting nexin 14 0.018514
CENPF centromere protein F, 350/400kDa 0.0184614
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0184312
CANX calnexin 0.0184214
AKAP13 A kinase (PRKA) anchor protein 13 0.0183943
TOP1 topoisomerase (DNA) I 0.0183851
SBF2 SET binding factor 2 0.0181804
AHR aryl hydrocarbon receptor 0.0180794
SPIDR scaffolding protein involved in DNA repair 0.0178575

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.360797
FTL ferritin, light polypeptide -0.164027
MT2A metallothionein 2A -0.159508
TMSB10 thymosin beta 10 -0.112611
IER3 immediate early response 3 -0.0658345
RPL19 ribosomal protein L19 -0.0602175
ACTG1 actin gamma 1 -0.0593958
RPL23 ribosomal protein L23 -0.0590952
IGF2 insulin-like growth factor 2 -0.0578355
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0553237
RPLP1 ribosomal protein, large, P1 -0.051656
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.050544
RPS21 ribosomal protein S21 -0.0500046
TFPI2 tissue factor pathway inhibitor 2 -0.0489459
USP3 ubiquitin specific peptidase 3 -0.0394705
DENND4A DENN/MADD domain containing 4A -0.038668
POTEF POTE ankyrin domain family, member F -0.0382898
TPT1 tumor protein, translationally-controlled 1 -0.0376089
RPLP0 ribosomal protein, large, P0 -0.0370678
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0369988
RPL8 ribosomal protein L8 -0.0366038
RPS25 ribosomal protein S25 -0.0347483
S100A10 S100 calcium binding protein A10 -0.0335639
EIF1 eukaryotic translation initiation factor 1 -0.0326986
PFN1 profilin 1 -0.0324976
RPS29 ribosomal protein S29 -0.0318286
RPS5 ribosomal protein S5 -0.0316431
RPS15 ribosomal protein S15 -0.0315241
RPS23 ribosomal protein S23 -0.0312896
GNAS GNAS complex locus -0.0308183
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0305013
RAB1A RAB1A, member RAS oncogene family -0.0303858
RPL28 ribosomal protein L28 -0.0298055
RPS8 ribosomal protein S8 -0.0290662
HMGA1 high mobility group AT-hook 1 -0.0274514
S100A6 S100 calcium binding protein A6 -0.0270707
TM4SF1 transmembrane 4 L six family member 1 -0.0267615
RPL35A ribosomal protein L35a -0.0267439
RPS6 ribosomal protein S6 -0.0257701
RPS11 ribosomal protein S11 -0.0253812
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0252571
RPS24 ribosomal protein S24 -0.025231
RPS16 ribosomal protein S16 -0.0247695
RHEB Ras homolog enriched in brain -0.024713
SRGN serglycin -0.0242525
ASTN2 astrotactin 2 -0.0238832
RPL36 ribosomal protein L36 -0.0236866
S100A9 S100 calcium binding protein A9 -0.0235426
RPS19 ribosomal protein S19 -0.0232238
LOC112694756 uncharaterized LOC112694756 -0.0231633
RPL34 ribosomal protein L34 -0.0227545
TAGLN2 transgelin 2 -0.022395
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0223715
WTAP Wilms tumor 1 associated protein -0.0215143
KLF6 Kruppel-like factor 6 -0.0214219
VIM vimentin -0.0210557
SLC38A1 solute carrier family 38, member 1 -0.0209666
ZFAND3 zinc finger, AN1-type domain 3 -0.0206064
OSBPL9 oxysterol binding protein-like 9 -0.020433
RPL32 ribosomal protein L32 -0.0204284
RPS20 ribosomal protein S20 -0.0201853
FAM168A family with sequence similarity 168, member A -0.0199148
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0198493
ZNF207 zinc finger protein 207 -0.0198351
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0194993
RPL31 ribosomal protein L31 -0.0194266
SERF2 small EDRK-rich factor 2 -0.0190187
NOP58 NOP58 ribonucleoprotein -0.018943
RPL38 ribosomal protein L38 -0.0189396
TMEM123 transmembrane protein 123 -0.0186234
RPS10 ribosomal protein S10 -0.0185928
KMT2E lysine (K)-specific methyltransferase 2E -0.0183469
MYL12B myosin, light chain 12B, regulatory -0.0181813
BTBD7 BTB (POZ) domain containing 7 -0.0180319
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0179662
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0178992
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.017883
IGFBP4 insulin-like growth factor binding protein 4 -0.0178406
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0176671
EGR1 early growth response 1 -0.0175778
C15ORF48 chromosome 15 open reading frame 48 -0.0174776
RTN4 reticulon 4 -0.0172878
RPL11 ribosomal protein L11 -0.0172656
HLA-B major histocompatibility complex, class I, B -0.0170455
PTK2 protein tyrosine kinase 2 -0.0167149
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0166735
RPS13 ribosomal protein S13 -0.016332
OLA1 Obg-like ATPase 1 -0.0160745
COTL1 coactosin-like F-actin binding protein 1 -0.0159771
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0159197
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0155975
UBC ubiquitin C -0.0155904
UPP1 uridine phosphorylase 1 -0.0155092
IST1 increased sodium tolerance 1 homolog (yeast) -0.0154088
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0153908
ZNF292 zinc finger protein 292 -0.0153306
WBP11 WW domain binding protein 11 -0.0152578
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0151062
RAB7A RAB7A, member RAS oncogene family -0.0149164
RPL39 ribosomal protein L39 -0.0148456