| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Diphenhydramine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Diphenhydramine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | 0.227841 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.155041 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0904924 |
| B2M | beta-2-microglobulin | 0.0842158 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.079069 |
| NDRG1 | N-myc downstream regulated 1 | 0.0774732 |
| LAMB3 | laminin, beta 3 | 0.0737334 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0733765 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0720817 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0716106 |
| ADAR | adenosine deaminase, RNA-specific | 0.0708078 |
| ABLIM1 | actin binding LIM protein 1 | 0.0663432 |
| FAM13A | family with sequence similarity 13, member A | 0.0631942 |
| RIGI | RNA sensor RIG-I | 0.0630123 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0628951 |
| KYNU | kynureninase | 0.057923 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0570221 |
| PRKD1 | protein kinase D1 | 0.0560848 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0542731 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0536242 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.0520818 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0516829 |
| SON | SON DNA binding protein | 0.0509522 |
| PGK1 | phosphoglycerate kinase 1 | 0.0501499 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0499505 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0499338 |
| XDH | xanthine dehydrogenase | 0.0499205 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0497339 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0494235 |
| RNF149 | ring finger protein 149 | 0.049261 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | 0.0484241 |
| LSAMP | limbic system-associated membrane protein | 0.0475475 |
| RNF213 | ring finger protein 213 | 0.0474201 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0465362 |
| RNF145 | ring finger protein 145 | 0.0465317 |
| CCNL1 | cyclin L1 | 0.0464493 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0455564 |
| SMAP1 | small ArfGAP 1 | 0.0450872 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0440998 |
| UBN2 | ubinuclein 2 | 0.0436906 |
| ATXN1 | ataxin 1 | 0.0433109 |
| NRG3 | neuregulin 3 | 0.0431746 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0431007 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0430996 |
| EHF | ets homologous factor | 0.0430333 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0428563 |
| PHF3 | PHD finger protein 3 | 0.0424697 |
| TOP1 | topoisomerase (DNA) I | 0.042179 |
| GDNF | glial cell derived neurotrophic factor | 0.0417436 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.0414452 |
| FAM120A | family with sequence similarity 120A | 0.0412262 |
| ANXA5 | annexin A5 | 0.0409964 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0407256 |
| HDAC4 | histone deacetylase 4 | 0.0407118 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.04032 |
| NHSL1 | NHS-like 1 | 0.0400171 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0393075 |
| ZFP36 | ZFP36 ring finger protein | 0.0388953 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0388327 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.038562 |
| FMN1 | formin 1 | 0.0385023 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0383568 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0383528 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0381406 |
| RBM6 | RNA binding motif protein 6 | 0.0379693 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0378309 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.0377382 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0376259 |
| IL1A | interleukin 1, alpha | 0.0373957 |
| PRELID2 | PRELI domain containing 2 | 0.0369331 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0364596 |
| PTGES2 | prostaglandin E synthase 2 | 0.0363801 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0363411 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0357003 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0356941 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0354112 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0348721 |
| DENND4A | DENN/MADD domain containing 4A | 0.0348419 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0345272 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0344675 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0344606 |
| ACTN1 | actinin, alpha 1 | 0.0343089 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0342736 |
| RFX7 | regulatory factor X, 7 | 0.0342722 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.034182 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0341203 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.034061 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0337254 |
| ELOVL7 | ELOVL fatty acid elongase 7 | 0.0335177 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0334653 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0330372 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0330146 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0323056 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0321676 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0320702 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.032037 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0319432 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.031923 |
| DUSP5 | dual specificity phosphatase 5 | 0.0318855 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0318416 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.230287 |
| FTL | ferritin, light polypeptide | -0.183887 |
| TMSB10 | thymosin beta 10 | -0.13028 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.107222 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.101698 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0967512 |
| PTMA | prothymosin, alpha | -0.0966795 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0906412 |
| SRPK2 | SRSF protein kinase 2 | -0.0888516 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0865988 |
| RPL35A | ribosomal protein L35a | -0.083518 |
| PTK2 | protein tyrosine kinase 2 | -0.0830689 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0819421 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.077143 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.070508 |
| ASPH | aspartate beta-hydroxylase | -0.0700921 |
| SVIL | supervillin | -0.0695801 |
| RPS6 | ribosomal protein S6 | -0.0674279 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0666226 |
| LMO7 | LIM domain 7 | -0.0664177 |
| S100A10 | S100 calcium binding protein A10 | -0.0651522 |
| PKM | pyruvate kinase, muscle | -0.0639279 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0635963 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0621455 |
| EZR | ezrin | -0.0618701 |
| RPS24 | ribosomal protein S24 | -0.0610379 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0601702 |
| VMP1 | vacuole membrane protein 1 | -0.0593615 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0589355 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0584963 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0576851 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0569596 |
| RPLP1 | ribosomal protein, large, P1 | -0.0566412 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0559792 |
| S100A6 | S100 calcium binding protein A6 | -0.0558411 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0548054 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0543323 |
| ANXA2 | annexin A2 | -0.0521702 |
| NPTN | neuroplastin | -0.0521052 |
| RPS19 | ribosomal protein S19 | -0.0512623 |
| VIM | vimentin | -0.0500584 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0494723 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0491752 |
| RPL31 | ribosomal protein L31 | -0.0491513 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.048261 |
| RPS4X | ribosomal protein S4, X-linked | -0.0480087 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0475285 |
| DICER1 | dicer 1, ribonuclease type III | -0.0472438 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0462132 |
| UBC | ubiquitin C | -0.0460158 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0459813 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0455543 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0445438 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0438765 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.04311 |
| IL6ST | interleukin 6 signal transducer | -0.0430606 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0424626 |
| CERS6 | ceramide synthase 6 | -0.0423716 |
| ATOSA | atos homolog A | -0.0419752 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0415006 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0414264 |
| RPL12 | ribosomal protein L12 | -0.0412612 |
| RPL23 | ribosomal protein L23 | -0.0406649 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0404382 |
| ARF1 | ADP-ribosylation factor 1 | -0.0401134 |
| CCNI | cyclin I | -0.0398134 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0393886 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0393307 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0389442 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0388106 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0386655 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.038046 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0380402 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0375362 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0375241 |
| RPS8 | ribosomal protein S8 | -0.0367656 |
| ACTG1 | actin gamma 1 | -0.036612 |
| MYO6 | myosin VI | -0.0364914 |
| RPS3 | ribosomal protein S3 | -0.0359802 |
| TAOK3 | TAO kinase 3 | -0.0358804 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0358361 |
| TMEM41B | transmembrane protein 41B | -0.0354076 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0352903 |
| ACVR1 | activin A receptor, type I | -0.035272 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0350653 |
| TMSB4X | thymosin beta 4, X-linked | -0.0346207 |
| MYO1E | myosin IE | -0.0342548 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0341021 |
| NF1 | neurofibromin 1 | -0.0340419 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0339307 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.033683 |
| SETD5 | SET domain containing 5 | -0.0334508 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0332425 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0328301 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0327614 |
| MCL1 | myeloid cell leukemia 1 | -0.0327551 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0327372 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0325003 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0324684 |
| MAP1B | microtubule-associated protein 1B | -0.0313003 |
