Diphenhydramine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diphenhydramine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.141737
FTH1 ferritin, heavy polypeptide 1 0.113523
ERRFI1 ERBB receptor feedback inhibitor 1 0.0987672
NDRG1 N-myc downstream regulated 1 0.0863023
IGFBP3 insulin-like growth factor binding protein 3 0.0820385
LAMB3 laminin, beta 3 0.0725381
NAMPT nicotinamide phosphoribosyltransferase 0.068436
LAMC2 laminin, gamma 2 0.0647866
TMSB4X thymosin beta 4, X-linked 0.0647172
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.062849
ARRDC3 arrestin domain containing 3 0.0579631
MYH9 myosin, heavy chain 9, non-muscle 0.0573945
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0510251
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0487511
CTSB cathepsin B 0.0469763
FAM13A family with sequence similarity 13, member A 0.045181
ELL2 elongation factor, RNA polymerase II, 2 0.0435602
ASPH aspartate beta-hydroxylase 0.0422423
KDM3A lysine (K)-specific demethylase 3A 0.0407561
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0381984
MSN moesin 0.0380225
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0376811
GRB10 growth factor receptor-bound protein 10 0.037548
TRIO trio Rho guanine nucleotide exchange factor 0.0364191
TOP1 topoisomerase (DNA) I 0.0359145
LMO7 LIM domain 7 0.0355424
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0333698
DSPP dentin sialophosphoprotein 0.033069
TSC22D2 TSC22 domain family, member 2 0.0319403
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0317314
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0311312
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0305543
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0304888
UBA6 ubiquitin-like modifier activating enzyme 6 0.0295907
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0293416
SFTPA2 surfactant protein A2 0.0283896
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0278584
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0277558
AHNAK2 AHNAK nucleoprotein 2 0.0268497
NRIP1 nuclear receptor interacting protein 1 0.0265254
VEGFA vascular endothelial growth factor A 0.0264816
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0262334
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0255742
EZR ezrin 0.0255006
ADAR adenosine deaminase, RNA-specific 0.025009
PLEC plectin 0.0249375
RNF145 ring finger protein 145 0.0249306
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0247959
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0242997
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0242565
MKI67 marker of proliferation Ki-67 0.0240891
MCTP2 multiple C2 domains, transmembrane 2 0.0239763
H1-0 H1.0 linker histone 0.0231993
ARHGAP29 Rho GTPase activating protein 29 0.0228876
SLTM SAFB-like, transcription modulator 0.0223454
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0208053
ZFP36L1 ZFP36 ring finger protein-like 1 0.0197585
BZW1 basic leucine zipper and W2 domains 1 0.0196952
TPR translocated promoter region, nuclear basket protein 0.0196148
TXNIP thioredoxin interacting protein 0.0194266
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.0190459
ESYT2 extended synaptotagmin-like protein 2 0.0187986
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0186
CD46 CD46 molecule, complement regulatory protein 0.0182763
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0182109
HP1BP3 heterochromatin protein 1, binding protein 3 0.017923
FLNA filamin A, alpha 0.0178319
MSMO1 methylsterol monooxygenase 1 0.0171191
PGK1 phosphoglycerate kinase 1 0.0170983
MATR3 matrin 3 0.0170944
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0170886
LAMA4 laminin, alpha 4 0.0169295
RAD23B RAD23 homolog B (S. cerevisiae) 0.0166532
TOP2B topoisomerase (DNA) II beta 180kDa 0.0164821
KLF7 Kruppel-like factor 7 (ubiquitous) 0.016394
CLIC1 chloride intracellular channel 1 0.0163106
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0162407
ANXA5 annexin A5 0.0162366
PRELID2 PRELI domain containing 2 0.0162027
DUSP10 dual specificity phosphatase 10 0.016194
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0161833
HOOK2 hook microtubule-tethering protein 2 0.0161087
MIER1 mesoderm induction early response 1, transcriptional regulator 0.015953
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0156241
TES testin LIM domain protein 0.0155993
RPS3A ribosomal protein S3A 0.0155349
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0155251
FHIT fragile histidine triad 0.0155094
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0154351
EREG epiregulin 0.01538
FNDC3B fibronectin type III domain containing 3B 0.0153326
KDM1A lysine (K)-specific demethylase 1A 0.0152104
BHLHE40 basic helix-loop-helix family, member e40 0.0151396
TFG TRK-fused gene 0.0149305
FAM3C family with sequence similarity 3, member C 0.0147835
ARHGAP10 Rho GTPase activating protein 10 0.0147386
CENPF centromere protein F, 350/400kDa 0.0146659
CCNY cyclin Y 0.0145525
RBM39 RNA binding motif protein 39 0.0144906
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.01446

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.268721
FTL ferritin, light polypeptide -0.156547
POTEF POTE ankyrin domain family, member F -0.142654
PTMA prothymosin, alpha -0.139188
TMSB10 thymosin beta 10 -0.131907
ACTG1 actin gamma 1 -0.120065
UBC ubiquitin C -0.113796
ZSWIM6 zinc finger, SWIM-type containing 6 -0.103396
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.101882
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0979186
S100A6 S100 calcium binding protein A6 -0.0800149
SAMD4A sterile alpha motif domain containing 4A -0.0709317
EXT1 exostosin glycosyltransferase 1 -0.0698309
TPT1 tumor protein, translationally-controlled 1 -0.0574622
HMGA1 high mobility group AT-hook 1 -0.0573507
RPS13 ribosomal protein S13 -0.0566571
LPP LIM domain containing preferred translocation partner in lipoma -0.0550997
RPL8 ribosomal protein L8 -0.0550312
RPL34 ribosomal protein L34 -0.0548053
RPL23 ribosomal protein L23 -0.0542523
RPLP1 ribosomal protein, large, P1 -0.052975
RPS8 ribosomal protein S8 -0.0527142
RPS27A ribosomal protein S27a -0.0520346
RPS3 ribosomal protein S3 -0.0488768
S100A10 S100 calcium binding protein A10 -0.0485602
RAB7A RAB7A, member RAS oncogene family -0.0482283
RPS23 ribosomal protein S23 -0.046124
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0458904
GNAS GNAS complex locus -0.0456982
RPLP0 ribosomal protein, large, P0 -0.0444632
ALCAM activated leukocyte cell adhesion molecule -0.0439854
RPS29 ribosomal protein S29 -0.0436761
RPLP2 ribosomal protein, large, P2 -0.0433988
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0421795
CCND1 cyclin D1 -0.0418697
ANKRD17 ankyrin repeat domain 17 -0.0404723
RPL9 ribosomal protein L9 -0.0403272
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0395266
VCL vinculin -0.0394877
PDLIM5 PDZ and LIM domain 5 -0.0394184
WASF2 WAS protein family, member 2 -0.0390506
ZFAND3 zinc finger, AN1-type domain 3 -0.0390313
EIF1 eukaryotic translation initiation factor 1 -0.0386599
RPL5 ribosomal protein L5 -0.0368826
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0358074
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0355697
VIM vimentin -0.035469
RPL35A ribosomal protein L35a -0.0353521
RPS25 ribosomal protein S25 -0.0353075
RPL19 ribosomal protein L19 -0.0351941
SEC31A SEC31 homolog A (S. cerevisiae) -0.0348363
RPL27A ribosomal protein L27a -0.0347296
ARHGAP20 Rho GTPase activating protein 20 -0.0346413
CDK13 cyclin-dependent kinase 13 -0.0345198
PKM pyruvate kinase, muscle -0.0341317
FBXO32 F-box protein 32 -0.0339436
RPL32 ribosomal protein L32 -0.033883
CCNI cyclin I -0.0338006
PALLD palladin, cytoskeletal associated protein -0.0330997
RPL28 ribosomal protein L28 -0.0329938
SLC38A1 solute carrier family 38, member 1 -0.0329325
MYO1E myosin IE -0.0327154
DTNA dystrobrevin, alpha -0.0326724
RPS6 ribosomal protein S6 -0.0322797
ERBIN erbb2 interacting protein -0.0322335
RPL15 ribosomal protein L15 -0.0321049
INTS6 integrator complex subunit 6 -0.0317536
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0315443
RHOA ras homolog family member A -0.0313733
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0313509
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0312801
RPL31 ribosomal protein L31 -0.0311883
USP53 ubiquitin specific peptidase 53 -0.0311412
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0310751
TM4SF1 transmembrane 4 L six family member 1 -0.030812
MCL1 myeloid cell leukemia 1 -0.0303356
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.030151
BLZF1 basic leucine zipper nuclear factor 1 -0.0301373
CTSD cathepsin D -0.0300093
RPS19 ribosomal protein S19 -0.0299469
ARF4 ADP-ribosylation factor 4 -0.0298794
RPL37A ribosomal protein L37a -0.0298691
LOC112694756 uncharaterized LOC112694756 -0.0298211
ZNF207 zinc finger protein 207 -0.0296458
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0295074
RPS10 ribosomal protein S10 -0.0295004
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0294905
TTC3 tetratricopeptide repeat domain 3 -0.0292204
KRT7 keratin 7, type II -0.0291912
FNIP1 folliculin interacting protein 1 -0.0288786
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0288443
FBXO34 F-box protein 34 -0.0288279
CALR calreticulin -0.0286655
RPS12 ribosomal protein S12 -0.0286626
EGR1 early growth response 1 -0.0284009
UBE2H ubiquitin-conjugating enzyme E2H -0.02782
RPS5 ribosomal protein S5 -0.0278185
MED13 mediator complex subunit 13 -0.027603
OCLN occludin -0.0274746
RAB5A RAB5A, member RAS oncogene family -0.0274645