| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Diphenhydramine perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Diphenhydramine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.171655 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.165627 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.147443 |
| FN1 | fibronectin 1 | 0.143673 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.126983 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110573 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.110039 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.109214 |
| PGK1 | phosphoglycerate kinase 1 | 0.0760163 |
| CANX | calnexin | 0.0746349 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0743735 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0735523 |
| EFNA5 | ephrin-A5 | 0.0720433 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0654985 |
| PTMA | prothymosin, alpha | 0.0646807 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.062601 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0597819 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0592309 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0591104 |
| MYOF | myoferlin | 0.0587343 |
| PM20D1 | peptidase M20 domain containing 1 | 0.058045 |
| B2M | beta-2-microglobulin | 0.0574923 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0572964 |
| COL5A2 | collagen, type V, alpha 2 | 0.0568602 |
| CENPF | centromere protein F, 350/400kDa | 0.0549307 |
| FAM13A | family with sequence similarity 13, member A | 0.0497212 |
| RPS2 | ribosomal protein S2 | 0.0496788 |
| RGS2 | regulator of G-protein signaling 2 | 0.0494049 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0491252 |
| MKI67 | marker of proliferation Ki-67 | 0.0473728 |
| ENO1 | enolase 1, (alpha) | 0.0469196 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0459555 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0456604 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0456033 |
| ANXA1 | annexin A1 | 0.0455231 |
| TMSB4X | thymosin beta 4, X-linked | 0.0450038 |
| SFTPA2 | surfactant protein A2 | 0.0437926 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0434425 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0422815 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0422198 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0420319 |
| LDHA | lactate dehydrogenase A | 0.0418181 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0415858 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0394726 |
| PCBP2 | poly(rC) binding protein 2 | 0.0391871 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.038486 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0380068 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0378672 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0371502 |
| INHBA | inhibin, beta A | 0.0363939 |
| RPL26 | ribosomal protein L26 | 0.0359778 |
| RACK1 | receptor for activated C kinase 1 | 0.0354991 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0354753 |
| NRCAM | neuronal cell adhesion molecule | 0.0353725 |
| RPS6 | ribosomal protein S6 | 0.0352077 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.035158 |
| TPI1 | triosephosphate isomerase 1 | 0.0348499 |
| PRELID2 | PRELI domain containing 2 | 0.0347971 |
| RPS3 | ribosomal protein S3 | 0.0344276 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0340891 |
| CUL4B | cullin 4B | 0.0335611 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0334794 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0334548 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.033384 |
| CTSL | cathepsin L | 0.0332349 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0331765 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0331604 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0327472 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0325081 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0323562 |
| SET | SET nuclear proto-oncogene | 0.0314322 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0305735 |
| BDNF | brain-derived neurotrophic factor | 0.0302735 |
| TPM3 | tropomyosin 3 | 0.0301591 |
| RPL37A | ribosomal protein L37a | 0.0300148 |
| RRBP1 | ribosome binding protein 1 | 0.0294801 |
| VIM | vimentin | 0.0290303 |
| STC1 | stanniocalcin 1 | 0.0288509 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.028831 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0287858 |
| RPS12 | ribosomal protein S12 | 0.0287183 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0283727 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0283488 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0282303 |
| FTL | ferritin, light polypeptide | 0.0274921 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0273796 |
| RAI1 | retinoic acid induced 1 | 0.0272438 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0265645 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0264289 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0263711 |
| GRAMD1B | GRAM domain containing 1B | 0.0260417 |
| TPR | translocated promoter region, nuclear basket protein | 0.0259197 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0259098 |
| CALR | calreticulin | 0.0256739 |
| RPL11 | ribosomal protein L11 | 0.0256404 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0255629 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0255439 |
| ZNF292 | zinc finger protein 292 | 0.02527 |
| PRRC2C | proline-rich coiled-coil 2C | 0.025054 |
| ARRDC3 | arrestin domain containing 3 | 0.025036 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.179733 |
| GDA | guanine deaminase | -0.139586 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.135927 |
| PDLIM5 | PDZ and LIM domain 5 | -0.128473 |
| KYNU | kynureninase | -0.0824006 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0703989 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0608767 |
| VCL | vinculin | -0.05842 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0579028 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0486064 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0485624 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0483276 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0449424 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0431061 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0428894 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0417444 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0414674 |
| UBC | ubiquitin C | -0.0413937 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0408638 |
| SMAD2 | SMAD family member 2 | -0.0406833 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0404376 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0403076 |
| FMNL2 | formin-like 2 | -0.0390098 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0389762 |
| NTN4 | netrin 4 | -0.0383225 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0382105 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0356927 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.034404 |
| JMJD1C | jumonji domain containing 1C | -0.0337968 |
| CDH13 | cadherin 13 | -0.033011 |
| ENAH | enabled homolog (Drosophila) | -0.0320545 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0320323 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0318584 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0317578 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0306369 |
| DST | dystonin | -0.0305053 |
| AUTS2 | autism susceptibility candidate 2 | -0.0300675 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0298594 |
| SMYD3 | SET and MYND domain containing 3 | -0.0296195 |
| INTS6 | integrator complex subunit 6 | -0.029035 |
| RTN1 | reticulon 1 | -0.0280578 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0279042 |
| VMP1 | vacuole membrane protein 1 | -0.0276718 |
| NABP1 | nucleic acid binding protein 1 | -0.0274018 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0271175 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0270994 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0267434 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0266828 |
| PTEN | phosphatase and tensin homolog | -0.0259749 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0258939 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0253254 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0251856 |
| RHEB | Ras homolog enriched in brain | -0.0250325 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0248765 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0243913 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0243671 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0243629 |
| FOXK1 | forkhead box K1 | -0.0242922 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0241267 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0240755 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0240486 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0233414 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0230664 |
| ZNF644 | zinc finger protein 644 | -0.0229881 |
| RTN4 | reticulon 4 | -0.0228443 |
| MYPN | myopalladin | -0.0225747 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0224174 |
| ATXN1 | ataxin 1 | -0.02196 |
| AOPEP | aminopeptidase O (putative) | -0.021947 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0218043 |
| PTK2 | protein tyrosine kinase 2 | -0.0216743 |
| BMERB1 | bMERB domain containing 1 | -0.0214975 |
| RAB31 | RAB31, member RAS oncogene family | -0.0212644 |
| STEAP1B | STEAP family member 1B | -0.0211107 |
| SRPK2 | SRSF protein kinase 2 | -0.0211006 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0210667 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.020747 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0206076 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.020594 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0205643 |
| RASAL2 | RAS protein activator like 2 | -0.0204876 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0204736 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0204614 |
| ANKRD17 | ankyrin repeat domain 17 | -0.020101 |
| USP53 | ubiquitin specific peptidase 53 | -0.0199861 |
| ACTN4 | actinin, alpha 4 | -0.0198173 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0193124 |
| RAB10 | RAB10, member RAS oncogene family | -0.0190391 |
| TUSC3 | tumor suppressor candidate 3 | -0.0190057 |
| CUX1 | cut-like homeobox 1 | -0.0188543 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0187873 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0185264 |
| GLCCI1 | glucocorticoid induced 1 | -0.0182536 |
| BMP6 | bone morphogenetic protein 6 | -0.0181905 |
| USP3 | ubiquitin specific peptidase 3 | -0.018178 |
| MCL1 | myeloid cell leukemia 1 | -0.0181612 |
| ZNF207 | zinc finger protein 207 | -0.0180872 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0180734 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0180091 |
| PUM2 | pumilio RNA-binding family member 2 | -0.01798 |
