Diphenhydramine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diphenhydramine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.342732
TMSB4X thymosin beta 4, X-linked 0.16677
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.127554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.119622
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105351
EEF2 eukaryotic translation elongation factor 2 0.100274
ENO1 enolase 1, (alpha) 0.0933707
RPS8 ribosomal protein S8 0.0852896
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0818282
EZR ezrin 0.0777736
GOLGA4 golgin A4 0.0772895
MKI67 marker of proliferation Ki-67 0.0729818
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0723739
SRRM2 serine/arginine repetitive matrix 2 0.0709657
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0685542
PCBP2 poly(rC) binding protein 2 0.0681506
ENO2 enolase 2 (gamma, neuronal) 0.0654967
CENPF centromere protein F, 350/400kDa 0.0644655
RPS2 ribosomal protein S2 0.0626883
TXNIP thioredoxin interacting protein 0.0603186
RPS6 ribosomal protein S6 0.0602567
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0570499
RPL37A ribosomal protein L37a 0.0569362
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0563895
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0554229
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0539116
ANKRD12 ankyrin repeat domain 12 0.0523797
PGK1 phosphoglycerate kinase 1 0.0510756
SET SET nuclear proto-oncogene 0.0501048
RPS3 ribosomal protein S3 0.0491917
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0490193
KTN1 kinectin 1 (kinesin receptor) 0.0484087
TPM4 tropomyosin 4 0.0483614
RPL26 ribosomal protein L26 0.0482043
SMC3 structural maintenance of chromosomes 3 0.0470019
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.045806
RPS12 ribosomal protein S12 0.0435939
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0421333
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0419758
ANXA1 annexin A1 0.0416611
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0413931
RPL12 ribosomal protein L12 0.0412809
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.041207
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0410855
KIF5B kinesin family member 5B 0.0395896
RPL35A ribosomal protein L35a 0.0394622
SOX6 SRY (sex determining region Y)-box 6 0.0379182
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0375112
RPL3 ribosomal protein L3 0.0371784
HDGF hepatoma-derived growth factor 0.0366059
B2M beta-2-microglobulin 0.0364864
LDHA lactate dehydrogenase A 0.0364296
ATF4 activating transcription factor 4 0.0364046
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0363679
TPI1 triosephosphate isomerase 1 0.0352466
BRD2 bromodomain containing 2 0.0343721
RPL31 ribosomal protein L31 0.0337744
TMF1 TATA element modulatory factor 1 0.0331786
RACK1 receptor for activated C kinase 1 0.0331297
ERRFI1 ERBB receptor feedback inhibitor 1 0.0328262
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0325689
HILPDA hypoxia inducible lipid droplet-associated 0.0313024
CSF1 colony stimulating factor 1 (macrophage) 0.0309975
EVI5 ecotropic viral integration site 5 0.030846
ANKRD36 ankyrin repeat domain 36 0.03006
SMC4 structural maintenance of chromosomes 4 0.0300267
XPO1 exportin 1 0.0298838
EIF4B eukaryotic translation initiation factor 4B 0.0296249
POTEF POTE ankyrin domain family, member F 0.0290316
RPS17 ribosomal protein S17 0.0289718
INSIG2 insulin induced gene 2 0.0287589
MATR3 matrin 3 0.0285068
RPS19 ribosomal protein S19 0.0281624
HJURP Holliday junction recognition protein 0.0281026
YBX1 Y box binding protein 1 0.0278528
SBF2 SET binding factor 2 0.0277554
FAM13A family with sequence similarity 13, member A 0.0276416
ARL4C ADP-ribosylation factor-like 4C 0.0273954
DIAPH3 diaphanous-related formin 3 0.0273916
PDE4B phosphodiesterase 4B, cAMP-specific 0.0273736
RPLP1 ribosomal protein, large, P1 0.0272064
RNMT RNA (guanine-7-) methyltransferase 0.0269636
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0266839
EEF1G eukaryotic translation elongation factor 1 gamma 0.0266042
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0264833
RPL11 ribosomal protein L11 0.0264197
AMOTL2 angiomotin like 2 0.0264188
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262481
PRELID2 PRELI domain containing 2 0.0261259
ANKRD36B ankyrin repeat domain 36B 0.0261229
PFN1 profilin 1 0.0260159
CKAP2 cytoskeleton associated protein 2 0.0258279
SFTPA2 surfactant protein A2 0.0256338
ZNF292 zinc finger protein 292 0.025539
TPR translocated promoter region, nuclear basket protein 0.0254409
SRSF11 serine/arginine-rich splicing factor 11 0.0253094
CD47 CD47 molecule 0.025193
RPL7 ribosomal protein L7 0.0250716
MYOF myoferlin 0.0250334
EGLN1 egl-9 family hypoxia-inducible factor 1 0.024897

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.160054
VCL vinculin -0.0969062
EGFR epidermal growth factor receptor -0.0942658
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.092182
FOXP1 forkhead box P1 -0.0868481
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0832065
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0754163
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0638184
ZFAND3 zinc finger, AN1-type domain 3 -0.0555717
PYGB phosphorylase, glycogen; brain -0.0507308
OSMR oncostatin M receptor -0.0483614
GLI3 GLI family zinc finger 3 -0.0457816
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0450395
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0450218
ZBTB20 zinc finger and BTB domain containing 20 -0.043991
DOCK3 dedicator of cytokinesis 3 -0.0420741
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0400032
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0395265
ZMYND8 zinc finger, MYND-type containing 8 -0.0388588
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0377989
PARD3 par-3 family cell polarity regulator -0.0375354
RIGI RNA sensor RIG-I -0.0371745
ADNP activity-dependent neuroprotector homeobox -0.0369008
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0355109
TAS2R14 taste receptor, type 2, member 14 -0.0354595
IARS1 isoleucyl-tRNA synthetase 1 -0.0354357
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.035374
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.035193
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0348222
ANKRD11 ankyrin repeat domain 11 -0.034392
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0338681
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0329549
ANK2 ankyrin 2, neuronal -0.0328123
TBC1D5 TBC1 domain family, member 5 -0.0317592
GARS1 glycyl-tRNA synthetase 1 -0.0311443
PKM pyruvate kinase, muscle -0.0310498
MLIP muscular LMNA-interacting protein -0.0307671
NF1 neurofibromin 1 -0.0306751
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0306256
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0300607
NBEA neurobeachin -0.0299639
ANKRD17 ankyrin repeat domain 17 -0.0297928
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.029786
SMYD3 SET and MYND domain containing 3 -0.0291841
PHF14 PHD finger protein 14 -0.0291481
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0290038
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.028302
SPIDR scaffolding protein involved in DNA repair -0.0281907
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0277281
PARD3B par-3 family cell polarity regulator beta -0.027333
TSC22D1 TSC22 domain family, member 1 -0.0266801
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0265799
LOC112694756 uncharaterized LOC112694756 -0.0265257
CUX1 cut-like homeobox 1 -0.0263428
NT5C2 5'-nucleotidase, cytosolic II -0.0263095
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0261861
EXOC4 exocyst complex component 4 -0.0261746
RTN4 reticulon 4 -0.0259391
TCF12 transcription factor 12 -0.0255978
GLI2 GLI family zinc finger 2 -0.0255968
ANKRD10 ankyrin repeat domain 10 -0.0252443
NPAS2 neuronal PAS domain protein 2 -0.0249861
STAU2 staufen double-stranded RNA binding protein 2 -0.024977
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 -0.0248823
HDLBP high density lipoprotein binding protein -0.0246729
RBM39 RNA binding motif protein 39 -0.0244476
ZNF644 zinc finger protein 644 -0.0240538
FER fer (fps/fes related) tyrosine kinase -0.0240413
EXT1 exostosin glycosyltransferase 1 -0.0240391
PTPRG protein tyrosine phosphatase, receptor type, G -0.0239436
PTK2 protein tyrosine kinase 2 -0.0238831
PRUNE2 prune homolog 2 (Drosophila) -0.0236893
USP34 ubiquitin specific peptidase 34 -0.0232935
MYO5C myosin VC -0.0231424
MTAP methylthioadenosine phosphorylase -0.0230836
AHI1 Abelson helper integration site 1 -0.0229562
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0226137
BBS9 Bardet-Biedl syndrome 9 -0.0225314
BCAS3 breast carcinoma amplified sequence 3 -0.0224966
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0223293
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0223151
ZNF438 zinc finger protein 438 -0.022261
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0222307
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0219115
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.021588
EXOC6B exocyst complex component 6B -0.0210349
DGKH diacylglycerol kinase, eta -0.021017
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0208882
HEG1 heart development protein with EGF-like domains 1 -0.0205802
ADAM10 ADAM metallopeptidase domain 10 -0.0205063
COG5 component of oligomeric golgi complex 5 -0.0202742
GSK3B glycogen synthase kinase 3 beta -0.020093
LRRC7 leucine rich repeat containing 7 -0.0200032
PKP4 plakophilin 4 -0.0199741
WARS1 tryptophanyl-tRNA synthetase 1 -0.0198921
MEIS2 Meis homeobox 2 -0.0198563
CDK13 cyclin-dependent kinase 13 -0.0198176
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0196269
AHNAK AHNAK nucleoprotein -0.0193757
BPTF bromodomain PHD finger transcription factor -0.0193723