Diphenhydramine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diphenhydramine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.180579
COL6A3 collagen, type VI, alpha 3 0.157745
ERRFI1 ERBB receptor feedback inhibitor 1 0.126768
ELL2 elongation factor, RNA polymerase II, 2 0.0801432
ARRDC3 arrestin domain containing 3 0.0779133
NAMPT nicotinamide phosphoribosyltransferase 0.0635401
MYH9 myosin, heavy chain 9, non-muscle 0.0529004
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0520917
ATP13A3 ATPase type 13A3 0.0518763
FLNA filamin A, alpha 0.050927
FAM13A family with sequence similarity 13, member A 0.0468114
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0440107
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0432967
CTSB cathepsin B 0.0428226
COL5A1 collagen, type V, alpha 1 0.0393666
ZMIZ1 zinc finger, MIZ-type containing 1 0.0353495
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0342367
CXCL8 chemokine (C-X-C motif) ligand 8 0.0320834
PTBP2 polypyrimidine tract binding protein 2 0.0315434
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0307767
KMT2E lysine (K)-specific methyltransferase 2E 0.0302512
TRA2A transformer 2 alpha homolog (Drosophila) 0.029679
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0294213
HOOK2 hook microtubule-tethering protein 2 0.0294058
C1D C1D nuclear receptor corepressor 0.0292779
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0291899
SHB Src homology 2 domain containing adaptor protein B 0.0287991
JARID2 jumonji, AT rich interactive domain 2 0.0276183
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0272871
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0267763
BHLHE40 basic helix-loop-helix family, member e40 0.0265484
RNF145 ring finger protein 145 0.0265198
TLN1 talin 1 0.0263342
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.02619
TMSB4X thymosin beta 4, X-linked 0.0261056
SDK1 sidekick cell adhesion molecule 1 0.0258102
ANXA5 annexin A5 0.0254192
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.025416
SMYD3 SET and MYND domain containing 3 0.024782
NRXN3 neurexin 3 0.0247217
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0244653
RASA3 RAS p21 protein activator 3 0.0244281
COG5 component of oligomeric golgi complex 5 0.0244111
TNIP1 TNFAIP3 interacting protein 1 0.0242212
ANO6 anoctamin 6 0.0241519
TPST1 tyrosylprotein sulfotransferase 1 0.0239111
RBM33 RNA binding motif protein 33 0.0236827
LAMB1 laminin, beta 1 0.0234893
CALCOCO2 calcium binding and coiled-coil domain 2 0.0232949
PUM1 pumilio RNA-binding family member 1 0.0231027
SPTBN1 spectrin, beta, non-erythrocytic 1 0.02294
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0225991
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0224858
OGA O-GlcNAcase 0.0222801
SETD5 SET domain containing 5 0.0222676
PUM2 pumilio RNA-binding family member 2 0.0220554
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0218062
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0216062
ANLN anillin, actin binding protein 0.0215495
AVL9 AVL9 homolog (S. cerevisiase) 0.0213936
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0213872
ANKRD17 ankyrin repeat domain 17 0.0212546
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0210826
PGM3 phosphoglucomutase 3 0.0209404
KDM3A lysine (K)-specific demethylase 3A 0.0208867
CD44 CD44 molecule (Indian blood group) 0.0208609
KIDINS220 kinase D-interacting substrate, 220kDa 0.0208281
RPS2 ribosomal protein S2 0.0206504
ANKRD36 ankyrin repeat domain 36 0.0205469
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0205421
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0205411
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0204027
GARS1 glycyl-tRNA synthetase 1 0.0203506
YTHDC1 YTH domain containing 1 0.0203471
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0201533
MSN moesin 0.0201158
ATP11B ATPase, class VI, type 11B 0.020049
SFTPA2 surfactant protein A2 0.019873
BCAR1 breast cancer anti-estrogen resistance 1 0.0197239
FCHO2 FCH domain only 2 0.0196803
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0196062
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0194313
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0193873
MARCHF6 membrane associated ring-CH-type finger 6 0.0193784
YEATS2 YEATS domain containing 2 0.019319
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.018938
MTREX Mtr4 exosome RNA helicase 0.0188256
PLEC plectin 0.0186693
SNX25 sorting nexin 25 0.018514
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0184817
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0182966
VCAM1 vascular cell adhesion molecule 1 0.018295
SET SET nuclear proto-oncogene 0.0182745
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0182153
TRIM44 tripartite motif containing 44 0.0181609
POM121 POM121 transmembrane nucleoporin 0.0181452
NCOA3 nuclear receptor coactivator 3 0.0181328
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0179608
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0178883
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0178865

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.383666
MT2A metallothionein 2A -0.161627
VIM vimentin -0.158678
HLA-B major histocompatibility complex, class I, B -0.145848
TMSB10 thymosin beta 10 -0.14278
TGFBI transforming growth factor, beta-induced, 68kDa -0.113599
B2M beta-2-microglobulin -0.103272
FN1 fibronectin 1 -0.102639
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0837647
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0774735
LOX lysyl oxidase -0.0708106
ENO1 enolase 1, (alpha) -0.067059
TPT1 tumor protein, translationally-controlled 1 -0.0666506
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0635584
IGFBP3 insulin-like growth factor binding protein 3 -0.0631077
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0597999
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0579896
ACTG1 actin gamma 1 -0.0574474
CCNI cyclin I -0.0510378
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0509835
TPM4 tropomyosin 4 -0.0489531
POTEF POTE ankyrin domain family, member F -0.0464974
SEC31A SEC31 homolog A (S. cerevisiae) -0.0462965
PRSS23 protease, serine, 23 -0.0460332
ASPH aspartate beta-hydroxylase -0.0445162
P4HB prolyl 4-hydroxylase, beta polypeptide -0.043964
ZMYND8 zinc finger, MYND-type containing 8 -0.0432944
RAI14 retinoic acid induced 14 -0.0428604
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0418975
AKAP12 A kinase (PRKA) anchor protein 12 -0.0407885
COL1A2 collagen, type I, alpha 2 -0.0406867
VCL vinculin -0.0402134
CALU calumenin -0.0398486
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0384683
MAP1B microtubule-associated protein 1B -0.0382719
ADAM9 ADAM metallopeptidase domain 9 -0.0378164
FBXO11 F-box protein 11 -0.036853
CBX3 chromobox homolog 3 -0.0365893
S100A6 S100 calcium binding protein A6 -0.0362771
EGR1 early growth response 1 -0.0353874
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0351479
F3 coagulation factor III (thromboplastin, tissue factor) -0.0350939
ANKRD12 ankyrin repeat domain 12 -0.0345732
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0342017
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0339771
HLA-C major histocompatibility complex, class I, C -0.0339471
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0339193
RPS6 ribosomal protein S6 -0.0337966
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.033573
PTMA prothymosin, alpha -0.0323322
RPLP1 ribosomal protein, large, P1 -0.0320136
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.031959
RPL36 ribosomal protein L36 -0.0319327
PDLIM5 PDZ and LIM domain 5 -0.0318061
PKM pyruvate kinase, muscle -0.0313687
NBEAL1 neurobeachin-like 1 -0.0312735
SDC4 syndecan 4 -0.0307416
UBC ubiquitin C -0.0306751
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0306393
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0300108
HIP1 huntingtin interacting protein 1 -0.0299628
GNAS GNAS complex locus -0.0297504
CLIC4 chloride intracellular channel 4 -0.0294954
SPAG9 sperm associated antigen 9 -0.0293692
RAP1B RAP1B, member of RAS oncogene family -0.0291419
NUCB2 nucleobindin 2 -0.0290563
PDE10A phosphodiesterase 10A -0.0290563
RPL19 ribosomal protein L19 -0.0290291
QKI QKI, KH domain containing, RNA binding -0.0288722
TCF12 transcription factor 12 -0.0285936
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.028484
FTL ferritin, light polypeptide -0.0279808
GPC6 glypican 6 -0.0277472
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.027423
WAC WW domain containing adaptor with coiled-coil -0.0273748
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0273515
S100A9 S100 calcium binding protein A9 -0.0272575
RPL11 ribosomal protein L11 -0.0271269
RPS16 ribosomal protein S16 -0.0270476
IL6 interleukin 6 -0.0268395
BBX bobby sox homolog (Drosophila) -0.0267762
RPL7A ribosomal protein L7a -0.0265571
TAGLN2 transgelin 2 -0.0265162
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0265106
PI3 peptidase inhibitor 3, skin-derived -0.0264901
S100A10 S100 calcium binding protein A10 -0.02634
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0260908
PFN1 profilin 1 -0.025949
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0259375
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0256637
ZFAND3 zinc finger, AN1-type domain 3 -0.0255251
CLTC clathrin, heavy chain (Hc) -0.0254152
BSG basigin (Ok blood group) -0.0254018
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.025382
PDIA3 protein disulfide isomerase family A, member 3 -0.0253396
KTN1 kinectin 1 (kinesin receptor) -0.0252227
WDR45B WD repeat domain 45B -0.0251506
ADAM10 ADAM metallopeptidase domain 10 -0.024981
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0247448
ARF4 ADP-ribosylation factor 4 -0.024625