Diphenhydramine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diphenhydramine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.117158
TOP2A topoisomerase (DNA) II alpha 170kDa 0.104301
VIM vimentin 0.0998117
FTH1 ferritin, heavy polypeptide 1 0.0802179
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0774223
TPX2 TPX2, microtubule-associated 0.0765948
NAMPT nicotinamide phosphoribosyltransferase 0.0707387
YAP1 Yes-associated protein 1 0.0701071
ANKRD28 ankyrin repeat domain 28 0.0696489
SMC4 structural maintenance of chromosomes 4 0.0694362
MKI67 marker of proliferation Ki-67 0.0689242
CENPF centromere protein F, 350/400kDa 0.0685417
CD44 CD44 molecule (Indian blood group) 0.0681788
CEP250 centrosomal protein 250kDa 0.062309
ZNF292 zinc finger protein 292 0.061699
IGFBP3 insulin-like growth factor binding protein 3 0.0614678
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.061188
TXNRD1 thioredoxin reductase 1 0.0610449
CHD1 chromodomain helicase DNA binding protein 1 0.0597297
KIF5B kinesin family member 5B 0.0592784
BASP1 brain abundant, membrane attached signal protein 1 0.0591863
ERRFI1 ERBB receptor feedback inhibitor 1 0.05297
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.052957
RBM39 RNA binding motif protein 39 0.0511761
ANLN anillin, actin binding protein 0.0498822
PDE4D phosphodiesterase 4D, cAMP-specific 0.0491534
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477636
CKAP2 cytoskeleton associated protein 2 0.047018
CSNK1A1 casein kinase 1, alpha 1 0.0464436
MYH9 myosin, heavy chain 9, non-muscle 0.0457991
DGKD diacylglycerol kinase, delta 130kDa 0.0437137
YBX3 Y box binding protein 3 0.0433159
ECT2 epithelial cell transforming 2 0.0417401
SGO2 shugoshin 2 0.0416619
THSD4 thrombospondin, type I, domain containing 4 0.0408354
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0401164
XPO1 exportin 1 0.0400154
TBC1D5 TBC1 domain family, member 5 0.0397576
MATR3 matrin 3 0.0397399
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0394492
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0390796
CKAP5 cytoskeleton associated protein 5 0.0390149
MIS18BP1 MIS18 binding protein 1 0.0389757
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385814
GOLGA4 golgin A4 0.0384918
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0375197
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0367679
TOP2B topoisomerase (DNA) II beta 180kDa 0.0361172
STK24 serine/threonine kinase 24 0.0360897
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0354639
KIAA1958 KIAA1958 0.0354508
KIAA1328 KIAA1328 0.0350456
DIAPH3 diaphanous-related formin 3 0.0348913
NAV2 neuron navigator 2 0.034722
ANKRD36 ankyrin repeat domain 36 0.034433
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0336895
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0332723
ELL2 elongation factor, RNA polymerase II, 2 0.0329622
EEF2 eukaryotic translation elongation factor 2 0.0326724
HJURP Holliday junction recognition protein 0.0322938
KIF23 kinesin family member 23 0.0322586
CAPRIN1 cell cycle associated protein 1 0.0321573
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0319806
SETD5 SET domain containing 5 0.0318293
PDE8A phosphodiesterase 8A 0.03174
KIF4A kinesin family member 4A 0.0317002
NCAPD2 non-SMC condensin I complex, subunit D2 0.0312462
SP3 Sp3 transcription factor 0.0308476
RNF145 ring finger protein 145 0.0308452
PTMS parathymosin 0.0303711
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.029826
SSR1 signal sequence receptor, alpha 0.0296938
NCOR1 nuclear receptor corepressor 1 0.0294837
SYNE2 spectrin repeat containing, nuclear envelope 2 0.02933
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0289535
SPAG9 sperm associated antigen 9 0.0288383
SEPTIN7 septin 7 0.0285752
ARHGAP21 Rho GTPase activating protein 21 0.0283231
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0280731
PRKCE protein kinase C, epsilon 0.0279499
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0278748
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0278045
CANX calnexin 0.0277996
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.0271189
WDPCP WD repeat containing planar cell polarity effector 0.0270322
NUCB2 nucleobindin 2 0.0268559
HILPDA hypoxia inducible lipid droplet-associated 0.0267405
ATRN attractin 0.0266396
SET SET nuclear proto-oncogene 0.0265779
BIRC2 baculoviral IAP repeat containing 2 0.0264738
BCLAF1 BCL2-associated transcription factor 1 0.0264692
CNTRL centriolin 0.0264408
SRSF11 serine/arginine-rich splicing factor 11 0.0263467
MBNL1 muscleblind-like splicing regulator 1 0.0263039
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0262849
DERA deoxyribose-phosphate aldolase (putative) 0.026094
PTMA prothymosin, alpha 0.0260905
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.025909
FXR1 fragile X mental retardation, autosomal homolog 1 0.0258659
PRELID2 PRELI domain containing 2 0.0258108

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.309667
HMGA2 high mobility group AT-hook 2 -0.131501
TPT1 tumor protein, translationally-controlled 1 -0.0986799
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0917575
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0829934
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0812193
INTS6 integrator complex subunit 6 -0.0793832
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0747706
PRKCA protein kinase C, alpha -0.0726301
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0652217
TMSB10 thymosin beta 10 -0.0644685
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0643368
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0640158
LOC112694756 uncharaterized LOC112694756 -0.0613753
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0596581
SQSTM1 sequestosome 1 -0.057704
GLS2 glutaminase 2 (liver, mitochondrial) -0.057522
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0570469
PRR16 proline rich 16 -0.0564044
SLC38A2 solute carrier family 38, member 2 -0.0555661
ZBTB20 zinc finger and BTB domain containing 20 -0.0530186
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0473304
RAI14 retinoic acid induced 14 -0.044795
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0441623
EGR1 early growth response 1 -0.0430622
UBC ubiquitin C -0.0427472
IGF2 insulin-like growth factor 2 -0.0415425
PCED1B PC-esterase domain containing 1B -0.0411025
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0410106
LDHA lactate dehydrogenase A -0.0399971
HLA-B major histocompatibility complex, class I, B -0.0386973
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0385652
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.037484
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0374562
PTK2 protein tyrosine kinase 2 -0.0370086
PTPRK protein tyrosine phosphatase, receptor type, K -0.0366029
AEBP2 AE binding protein 2 -0.0362858
PODXL podocalyxin-like -0.0355033
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0346461
GPC5 glypican 5 -0.0345524
COL5A1 collagen, type V, alpha 1 -0.0343997
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0343172
SH3KBP1 SH3-domain kinase binding protein 1 -0.0341783
PRSS23 protease, serine, 23 -0.0340582
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0340513
LPP LIM domain containing preferred translocation partner in lipoma -0.0335797
RIGI RNA sensor RIG-I -0.0333172
EGFR epidermal growth factor receptor -0.0328644
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0321067
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0317285
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0311852
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0310574
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0306166
ITGAV integrin, alpha V -0.0305545
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0302338
NDRG1 N-myc downstream regulated 1 -0.0300587
SPDYA speedy/RINGO cell cycle regulator family member A -0.0300446
JUN jun proto-oncogene -0.0296007
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0295414
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0291412
ATG7 autophagy related 7 -0.0286501
FUS FUS RNA binding protein -0.0285889
RAB1A RAB1A, member RAS oncogene family -0.0284323
CEMIP2 cell migration inducing hyaluronidase 2 -0.0281421
CCND1 cyclin D1 -0.028013
IARS1 isoleucyl-tRNA synthetase 1 -0.027856
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0278456
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0277345
SAMD4A sterile alpha motif domain containing 4A -0.0275419
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0273353
RABGAP1L RAB GTPase activating protein 1-like -0.027316
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0272868
SIK2 salt-inducible kinase 2 -0.0269505
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0268056
SDCCAG8 serologically defined colon cancer antigen 8 -0.0268034
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.026629
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0264889
EXT1 exostosin glycosyltransferase 1 -0.0263377
DPYD dihydropyrimidine dehydrogenase -0.0263351
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0263205
ATM ATM serine/threonine kinase -0.0262262
IER3 immediate early response 3 -0.0262128
DST dystonin -0.0262083
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0261842
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0261767
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0261224
BICD1 bicaudal D homolog 1 (Drosophila) -0.0260109
SOD2 superoxide dismutase 2, mitochondrial -0.0258131
PRH1 proline-rich protein HaeIII subfamily 1 -0.0256982
SEC31A SEC31 homolog A (S. cerevisiae) -0.0256911
THBS1 thrombospondin 1 -0.0256278
ARB2A ARB2 cotranscriptional regulator A -0.0253996
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0253611
CDCP1 CUB domain containing protein 1 -0.0251455
PTPRG protein tyrosine phosphatase, receptor type, G -0.0250808
S100A10 S100 calcium binding protein A10 -0.0249796
NAV3 neuron navigator 3 -0.0249329
KIAA1671 KIAA1671 -0.0247589
CMIP c-Maf inducing protein -0.0246551
UBE2H ubiquitin-conjugating enzyme E2H -0.0245162