Diphenhydramine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diphenhydramine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diphenhydramine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.165849
NAMPT nicotinamide phosphoribosyltransferase 0.112167
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.103997
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0746626
AHR aryl hydrocarbon receptor 0.0680277
PRRC2C proline-rich coiled-coil 2C 0.066921
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0637515
TXNIP thioredoxin interacting protein 0.0590424
FN1 fibronectin 1 0.0577546
TPR translocated promoter region, nuclear basket protein 0.0571118
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0533016
OSMR oncostatin M receptor 0.050984
ITGA1 integrin, alpha 1 0.0491925
CANX calnexin 0.048439
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0466839
TMSB4X thymosin beta 4, X-linked 0.0464033
ERRFI1 ERBB receptor feedback inhibitor 1 0.0463622
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0446561
SMOX spermine oxidase 0.0440299
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0366495
H1-0 H1.0 linker histone 0.0365831
RUNX2 runt-related transcription factor 2 0.036502
CENPF centromere protein F, 350/400kDa 0.0352435
MKI67 marker of proliferation Ki-67 0.0340924
OGA O-GlcNAcase 0.0333118
FAM13A family with sequence similarity 13, member A 0.0333023
KDM3A lysine (K)-specific demethylase 3A 0.0310247
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0308236
CLTC clathrin, heavy chain (Hc) 0.0307895
IFI16 interferon, gamma-inducible protein 16 0.0299494
EREG epiregulin 0.029153
DOCK5 dedicator of cytokinesis 5 0.0279061
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0276386
FNBP1 formin binding protein 1 0.0273979
RRBP1 ribosome binding protein 1 0.0273228
CAB39 calcium binding protein 39 0.0261282
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.025865
FBXL5 F-box and leucine-rich repeat protein 5 0.025309
PELO pelota homolog (Drosophila) 0.0246702
RB1CC1 RB1-inducible coiled-coil 1 0.0245577
SEC23A Sec23 homolog A (S. cerevisiae) 0.0245487
ETNK1 ethanolamine kinase 1 0.0243753
NRP1 neuropilin 1 0.0242278
TMEM156 transmembrane protein 156 0.0237978
ACBD3 acyl-CoA binding domain containing 3 0.0235854
ZC3H11A zinc finger CCCH-type containing 11A 0.0233219
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0231624
PRELID2 PRELI domain containing 2 0.0226147
PNN pinin, desmosome associated protein 0.022508
FBXO32 F-box protein 32 0.022386
MCTP2 multiple C2 domains, transmembrane 2 0.0223689
VEGFC vascular endothelial growth factor C 0.0223171
MIS18BP1 MIS18 binding protein 1 0.022314
NIPBL Nipped-B homolog (Drosophila) 0.022083
AHNAK2 AHNAK nucleoprotein 2 0.022035
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0217868
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0216396
VEGFA vascular endothelial growth factor A 0.0216348
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0214803
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0206574
BASP1 brain abundant, membrane attached signal protein 1 0.020445
LTBP1 latent transforming growth factor beta binding protein 1 0.0204427
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0203699
ZNF841 zinc finger protein 841 0.0203628
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0201356
AKAP9 A kinase (PRKA) anchor protein 9 0.0200668
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0200187
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0197219
BZW1 basic leucine zipper and W2 domains 1 0.0196979
DST dystonin 0.0196229
ARRDC3 arrestin domain containing 3 0.0195888
CKAP2 cytoskeleton associated protein 2 0.019079
KIF5B kinesin family member 5B 0.0187905
FAF2 Fas associated factor family member 2 0.0187767
ETV6 ets variant 6 0.0187339
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0186696
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0185995
SON SON DNA binding protein 0.018361
CD44 CD44 molecule (Indian blood group) 0.0181509
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0179378
TMCO1 transmembrane and coiled-coil domains 1 0.0178418
AFDN afadin, adherens junction formation factor 0.0177967
YBX1 Y box binding protein 1 0.017717
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0175527
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.017487
ELL2 elongation factor, RNA polymerase II, 2 0.0174636
FMN1 formin 1 0.0173404
RNF24 ring finger protein 24 0.017339
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0172023
HOMER2 homer scaffolding protein 2 0.017172
ARHGAP5 Rho GTPase activating protein 5 0.0169708
MAP2K4 mitogen-activated protein kinase kinase 4 0.0168656
RBM39 RNA binding motif protein 39 0.0167302
CARD16 caspase recruitment domain family, member 16 0.0167036
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0166431
TMEM87A transmembrane protein 87A 0.0160414
TMF1 TATA element modulatory factor 1 0.0159596
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0157958
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.015661
BHLHE40 basic helix-loop-helix family, member e40 0.015474

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.375445
PTMA prothymosin, alpha -0.125825
FTL ferritin, light polypeptide -0.111024
NRG1 neuregulin 1 -0.109036
TMSB10 thymosin beta 10 -0.105767
HLA-B major histocompatibility complex, class I, B -0.0912539
TPT1 tumor protein, translationally-controlled 1 -0.0869966
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0859474
INTS6 integrator complex subunit 6 -0.0813574
RPS6 ribosomal protein S6 -0.0792415
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0766683
NDRG1 N-myc downstream regulated 1 -0.075046
RPL31 ribosomal protein L31 -0.069369
SQSTM1 sequestosome 1 -0.0680824
ACTG1 actin gamma 1 -0.0675247
RPL35A ribosomal protein L35a -0.0660712
VIM vimentin -0.0641719
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0593146
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0556046
RPS11 ribosomal protein S11 -0.0552317
ENO2 enolase 2 (gamma, neuronal) -0.0549081
SOD2 superoxide dismutase 2, mitochondrial -0.0529684
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0519822
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0496554
RPS8 ribosomal protein S8 -0.0496081
RPS23 ribosomal protein S23 -0.0488832
IFI27 interferon, alpha-inducible protein 27 -0.0479739
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0478675
RPS29 ribosomal protein S29 -0.0477722
RPL37 ribosomal protein L37 -0.0474526
RPS25 ribosomal protein S25 -0.0461304
STC2 stanniocalcin 2 -0.0444684
RAB7A RAB7A, member RAS oncogene family -0.0438967
RPL23 ribosomal protein L23 -0.0434295
POTEF POTE ankyrin domain family, member F -0.0423727
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.042206
CTSD cathepsin D -0.0420192
RPL9 ribosomal protein L9 -0.0410914
RPS24 ribosomal protein S24 -0.0410238
AEBP2 AE binding protein 2 -0.0398014
SLC38A2 solute carrier family 38, member 2 -0.0397244
S100A10 S100 calcium binding protein A10 -0.0386016
RPL38 ribosomal protein L38 -0.0384183
FMNL2 formin-like 2 -0.038027
LRRC23 leucine rich repeat containing 23 -0.0375916
PKM pyruvate kinase, muscle -0.0375184
RHEB Ras homolog enriched in brain -0.0373327
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.037015
RPL34 ribosomal protein L34 -0.0367858
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0367713
TRIO trio Rho guanine nucleotide exchange factor -0.036287
PTK2 protein tyrosine kinase 2 -0.0362605
UBC ubiquitin C -0.0361097
IER3 immediate early response 3 -0.0359973
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0359871
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0358991
RPL37A ribosomal protein L37a -0.0358889
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0355145
RPL28 ribosomal protein L28 -0.0354817
MCL1 myeloid cell leukemia 1 -0.0353075
GRB10 growth factor receptor-bound protein 10 -0.0349044
RPS5 ribosomal protein S5 -0.0347263
RPS27 ribosomal protein S27 -0.0340426
EGR1 early growth response 1 -0.033933
CTBP2 C-terminal binding protein 2 -0.0339329
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0336792
PARD3 par-3 family cell polarity regulator -0.0335606
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0331808
MRPS6 mitochondrial ribosomal protein S6 -0.033158
RPS16 ribosomal protein S16 -0.0328159
RTN4 reticulon 4 -0.0325735
FLNB filamin B, beta -0.032507
CADM1 cell adhesion molecule 1 -0.0322775
QKI QKI, KH domain containing, RNA binding -0.0318065
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0312381
RPS27A ribosomal protein S27a -0.031203
WNK1 WNK lysine deficient protein kinase 1 -0.0311789
HMGA1 high mobility group AT-hook 1 -0.0311325
RPLP1 ribosomal protein, large, P1 -0.0307242
RPLP2 ribosomal protein, large, P2 -0.0306647
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0306495
JAK1 Janus kinase 1 -0.030123
RPS13 ribosomal protein S13 -0.0300345
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0297147
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0291581
CCDC138 coiled-coil domain containing 138 -0.0291508
NXN nucleoredoxin -0.0290201
FBXO11 F-box protein 11 -0.0289951
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0288657
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0287339
RPS14 ribosomal protein S14 -0.0287096
IFI6 interferon, alpha-inducible protein 6 -0.0284515
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284372
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0283474
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0281776
HLA-A major histocompatibility complex, class I, A -0.0279481
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0279477
GNAS GNAS complex locus -0.0278394
RPS15 ribosomal protein S15 -0.0276395
ZFAND3 zinc finger, AN1-type domain 3 -0.0273096