Diphtheria Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys. (Experimental Factor Ontology, EFO_0005549)
External Link https://www.disgenet.org/browser/0/1/0/C0012546
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Genes

140 genes associated with the disease Diphtheria in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AFP alpha-fetoprotein
AGRP agouti related neuropeptide
ALB albumin
ANK1 ankyrin 1, erythrocytic
APOL1 apolipoprotein L, 1
APP amyloid beta (A4) precursor protein
ATN1 atrophin 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BHLHE22 basic helix-loop-helix family, member e22
C4BPA complement component 4 binding protein, alpha
CARD14 caspase recruitment domain family, member 14
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD19 CD19 molecule
CD1D CD1d molecule
CD207 CD207 molecule, langerin
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CLEC9A C-type lectin domain family 9, member A
COL11A2 collagen, type XI, alpha 2
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DMP1 dentin matrix acidic phosphoprotein 1
DPH2 DPH2 homolog (S. cerevisiae)
EEF2 eukaryotic translation elongation factor 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENOSF1 enolase superfamily member 1
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
EPX eosinophil peroxidase
F11 coagulation factor XI
F2R coagulation factor II (thrombin) receptor
FADD Fas (TNFRSF6)-associated via death domain
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FEV FEV (ETS oncogene family)
FGF2 fibroblast growth factor 2 (basic)
FOXD1 forkhead box D1
FOXO1 forkhead box O1
FOXP3 forkhead box P3
GCG glucagon
GCGR glucagon receptor
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GCNT7 glucosaminyl (N-acetyl) transferase family member 7
GFAP glial fibrillary acidic protein
GH1 growth hormone 1
GLB1 galactosidase, beta 1
GLP1R glucagon-like peptide 1 receptor
GPI glucose-6-phosphate isomerase
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRP gastrin-releasing peptide
GSTK1 glutathione S-transferase kappa 1
HBEGF heparin-binding EGF-like growth factor
HCRT hypocretin (orexin) neuropeptide precursor
HDC histidine decarboxylase
HPGDS hematopoietic prostaglandin D synthase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IGF2 insulin-like growth factor 2
IL13 interleukin 13
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL3 interleukin 3
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL7 interleukin 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JAK3 Janus kinase 3
KLK3 kallikrein-related peptidase 3
KRT71 keratin 71, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYZ lysozyme
MAP6 microtubule-associated protein 6
MECP2 methyl CpG binding protein 2
MMUT methylmalonyl-CoA mutase
MOG myelin oligodendrocyte glycoprotein
MRC1 mannose receptor, C type 1
MSLN mesothelin
MUC1 mucin 1, cell surface associated
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOTCH1 notch 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPY neuropeptide Y
P4HB prolyl 4-hydroxylase, beta polypeptide
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAUR plasminogen activator, urokinase receptor
PLXNA3 plexin A3
POMC proopiomelanocortin
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1
PPP1R42 protein phosphatase 1, regulatory subunit 42
PRDX2 peroxiredoxin 2
PRNP prion protein
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RAD51 RAD51 recombinase
RAG1 recombination activating gene 1
RECQL4 RecQ protein-like 4
SAGE1 sarcoma antigen 1
SFTPC surfactant protein C
SFXN1 sideroflexin 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC26A5 solute carrier family 26 (anion exchanger), member 5
SLC35D3 solute carrier family 35, member D3
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SNCAIP synuclein, alpha interacting protein
SST somatostatin
TAT tyrosine aminotransferase
TBCA tubulin folding cofactor A
TEK TEK tyrosine kinase, endothelial
TG thyroglobulin
TNF tumor necrosis factor
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSLP thymic stromal lymphopoietin
TSPYL2 TSPY-like 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB46 zinc finger and BTB domain containing 46
ZGLP1 zinc finger, GATA-like protein 1