| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. (Chemical Entities of Biological Interest Ontology, CHEBI_4653) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3108 |
| Similar Terms | |
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200 proteins with high or low expression in Dipyridamole relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 2.11 |
| COL17A1 | collagen, type XVII, alpha 1 | 1.96 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.96 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.97 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.94 |
| SLC16A6 | solute carrier family 16, member 6 | 0.92 |
| PDE7A | phosphodiesterase 7A | 0.84 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.7 |
| MT2A | metallothionein 2A | 0.7 |
| PLAUR | plasminogen activator, urokinase receptor | 0.66 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.64 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.61 |
| MT1E | metallothionein 1E | 0.61 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.61 |
| MT1X | metallothionein 1X | 0.6 |
| AREG | amphiregulin | 0.58 |
| PSAP | prosaposin | 0.57 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.56 |
| SYTL2 | synaptotagmin-like 2 | 0.56 |
| ATXN1L | ataxin 1-like | 0.54 |
| CES3 | carboxylesterase 3 | 0.53 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | 0.53 |
| TTPA | tocopherol (alpha) transfer protein | 0.52 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.51 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.5 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.48 |
| FBXO41 | F-box protein 41 | 0.48 |
| H2AZ1 | H2A.Z variant histone 1 | 0.47 |
| FDX1 | ferredoxin 1 | 0.47 |
| ADPRH | ADP-ribosylarginine hydrolase | 0.47 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.46 |
| MT1F | metallothionein 1F | 0.46 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.45 |
| SLC25A39 | solute carrier family 25, member 39 | 0.45 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | 0.44 |
| RNF126 | ring finger protein 126 | 0.44 |
| ZC3H10 | zinc finger CCCH-type containing 10 | 0.43 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.41 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.41 |
| ACTB | actin, beta | 0.41 |
| BRD8 | bromodomain containing 8 | 0.41 |
| RCAN3 | RCAN family member 3 | 0.4 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.4 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.4 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.4 |
| NKTR | natural killer cell triggering receptor | 0.4 |
| PDLIM3 | PDZ and LIM domain 3 | 0.4 |
| RAB27B | RAB27B, member RAS oncogene family | 0.4 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.4 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.4 |
| TMC5 | transmembrane channel-like 5 | 0.39 |
| FOXC1 | forkhead box C1 | 0.39 |
| SMIM19 | small integral membrane protein 19 | 0.39 |
| TUSC2 | tumor suppressor candidate 2 | 0.39 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.39 |
| SOCS6 | suppressor of cytokine signaling 6 | 0.39 |
| EED | embryonic ectoderm development | 0.39 |
| B2M | beta-2-microglobulin | 0.38 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.38 |
| CSTF2T | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant | 0.38 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.38 |
| ENO1 | enolase 1, (alpha) | 0.38 |
| SHANK3 | SH3 and multiple ankyrin repeat domains 3 | 0.38 |
| HIST1H1T | histone cluster 1, H1t | 0.38 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.37 |
| TMSB10 | thymosin beta 10 | 0.37 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.37 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | 0.37 |
| ZNF33A | zinc finger protein 33A | 0.37 |
| ZNF354B | zinc finger protein 354B | 0.37 |
| HOXB9 | homeobox B9 | 0.37 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.37 |
| WASHC4 | WASH complex subunit 4 | 0.36 |
| TRIM29 | tripartite motif containing 29 | 0.36 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.36 |
| PTMA | prothymosin, alpha | 0.36 |
| TBX3 | T-box 3 | 0.35 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.35 |
| H1-0 | H1.0 linker histone | 0.35 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.35 |
| THAP9 | THAP domain containing 9 | 0.35 |
| RNF220 | ring finger protein 220 | 0.35 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.35 |
| IQCG | IQ motif containing G | 0.35 |
| POLK | polymerase (DNA directed) kappa | 0.34 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.34 |
| ARG2 | arginase 2 | 0.34 |
| ICOSLG | inducible T-cell co-stimulator ligand | 0.34 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.34 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.34 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | 0.34 |
| RREB1 | ras responsive element binding protein 1 | 0.33 |
| RMI2 | RecQ mediated genome instability 2 | 0.33 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.33 |
| RNASET2 | ribonuclease T2 | 0.33 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.33 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.33 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.33 |
| NOTCH3 | notch 3 | 0.33 |
| CMIP | c-Maf inducing protein | 0.33 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -1.51 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | -1.07 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.82 |
| SLC30A5 | solute carrier family 30 (zinc transporter), member 5 | -0.77 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.64 |
| MLF1 | myeloid leukemia factor 1 | -0.61 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.56 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.55 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.54 |
| CAMTA2 | calmodulin binding transcription activator 2 | -0.53 |
| CCN2 | cellular communication network factor 2 | -0.49 |
| RCE1 | Ras converting CAAX endopeptidase 1 | -0.49 |
| PRMT6 | protein arginine methyltransferase 6 | -0.48 |
| PRKAB2 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | -0.46 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.46 |
| CLCN6 | chloride channel, voltage-sensitive 6 | -0.46 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.46 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.44 |
| FADS1 | fatty acid desaturase 1 | -0.43 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | -0.42 |
| LOXL2 | lysyl oxidase-like 2 | -0.41 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.41 |
| LYRM1 | LYR motif containing 1 | -0.4 |
| LIX1L | Lix1 homolog (chicken) like | -0.39 |
| CCNQ | cyclin Q | -0.39 |
| TRIML2 | tripartite motif family-like 2 | -0.38 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.36 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.35 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.35 |
| SLC38A2 | solute carrier family 38, member 2 | -0.35 |
| ZNF100 | zinc finger protein 100 | -0.35 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.35 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | -0.34 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.34 |
| CES2 | carboxylesterase 2 | -0.34 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.34 |
| KIAA0556 | KIAA0556 | -0.33 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | -0.33 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.33 |
| NHEJ1 | nonhomologous end-joining factor 1 | -0.33 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.33 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.33 |
| MB21D2 | Mab-21 domain containing 2 | -0.33 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.32 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.32 |
| MAP2 | microtubule-associated protein 2 | -0.32 |
| RHOD | ras homolog family member D | -0.32 |
| CKM | creatine kinase, muscle | -0.32 |
| FICD | FIC domain containing | -0.32 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.32 |
| ANO8 | anoctamin 8 | -0.32 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | -0.31 |
| KCTD17 | potassium channel tetramerization domain containing 17 | -0.31 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.31 |
| CCDC158 | coiled-coil domain containing 158 | -0.31 |
| RITA1 | RBPJ interacting and tubulin associated 1 | -0.31 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.31 |
| TRIM23 | tripartite motif containing 23 | -0.3 |
| DHCR24 | 24-dehydrocholesterol reductase | -0.3 |
| TET3 | tet methylcytosine dioxygenase 3 | -0.3 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.3 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | -0.3 |
| HBA1 | hemoglobin, alpha 1 | -0.3 |
| GAS8 | growth arrest-specific 8 | -0.3 |
| CSNK1G1 | casein kinase 1, gamma 1 | -0.29 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.29 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | -0.29 |
| MOSPD1 | motile sperm domain containing 1 | -0.29 |
| F2 | coagulation factor II (thrombin) | -0.29 |
| SEPTIN4 | septin 4 | -0.28 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.28 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.28 |
| AXL | AXL receptor tyrosine kinase | -0.28 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.28 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.28 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | -0.28 |
| FRK | fyn-related Src family tyrosine kinase | -0.27 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.27 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -0.27 |
| TMEM200A | transmembrane protein 200A | -0.27 |
| IL10RB | interleukin 10 receptor, beta | -0.27 |
| TC2N | tandem C2 domains, nuclear | -0.27 |
| ADAM22 | ADAM metallopeptidase domain 22 | -0.27 |
| DMD | dystrophin | -0.27 |
| RHOQ | ras homolog family member Q | -0.27 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | -0.27 |
| LYST | lysosomal trafficking regulator | -0.27 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.26 |
| VTN | vitronectin | -0.26 |
| SCARA3 | scavenger receptor class A, member 3 | -0.26 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.26 |
| DLG2 | discs, large homolog 2 (Drosophila) | -0.26 |
| ALS2CL | ALS2 C-terminal like | -0.26 |
| RRAS | related RAS viral (r-ras) oncogene homolog | -0.26 |
| DES | desmin | -0.26 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | -0.25 |
| CCN1 | cellular communication network factor 1 | -0.25 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | -0.25 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.25 |
| BCO2 | beta-carotene oxygenase 2 | -0.25 |
