Docetaxel (Trihydrate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.137548
PTMA prothymosin, alpha 0.123428
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.102656
SQSTM1 sequestosome 1 0.0928043
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0906673
CALR calreticulin 0.0701045
RPS3 ribosomal protein S3 0.0652852
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0641207
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0623541
COL1A2 collagen, type I, alpha 2 0.0578476
RPLP2 ribosomal protein, large, P2 0.0573993
RPS6 ribosomal protein S6 0.0563307
TPT1 tumor protein, translationally-controlled 1 0.0537838
GOLGA4 golgin A4 0.0535838
UBC ubiquitin C 0.0531061
RPS27A ribosomal protein S27a 0.0530295
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0519824
RPS8 ribosomal protein S8 0.0480339
FLNA filamin A, alpha 0.0475801
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0474431
RPL12 ribosomal protein L12 0.0464828
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0461226
NAP1L1 nucleosome assembly protein 1-like 1 0.0460734
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0439196
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0433214
RPL37A ribosomal protein L37a 0.0432516
EIF1 eukaryotic translation initiation factor 1 0.0403687
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0399492
SRRM2 serine/arginine repetitive matrix 2 0.0396115
ADM adrenomedullin 0.0394013
RPL36 ribosomal protein L36 0.0390366
RPS19 ribosomal protein S19 0.0385902
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0383722
RPL23 ribosomal protein L23 0.0383266
NDRG1 N-myc downstream regulated 1 0.0368129
CAVIN1 caveolae associated protein 1 0.0366632
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0364298
RPS12 ribosomal protein S12 0.0362355
THBS2 thrombospondin 2 0.0353371
RPL26 ribosomal protein L26 0.035307
RPL32 ribosomal protein L32 0.0352765
MYH9 myosin, heavy chain 9, non-muscle 0.0343995
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0343915
MXI1 MAX interactor 1, dimerization protein 0.0340444
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.033838
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0333491
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.032773
NAV2 neuron navigator 2 0.0316345
FTL ferritin, light polypeptide 0.0312619
RPL38 ribosomal protein L38 0.0311495
RPL31 ribosomal protein L31 0.0309345
RPL19 ribosomal protein L19 0.0300842
WSB1 WD repeat and SOCS box containing 1 0.0291521
RPL37 ribosomal protein L37 0.0290962
CLU clusterin 0.0284581
RPL11 ribosomal protein L11 0.0282703
STC1 stanniocalcin 1 0.0279691
FGFR1 fibroblast growth factor receptor 1 0.0276732
RPLP1 ribosomal protein, large, P1 0.0276675
RPL28 ribosomal protein L28 0.0275466
NFE2L1 nuclear factor, erythroid 2-like 1 0.027545
RPS14 ribosomal protein S14 0.0274328
AHNAK2 AHNAK nucleoprotein 2 0.0268639
ELL2 elongation factor, RNA polymerase II, 2 0.0266042
RPS27 ribosomal protein S27 0.0264298
EEF2 eukaryotic translation elongation factor 2 0.0261296
KDM3A lysine (K)-specific demethylase 3A 0.0257635
FMNL2 formin-like 2 0.0253213
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0252636
RPL7A ribosomal protein L7a 0.025019
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.0249344
RPS17 ribosomal protein S17 0.0248142
RPS24 ribosomal protein S24 0.0242791
TUBB2A tubulin, beta 2A class IIa 0.0241136
RHOBTB3 Rho-related BTB domain containing 3 0.0239819
RPL13A ribosomal protein L13a 0.0239256
RPS4X ribosomal protein S4, X-linked 0.0236347
RPS13 ribosomal protein S13 0.0235486
KLF6 Kruppel-like factor 6 0.0230155
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.022985
PNISR PNN-interacting serine/arginine-rich protein 0.0229408
RPS11 ribosomal protein S11 0.0226712
SFTPA2 surfactant protein A2 0.0222626
RPS23 ribosomal protein S23 0.0221789
DPYSL2 dihydropyrimidinase-like 2 0.021557
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0212902
RPS16 ribosomal protein S16 0.0212621
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0210748
ITSN2 intersectin 2 0.0209928
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.020987
EIF4A1 eukaryotic translation initiation factor 4A1 0.020793
CAPN2 calpain 2, (m/II) large subunit 0.0206867
SERTAD2 SERTA domain containing 2 0.0206535
TMSB4X thymosin beta 4, X-linked 0.020577
BACE2 beta-site APP-cleaving enzyme 2 0.0205759
RSL1D1 ribosomal L1 domain containing 1 0.0203856
RACK1 receptor for activated C kinase 1 0.0203407
RRBP1 ribosome binding protein 1 0.0202695
SBF2 SET binding factor 2 0.0202635
RPL35 ribosomal protein L35 0.0201618

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.194148
PODXL podocalyxin-like -0.142128
MAP1B microtubule-associated protein 1B -0.130934
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.128527
B2M beta-2-microglobulin -0.115183
SUCNR1 succinate receptor 1 -0.113289
FN1 fibronectin 1 -0.107144
NAV1 neuron navigator 1 -0.0976443
PLAT plasminogen activator, tissue -0.0926282
TAGLN2 transgelin 2 -0.0849905
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0833948
VIM vimentin -0.081627
COL5A1 collagen, type V, alpha 1 -0.0810114
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0807901
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0793622
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0730432
CDH13 cadherin 13 -0.0721641
COL8A1 collagen, type VIII, alpha 1 -0.0702353
MX2 MX dynamin-like GTPase 2 -0.0686636
ABI3BP ABI family, member 3 (NESH) binding protein -0.0678726
SLC39A11 solute carrier family 39, member 11 -0.0676949
PRSS23 protease, serine, 23 -0.06732
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0578625
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0542823
LDHA lactate dehydrogenase A -0.0520801
POTEF POTE ankyrin domain family, member F -0.0492129
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.048993
SORBS2 sorbin and SH3 domain containing 2 -0.047971
LOX lysyl oxidase -0.0479084
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0448032
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0442934
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0434852
CD59 CD59 molecule, complement regulatory protein -0.0429017
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0428694
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0417811
COPA coatomer protein complex, subunit alpha -0.0416565
CYTH3 cytohesin 3 -0.0400581
FNDC3A fibronectin type III domain containing 3A -0.0397945
COL5A2 collagen, type V, alpha 2 -0.0386094
TPM1 tropomyosin 1 (alpha) -0.0379857
KRT81 keratin 81, type II -0.0379492
RTN4 reticulon 4 -0.0377737
LRRC17 leucine rich repeat containing 17 -0.037751
SAMD9 sterile alpha motif domain containing 9 -0.0374534
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0372238
ZBTB20 zinc finger and BTB domain containing 20 -0.0370572
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0368321
RNF213 ring finger protein 213 -0.0367319
IFITM1 interferon induced transmembrane protein 1 -0.0361158
DCLK2 doublecortin-like kinase 2 -0.0357717
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0357313
GLIS3 GLIS family zinc finger 3 -0.0355669
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0345374
S100A6 S100 calcium binding protein A6 -0.0344975
MRPS6 mitochondrial ribosomal protein S6 -0.034172
RIGI RNA sensor RIG-I -0.0337328
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0334419
MYADM myeloid-associated differentiation marker -0.0334146
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.033337
SLC38A1 solute carrier family 38, member 1 -0.032875
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0324463
CKAP4 cytoskeleton-associated protein 4 -0.0311406
PLXNA2 plexin A2 -0.0311067
IL7R interleukin 7 receptor -0.0310275
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0310125
OASL 2'-5'-oligoadenylate synthetase-like -0.0301694
ADAM9 ADAM metallopeptidase domain 9 -0.0298335
VEGFC vascular endothelial growth factor C -0.0297974
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0293257
VCL vinculin -0.0279688
DGKG diacylglycerol kinase, gamma 90kDa -0.0279658
SPDL1 spindle apparatus coiled-coil protein 1 -0.0278887
S100A11 S100 calcium binding protein A11 -0.0274308
MEIS2 Meis homeobox 2 -0.0270147
PDE4D phosphodiesterase 4D, cAMP-specific -0.0267838
FRMD4A FERM domain containing 4A -0.0266531
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0265592
ARL4C ADP-ribosylation factor-like 4C -0.0264732
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0263877
AKAP12 A kinase (PRKA) anchor protein 12 -0.0261342
CYB5R3 cytochrome b5 reductase 3 -0.0259912
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0254195
CUX1 cut-like homeobox 1 -0.0253236
SPAG9 sperm associated antigen 9 -0.0253179
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0250891
SRPK2 SRSF protein kinase 2 -0.0249483
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0246553
RAD51B RAD51 paralog B -0.024592
ZNF148 zinc finger protein 148 -0.0243812
PGK1 phosphoglycerate kinase 1 -0.0240458
PCDH7 protocadherin 7 -0.0240338
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.023905
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0238852
WARS1 tryptophanyl-tRNA synthetase 1 -0.0238013
ZMYND8 zinc finger, MYND-type containing 8 -0.0237574
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.023336
S100A4 S100 calcium binding protein A4 -0.0231837
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0230589
MBNL1 muscleblind-like splicing regulator 1 -0.0229509
JAZF1 JAZF zinc finger 1 -0.0227142