Docetaxel (Trihydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.177547
SPTBN1 spectrin, beta, non-erythrocytic 1 0.079892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0791051
TXNRD1 thioredoxin reductase 1 0.073744
FRMD4A FERM domain containing 4A 0.0685603
IGFBP3 insulin-like growth factor binding protein 3 0.0664106
CD44 CD44 molecule (Indian blood group) 0.0645894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0630549
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0608869
CALR calreticulin 0.0607911
PLK2 polo-like kinase 2 0.0576242
MYH9 myosin, heavy chain 9, non-muscle 0.0492576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0450672
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0450245
SON SON DNA binding protein 0.0449852
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0449041
MKI67 marker of proliferation Ki-67 0.0448957
EHBP1 EH domain binding protein 1 0.0416326
NAV2 neuron navigator 2 0.0407434
CCL2 chemokine (C-C motif) ligand 2 0.0398951
CALU calumenin 0.0393972
MAP1B microtubule-associated protein 1B 0.0381471
MX1 MX dynamin-like GTPase 1 0.0376244
SET SET nuclear proto-oncogene 0.0375279
FAT1 FAT atypical cadherin 1 0.0372836
RPL26 ribosomal protein L26 0.0365449
RPLP2 ribosomal protein, large, P2 0.0365064
TPM3 tropomyosin 3 0.0350207
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0347071
SRRM2 serine/arginine repetitive matrix 2 0.0342252
CENPF centromere protein F, 350/400kDa 0.0341912
VCAN versican 0.03352
FLNA filamin A, alpha 0.0334344
PDIA4 protein disulfide isomerase family A, member 4 0.031551
GLIS3 GLIS family zinc finger 3 0.0311715
LAMB1 laminin, beta 1 0.0310848
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0310652
RPS2 ribosomal protein S2 0.0302768
ANXA1 annexin A1 0.0288556
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0284744
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0284589
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0282415
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0282367
RPS4X ribosomal protein S4, X-linked 0.027938
RPS12 ribosomal protein S12 0.0272033
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0270881
RNF213 ring finger protein 213 0.0267318
HDGF hepatoma-derived growth factor 0.0264372
CBX3 chromobox homolog 3 0.0261171
HDAC9 histone deacetylase 9 0.0249254
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0247439
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0244609
RSL1D1 ribosomal L1 domain containing 1 0.0244073
RPL21 ribosomal protein L21 0.0243571
PTGR1 prostaglandin reductase 1 0.0243105
NFE2L1 nuclear factor, erythroid 2-like 1 0.0240604
SEM1 SEM1 26S proteasome subunit 0.0239738
AKAP9 A kinase (PRKA) anchor protein 9 0.0237096
CANX calnexin 0.0236788
CP ceruloplasmin (ferroxidase) 0.0236308
NRP1 neuropilin 1 0.0230646
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0229903
RPS3 ribosomal protein S3 0.0227853
EXOC4 exocyst complex component 4 0.0227076
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0225535
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0223154
RPL12 ribosomal protein L12 0.0220153
RIGI RNA sensor RIG-I 0.0219911
RBBP6 retinoblastoma binding protein 6 0.0219817
SLFN5 schlafen family member 5 0.0218358
CKAP2 cytoskeleton associated protein 2 0.021459
COL4A2 collagen, type IV, alpha 2 0.0214018
IFI44L interferon-induced protein 44-like 0.0213064
PDAP1 PDGFA associated protein 1 0.0207336
DPYSL3 dihydropyrimidinase-like 3 0.0207241
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0206208
NRP2 neuropilin 2 0.0204713
SMYD3 SET and MYND domain containing 3 0.0202653
NLGN1 neuroligin 1 0.0201899
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0201707
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0201689
GOLGA4 golgin A4 0.0194974
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0187915
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.0186764
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0185167
CENPE centromere protein E, 312kDa 0.0185011
RPS17 ribosomal protein S17 0.0184557
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0181268
HSPA8 heat shock 70kDa protein 8 0.0181011
TLN1 talin 1 0.017929
CLTC clathrin, heavy chain (Hc) 0.0179068
RPL3 ribosomal protein L3 0.0176408
PHF14 PHD finger protein 14 0.0175243
RPS15A ribosomal protein S15a 0.0174078
CAPRIN1 cell cycle associated protein 1 0.0174062
RPL32 ribosomal protein L32 0.0172837
PNN pinin, desmosome associated protein 0.0172193
IGFBP7 insulin-like growth factor binding protein 7 0.017135
METTL15 methyltransferase like 15 0.0171045
SLC35F3 solute carrier family 35, member F3 0.0170373

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.185805
B2M beta-2-microglobulin -0.118639
RPL35A ribosomal protein L35a -0.105515
NDRG1 N-myc downstream regulated 1 -0.10311
POTEF POTE ankyrin domain family, member F -0.101128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0899951
RAB1A RAB1A, member RAS oncogene family -0.0853383
VIM vimentin -0.0832111
HLA-B major histocompatibility complex, class I, B -0.0751779
UGCG UDP-glucose ceramide glucosyltransferase -0.0648833
P4HB prolyl 4-hydroxylase, beta polypeptide -0.064677
SOD2 superoxide dismutase 2, mitochondrial -0.0632299
RHEB Ras homolog enriched in brain -0.0630302
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0622629
RTN4 reticulon 4 -0.0618609
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.060768
NAMPT nicotinamide phosphoribosyltransferase -0.0602236
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0596392
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0582206
MT2A metallothionein 2A -0.0571288
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0556535
CYB5R3 cytochrome b5 reductase 3 -0.0552801
CTSD cathepsin D -0.0547849
ATP13A3 ATPase type 13A3 -0.0543987
HLA-E major histocompatibility complex, class I, E -0.0541352
FTH1 ferritin, heavy polypeptide 1 -0.0530177
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0529068
PTBP3 polypyrimidine tract binding protein 3 -0.0525782
MARCHF6 membrane associated ring-CH-type finger 6 -0.051202
RPLP1 ribosomal protein, large, P1 -0.0496241
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0495838
CADM1 cell adhesion molecule 1 -0.0494928
FMNL2 formin-like 2 -0.0480605
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0467429
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0459897
TPT1 tumor protein, translationally-controlled 1 -0.0457615
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0453594
ADAM9 ADAM metallopeptidase domain 9 -0.0437029
ITGAV integrin, alpha V -0.0433453
ZFAND3 zinc finger, AN1-type domain 3 -0.04206
ANKRD33B ankyrin repeat domain 33B -0.0418828
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0412579
TRAM1 translocation associated membrane protein 1 -0.040526
ANKRD10 ankyrin repeat domain 10 -0.0402902
TKT transketolase -0.040076
ADGRG1 adhesion G protein-coupled receptor G1 -0.0399715
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0398125
RAB2A RAB2A, member RAS oncogene family -0.0397459
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0396517
RPS8 ribosomal protein S8 -0.0396142
GNAS GNAS complex locus -0.0395051
SPAG9 sperm associated antigen 9 -0.0391856
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0384301
WAC WW domain containing adaptor with coiled-coil -0.0383166
TPM1 tropomyosin 1 (alpha) -0.0372067
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.037013
RPL7 ribosomal protein L7 -0.0369514
DENND4A DENN/MADD domain containing 4A -0.0369225
ANXA5 annexin A5 -0.0368556
EIF1 eukaryotic translation initiation factor 1 -0.0366037
IFRD1 interferon-related developmental regulator 1 -0.0358918
RAP1B RAP1B, member of RAS oncogene family -0.0356642
SDCBP syndecan binding protein (syntenin) -0.0349111
RBM39 RNA binding motif protein 39 -0.0347349
LITAF lipopolysaccharide-induced TNF factor -0.0345672
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0345319
FBXO11 F-box protein 11 -0.0341886
QKI QKI, KH domain containing, RNA binding -0.0341658
TSC22D2 TSC22 domain family, member 2 -0.0339826
MTDH metadherin -0.0337017
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0334457
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0332483
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0332087
ATP5F1B ATP synthase F1 subunit beta -0.0332016
VDAC1 voltage-dependent anion channel 1 -0.0330976
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0329315
PARD3 par-3 family cell polarity regulator -0.0328322
TMEM165 transmembrane protein 165 -0.0325606
ARL4C ADP-ribosylation factor-like 4C -0.0325354
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0323963
ALCAM activated leukocyte cell adhesion molecule -0.0322706
COPA coatomer protein complex, subunit alpha -0.032169
ADAM17 ADAM metallopeptidase domain 17 -0.0320303
RPS24 ribosomal protein S24 -0.0319102
KMT2C lysine (K)-specific methyltransferase 2C -0.0313823
INTS6 integrator complex subunit 6 -0.0311704
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0311136
COTL1 coactosin-like F-actin binding protein 1 -0.0310419
KMT2E lysine (K)-specific methyltransferase 2E -0.0310143
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0309716
KCTD9 potassium channel tetramerization domain containing 9 -0.0308469
TFPI2 tissue factor pathway inhibitor 2 -0.0305475
INSIG1 insulin induced gene 1 -0.0305213
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0304395
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0302795
TMSB10 thymosin beta 10 -0.0302189
RPL31 ribosomal protein L31 -0.0301397
TFG TRK-fused gene -0.0298665
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0296677
CTBP2 C-terminal binding protein 2 -0.0296629