Docetaxel (Trihydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0405776
TMSB4X thymosin beta 4, X-linked 0.0403053
FGFR1 fibroblast growth factor receptor 1 0.0346194
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.033046
OGA O-GlcNAcase 0.0284575
MACF1 microtubule-actin crosslinking factor 1 0.0262363
MKI67 marker of proliferation Ki-67 0.0256327
ARHGAP21 Rho GTPase activating protein 21 0.0255938
ANKRD11 ankyrin repeat domain 11 0.024729
HMGA2 high mobility group AT-hook 2 0.0246002
CAPRIN1 cell cycle associated protein 1 0.0242144
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0240593
CALR calreticulin 0.0239679
RANBP17 RAN binding protein 17 0.0228419
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0221794
TOP2B topoisomerase (DNA) II beta 180kDa 0.0221219
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0217556
SFPQ splicing factor proline/glutamine-rich 0.02158
DOCK3 dedicator of cytokinesis 3 0.0213932
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0210666
MAML3 mastermind-like 3 (Drosophila) 0.0208054
ZFAND3 zinc finger, AN1-type domain 3 0.0206755
TRIO trio Rho guanine nucleotide exchange factor 0.020514
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0200534
MARCHF6 membrane associated ring-CH-type finger 6 0.0189916
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0186625
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0186037
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0181562
NBEA neurobeachin 0.0177584
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0173873
H1-4 H1.4 linker histone, cluster member 0.0173002
ARHGAP26 Rho GTPase activating protein 26 0.0171558
PUM2 pumilio RNA-binding family member 2 0.0167612
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0166953
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0166261
SIK3 SIK family kinase 3 0.0164015
SOBP sine oculis binding protein homolog (Drosophila) 0.0163209
CENPE centromere protein E, 312kDa 0.0162833
NAV1 neuron navigator 1 0.0161203
SMYD3 SET and MYND domain containing 3 0.0159078
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0158919
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0158879
CDK8 cyclin-dependent kinase 8 0.0158238
CCSER2 coiled-coil serine-rich protein 2 0.0156902
CARD16 caspase recruitment domain family, member 16 0.0155368
MYH9 myosin, heavy chain 9, non-muscle 0.01533
YEATS2 YEATS domain containing 2 0.0152692
TJP1 tight junction protein 1 0.0150762
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0150299
FUS FUS RNA binding protein 0.0148083
NCOR2 nuclear receptor corepressor 2 0.0147892
DST dystonin 0.014775
SPTBN1 spectrin, beta, non-erythrocytic 1 0.014573
CCNB1 cyclin B1 0.0144203
HSPA8 heat shock 70kDa protein 8 0.0142014
DPY19L1 dpy-19-like 1 (C. elegans) 0.0141823
MYEF2 myelin expression factor 2 0.0140642
HBP1 HMG-box transcription factor 1 0.0140409
CNN3 calponin 3, acidic 0.0139208
CKAP5 cytoskeleton associated protein 5 0.0137531
MAP1B microtubule-associated protein 1B 0.0136696
KIAA1549 KIAA1549 0.0136558
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0135904
TFRC transferrin receptor 0.0135091
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.013506
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0133849
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0133511
SP3 Sp3 transcription factor 0.0131588
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0131262
CBFB core-binding factor, beta subunit 0.0131227
ZC3H14 zinc finger CCCH-type containing 14 0.013103
PBX3 pre-B-cell leukemia homeobox 3 0.0130885
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0130608
DROSHA drosha, ribonuclease type III 0.0129733
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0126207
USP9X ubiquitin specific peptidase 9, X-linked 0.012606
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.0126029
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0125538
RUFY1 RUN and FYVE domain containing 1 0.012501
XRN1 5'-3' exoribonuclease 1 0.0124741
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0124485
RPS18 ribosomal protein S18 0.0124324
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0124055
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0123746
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0123665
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.012363
CDKN3 cyclin-dependent kinase inhibitor 3 0.0123351
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0122327
HEATR1 HEAT repeat containing 1 0.012065
BLTP1 bridge-like lipid transfer protein family member 1 0.0120524
TLK2 tousled-like kinase 2 0.0120175
ADAM17 ADAM metallopeptidase domain 17 0.0120117
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.0119909
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0119601
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0119456
THBS1 thrombospondin 1 0.0118873
PRELID2 PRELI domain containing 2 0.0118208
CNTRL centriolin 0.0116985
KIF5B kinesin family member 5B 0.0116809
FAM219A family with sequence similarity 219, member A 0.0116525

decreased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript -0.301779
VIM vimentin -0.224746
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184784
RPLP1 ribosomal protein, large, P1 -0.0996419
MT2A metallothionein 2A -0.0843575
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0776901
SOX4 SRY (sex determining region Y)-box 4 -0.0772259
LDHA lactate dehydrogenase A -0.071257
RPS6 ribosomal protein S6 -0.0706308
RPS8 ribosomal protein S8 -0.0667039
PKM pyruvate kinase, muscle -0.0644776
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0577089
CADM2 cell adhesion molecule 2 -0.0545438
FTL ferritin, light polypeptide -0.0539681
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0509291
IER3 immediate early response 3 -0.0505156
RPS23 ribosomal protein S23 -0.0497392
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0494452
DEK DEK proto-oncogene -0.0464111
RPL35A ribosomal protein L35a -0.0458736
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0457769
ATP5F1B ATP synthase F1 subunit beta -0.0455064
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0451833
RPS19 ribosomal protein S19 -0.0442927
RPL7 ribosomal protein L7 -0.0431489
ACTG1 actin gamma 1 -0.0412036
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0407866
EGR1 early growth response 1 -0.0406953
RPL34 ribosomal protein L34 -0.0406724
HMGA1 high mobility group AT-hook 1 -0.0399016
TMSB10 thymosin beta 10 -0.0394602
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0390422
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0381072
RPLP0 ribosomal protein, large, P0 -0.0364926
RACK1 receptor for activated C kinase 1 -0.0362417
B2M beta-2-microglobulin -0.0358905
KMT2E lysine (K)-specific methyltransferase 2E -0.0357048
EEF2 eukaryotic translation elongation factor 2 -0.035533
WAC WW domain containing adaptor with coiled-coil -0.034282
FTH1 ferritin, heavy polypeptide 1 -0.0340716
VCL vinculin -0.0339625
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.033666
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0334128
TIMP1 TIMP metallopeptidase inhibitor 1 -0.033378
RPL23 ribosomal protein L23 -0.0330165
RPL36 ribosomal protein L36 -0.0329521
POTEF POTE ankyrin domain family, member F -0.0324854
RPLP2 ribosomal protein, large, P2 -0.0324065
NFIB nuclear factor I/B -0.0313047
SMC4 structural maintenance of chromosomes 4 -0.0311163
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0310231
ENO1 enolase 1, (alpha) -0.0307485
DDIT4 DNA-damage-inducible transcript 4 -0.0293224
RPS13 ribosomal protein S13 -0.0290893
RPS29 ribosomal protein S29 -0.0289153
BPTF bromodomain PHD finger transcription factor -0.0283389
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0280034
FNIP1 folliculin interacting protein 1 -0.0277813
PRKG1 protein kinase, cGMP-dependent, type I -0.0273447
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0271464
S100A9 S100 calcium binding protein A9 -0.0267433
PDIA3 protein disulfide isomerase family A, member 3 -0.026463
RPL18 ribosomal protein L18 -0.0261069
PEG10 paternally expressed 10 -0.0259051
SEPTIN7 septin 7 -0.0258136
HMGB1 high mobility group box 1 -0.0256349
RPL11 ribosomal protein L11 -0.0255188
RAB7A RAB7A, member RAS oncogene family -0.025448
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0253723
ARID4B AT rich interactive domain 4B (RBP1-like) -0.025249
FAM162A family with sequence similarity 162, member A -0.0247712
BRD4 bromodomain containing 4 -0.0241607
BCOR BCL6 corepressor -0.024114
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0239183
RPL28 ribosomal protein L28 -0.0232954
RPL12 ribosomal protein L12 -0.0232838
PCBP2 poly(rC) binding protein 2 -0.0229902
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0229486
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0229376
RPS20 ribosomal protein S20 -0.0228438
FNDC3B fibronectin type III domain containing 3B -0.0228114
RPL37A ribosomal protein L37a -0.0227488
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0227302
PHIP pleckstrin homology domain interacting protein -0.0227094
LOC102724023 ES1 protein homolog, mitochondrial -0.0226295
OPTN optineurin -0.0225847
RPS5 ribosomal protein S5 -0.022483
RPL5 ribosomal protein L5 -0.0224555
EZR ezrin -0.0224288
GPC6 glypican 6 -0.0224242
VEGFA vascular endothelial growth factor A -0.0223278
TAPBP TAP binding protein (tapasin) -0.0222094
COL5A2 collagen, type V, alpha 2 -0.0219481
CENPF centromere protein F, 350/400kDa -0.0217254
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0216228
EIF1 eukaryotic translation initiation factor 1 -0.0216038
NFIA nuclear factor I/A -0.0215725
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0215314
PRRC2C proline-rich coiled-coil 2C -0.0214539
AFF4 AF4/FMR2 family, member 4 -0.0213284